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1. 发明申请

WO2010144755A3 COMPOSITIONS AND METHODS FOR DELIVERY OF MATERIALS 审中-公开
标题翻译：用于输送材料的组合物和方法
公开(公告)号：WO2010144755A3
公开(公告)日：2011-04-21
申请号：PCT/US2010038239
申请日：2010-06-11
申请人： LANDEC CORP , TAFT DAVID , BALACHANDER NATARAJAN , BITLER STEVEN P , ZHENG QIANG , OTTENSMANN SANDRA
发明人： TAFT DAVID , BALACHANDER NATARAJAN , BITLER STEVEN P , ZHENG QIANG , OTTENSMANN SANDRA
IPC分类号： A61K9/32 , A61K9/20 , A61K9/22 , A61K47/30
CPC分类号： A61K8/416 , A01N25/10 , A61K47/61 , A61K2800/57 , A61Q17/04 , A61Q19/00 , A61Q19/10
摘要： Compositions for delivering release materials, for example drugs, agricultural materials, other bioactive materials, cosmetic materials, organic or inorganic compounds which take part in or catalyse a chemical reaction, a fragrance-emitting material for a vaporizer, or a lubricating material. The release material is associated with a crystalline carrier. The carrier may be a crystalline polymer containing a plurality of crystalline groups or a crystalline monomer which contains a single crystalline group, the crystalline group preferably comprising a straight chain polymethylene radical containing at least 16 carbon atoms. Some of the carriers are obtained by modifying hyaluronic acid, collagen, gelatin, a polysaccharide, a carbohydrate or cyclodextran. The release material may contain a similar crystalline group, for example may be an active compound which has been modified to introduce a crystalline group.
摘要翻译：用于输送释放材料的组合物，例如药物，农业材料，其他生物活性材料，化妆品材料，参与或催化化学反应的有机或无机化合物，用于蒸发器的发泡材料或润滑材料。释放材料与结晶载体结合。载体可以是含有多个结晶基团的结晶聚合物或含有单一结晶基团的结晶单体，该结晶基团优选包含含有至少16个碳原子的直链多亚甲基基团。一些载体通过修饰透明质酸，胶原，明胶，多糖，碳水化合物或环糊精得到。释放材料可以含有相似的结晶基团，例如可以是经修饰以引入结晶基团的活性化合物。

2. 发明申请

WO2009073192A2 SYSTEMS AND METHODS FOR DELIVERY OF MATERIALS 审中-公开
标题翻译：用于输送材料的系统和方法
公开(公告)号：WO2009073192A2
公开(公告)日：2009-06-11
申请号：PCT/US2008/013335
申请日：2008-12-03
申请人： LANDEC CORPORATION , TAFT, David, D. , BITLER, Steven, P. , ZHENG, Qiang , TZANNIS, Stelios, T. , BELL, Adam, W , DAI, Wei-guo , OTTENSMANN, Sandra, N , BALACHANDER, Natarajan
发明人： TAFT, David, D. , BITLER, Steven, P. , ZHENG, Qiang , TZANNIS, Stelios, T. , BELL, Adam, W , DAI, Wei-guo , OTTENSMANN, Sandra, N , BALACHANDER, Natarajan
IPC分类号： A61K47/32 , A61K38/02 , A61K31/136 , A61K31/519 , A61K31/5513
CPC分类号： A61K9/146 , A61K9/1647 , A61K31/136 , A61K31/196 , A61K31/519 , A61K31/5513 , A61K47/34
摘要： Systems and methods for delivering release materials, for example drugs and other bioactive materials. Crystalline polymeric systems, referred to as CYC carriers, are associated with the release materials, through chemical bonding or through physical association. The crystallinity of the CYC carriers results from the presence of crystallizable side chains, for example long chain n-alkyl moieties, which results in relatively low and sharp melting temperatures. One class of CYC carriers, referred to as CYSC polymers, have a majority of the crystallizable side chains pendant from the polymer backbone. Another class of CYC carriers, referred to as ECC polymers, have a majority of the crystallizable side chains attached to terminal units of the polymer backbone. The ECC polymers can for example be obtained by modification of PLGA polymers. The CYC carriers in another class of non-polymeric. Some CYC carriers, referred to as CYC assemblies, have enhanced crystallinity as a result of the physical association of crystallizable moieties which are present in different types of molecule, for example between a polymer containing crystallizable moieties and a monomer containing crystallizable moieties. For some uses, particularly the delivery of drugs, a bioerodable CYC carrier is preferably used.
摘要翻译：用于递送释放材料的系统和方法，例如药物和其他生物活性材料。被称为CYC载体的结晶聚合物体系通过化学键合或物理缔合与释放材料相关联。 CYC载体的结晶度来自可结晶侧链的存在，例如长链正烷基部分，其导致相对低且尖锐的熔化温度。一类CYC载体，被称为CYSC聚合物，其大部分可结晶侧链悬垂在聚合物骨架上。称为ECC聚合物的另一类CYC载体的大部分可结晶侧链连接到聚合物骨架的末端单元。 ECC聚合物可以例如通过改性PLGA聚合物而获得。另一类非聚合物CYC载体。由于存在于不同类型分子中的可结晶部分（例如在含有可结晶部分的聚合物和含有可结晶部分的单体之间）的物理缔合，一些称为CYC组装的CYC载体具有增强的结晶度。对于某些用途，特别是药物的输送，优选使用生物可蚀性CYC载体。

