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    • 4. 发明申请
    • ENRICHMENT OF SMALL NUCLEIC ACIDS
    • 小核酸的增殖
    • WO2016065295A1
    • 2016-04-28
    • PCT/US2015/057179
    • 2015-10-23
    • KIM, Dae HyunGUNDLING, GerardMARBLE, Herbert A.ESHOO, Mark W.
    • KIM, Dae HyunGUNDLING, GerardMARBLE, Herbert A.ESHOO, Mark W.
    • B01D15/34
    • C12N15/101C12N15/1003C12N15/1006C12N15/1013C12N15/1017
    • Provided herein is technology related to processing samples of nucleic acids and particularly, but not exclusively, to methods for enriching samples for small nucleic acids, such as small circulating cell-free DNA. Apoptotic fetal trophoblasts shed cffDNA directly into maternal blood in the placenta during gestation. It is estimated that cffDNAs are liberated into maternal plasma at a rate of approximately 20,000 per minute in 2.5 liters of maternal plasma (approximate total blood volume of a typical female is 5 liters) and are detected by some tests in circulating maternal plasma by approximately the 10th or 11th week of gestation and, in some studies, as early as the 5th week (see, e.g., Holmberg et al (2013), PLoS One 8(8):e73068) or, by some tests, as early as the 18th day of gestation (see, e.g., Guibert et al (2003) Hum Reprod 18:1733-6). A quasi-steady state relationship exists between cffDNA biogenesis in maternal plasma and cffDNA degradation by maternal plasma nucleases.
    • 本文提供了涉及处理核酸样品的技术,特别但并非排他地涉及用于富集小核酸样品(如小循环无细胞DNA)的方法。 凋亡胎儿滋养细胞在妊娠期间将cffDNA直接转入胎盘中的母体血液中。 据估计,在2.5升母体血浆(典型雌性的大概总血容量为5升)中,cffDNA以每分钟约20,000次的速率释放到母体血浆中,并且通过在母体血浆循环中的一些测试来检测大约 妊娠第10周或第11周,有些研究早在第5周(参见Holmberg等(2013),PLoS One 8(8):e73068),或者通过一些测试,早在18日 妊娠日(参见例如Guibert等(2003)Hum Reprod 18:1733-6)。 母体血浆cffDNA生物发生与母体血浆核酸酶cffDNA降解之间存在准稳态关系。
    • 6. 发明申请
    • EASY HANDWRITING USER INTERFACE SYSTEM AND METHOD FOR PEN-INPUT DISPLAY
    • 易于手写用户界面系统和笔输入显示方法
    • WO2008105574A1
    • 2008-09-04
    • PCT/KR2007/002058
    • 2007-04-26
    • EWHA UNIVERSITY INDUSTRY COLLABORATION FOUNDATIONKIM, Myung-JunKIM, Dae Hyun
    • KIM, Myung-JunKIM, Dae Hyun
    • G06F3/033
    • G06K9/00436G06F3/04883
    • Provided are handwriting user interface system and method for pen-input display. When the handwriting input function is activated by user, a transparent handwriting input window is displayed overlapping the current working window. Then, the user's pen input value is inputted through a touch screen and the pen input value is recognized in response to the activation of the pen input recognition function. The recognition result is displayed in the transparent handwriting input window. In response to the activation of the recognition result input function, the recognition result is transferred to the working area of the working window. Consequently, a working window in which the user's pen input value is inputted in the working area is obtained. When there is two or more pen input values and they are recognized in order, each of the recognition results is preferably recognized as an independent entity. The handwriting user interface system and method for pen-input display enable easy handwriting input and allow various additional applications.
    • 提供笔画用户界面系统和笔输入显示方式。 当用户激活手写输入功能时,显示与当前工作窗口重叠的透明手写输入窗口。 然后,通过触摸屏输入用户的笔输入值,并且响应于笔输入识别功能的激活识别笔输入值。 识别结果显示在透明手写输入窗口中。 响应于识别结果输入功能的激活,识别结果被传送到工作窗口的工作区域。 因此,获得在工作区域中输入用户笔输入值的工作窗口。 当有两个或多个笔输入值并且按顺序确认时,每个识别结果优选地被识别为独立实体。 用于笔式输入显示的手写用户界面系统和方法能够轻松进行手写输入并允许各种附加应用。
    • 9. 发明申请
    • BOOK CONTAINING EDUCATION MEANS FOR TEACHING PROFESSIONAL CALCULATOR AND FINANCE TRAINING SIMULATION METHOD USING THE SAME
    • 具有教学专业计算器和财务培训的教学手段的模拟方法
    • WO2009123378A1
    • 2009-10-08
    • PCT/KR2008/002934
    • 2008-05-26
    • KIM, Dae Hyun
    • KIM, Dae Hyun
    • G06Q50/00
    • G06Q10/10G06Q40/02
    • Disclosed herein are financial calculator teaching material and a financial education simulation method. The financial calculator teaching material for teaching usage of a financial calculator, including a financial situation presentation section provided in story form, a fund calculation process presentation section for presenting a fund calculation procedure, including one or more calculation processes, in order to enable fund calculation to be performed for a financial situation presented by the financial situation presentation section, a fund calculation performance result display section for providing result values of the fund calculation for the financial situation in image form and/or in chart form, and a financial calculator usage presentation section for providing usage of a preset type of financial calculator in order to enable fund calculation to be performed for the financial situation.
    • 本文披露了金融计算器教材和金融教育模拟方法。 用于教学使用金融计算器的金融计算器教学材料,包括以故事形式提供的财务状况呈现部分,用于呈现包括一个或多个计算过程的资金计算过程的资金计算过程呈现部分,以便能够进行资金计算 执行财务状况呈现部分呈现的财务状况,用于以图像形式和/或图表形式提供财务状况的资金计算的结果值的资金计算表现结果显示部分,以及金融计算器使用呈现 部分,用于提供预设类型的金融计算器的使用,以便为财务状况执行资金计算。