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1. 发明申请

WO2007035666A2 ELECTROKINETIC INFUSION PUMP SYSTEM 审中-公开
标题翻译：电动注入泵系统
公开(公告)号：WO2007035666A2
公开(公告)日：2007-03-29
申请号：PCT/US2006/036340
申请日：2006-09-18
申请人： LIFESCAN, INC. , KRULEVITCH, Peter , BENETT, William , ROBERTS, Neil, E. , BOHM, Sebastian , SIEH, Zara
发明人： KRULEVITCH, Peter , BENETT, William , ROBERTS, Neil, E. , BOHM, Sebastian , SIEH, Zara
IPC分类号： A61M1/00
CPC分类号： A61M5/14244 , A61M5/14248 , A61M5/1452 , A61M5/16831 , A61M5/172 , A61M2005/14513 , A61M2205/3317 , A61M2205/3389
摘要： Various methods and devices are provided for delivering an infusion liquid using an electrokinetic infusion pump. The electrokinetic infusion pump can generally include an infusion housing having an infusion reservoir. The infusion reservoir has an infusion outlet and is capable of containing an infusion liquid. A plunger is movably coupled to the infusion housing and is adapted to be manually displaced relative to the infusion housing to load the infusion reservoir with infusion liquid. A movable partition can be disposed within the infusion housing and has a first surface in communication with an electrokinetic solution and a second surface, isolated from the first surface, in communication with the infusion reservoir. The electrokinetic infusion pump can further include an electrokinetic engine integrated within the plunger and adapted to selectively deliver electric potential across an electrokinetic porous media to cause the electrokinetic solution within the electrokinetic engine to displace the movable partition to effect delivery of at least a portion of the infusion liquid through the infusion outlet.
摘要翻译：提供了使用电动输液泵输送输液的各种方法和装置。电动输液泵通常可以包括具有输液容器的输液壳体。输液容器具有输液出口并且能够容纳输注液体。柱塞可移动地联接到输液壳体并适于相对于输液壳体手动移位以将输液储液器装载输液。可移动分隔件可以设置在输液壳体内并且具有与电动溶液连通的第一表面和与输液储存器连通的与第一表面隔开的第二表面。电动输液泵可以进一步包括集成在柱塞内的电动发动机，并且适于在电动多孔介质上选择性地递送电势，以使电动力发动机内的电动力溶液移位可动分隔物以实现至少一部分输液通过输液出口。

2. 发明申请

WO2010009382A2 ANALYTE MEASUREMENT AND MANAGEMENT DEVICE AND ASSOCIATED METHODS 审中-公开
标题翻译：分析测量和管理设备及相关方法
公开(公告)号：WO2010009382A2
公开(公告)日：2010-01-21
申请号：PCT/US2009/050971
申请日：2009-07-17
申请人： LIFESCAN, INC. , SIEH, Zara , HORWITZ, David , PRICE, David , KRULEVITCH, Peter , SAVAGE, Donna , SHARTLE, Robert
发明人： SIEH, Zara , HORWITZ, David , PRICE, David , KRULEVITCH, Peter , SAVAGE, Donna , SHARTLE, Robert
IPC分类号： A61B5/00 , G06F3/048 , H04L9/32 , G08B1/08 , G06F15/16 , G06N5/02
CPC分类号： A61B5/4839 , A61B5/14532 , G06F19/00 , G06F19/3418 , G06F19/3468 , G16H40/63
摘要： Various embodiments of a diabetes management system are provided. One exemplary system may include an analyte measurement device and a therapeutic agent delivery device. The measurement device includes a measurement unit, display, and first wireless module. The therapeutic agent delivery device has a delivery device housing, delivery mechanism disposed in the housing that delivers a dosage of the agent to the user upon actuation by the user or health care provider, and a second wireless module. The second module, automatically, without prompting from a user or any active input or action by the user, transmits a signal to the first wireless module indicative of: (a) type of therapeutic agent delivered; and (b) amount of therapeutic agent delivered to the user; or (c) type of therapeutic agent device from which the therapeutic agent was administered. Also described are diabetes management devices and methods.
摘要翻译：提供了糖尿病管理系统的各种实施例。一个示例性系统可以包括分析物测量装置和治疗剂递送装置。测量装置包括测量单元，显示器和第一无线模块。治疗剂递送装置具有输送装置壳体，设置在壳体中的输送机构，其在用户或医疗保健提供者致动时将剂量的剂量递送给使用者，以及第二无线模块。自动地，第二模块在不提示用户或用户的任何有效输入或动作的情况下，向第一无线模块发送指示：（a）递送的治疗剂的类型; 和（b）递送给使用者的治疗剂量; 或（c）施用治疗剂的治疗剂装置的类型。还描述了糖尿病管理装置和方法。