3. 发明申请

WO2008070118A9 DRUG DELIVERY 审中-公开
标题翻译：药物递送
公开(公告)号：WO2008070118A9
公开(公告)日：2008-09-18
申请号：PCT/US2007024909
申请日：2007-12-04
申请人： LANDEC CORP , TAFT DAVID D , BITLER STEVEN P , ZHENG QIANG , TZANNIS STELIOS T , BELL ADAM WARWICK
发明人： TAFT DAVID D , BITLER STEVEN P , ZHENG QIANG , TZANNIS STELIOS T , BELL ADAM WARWICK
IPC分类号： A61K9/52 , A61K9/22
CPC分类号： A61K9/0024 , A61K9/0019 , A61K9/146
摘要： Formulations of drugs and crystalline side chain polymers to provide controlled and/or sustained release drug formulations.
摘要翻译：制备药物和结晶侧链聚合物以提供受控和/或缓释药物制剂。

4. 发明申请

WO2009073192A3 SYSTEMS AND METHODS FOR DELIVERY OF MATERIALS 审中-公开
标题翻译：用于输送材料的系统和方法
公开(公告)号：WO2009073192A3
公开(公告)日：2009-10-22
申请号：PCT/US2008013335
申请日：2008-12-03
申请人： LANDEC CORP , TAFT DAVID D , BITLER STEVEN P , ZHENG QIANG , TZANNIS STELIOS T , BELL ADAM W , DAI WEI-GUO , OTTENSMANN SANDRA N , BALACHANDER NATARAJAN
发明人： TAFT DAVID D , BITLER STEVEN P , ZHENG QIANG , TZANNIS STELIOS T , BELL ADAM W , DAI WEI-GUO , OTTENSMANN SANDRA N , BALACHANDER NATARAJAN
IPC分类号： A61K9/16 , A61K31/196 , A61K31/519 , A61P25/18 , A61P29/00
CPC分类号： A61K9/146 , A61K9/1647 , A61K31/136 , A61K31/196 , A61K31/519 , A61K31/5513 , A61K47/34
摘要： Systems and methods for delivering release materials, for example drugs and other bioactive materials. Crystalline polymeric systems, referred to as CYC carriers, are associated with the release materials, through chemical bonding or through physical association. The crystallinity of the CYC carriers results from the presence of crystallizable side chains, for example long chain n-alkyl moieties, which results in relatively low and sharp melting temperatures. One class of CYC carriers, referred to as CYSC polymers, have a majority of the crystallizable side chains pendant from the polymer backbone. Another class of CYC carriers, referred to as ECC polymers, have a majority of the crystallizable side chains attached to terminal units of the polymer backbone. The ECC polymers can for example be obtained by modification of PLGA polymers. The CYC carriers in another class of non-polymeric. Some CYC carriers, referred to as CYC assemblies, have enhanced crystallinity as a result of the physical association of crystallizable moieties which are present in different types of molecule, for example between a polymer containing crystallizable moieties and a monomer containing crystallizable moieties. For some uses, particularly the delivery of drugs, a bioerodable CYC carrier is preferably used.
摘要翻译：用于输送释放材料的系统和方法，例如药物和其他生物活性材料。称为CYC载体的结晶聚合体系通过化学键合或通过物理缔合与释放材料相关联。 CYC载体的结晶度来自可结晶侧链的存在，例如长链正烷基部分，这导致相对低的和尖锐的熔融温度。称为CYSC聚合物的一类CYC载体具有从聚合物主链悬挂的大部分可结晶侧链。称为ECC聚合物的另一类CYC载体具有连接至聚合物主链末端单元的大部分可结晶侧链。 ECC聚合物可以例如通过改性PLGA聚合物获得。 CYC载体在另一类非聚合物中。一些称为CYC组件的CYC载体由于存在于不同类型分子中的可结晶部分的物理结合而具有增强的结晶度，例如在含可结晶部分的聚合物和含可结晶部分的单体之间。对于一些用途，特别是药物的递送，优选使用生物侵蚀性CYC载体。

