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1. 发明申请

WO2012099557A3 FATTY ACID INHIBITORS 审中-公开
标题翻译：脂肪酸抑制剂
公开(公告)号：WO2012099557A3
公开(公告)日：2012-10-26
申请号：PCT/US2010055100
申请日：2010-11-02
申请人： COMPLEXA INC , BRANCHAUD BRUCE
发明人： BRANCHAUD BRUCE
IPC分类号： A61K31/185 , A61K31/336 , A61K31/337 , A61K31/70
CPC分类号： C07D303/48 , C07C57/03 , C07C205/55 , C07C2601/02 , C07D203/08 , C07D205/04 , C07D303/38 , C07D305/04 , C07D305/06 , C07D305/08 , C07D331/02 , C07D331/04
摘要： Fatty acid inhibitors, pharmaceutical compositions including fatty acid inhibitors, methods for using fatty acid inhibitors to treat a variety of diseases, and methods for preparing fatty acid inhibitors are provided herein.
摘要翻译：本文提供了脂肪酸抑制剂，包括脂肪酸抑制剂的药物组合物，使用脂肪酸抑制剂治疗各种疾病的方法以及制备脂肪酸抑制剂的方法。

2. 发明申请

WO2010039897A2 NANOCRYSTALS WITH FUNCTIONAL LIGANDS 审中-公开
标题翻译：具有功能配体的纳米晶体
公开(公告)号：WO2010039897A2
公开(公告)日：2010-04-08
申请号：PCT/US2009/059117
申请日：2009-09-30
申请人： LIFE TECHNOLOGIES CORPORATION , TULSKY, Eric , WELCH, Eric , BRANCHAUD, Bruce , ROZHKOV, Roman
发明人： TULSKY, Eric , WELCH, Eric , BRANCHAUD, Bruce , ROZHKOV, Roman
IPC分类号： B82B3/00 , B82B1/00
CPC分类号： C09K11/025 , C09K11/883 , Y10T428/2998
摘要： Coated fluorescent semiconductor nanoparticles having an organic surface layer of multi-functional surface ligands that include a nanocrystal binding center and one or more covalently attached functional groups or reactive functional groups are described as well as water-dispersible nanoparticles having an organic surface layer or multi-functional surface ligands and methods for the preparation and use of such coated nanoparticles.
摘要翻译：描述了具有包含纳米晶体结合中心和一个或多个共价连接的官能团或反应性官能团的多官能表面配体的有机表面层的涂覆的荧光半导体纳米粒子以及水分散性纳米粒子具有有机表面层或多功能表面配体以及用于制备和使用这种涂覆的纳米颗粒的方法。

3. 发明申请

WO2009134383A3 VINYL SUBSTITUTED FATTY ACIDS 审中-公开
标题翻译： VINYL替代脂肪酸
公开(公告)号：WO2009134383A3
公开(公告)日：2010-01-21
申请号：PCT/US2009002628
申请日：2009-04-30
申请人： COMPLEXA INC , FREEMAN BRUCE A , BRANCHAUD BRUCE
发明人： FREEMAN BRUCE A , BRANCHAUD BRUCE
IPC分类号： C07C205/50 , A61K31/201 , A61P7/00 , A61P9/00 , A61P13/00 , A61P15/00 , A61P17/00 , A61P19/00 , A61P25/00
CPC分类号： C07C205/50
摘要： Activated fatty acids, pharmaceutical compositions including activated fatty acids, methods for using activated fatty acids to treat a variety of diseases, and methods for preparing activated fatty acids are provided herein.
摘要翻译：本文提供活性脂肪酸，包括活性脂肪酸的药物组合物，使用活性脂肪酸治疗各种疾病的方法和制备活性脂肪酸的方法。

4. 发明申请

WO2005110396A3 NITRATED LIPIDS AND METHODS OF MAKING AND USING THEREOF 审中-公开
标题翻译：硝酸脂及其制备和使用方法
公开(公告)号：WO2005110396A3
公开(公告)日：2007-03-01
申请号：PCT/US2005014305
申请日：2005-04-26
申请人： UAB RESEARCH FOUNDATION , FREEMAN BRUCE A , SCHOPFER FRANCISCO , O'DONNELL VALERIE , BAKER PAUL , CHEN EUGENE , BRANCHAUD BRUCE
发明人： FREEMAN BRUCE A , SCHOPFER FRANCISCO , O'DONNELL VALERIE , BAKER PAUL , CHEN EUGENE , BRANCHAUD BRUCE
IPC分类号： C07C229/00 , A61K31/21
CPC分类号： A61K31/201 , A61K31/202 , A61K31/21 , A61K31/575 , A61K45/06 , C07B43/02 , C07C205/03 , C07C205/50 , C07C205/51
摘要： Described herein are nitrated lipids and methods of making and using the nitrated lipids.
摘要翻译：本文描述的是硝化脂质和制备和使用硝化脂质的方法。