3. 发明申请

WO2010098931A1 DRUG DELIVERY MANAGEMENT SYSTEMS AND METHODS 审中-公开
标题翻译：药物递送管理系统和方法
公开(公告)号：WO2010098931A1
公开(公告)日：2010-09-02
申请号：PCT/US2010/022245
申请日：2010-01-27
申请人： LIFESCAN, INC. , KRULEVITCH, Peter , WILK, Robert , KRAFT, Ulrich , SIEH, Zara , ZHAO, Mitch
发明人： KRULEVITCH, Peter , WILK, Robert , KRAFT, Ulrich , SIEH, Zara , ZHAO, Mitch
IPC分类号： A61M5/00
CPC分类号： A61M5/315 , A61B5/002 , A61B5/14532 , A61M5/24 , A61M5/3129 , A61M5/3146 , A61M5/31525 , A61M5/31551 , A61M2005/3126 , A61M2005/3142 , A61M2205/14 , A61M2205/18 , A61M2205/215 , A61M2205/3317 , A61M2205/3553 , A61M2205/3561 , A61M2205/3569 , A61M2205/3584 , A61M2205/3592 , A61M2205/52 , A61M2205/581 , A61M2205/583 , A61M2205/584 , A61M2205/6054 , A61M2205/6081 , A61M2205/8212 , A61M2209/04 , G01D5/1655 , G06F19/00 , G06F19/3468
摘要： Various embodiments of a "smart" drug delivery pen are provided which include a drug delivery pen having an inertial sensor or accelerometer. A system is also provided that includes the smart drug pen in conjunction with a data management unit(s) DMU. Various exemplary methods for use of the pens and systems are also described and illustrated.
摘要翻译：提供了一种“智能”药物递送笔的各种实施例，其包括具有惯性传感器或加速度计的药物输送笔。还提供了一种系统，其包括结合数据管理单元DMU的智能药笔。还描述和示出了用于笔和系统的各种示例性方法。

4. 发明申请

WO2010098928A1 DRUG DELIVERY SYSTEM 审中-公开
标题翻译：药物递送系统
公开(公告)号：WO2010098928A1
公开(公告)日：2010-09-02
申请号：PCT/US2010/022241
申请日：2010-01-27
申请人： LIFESCAN, INC. , KRULEVITCH, Peter , WILK, Robert , KRAFT, Ulrich , SAVAGE, Donna , FOLEY, Nick , GLENCROSS, James , SHEPHERD, David , SIEH, Zara
发明人： KRULEVITCH, Peter , WILK, Robert , KRAFT, Ulrich , SAVAGE, Donna , FOLEY, Nick , GLENCROSS, James , SHEPHERD, David , SIEH, Zara
IPC分类号： A61M5/315
CPC分类号： A61M5/315 , A61B5/002 , A61B5/14532 , A61M5/24 , A61M5/3129 , A61M5/3146 , A61M5/31525 , A61M5/31551 , A61M2005/3126 , A61M2005/3142 , A61M2205/14 , A61M2205/18 , A61M2205/215 , A61M2205/3317 , A61M2205/3553 , A61M2205/3561 , A61M2205/3569 , A61M2205/3584 , A61M2205/3592 , A61M2205/52 , A61M2205/581 , A61M2205/583 , A61M2205/584 , A61M2205/6054 , A61M2205/6081 , A61M2205/8212 , A61M2209/04 , G01D5/1655 , G06F19/00 , G06F19/3468
摘要： Various embodiments of a "smart" drug delivery system are provided which includes an add-on module and a reusable or disposable drug pen. Upon attachment to the pen, the add-on module may: determine dosage selected, injection of selected dosage, duration of injection, time of injection, whether the pen has been primed or shaken to thoroughly mix up insulin mixtures, transmit information relating to insulin dosage and injection to a data management unit, provide reminders, error warning or messages on improper usage or reusage of needles, track amount of drug remaining on board the pen or duration of usage of pen with respect to expiry of the drug on board, or provide an audible alarm for locating misplaced pen and module.
摘要翻译：提供了“智能”药物递送系统的各种实施例，其包括附加模块和可重复使用或一次性药物笔。附加模块可以：确定所选择的剂量，所选剂量的注射，注射持续时间，注射时间，笔是否被引发或摇动以充分混合胰岛素混合物，传输与胰岛素相关的信息剂量和注射到数据管理单元，提供提醒，错误警告或关于不正确使用或重复使用针头的信息，轨道上留下的药物量或笔的使用持续时间，以及在药物到期时的使用时间，或提供用于定位放错的笔和模块的声音报警器。

5. 发明申请

WO2008157212A1 FLEXIBLE CANNULA OR MEDICAL DEVICE CONDUIT 审中-公开
标题翻译：柔性肛门或医疗器械导管
公开(公告)号：WO2008157212A1
公开(公告)日：2008-12-24
申请号：PCT/US2008/066667
申请日：2008-06-12
申请人： LIFESCAN, INC. , CORDIS CORPORATION , KRULEVITCH, Peter , OLSON, Lorin, P. , SIEH, Zara , SAVAGE, Donna , CICHOCKI, Frank, R.
发明人： KRULEVITCH, Peter , OLSON, Lorin, P. , SIEH, Zara , SAVAGE, Donna , CICHOCKI, Frank, R.
IPC分类号： A61M5/158 , A61M5/32 , A61M25/00
CPC分类号： A61M5/158 , A61M5/3275 , A61M5/329 , A61M25/0009 , A61M25/0068 , A61M25/007 , A61M2005/1585 , A61M2005/1587 , A61M2205/0266
摘要： A flexible cannula of medical device conduit (1300) includes an elongated framework (1302) formed from a flexible material (e.g., Nitinol) with a body portion, sharp head (1310), distal end ans proximal end. The flexible medical device conduit also includes a flexible tube (1314) at least partially jacketing the elongated framework between the distal end and the proximal end. Moreover, the sharp head is disposed at the distal end and is configured for subcutaneous skin insertion and the elongated framework and flexible tube define at least one conduit (1315) between the elongated framework and the flexible tube, the conduit having an opening at the distal end.
摘要翻译：医疗器械导管（1300）的柔性套管包括由柔性材料（例如镍钛诺）形成的细长骨架（1302），其具有主体部分，尖头（1310），远端和近端。柔性医疗装置导管还包括柔性管（1314），该柔性管至少部分地将细长骨架夹在远端和近端之间。此外，尖头设置在远端并且构造成用于皮下皮肤插入，并且细长骨架和柔性管限定细长框架和柔性管之间的至少一个导管（1315），所述导管在远端处具有开口结束。

