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1. 发明申请

US20050163789A9 Nucleic acid molecules, polypeptides and uses therefor, including diagnosis and treatment of Alzheimer's disease 审中-公开
标题翻译：核酸分子，多肽及其用途，包括阿尔茨海默病的诊断和治疗
公开(公告)号：US20050163789A9
公开(公告)日：2005-07-28
申请号：US10264309
申请日：2002-10-03
申请人： L. Durham , David Friedman , Herath Mudiyanselage Herath , Lida Kimmel , Rajesh Parekh , David Potter , Christian Rohlff , B. Silber , Peter Snyder , Holly Soares , Thomas Stiger , P. Sunderland , Robert Townsend , W. White , Stephen Williams
发明人： L. Durham , David Friedman , