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    • 4. 发明申请
    • LAB-ON-A-CHIP COMPRISING A MIXING CHAMBER
    • 包括混合室的LAB-ON-A-CHIP
    • WO2008143415A1
    • 2008-11-27
    • PCT/KR2008/002561
    • 2008-05-07
    • LST KOREA. INC.LEE, Ji HoonKIM, Young TeckSUH, Hee Sang
    • LEE, Ji HoonKIM, Young TeckSUH, Hee Sang
    • G01N21/64
    • G01N21/645B01F5/0256B01F13/0059B01L3/5027B01L2300/0816B01L2300/0867B01L2300/0877B01L2300/0887
    • A lab-on-a-chip 1 comprising a mixing chamber comprises a first panel 10 and a second panel 30, which are formed of a transparent material, the first panel 10 including: a reagent injection part 11 formed to inject a reagent; a sample injection part 13 formed to inject a sample; a reagent channel 15 extended from the reagent injection part 11 at a predetermined width; a sample injection channel 17 extended from the sample injection part 13 at a predetermined width; a mixing chamber 19 formed at a place where the reagent channel 15 meets the sample channel 17, mixing a reagent with a sample; a mixing channel 21 extended from the mixing chamber 19 at a predetermined angle with respect to the reagent channel 15 and the sample channel 17, and a detection part 14 formed at the end of the mixing channel 21, and the second panel 30 including: a reagent injection hole 31 which is a through hole connected to the reagent injection part 11; a sample injection hole 33 which is a through hole connected to the sample injection part 13; and an exhaust hole 35 which is a through hole connected to the detection part 14, wherein the mixing chamber 19 is wider than the reagent channel 15 or the sample channel 17. In this case, the sample is mixed with the reagent uniformly and promptly without a narrow and complicate mixing channel which is difficult to be processed. The low concentration of sample was quantified with excellent reproducibility within statistical error range using the lab-on-a-chip, 1 with chemiluminescence detection.
    • 包括混合室的实验室1包括由透明材料形成的第一面板10和第二面板30,第一面板10包括:形成为注入试剂的试剂注入部分11; 形成为注入样品的样品注入部13; 从试剂注入部11以规定的宽度延伸的试剂流路15; 从样品注射部13以预定宽度延伸的样品注入通道17; 混合室19形成在试剂通道15与样品通道17相遇的地方,将试剂与样品混合; 从混合室19相对于试剂通道15和样品通道17以预定角度延伸的混合通道21以及形成在混合通道21的端部的检测部分14,第二面板30包括: 与试剂注射部11连接的通孔的试剂注入孔31; 样品注入孔33,其是与样品注射部13连接的通孔; 以及与检测部14连接的通孔的排气孔35,其中混合室19比试剂通道15或样品通道17宽。在这种情况下,样品与试剂均匀且迅速地混合而没有 一个难以处理的窄而复杂​​的混合通道。 使用实验室上的片上实验室1,在化学发光检测下,在统计学误差范围内以极好的重复性定量样品的低浓度。