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1. 发明专利

JP2010048812A Nanocrystals 有权
标题翻译：纳米晶体
公开(公告)号：JP2010048812A
公开(公告)日：2010-03-04
申请号：JP2009239956
申请日：2009-10-19
申请人： Life Technologies Corp , ライフテクノロジーズコーポレーション
发明人： NAASANI IMAD
IPC分类号： G01N21/78 , G01N33/543 , B82B1/00 , C01B19/04 , C09K11/08 , G01N33/58
CPC分类号： B82Y15/00 , G01N33/588 , Y10T428/25 , Y10T428/2991 , Y10T428/2993 , Y10T428/2998 , Y10T428/31721
摘要： PROBLEM TO BE SOLVED: To provide a new compositional compound having nanocrystals provided with functional and higher fluorescence property. SOLUTION: Compositions of functionalized, fluorescent nanocrystals have fluorescent nanocrystals coated with an imidazole-containing compound, composition of functionalized, fluorescent nanocrystals having fluorescent nanocrystals coated with the imidazole-containing compound and cross-linked with a phosphine cross-linking compound, composition of functionalized, fluorescent nanocrystals having effective chemical bond with molecular probe, a process to produce the functionalized, fluorescent nanocrystals, and a process to utilize the functionalized, fluorescent nanocrystals in a detecting device. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供具有功能和更高荧光特性的具有纳米晶体的新的组成化合物。官能化的荧光纳米晶体的组合物具有用含咪唑的化合物涂覆的荧光纳米晶体，具有涂覆有含咪唑的化合物并与膦交联化合物交联的荧光纳米晶体的官能化的荧光纳米晶体的组合物，具有与分子探针有效化学键的官能化荧光纳米晶体的组成，产生官能化荧光纳米晶体的方法，以及在检测装置中利用官能化的荧光纳米晶体的方法。版权所有（C）2010，JPO＆INPIT

2. 发明申请

WO2010040111A3 SULFONATE MODIFIED NANOCRYSTALS 审中-公开
标题翻译：磺酸盐改性纳米晶体
公开(公告)号：WO2010040111A3
公开(公告)日：2010-07-15
申请号：PCT/US2009059456
申请日：2009-10-02
申请人： LIFE TECHNOLOGIES CORP , TULSKY ERIC , WELCH ERIC , BRANCHAUD BRUCE , MAURO JOHN , NAASANI IMAD
发明人： TULSKY ERIC , WELCH ERIC , BRANCHAUD BRUCE , MAURO JOHN , NAASANI IMAD
IPC分类号： B82B1/00 , B82B3/00
CPC分类号： B82Y30/00 , B01J13/22 , B82Y40/00 , C09B68/42 , C09B68/4257 , C09B68/44 , C09B68/441 , C09B68/443 , C09K11/025
摘要： A nanoparticle having one or more phosphonates or phosphinate ligands on their surface can be converted into nanoparticles with sulfonate ligands on their surface, by contacting the phosphonate-containing nanoparticles with a silylsulfonate reagent. Such nanoparticles are activated toward reactions with nucleophilic groups; thus the method provides activated nanoparticles, and methods of making and using them to produce modified nanoparticles.
摘要翻译：通过使含膦酸盐的纳米粒子与甲硅烷基磺酸盐试剂接触，可以在其表面上具有一个或多个膦酸盐或次膦酸盐配体的纳米粒子转化成在其表面上具有磺酸盐配体的纳米粒子。这种纳米颗粒被激活以与亲核基团反应; 因此该方法提供活化的纳米粒子，以及制造和使用它们来制造改性纳米粒子的方法。

3. 发明申请

WO2010111691A3 CONJUGATES OF BIOMOLECULES TO NANOPARTICLES 审中-公开
标题翻译：生物分子与纳米颗粒的缀合物
公开(公告)号：WO2010111691A3
公开(公告)日：2011-03-31
申请号：PCT/US2010028974
申请日：2010-03-26
申请人： LIFE TECHNOLOGIES CORP , NIKIFOROV THEO , MAZUR DANIEL , PEDG XINZHAN , LINCECUM TOMMIE , BELOSLUDTSEV YURI , REESE HOWARD , GREMYACHINSKIY DMITRIY , ROZHKOV ROMAN , MAURO JOHN , BEECHEM JOSEPH , TULSKY ERIC , NAASANI IMAD , HALEY KARI , TREADWAY JOSEPH
发明人： NIKIFOROV THEO , MAZUR DANIEL , PEDG XINZHAN , LINCECUM TOMMIE , BELOSLUDTSEV YURI , REESE HOWARD , GREMYACHINSKIY DMITRIY , ROZHKOV ROMAN , MAURO JOHN , BEECHEM JOSEPH , TULSKY ERIC , NAASANI IMAD , HALEY KARI , TREADWAY JOSEPH
IPC分类号： C12Q1/48 , C12Q1/68 , G01N33/52 , G01N33/573
CPC分类号： C12N9/96 , C07H19/20 , C12N9/1241 , C12N9/1252 , C12Q1/6818 , C12Q1/6869 , C12Y207/07 , C12Y207/07007 , G01N21/6428 , G01N33/582 , G01N2021/6432
摘要： Disclosed herein are conjugates comprising a biomolecule linked to a label that have biological activity and are useful in a wide variety of biological applications. For example, provided herein are polymerase-nanoparticle conjugates including a polymerase linked to a nanoparticle, wherein the conjugate has polymerase activity. Such conjugates can exhibit reduced aggregation and improved stochiometries wherein the average biomolecule: nanoparticle ratio approaches or equals 1 :1. Also disclosed herein are improved methods for preparing such conjugates, and methods and systems for using such conjugates in biological applications such as nucleotide incorporation, primer extension and single molecule sequencing.
摘要翻译：本文公开了包含与标签连接的生物分子的缀合物，所述生物分子具有生物活性并且可用于各种生物应用。例如，本文提供了聚合酶 - 纳米颗粒缀合物，其包括连接至纳米颗粒的聚合酶，其中缀合物具有聚合酶活性。这种缀合物可表现出降低的聚集和改进的化学计量学，其中平均生物分子：纳米颗粒比例接近或等于1：1。本文还公开了用于制备这种缀合物的改进方法，以及在生物应用中使用这种缀合物的方法和系统，所述生物应用例如核苷酸掺入，引物延伸和单分子测序。

4. 发明申请

WO2010111691A9 CONJUGATES OF BIOMOLECULES TO NANOPARTICLES 审中-公开
标题翻译：生物分子与纳米颗粒的结合
公开(公告)号：WO2010111691A9
公开(公告)日：2011-01-06
申请号：PCT/US2010028974
申请日：2010-03-26
申请人： LIFE TECHNOLOGIES CORP , NIKIFOROV THEO , MAZUR DANIEL , PEDG XINZHAN , LINCECUM TOMMIE , BELOSLUDTSEV YURI , REESE HOWARD , GREMYACHINSKIY DMITRIY , ROZHKOV ROMAN , MAURO JOHN , BEECHEM JOSEPH , TULSKY ERIC , NAASANI IMAD , HALEY KARI , TREADWAY JOSEPH
发明人： NIKIFOROV THEO , MAZUR DANIEL , PEDG XINZHAN , LINCECUM TOMMIE , BELOSLUDTSEV YURI , REESE HOWARD , GREMYACHINSKIY DMITRIY , ROZHKOV ROMAN , MAURO JOHN , BEECHEM JOSEPH , TULSKY ERIC , NAASANI IMAD , HALEY KARI , TREADWAY JOSEPH
IPC分类号： C12Q1/48 , C12Q1/68 , G01N33/52 , G01N33/573
CPC分类号： C12N9/96 , C07H19/20 , C12N9/1241 , C12N9/1252 , C12Q1/6818 , C12Q1/6869 , C12Y207/07 , C12Y207/07007 , G01N21/6428 , G01N33/582 , G01N2021/6432
摘要： Disclosed herein are conjugates comprising a biomolecule linked to a label that have biological activity and are useful in a wide variety of biological applications. For example, provided herein are polymerase-nanoparticle conjugates including a polymerase linked to a nanoparticle, wherein the conjugate has polymerase activity. Such conjugates can exhibit reduced aggregation and improved stochiometries wherein the average biomolecule: nanoparticle ratio approaches or equals 1 :1. Also disclosed herein are improved methods for preparing such conjugates, and methods and systems for using such conjugates in biological applications such as nucleotide incorporation, primer extension and single molecule sequencing.
摘要翻译：本文公开了包含连接到具有生物活性并可用于多种生物应用的标签的生物分子的缀合物。例如，本文提供了聚合酶 - 纳米颗粒缀合物，其包括与纳米颗粒连接的聚合酶，其中缀合物具有聚合酶活性。这样的缀合物可以表现出减少的聚集和改进的沉淀物，其中平均生物分子：纳米颗粒比接近或等于1:1。本文还公开了制备这种缀合物的改进方法，以及在生物应用中使用这种缀合物的方法和系统，例如核苷酸掺入，引物延伸和单分子测序。

5. 发明专利

AT556126T 未知
公开(公告)号：AT556126T
公开(公告)日：2012-05-15
申请号：AT05858281
申请日：2005-10-28
申请人： LIFE TECHNOLOGIES CORP
发明人： NAASANI IMAD
IPC分类号： C09K11/54 , G01N33/58
摘要： Functionalized fluorescent nanocrystal compositions and methods for making and using these compositions are disclosed. The compositions are fluorescent nanocrystals coated with at least one material. The coating material has chemical compounds or ligands with functional groups or moieties with conjugated electrons and moieties for imparting solubility to coated fluorescent nanocrystals in aqueous solutions. The coating material provides for functionalized fluorescent nanocrystal compositions which are water soluble, chemically stable, and emit light with a high quantum yield and/or luminescence efficiency when excited with light. The coating material may also have chemical compounds or ligands with moieties for bonding to target molecules and cells as well as moieties for cross-linking the coating. In the presence of reagents suitable for reacting to form capping layers, the compounds in the coating may form a capping layer on the fluorescent nanocrystal with the coating compounds operably bonded to the capping layer.

6. 发明专利

AT448077T 未知
公开(公告)号：AT448077T
公开(公告)日：2009-11-15
申请号：AT02803277
申请日：2002-09-17
申请人： LIFE TECHNOLOGIES CORP
发明人： NAASANI IMAD
IPC分类号： B32B9/00 , G01N33/543 , B82B1/00 , C01B19/04 , C09K11/08 , G01N33/58
摘要： Provided herein are compositions of functionalized, fluorescent nanocrystals comprising fluorescent nanocrystals coated with an imidazole-containing compound; compositions of funcionalized, fluorescent nanocrystals comprising fluorescent nanocrystals coated with an imidazole-containing compound and cross-linked with a phosphine cross-linking compound; compositions of functionalized fluorescent nanocrystals operably bound to molecular probe; a process of making funcionalized, fluorescent nanocrystals; and a process of using funcionalized, fluorescent nanocrystals in a detection system.

7. 发明专利

DE60234382D1 未知
公开(公告)号：DE60234382D1
公开(公告)日：2009-12-24
申请号：DE60234382
申请日：2002-09-17
申请人： LIFE TECHNOLOGIES CORP
发明人： NAASANI IMAD
IPC分类号： B32B9/00 , G01N33/543 , B82B1/00 , C01B19/04 , C09K11/08 , G01N33/58
摘要： Provided herein are compositions of functionalized, fluorescent nanocrystals comprising fluorescent nanocrystals coated with an imidazole-containing compound; compositions of funcionalized, fluorescent nanocrystals comprising fluorescent nanocrystals coated with an imidazole-containing compound and cross-linked with a phosphine cross-linking compound; compositions of functionalized fluorescent nanocrystals operably bound to molecular probe; a process of making funcionalized, fluorescent nanocrystals; and a process of using funcionalized, fluorescent nanocrystals in a detection system.

8. 发明公开

EP2342161A4 SULFONATE MODIFIED NANOCRYSTALS 审中-公开
标题翻译： SULFONATMODIFIZIERTE NANOKRISTALLE
公开(公告)号：EP2342161A4
公开(公告)日：2012-11-07
申请号：EP09818600
申请日：2009-10-02
申请人： LIFE TECHNOLOGIES CORP
发明人： TULSKY ERIC , WELCH ERIC , BRANCHAUD BRUCE , MAURO JOHN , NAASANI IMAD
IPC分类号： B82B1/00 , B82B3/00 , C09K11/02
CPC分类号： B82Y30/00 , B01J13/22 , B82Y40/00 , C09B68/42 , C09B68/4257 , C09B68/44 , C09B68/441 , C09B68/443 , C09K11/025
摘要： A nanoparticle having one or more phosphonates or phosphinate ligands on their surface can be converted into nanoparticles with sulfonate ligands on their surface, by contacting the phosphonate-containing nanoparticles with a silylsulfonate reagent. Such nanoparticles are activated toward reactions with nucleophilic groups; thus the method provides activated nanoparticles, and methods of making and using them to produce modified nanoparticles.

9. 发明公开

EP2323947A4 WATER-DISPERSABLE NANOPARTICLES 失效转让
标题翻译： WASSERLÖSLICHENANOPARTIKEL
公开(公告)号：EP2323947A4
公开(公告)日：2015-03-11
申请号：EP09840552
申请日：2009-08-06
申请人： LIFE TECHNOLOGIES CORP
发明人： TULSKY ERIC , HALEY KARI , NAASANI IMAD , MAURO JOHN MATTHEW , ROZHKOV ROMAN , TREADWAY JOESEPH A
IPC分类号： B82B1/00 , B82B3/00
CPC分类号： G01N33/588 , B01J13/14 , B22F1/0022 , B22F1/02 , B82Y30/00 , G01N1/30 , G01N21/64 , G01N2001/302 , Y10S977/773 , Y10S977/81 , Y10S977/834 , Y10S977/902
摘要： Provided herein are methods for making water-soluble nanoparticles comprising a core/shell nanocrystal that is coated with a surface layer comprising enough hydrophilic ligands to render the nanoparticle water soluble or water dispersable. Methods for crosslinking molecules on the surface of a nanoparticle, which methods can be used on the above water-soluble nanoparticles also are provided. Nanoparticle compositions resulting from these methods are also provided.
摘要翻译：本文提供了制备包含核/壳纳米晶体的水溶性纳米颗粒的方法，其涂覆有包含足够的亲水配体的表面层，以使纳米颗粒水溶性或水分散。还提供了在纳米颗粒表面上交联分子的方法，该方法可用于上述水溶性纳米颗粒。还提供了由这些方法得到的纳米颗粒组合物。

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