5. 发明申请

WO2012142003A3 CHEMICAL LIGATION 审中-公开
标题翻译：化学发光
公开(公告)号：WO2012142003A3
公开(公告)日：2013-02-28
申请号：PCT/US2012032802
申请日：2012-04-09
申请人： LIFE TECHNOLOGIES CORP , YING LAI-QIANG , BRANCHAUD BRUCE
发明人： YING LAI-QIANG , BRANCHAUD BRUCE
IPC分类号： C12Q1/68 , G01N33/48 , G01N33/542
CPC分类号： C12Q1/6883 , C12Q1/6827 , G01N33/542 , C12Q2523/109 , C12Q2525/155
摘要： Methods comprising chemical ligation of oligonucleotides are provided. In some embodiments, methods of detecting a polymorphisms in nucleic acids are provided. In some embodiments, methods of detecting at least one analyte are provided. In some embodiments, methods of labeling solid support particles are provided. Kits comprising oligonucleotides with chemically ligatable moieties are also provided.
摘要翻译：提供包括化学连接寡核苷酸的方法。在一些实施方案中，提供了检测核酸多态性的方法。在一些实施方案中，提供了检测至少一种分析物的方法。在一些实施方案中，提供了标记固体支持物颗粒的方法。还提供了包含具有化学可连接部分的寡核苷酸的试剂盒。

6. 发明申请

WO2012142003A2 CHEMICAL LIGATION 审中-公开
标题翻译：化学发光
公开(公告)号：WO2012142003A2
公开(公告)日：2012-10-18
申请号：PCT/US2012/032802
申请日：2012-04-09
申请人： LIFE TECHNOLOGIES CORPORATION , YING, Lai-Qiang , BRANCHAUD, Bruce
发明人： YING, Lai-Qiang , BRANCHAUD, Bruce
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6827 , G01N33/542 , C12Q2523/109 , C12Q2525/155
摘要： Methods comprising chemical ligation of oligonucleotides are provided. In some embodiments, methods of detecting a polymorphisms in nucleic acids are provided. In some embodiments, methods of detecting at least one analyte are provided. In some embodiments, methods of labeling solid support particles are provided. Kits comprising oligonucleotides with chemically ligatable moieties are also provided.
摘要翻译：提供包括化学连接寡核苷酸的方法。在一些实施方案中，提供了检测核酸多态性的方法。在一些实施方案中，提供了检测至少一种分析物的方法。在一些实施方案中，提供了标记固体支持物颗粒的方法。还提供了包含具有化学可连接部分的寡核苷酸的试剂盒。

7. 发明申请

WO2005110396A2 NITRATED LIPIDS AND METHODS OF MAKING AND USING THEREOF 审中-公开
标题翻译：硝酸脂和其制备和使用方法
公开(公告)号：WO2005110396A2
公开(公告)日：2005-11-24
申请号：PCT/US2005/014305
申请日：2005-04-26
申请人： UAB RESEARCH FOUNDATION , FREEMAN, Bruce, A. , SCHOPFER, Francisco , O'DONNELL, Valerie , BAKER, Paul , CHEN, Eugene , BRANCHAUD, Bruce
发明人： FREEMAN, Bruce, A. , SCHOPFER, Francisco , O'DONNELL, Valerie , BAKER, Paul , CHEN, Eugene , BRANCHAUD, Bruce
IPC分类号： A61K31/21
CPC分类号： A61K31/201 , A61K31/202 , A61K31/21 , A61K31/575 , A61K45/06 , C07B43/02 , C07C205/03 , C07C205/50 , C07C205/51
摘要： Described herein are nitrated lipids and methods of making and using the nitrated lipids.
摘要翻译：本文描述了硝化脂质和制备和使用硝化脂质的方法。

8. 发明申请

WO2012109279A3 COMPOSITIONS AND METHODS FOR STABILIZING SUSCEPTIBLE COMPOUNDS 审中-公开
标题翻译：稳定化合物的组合物和方法
公开(公告)号：WO2012109279A3
公开(公告)日：2012-10-04
申请号：PCT/US2012024194
申请日：2012-02-07
申请人： LIFE TECHNOLOGIES CORP , FIKE RICHARD , BRANCHAUD BRUCE , BARRETT SHAWN
发明人： FIKE RICHARD , BRANCHAUD BRUCE , BARRETT SHAWN
IPC分类号： C12N5/00
CPC分类号： C12N5/0018 , C12N2500/34 , C12N2500/46
摘要： Methods for increasing the stability of, or protecting, labile components such as ethanolamine, growth factors, vitamins, etc., in compositions such as a cell culture medium. Stability of the labile compound is increased either, by derivatization of the labile compound with chemicals, or by sequestering the labile compound. Sequestering can be done either by encapsulation within a microcapsule, or by the use of sequestering agents. Encapsulation includes the encapsulation of dendrimers complexes of susceptible compounds within the microcapsule, thereby providing the controlled release of the susceptible compound that was protected.These methods may improve and extend storage conditions of compositions comprising the labile compounds, improve shipping and handling of compositions comprising the labile compounds, such as dry media formulations, at room temperature rather than at lower temperatures thereby decreasing shipping costs. Stabilization of labile compounds in compositions such as dry format media can be viewed as a contribution to green technology.
摘要翻译：提高组合物如细胞培养基中稳定性或保护不稳定组分如乙醇胺，生长因子，维生素等的方法。不稳定化合物的稳定性增加，或者通过用化学物质衍生不稳定化合物，或者通过隔离不稳定化合物。螯合可以通过封装在微胶囊内或通过使用螯合剂来完成。封装包括将敏感化合物的树枝状聚合物复合物包封在微胶囊内，从而提供受保护的敏感化合物的受控释放。这些方法可以改善和延长包含不稳定化合物的组合物的储存条件，改善运输和处理包含不稳定的化合物，例如干燥介质配方，在室温下而不是在较低的温度下，从而降低运输成本。稳定化合物中的不稳定化合物如干式介质可以被看作是对绿色技术的贡献。