5. 发明申请

WO2008070165A1 DRUG-CONTAINING COMPOSITIONS AND THEIR USE 审中-公开
标题翻译：含药组合物及其使用
公开(公告)号：WO2008070165A1
公开(公告)日：2008-06-12
申请号：PCT/US2007/025032
申请日：2007-12-05
申请人： LANDEC CORPORATION , TAFT, David, D. , BITLER, Steven, P. , ZHENG, Qiang , TZANNIS, Stelios, T. , BELL, Adam, Warwick
发明人： TAFT, David, D. , BITLER, Steven, P. , ZHENG, Qiang , TZANNIS, Stelios, T. , BELL, Adam, Warwick
IPC分类号： A61K47/30 , A61K47/32 , A61K9/10 , A61K9/20 , A61K9/32
CPC分类号： A61K9/0024 , A61K9/0019 , A61K9/146
摘要： Formulations of drugs and crystalline side chain polymers to provide controlled and/or sustained release drug formulations.
摘要翻译：制备药物和结晶侧链聚合物以提供受控和/或缓释药物制剂。

6. 发明申请

WO2003033558A2 HIGH INDEX CURABLE PHOTOCHROMIC COMPOSITION AND ITS PROCESS 审中-公开
标题翻译：高指数可固化光致变色组合物及其工艺
公开(公告)号：WO2003033558A2
公开(公告)日：2003-04-24
申请号：PCT/EP2002/011431
申请日：2002-10-11
申请人： RODENSTOCK GMBH , ZHENG, Qiang , NELSON, Donald, Scott , CARPER, Charles, William, Jr. , MELZIG, Manfred , SCHUSTER, Herbert , ZINNER, Herbert
发明人： ZHENG, Qiang , NELSON, Donald, Scott , CARPER, Charles, William, Jr. , MELZIG, Manfred , SCHUSTER, Herbert , ZINNER, Herbert
IPC分类号： C08F222/10
CPC分类号： C08F222/1006 , G02B1/041 , C08L33/14
摘要： There is provided a high refractive index, curable, synthetic resin composition comprising a core resin composition composed of a mixture of ethylenically unsatured compounds, and an initiation system containing both photo and thermal initiators, particularly a photochromic resin composition which further includes at least one photochromic dye. There is also provided a curing process, which includes a combination of multi-step radiation curing a thermal annealing. Articles produced of the cured composition exhibit superior physical and, in appropriate cases, photochromic properties and can be easily mass produced on a commercial scale due to short processing time and use of readily available chemicals.
摘要翻译：提供了一种高折射率，可固化的合成树脂组合物，其包含由烯属不成熟化合物的混合物组成的芯树脂组合物和含有光引发剂和热引发剂的引发体系，特别是光致变色树脂组合物，其还包含至少一种光致变色染料。还提供了固化过程，其包括多步辐射固化热退火的组合。由固化的组合物制成的制品表现出优异的物理性质，并且在合适的情况下表现出光致变色性质，并且由于加工时间短和使用容易获得的化学品，可以以商业规模容易地批量生产。

