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1. 发明申请

WO2009073192A3 SYSTEMS AND METHODS FOR DELIVERY OF MATERIALS 审中-公开
标题翻译：用于输送材料的系统和方法
公开(公告)号：WO2009073192A3
公开(公告)日：2009-10-22
申请号：PCT/US2008013335
申请日：2008-12-03
申请人： LANDEC CORP , TAFT DAVID D , BITLER STEVEN P , ZHENG QIANG , TZANNIS STELIOS T , BELL ADAM W , DAI WEI-GUO , OTTENSMANN SANDRA N , BALACHANDER NATARAJAN
发明人： TAFT DAVID D , BITLER STEVEN P , ZHENG QIANG , TZANNIS STELIOS T , BELL ADAM W , DAI WEI-GUO , OTTENSMANN SANDRA N , BALACHANDER NATARAJAN
IPC分类号： A61K9/16 , A61K31/196 , A61K31/519 , A61P25/18 , A61P29/00
CPC分类号： A61K9/146 , A61K9/1647 , A61K31/136 , A61K31/196 , A61K31/519 , A61K31/5513 , A61K47/34
摘要： Systems and methods for delivering release materials, for example drugs and other bioactive materials. Crystalline polymeric systems, referred to as CYC carriers, are associated with the release materials, through chemical bonding or through physical association. The crystallinity of the CYC carriers results from the presence of crystallizable side chains, for example long chain n-alkyl moieties, which results in relatively low and sharp melting temperatures. One class of CYC carriers, referred to as CYSC polymers, have a majority of the crystallizable side chains pendant from the polymer backbone. Another class of CYC carriers, referred to as ECC polymers, have a majority of the crystallizable side chains attached to terminal units of the polymer backbone. The ECC polymers can for example be obtained by modification of PLGA polymers. The CYC carriers in another class of non-polymeric. Some CYC carriers, referred to as CYC assemblies, have enhanced crystallinity as a result of the physical association of crystallizable moieties which are present in different types of molecule, for example between a polymer containing crystallizable moieties and a monomer containing crystallizable moieties. For some uses, particularly the delivery of drugs, a bioerodable CYC carrier is preferably used.
摘要翻译：用于输送释放材料的系统和方法，例如药物和其他生物活性材料。称为CYC载体的结晶聚合体系通过化学键合或通过物理缔合与释放材料相关联。 CYC载体的结晶度来自可结晶侧链的存在，例如长链正烷基部分，这导致相对低的和尖锐的熔融温度。称为CYSC聚合物的一类CYC载体具有从聚合物主链悬挂的大部分可结晶侧链。称为ECC聚合物的另一类CYC载体具有连接至聚合物主链末端单元的大部分可结晶侧链。 ECC聚合物可以例如通过改性PLGA聚合物获得。 CYC载体在另一类非聚合物中。一些称为CYC组件的CYC载体由于存在于不同类型分子中的可结晶部分的物理结合而具有增强的结晶度，例如在含可结晶部分的聚合物和含可结晶部分的单体之间。对于一些用途，特别是药物的递送，优选使用生物侵蚀性CYC载体。

2. 发明申请

WO2008070118A9 DRUG DELIVERY 审中-公开
标题翻译：药物递送
公开(公告)号：WO2008070118A9
公开(公告)日：2008-09-18
申请号：PCT/US2007024909
申请日：2007-12-04
申请人： LANDEC CORP , TAFT DAVID D , BITLER STEVEN P , ZHENG QIANG , TZANNIS STELIOS T , BELL ADAM WARWICK
发明人： TAFT DAVID D , BITLER STEVEN P , ZHENG QIANG , TZANNIS STELIOS T , BELL ADAM WARWICK
IPC分类号： A61K9/52 , A61K9/22
CPC分类号： A61K9/0024 , A61K9/0019 , A61K9/146
摘要： Formulations of drugs and crystalline side chain polymers to provide controlled and/or sustained release drug formulations.
摘要翻译：制备药物和结晶侧链聚合物以提供受控和/或缓释药物制剂。