6. 发明申请

WO2010098929A1 DRUG DELIVERY MANAGEMENT SYSTEMS AND METHODS 审中-公开
标题翻译：药物递送管理系统和方法
公开(公告)号：WO2010098929A1
公开(公告)日：2010-09-02
申请号：PCT/US2010/022242
申请日：2010-01-27
申请人： LIFESCAN, INC. , KRULEVITCH, Peter , WILK, Robert , KRAFT, Ulrich , SAVAGE, Donna , FOLEY, Nick , GLENCROSS, James , SHEPHERD, David , SIEH, Zara , PRICE, David, M., D.
发明人： KRULEVITCH, Peter , WILK, Robert , KRAFT, Ulrich , SAVAGE, Donna , FOLEY, Nick , GLENCROSS, James , SHEPHERD, David , SIEH, Zara , PRICE, David, M., D.
IPC分类号： A61B5/00 , A61K38/28
CPC分类号： A61M5/315 , A61B5/002 , A61B5/14532 , A61M5/24 , A61M5/3129 , A61M5/3146 , A61M5/31525 , A61M5/31551 , A61M2005/3126 , A61M2005/3142 , A61M2205/14 , A61M2205/18 , A61M2205/215 , A61M2205/3317 , A61M2205/3553 , A61M2205/3561 , A61M2205/3569 , A61M2205/3584 , A61M2205/3592 , A61M2205/52 , A61M2205/581 , A61M2205/583 , A61M2205/584 , A61M2205/6054 , A61M2205/6081 , A61M2205/8212 , A61M2209/04 , G01D5/1655 , G06F19/00 , G06F19/3468
摘要： Various embodiments of a "smart" drug delivery system are provided which includes an add-on module and a reusable or disposable drug pen in conjunction with a data management unit(s) DMU. Upon attachment to the pen, the add-on module may: determine dosage selected, injection of selected dosage, duration of injection, time of injection, whether the pen has been primed or shaken to thoroughly mix up insulin mixtures, transmit information relating to insulin dosage and injection to a data management unit, provide reminders, error warning or messages on improper usage or reusage of needles, track amount of drug remaining on board the pen or duration of usage of pen with respect to expiry of the drug on board, or provide an audible alarm for locating misplaced pen and module. Methods of using the drug delivery system are also described.
摘要翻译：提供了“智能”药物递送系统的各种实施例，其包括与数据管理单元DMU结合的附加模块和可重复使用或一次性药物笔。附加模块可以：确定所选择的剂量，所选剂量的注射，注射持续时间，注射时间，笔是否被引发或摇动以充分混合胰岛素混合物，传输与胰岛素相关的信息剂量和注射到数据管理单元，提供提醒，错误警告或关于不正确使用或重复使用针头的信息，轨道上留下的药物量或笔的使用持续时间，以及在药物到期时的使用时间，或提供用于定位放错的笔和模块的声音报警器。还描述了使用药物递送系统的方法。