7. 发明申请

WO2018191302A1 PROTECTIVE FILMS FOR PRINTED ELECTROCHEMICAL CELLS AND METHODS OF PACKAGING ELECTROCHEMICAL CELLS 审中-公开
公开(公告)号：WO2018191302A1
公开(公告)日：2018-10-18
申请号：PCT/US2018/026960
申请日：2018-04-10
申请人： IMPRINT ENERGY, INC. , MACKENZIE, John, Devin , ZHENG, Qiang , SMITHYMAN, Jesse , HO, Christine
发明人： MACKENZIE, John, Devin , ZHENG, Qiang , SMITHYMAN, Jesse , HO, Christine
IPC分类号： H01M2/02 , H01M10/52 , H01M10/04 , H01M10/0585 , H01M6/40
摘要： Electrochemical cells with a protective film that is permeable to hydrogen, or that include a catalyst that facilitates formation of mobile hydrogen species, that promotes sequestration or gettering of hydrogen or oxygen, and/or that facilitates conversion of hydrogen or oxygen to H 2 O, are disclosed.

8. 发明申请

WO2010144755A2 COMPOSITIONS AND METHODS FOR DELIVERY OF MATERIALS 审中-公开
标题翻译：用于输送材料的组合物和方法
公开(公告)号：WO2010144755A2
公开(公告)日：2010-12-16
申请号：PCT/US2010/038239
申请日：2010-06-11
申请人： LANDEC CORPORATION , TAFT, David , BALACHANDER, Natarajan , BITLER, Steven, P. , ZHENG, Qiang , OTTENSMANN, Sandra
发明人： TAFT, David , BALACHANDER, Natarajan , BITLER, Steven, P. , ZHENG, Qiang , OTTENSMANN, Sandra
IPC分类号： A61K9/32 , A61K9/22 , A61K9/20 , A61K47/30
CPC分类号： A61K8/416 , A01N25/10 , A61K47/61 , A61K2800/57 , A61Q17/04 , A61Q19/00 , A61Q19/10
摘要： Compositions for delivering release materials, for example drugs, agricultural materials, other bioactive materials, cosmetic materials, organic or inorganic compounds which take part in or catalyse a chemical reaction, a fragrance-emitting material for a vaporizer, or a lubricating material. The release material is associated with a crystalline carrier. The carrier may be a crystalline polymer containing a plurality of crystalline groups or a crystalline monomer which contains a single crystalline group, the crystalline group preferably comprising a straight chain polymethylene radical containing at least 16 carbon atoms. Some of the carriers are obtained by modifying hyaluronic acid, collagen, gelatin, a polysaccharide, a carbohydrate or cyclodextran. The release material may contain a similar crystalline group, for example may be an active compound which has been modified to introduce a crystalline group.
摘要翻译：用于输送释放材料的组合物，例如药物，农业材料，其他生物活性材料，化妆品材料，参与或催化化学反应的有机或无机化合物，用于蒸发器的发泡材料或润滑材料。释放材料与结晶载体结合。载体可以是含有多个结晶基团的结晶聚合物或含有单一结晶基团的结晶单体，该结晶基团优选包含含有至少16个碳原子的直链多亚甲基基团。一些载体通过修饰透明质酸，胶原，明胶，多糖，碳水化合物或环糊精得到。释放材料可以含有相似的结晶基团，例如可以是经修饰以引入结晶基团的活性化合物。