9. 发明申请

WO2012109279A2 COMPOSITIONS AND METHODS FOR STABILIZING SUSCEPTIBLE COMPOUNDS 审中-公开
标题翻译：用于稳定可疑化合物的组合物和方法
公开(公告)号：WO2012109279A2
公开(公告)日：2012-08-16
申请号：PCT/US2012/024194
申请日：2012-02-07
申请人： LIFE TECHNOLOGIES CORPORATION , FIKE, Richard , BRANCHAUD, Bruce , BARRETT, Shawn
发明人： FIKE, Richard , BRANCHAUD, Bruce , BARRETT, Shawn
IPC分类号： C12N5/00
CPC分类号： C12N5/0018 , C12N2500/34 , C12N2500/46
摘要： Methods for increasing the stability of, or protecting, labile components such as ethanolamine, growth factors, vitamins, etc., in compositions such as a cell culture medium. Stability of the labile compound is increased either, by derivatization of the labile compound with chemicals, or by sequestering the labile compound. Sequestering can be done either by encapsulation within a microcapsule, or by the use of sequestering agents. Encapsulation includes the encapsulation of dendrimers complexes of susceptible compounds within the microcapsule, thereby providing the controlled release of the susceptible compound that was protected.These methods may improve and extend storage conditions of compositions comprising the labile compounds, improve shipping and handling of compositions comprising the labile compounds, such as dry media formulations, at room temperature rather than at lower temperatures thereby decreasing shipping costs. Stabilization of labile compounds in compositions such as dry format media can be viewed as a contribution to green technology.
摘要翻译：在诸如细胞培养基的组合物中增加不稳定组分如乙醇胺，生长因子，维生素等的稳定性或保护的方法。不稳定化合物的稳定性也通过不稳定化合物与化学品的衍生化或通过螯合不稳定化合物而增加。螯合可以通过在微胶囊内包封或通过使用螯合剂进行。封装包括在微胶囊中包封易感化合物的树枝状大分子复合物，从而提供受保护的易感化合物的受控释放。这些方法可以改善和延长包含不稳定化合物的组合物的储存条件，改善包含不稳定的化合物，例如干介质制剂，而不是在较低的温度下，从而降低运输成本。不稳定化合物在组合物如干式培养基中的稳定可被视为对绿色技术的贡献。

10. 发明申请

WO2012058635A1 BIOTIN DERIVATIVES 审中-公开
标题翻译：生物衍生物
公开(公告)号：WO2012058635A1
公开(公告)日：2012-05-03
申请号：PCT/US2011/058455
申请日：2011-10-28
申请人： LIFE TECHNOLOGIES CORPORATION , YING, Lai-Qiang , YUE, Stephen , BRANCHAUD, Bruce , ZHANG, Yu-Zhong
发明人： YING, Lai-Qiang , YUE, Stephen , BRANCHAUD, Bruce , ZHANG, Yu-Zhong
IPC分类号： C12Q1/00
CPC分类号： C07D495/04 , C07B2200/11 , C07D403/12 , C07K1/13 , C07K1/22 , C07K16/42 , C07K2317/20 , C07K2317/92 , C08B37/00 , C09B11/24 , C09K11/06 , C09K2211/1007 , C09K2211/1088 , C12N5/0636 , C12N5/0637 , C12N5/0638 , G01N33/532 , G01N33/533 , G01N33/54353 , G01N33/58 , G01N33/582 , G01N33/6803
摘要： Biotin derivatives, methods of using the biotin derivatives and kits comprising the biotin derivatives. In some embodiments, the biotin derivatives can be separated from streptavidin under less harsh conditions than are required for biotin. Accordingly, in some embodiments, the biotin derivatives are better suited for applications in which it would be desirable to dissociate the biotin derivative from streptavidin under less harsh conditions, such as to maintain the structural integrity and/or viability of the moiety attached to the biotin derivative.
摘要翻译：生物素衍生物，使用生物素衍生物的方法和包含生物素衍生物的试剂盒。在一些实施方案中，生物素衍生物可以在比生物素所需要的恶劣条件下与链霉抗生物素蛋白分离。因此，在一些实施方案中，生物素衍生物更适合于在较不苛刻的条件下将生物素衍生物从链霉抗生物素蛋白解离的应用，例如维持连接于生物素的部分的结构完整性和/或存活力衍生物。

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