7. 发明申请

WO2010098927A1 MEDICAL MODULE FOR DRUG DELIVERY PEN 审中-公开
标题翻译：药物输送笔的医疗模块
公开(公告)号：WO2010098927A1
公开(公告)日：2010-09-02
申请号：PCT/US2010/022236
申请日：2010-01-27
申请人： LIFESCAN, INC. , KRULEVITCH, Peter , WILK, Robert , KRAFT, Ulrich , SAVAGE, Donna , FOLEY, Nick , GLENCROSS, James , SHEPHERD, David , SIEH, Zara
发明人： KRULEVITCH, Peter , WILK, Robert , KRAFT, Ulrich , SAVAGE, Donna , FOLEY, Nick , GLENCROSS, James , SHEPHERD, David , SIEH, Zara
IPC分类号： A61M5/315
CPC分类号： A61M5/315 , A61B5/002 , A61B5/14532 , A61M5/24 , A61M5/3129 , A61M5/3146 , A61M5/31525 , A61M5/31551 , A61M2005/3126 , A61M2005/3142 , A61M2205/14 , A61M2205/18 , A61M2205/215 , A61M2205/3317 , A61M2205/3553 , A61M2205/3561 , A61M2205/3569 , A61M2205/3584 , A61M2205/3592 , A61M2205/52 , A61M2205/581 , A61M2205/583 , A61M2205/584 , A61M2205/6054 , A61M2205/6081 , A61M2205/8212 , A61M2209/04 , G01D5/1655 , G06F19/00 , G06F19/3468
摘要： Various embodiments of a medical module are provided which includes a primary module housing, a secondary module housing, a dosage sensor, a power source, and a microcontroller. The module is configured to be attached to a disposable drug delivery pen or a reusable drug delivery pen so that the module may: determine dosage selected, injection of selected dosage, duration of injection, time of injection, whether the pen has been primed or shaken to thoroughly mix up insulin mixtures, transmit information relating to insulin dosage and injection to a data management unit, provide reminders, error warning or messages on improper usage or reusage of needles, track amount of drug remaining on board the pen or duration of usage of pen with respect to expiry of the drug on board, or provide an audible alarm for locating misplaced pen and module.
摘要翻译：提供了包括主模块外壳，次模块外壳，剂量传感器，电源和微控制器的医疗模块的各种实施例。模块被配置为附接到一次性药物输送笔或可重复使用的药物递送笔，使得模块可以：确定所选择的剂量，所选剂量的注射，注射持续时间，注射时间，是否已经被注射或摇动彻底混合胰岛素混合物，将与胰岛素剂量和注射相关的信息传输到数据管理单元，提供提醒，错误警告或关于不当使用或重复使用针头的消息，跟踪笔上留下的药物的量或使用持续时间关于药物到期的笔，或提供用于定位放错的笔和模块的声音报警器。

8. 发明申请

WO2009137661A1 ANALYTE MEASUREMENT AND MANAGEMENT DEVICE AND ASSOCIATED METHODS 审中-公开
标题翻译：分析测量和管理设备及相关方法
公开(公告)号：WO2009137661A1
公开(公告)日：2009-11-12
申请号：PCT/US2009/043125
申请日：2009-05-07
申请人： LIFESCAN, INC. , SIEH, Zara , HORWITZ, David , PRICE, David , KRULEVITCH, Peter , SAVAGE, Donna , SHARLTE, Robert
发明人： SIEH, Zara , HORWITZ, David , PRICE, David , KRULEVITCH, Peter , SAVAGE, Donna , SHARLTE, Robert
IPC分类号： A61B5/00 , A61M5/172
CPC分类号： A61B5/4839 , A61B5/14532 , A61M5/14244 , A61M5/1723 , A61M2005/14208 , G06F19/00
摘要： A method for measuring and managing an analyte (e.g., blood glucose) in a bodily fluid includes storing a therapeutic administration protocol in a memory module of an analyte measurement and management device and measuring the analyte in the bodily fluid sample using an analyte measurement module of the device. The method also includes calculating, with a processor module of the device, a recommended therapeutic agent dosage (for example, an insulin dosage) and a recommended administration time for user-activated delivery of the dosage by employing the therapeutic administration protocol. The method further includes displaying the recommended therapeutic agent dosage and administration time to a user on a visual display of the device, delivering a therapeutic agent dosage to the user via a user-activated therapeutic agent delivery device, and detecting the user-activated administration of the therapeutic agent using a delivery device communication module of the device. In addition, the method includes communicating the aforementioned detection to the processor module and/or memory module using the delivery device communication module. The method employs analyte measurement, memory, processor, and delivery device modules, as well as a visual display, and user interface that are integrated as a single hand-held unit.
摘要翻译：用于测量和管理体液中的分析物（例如，血糖）的方法包括将分析物测量和管理装置的存储器模块中的治疗性给药方案存储在体液样品中，并使用分析物测量模块装置。该方法还包括利用该设备的处理器模块，通过使用治疗性给药方案来计算推荐的治疗剂剂量（例如，胰岛素剂量）和用户激活的剂量递送的推荐给药时间。该方法还包括在设备的视觉显示上向用户显示推荐的治疗剂剂量和给药时间，经由用户激活的治疗剂递送装置向用户递送治疗剂剂量，以及检测用户激活的给药时间所述治疗剂使用所述装置的递送装置通信模块。此外，该方法包括使用传送设备通信模块将上述检测传送到处理器模块和/或存储器模块。该方法采用分析物测量，存储器，处理器和传送设备模块，以及作为单个手持单元集成的可视显示器和用户界面。