9. 发明申请

WO0028091A9 SYSTEMS FOR THE ANALYSIS OF GENE EXPRESSION DATA 审中-公开
标题翻译：基因表达数据分析系统
公开(公告)号：WO0028091A9
公开(公告)日：2002-08-22
申请号：PCT/US9927072
申请日：1999-11-12
申请人： SCIOS INC , ZHENG QIANG , GARRARD LISA
发明人： ZHENG QIANG , GARRARD LISA
IPC分类号： G06F19/20 , C12Q1/68 , G01N31/00 , G01N33/48 , G01N33/50 , G06F19/00
CPC分类号： G06F19/20
摘要： The present invention relates to systems, integrated computer sofwater programs, and related methods for manipualtion and analysis of gene expression data. The methods of the invention are particularly suited for use with gene expression data generated with microarray and genechip technologies. A particular embodiment of the invention relates to systems utilizing clustering algorithms, which may be used to correlate temporal patterns of gene expression. The invention also relates to graphical tools, search and sort functions for viewing both the original and processed gene expression data. The present invention also relates to a graphical user interface for data clustering, graphical viewing, and browsing.
摘要翻译：本发明涉及系统，综合计算机软件程序以及用于操作和分析基因表达数据的相关方法。本发明的方法特别适用于用微阵列和基因技术生成的基因表达数据。本发明的一个具体实施例涉及利用聚类算法的系统，其可用于相关基因表达的时间模式。本发明还涉及图形工具，用于查看原始和经处理的基因表达数据的搜索和分类功能。本发明还涉及用于数据聚类，图形查看和浏览的图形用户界面。

10. 发明申请

WO2010141806A2 COMPOSITIONS AND METHODS FOR DELIVERY OF MATERIALS 审中-公开
标题翻译：用于输送材料的组合物和方法
公开(公告)号：WO2010141806A2
公开(公告)日：2010-12-09
申请号：PCT/US2010/037382
申请日：2010-06-04
申请人： LANDEC CORPORATION , BALACHANDER, Natarajan , TAFT, David , ZHENG, Qiang , BITLER, Steven, P. , HAJDUK, Damian, A.
发明人： BALACHANDER, Natarajan , TAFT, David , ZHENG, Qiang , BITLER, Steven, P. , HAJDUK, Damian, A.
IPC分类号： A61K9/32 , A61K9/22 , A61K9/20 , A61K9/24 , A61K47/30
CPC分类号： A01N25/28 , A01N25/10 , A01N25/12 , A01N51/00
摘要： Compositions for the controlled delivery of active ingredients, for example, drugs, cosmetic materials, and agricultural materials. The compositions include a multiplicity of particles, each of the particles comprising (1) a microstructure comprising a semicrystalline polymer which has a peak melting temperature, Tp, of at least 20°C, and (2) the active ingredient. The microstructure comprises (i) crystalline domains of the semicrystalline polymer, the crystalline domains being separate from each other, and (ii) amorphous domains of the semicrystalline polymer, the amorphous domains providing a multiplicity of tortuous paths between the crystalline domains. At least part of the active ingredient is present in the amorphous domains. One of many valuable uses for the compositions is to provide a coating on a seed, for example a coating containing one or more of an insecticide, a fungicide, a nutrient, a biotic, a growth regulator and an herbicide.
摘要翻译：用于控制递送活性成分的组合物，例如药物，化妆品材料和农业材料。组合物包括多个颗粒，每个颗粒包含（1）包含半结晶聚合物的微结构，其具有至少20℃的峰值熔融温度Tp，和（2）活性成分。微结构包括（i）半结晶聚合物的结晶域，结晶域彼此分离，和（ii）半结晶聚合物的无定形区域，无定形畴在结晶域之间提供多个曲折路径。至少部分活性成分存在于无定形区域中。组合物的许多有价值的用途之一是在种子上提供涂层，例如包含杀虫剂，杀真菌剂，营养物，生物，生长调节剂和除草剂中的一种或多种的涂层。

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