3. 发明申请

WO9513039A3 ORTHOPEDIC CASTS 审中-公开
公开(公告)号：WO9513039A3
公开(公告)日：1995-07-20
申请号：PCT/US9413007
申请日：1994-11-08
申请人： LANDEC CORP , GREENE LAWRENCE C , DAHLEN BURTON L , LARSON ANDREW W , TAFT DAVID D , BITLER STEVEN P
发明人： GREENE LAWRENCE C , DAHLEN BURTON L , LARSON ANDREW W , TAFT DAVID D , BITLER STEVEN P
IPC分类号： A61F5/058 , A61F13/04 , A61L15/12 , A61F5/04
CPC分类号： A61L15/12 , A61F5/058 , A61F13/04 , A61F13/041 , Y10S264/71 , Y10S428/913 , Y10S524/921 , Y10T428/1314 , Y10T428/1328 , Y10T428/1334 , Y10T428/1362 , Y10T428/1372 , Y10T428/1376 , Y10T428/1386 , Y10T428/139 , Y10T428/1393 , Y10T428/24322 , Y10T428/24331 , Y10T442/2811 , C08L67/04
摘要： Heat-recoverable orthopedic casts include a support which is maintained in an elastically deformed condition by a casting polymer, e.g. a polycaprolactone (PCL) or a side chain crystallizable polymer having a relatively low melting point. The cast is placed around the limb and is then heated. The casting polymer softens and the cast recovers around the limb. A liner is preferably placed between the cast and the limb, especially when the casting polymer is PCL or has a comparable or higher melting point. For high strength casts, the support is preferably an open-mesh knitted fabric which, when fully relaxed, contains at most 300 holes per inch2 (at most 45 holes per cm2). Such a fabric, when it is extensible to a maximum of 15 to 40 %, is also useful as casting tape which comprises a curable polymer casting composition, e.g. a water-curable polyurethane prepolymer. As illustrated in Figures 1 and 2, a stockinette liner (2) is preferably placed between the cast (1) and the limb as a thermal barrier. A reinforcing component may be used to strengthen the recovered cast. Suitable reinforcing components include (A) polyurethane precursors which are applied to the cast before or after recovery, and are polymerized during or after recovery, and (B) thermoplastic materials which are applied hot to the recovered cast. Casts made in this way can be divided to make splints which can be easily removed and replaced.

4. 发明申请

WO2005062838A3 CONTAINERS 审中-公开
标题翻译：集装箱
公开(公告)号：WO2005062838A3
公开(公告)日：2006-08-31
申请号：PCT/US2004042832
申请日：2004-12-21
申请人： APIO INC , CLARKE RAYMOND , TAFT DAVID D
发明人： CLARKE RAYMOND , TAFT DAVID D
IPC分类号： A23B7/00 , B65D81/26
CPC分类号： A23B7/148 , B65D81/263 , Y10T428/269
摘要： Respiring biological materials can be stored in a sealed container having (i) an interior surface at least partly composed of a hydrophilic polymer composition and (ii) an auxiliary component through which oxygen and carbon dioxide can enter or leave the packaging atmosphere within the container.
摘要翻译：呼吸生物材料可以储存在密封容器中，该密封容器具有至少部分由亲水性聚合物组合物组成的内表面和（ii）辅助组分，氧和二氧化碳可以通过该辅助组分进入或离开容器内的包装气氛。

5. 发明专利

JPH11256043A SHRINKAGE-LOWERING AGENT FOR CROSSLINKABLE RESIN 失效
公开(公告)号：JPH11256043A
公开(公告)日：1999-09-21
申请号：JP991599
申请日：1999-01-18
申请人： LANDEC CORP
发明人： TAFT DAVID D , BITLER STEVEN P
IPC分类号： C08F4/06 , C08L101/00
摘要： PROBLEM TO BE SOLVED: To provide a shrinkage-lowering agent which prevents a crosslinkable resin system from curing shrinkage. SOLUTION: There is provided a composition used as a shrinkage-lowering agent (LPA) in the preparation of a molding containing a crosslinked polymer, wherein (a) the composition contains a crystalline polymer having an onset of melting temperature To and a peak melting temperature Tp , wherein (i) the peak melting temperature Tp is at least 30 deg.C and (ii) Tp -To is equal to a temperature less than Tp , and (b) the crystalline polymer is in the form of particles capable of being uniformly suspended in the matrix substance being a precursor of the crosslinked polymer.

6. 发明公开

EP2101745A4 DELIVERY OF DRUGS 审中-公开
标题翻译：分布中药研究与
公开(公告)号：EP2101745A4
公开(公告)日：2009-12-30
申请号：EP07862547
申请日：2007-12-04
申请人： LANDEC CORP
发明人： TAFT DAVID D , BITLER STEVEN P , ZHENG QIANG , TZANNIS STELIOS T , BELL ADAM WARWICK
IPC分类号： A61K9/52 , A61K9/22
CPC分类号： A61K9/0024 , A61K9/0019 , A61K9/146

7. 发明专利

CA2670749A1 DRUG DELIVERY 未知
公开(公告)号：CA2670749A1
公开(公告)日：2008-06-12
申请号：CA2670749
申请日：2007-12-04
申请人： LANDEC CORP
发明人： TAFT DAVID D , ZHENG QIANG , BITLER STEVEN P , BELL ADAM WARWICK , TZANNIS STELIOS T
IPC分类号： A61K9/52 , A61K9/22
摘要： Formulations of drugs and crystalline side chain polymers to provide cont rolled and/or sustained release drug formulations.