9. 发明申请

WO2007035563A3 MALFUNCTION DETECTION VIA PRESSURE PULSATION 审中-公开
公开(公告)号：WO2007035563A3
公开(公告)日：2007-03-29
申请号：PCT/US2006/036164
申请日：2006-09-18
申请人： LIFESCAN, INC. , KRULEVITCH, Peter , BOHM, Sebastian , ZHAO, Mingqi , ANEX, Deon
发明人： KRULEVITCH, Peter , BOHM, Sebastian , ZHAO, Mingqi , ANEX, Deon
IPC分类号： B01D57/02
摘要： Systems and methods of detecting occlusions and fluid-loss conditions (e.g., disconnects and/or leakages) in an infusion pump are discussed. For example, electrokinetic infusion pumps may develop an occlusion in the fluid flow path, which can disrupt control of fluid dispersed from the pump. As well, an infusion set disconnect can also result in a fluid-loss that can be disruptive. Such disruptions can be troublesome to systems that control the infusion pump, such as closed loop controllers. Accordingly, systems and methods described herein can be used to detect such occlusions and fluid-loss conditions during infusion pump operation. For example, a position sensor can be used to monitor fluid flow from the infusion pump, with the measurement being compared with an expected value to detect an occlusion or fluid-loss condition. Other algorithms for utilizing the position sensor are also described.

10. 发明申请

WO2007035564A2 MALFUNCTION DETECTION WITH DERIVATIVE CALCULATION 审中-公开
标题翻译：具有衍生计算的故障检测
公开(公告)号：WO2007035564A2
公开(公告)日：2007-03-29
申请号：PCT/US2006/036165
申请日：2006-09-18
申请人： LIFESCAN, INC. , KRULEVITCH, Peter , BOHM, Sebastian , ZHAO, Minggi , ANEX, Deon
发明人： KRULEVITCH, Peter , BOHM, Sebastian , ZHAO, Minggi , ANEX, Deon
IPC分类号： A61M1/00
CPC分类号： A61M5/14244 , A61M5/14248 , A61M5/1452 , A61M5/16831 , A61M5/172 , A61M2005/14513 , A61M2205/3317 , A61M2205/3389
摘要： Systems and methods of detecting occlusions and fluid-loss conditions (e.g., disconnects and/or leakages) in an infusion pump are discussed. For example, electrokinetic infusion pumps may develop an occlusion in the fluid flow path, which can disrupt control of fluid dispersed from the pump. As well, an infusion set disconnect can also result in a fluid-loss that can be disruptive. Such disruptions can be troublesome to systems that control the infusion pump, such as closed loop controllers. Accordingly, systems and methods described herein can be used to detect such occlusions and fluid-loss conditions during infusion pump operation. For example, a position sensor can be used to monitor fluid flow from the infusion pump, with the measurement being compared with an expected value to detect an occlusion or fluid-loss condition. Other algorithms for utilizing the position sensor are also described.
摘要翻译：讨论了检测输液泵中的闭塞和流体损失状况（例如断开和/或泄漏）的系统和方法。例如，电动输液泵可能在流体流动路径中产生闭塞，这可能破坏从泵分散的流体的控制。同样，输液器断开也可能导致流体损失，这可能是破坏性的。对于控制输液泵的系统，例如闭环控制器，这种中断可能是麻烦的。因此，本文所述的系统和方法可用于在输注泵操作期间检测这种闭塞和流体损失状况。例如，位置传感器可用于监测来自输注泵的流体流动，其中测量值与预期值进行比较以检测堵塞或流体损失状况。还描述了用于利用位置传感器的其它算法。

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