8. 发明专利

CA2707666A1 SYSTEMS AND METHODS FOR DELIVERY OF MATERIALS 未知
公开(公告)号：CA2707666A1
公开(公告)日：2009-06-11
申请号：CA2707666
申请日：2008-12-03
申请人： LANDEC CORP
发明人： TAFT DAVID D , BITLER STEVEN P , ZHENG QIANG , TZANNIS STELIOS T , BELL ADAM W , DAI WEI-GUO , OTTENSMANN SANDRA N , BALACHANDER NATARAJAN
IPC分类号： A61K47/32 , A61K31/136 , A61K31/196 , A61K31/519 , A61K31/5513 , A61K38/02 , A61P25/18 , A61P29/00
摘要： Systems and methods for delivering release materials, for example drugs and other bioactive materials. Crystalline polymeric systems, referred to as CYC carriers, are associated with the release materials, through chemical bonding or through physical association. The crystallinity of the CYC carriers results from the presence of crystallizable side chains, for example long chain n-alkyl moieties, which results in relatively low and sharp melting temperatures. One class of CYC carriers, referred to as CYSC polymers, have a majority of the crystallizable side chains pendant from the polymer backbone. Another class of CYC carriers, referred to as ECC polymers, have a majority of the crystallizable side chains attached to terminal units of the polymer backbone. The ECC polymers can for example be obtained by modification of PLGA polymers. The CYC carriers in another class of non-polymeric. Some CYC carriers, referred to as CYC assemblies, have enhanced crystallinity as a result of the physical association of crystallizable moieties which are present in different types of molecule, for example between a polymer containing crystallizable moieties and a monomer containing crystallizable moieties. For some uses, particularly the delivery of drugs, a bioerodable CYC carrier is preferably used.

9. 发明专利

CA2173967A1 ORTHOPEDIC CASTS 未知
公开(公告)号：CA2173967A1
公开(公告)日：1995-05-18
申请号：CA2173967
申请日：1994-11-08
申请人： LANDEC CORP
发明人： GREENE LAWRENCE C , DAHLEN BURTON L , LARSON ANDREW W , TAFT DAVID D , BITLER STEVEN P
IPC分类号： A61F13/04 , A61F5/04 , A61F5/058 , A61L15/07
摘要： Heat-recoverable orthopedic casts include a support which is maintained in an elastically deformed condition by a casting polymer, e.g. a polycaprolactone (PCL) or a side chain crystallizable polymer having a relatively low melting point. The cast is placed around the limb and is then heated. The casting polymer softens and the cast recovers around the limb. A liner is preferably placed between the cast and the limb, especially when the casting polymer is PCL or has a comparable or higher melting point. For high strength casts, the support is preferably an open-mesh knitted fabric which, when fully relaxed, contains at most 300 holes per inch2 (at most 45 holes per cm2). Such a fabric, when it is extensible to a maximum of 15 to 40 %, is also useful as casting tape which comprises a curable polymer casting composition, e.g. a water-curable polyurethane prepolymer. As illustrated in Figures 1 and 2, a stockinette liner (2) is preferably placed between the cast (1) and the limb as a thermal barrier. A reinforcing component may be used to strengthen the recovered cast. Suitable reinforcing components include (A) polyurethane precursors which are applied to the cast before or after recovery, and are polymerized during or after recovery, and (B) thermoplastic materials which are applied hot to the recovered cast. Casts made in this way can be divided to make splints which can be easily removed and replaced.

10. 发明专利

AU2008331815A1 Systems and methods for delivery of materials 未知
公开(公告)号：AU2008331815A1
公开(公告)日：2009-06-11
申请号：AU2008331815
申请日：2008-12-03
申请人： LANDEC CORP
发明人： ZHENG QIANG , TAFT DAVID D , OTTENSMANN SANDRA N , TZANNIS STELIOS T , BITLER STEVEN P , BELL ADAM W , DAI WEI-GUO , BALACHANDER NATARAJAN
IPC分类号： A61K9/16 , A61K31/196 , A61K31/519 , A61P25/18 , A61P29/00
摘要： A release composition for agricultural applications which comprises an ECC polymer and a release material associated with the ECC polymer, wherein the release material is a fertilizer, biocide, insecticide or fungicide, and wherein the ECC polymer is defined as a polymer (A) which comprises polymeric molecules having a backbone and comprising at least one moiety which has the formula -b-Cy, wherein the -b-Cy moiety either (a) forms part of a repeating unit of the backbone, the repeating unit having the formula (1) below where Y ch is a moiety forming part of the backbone, b is a bond or moiety which links the Cy moiety to Y ch , and Cy is a moiety which is associated with other moieties to provide the ECC polymer with crystallinity, or (b) forms part of a terminal unit of the backbone, the terminal unit having the formula (2) below -Y term - b-Cy(2) where Y term is a moiety at the end of the backbone, and b and Cy are as defined in formula (1); (B) in which at least 50% by weight of the Cy moieties are present in terminal units of formula (2); and (C) which has a crystalline melting temperature, Tp, of at least 0°C and a H of at least 3J/g which results from association of the Cy moieties.

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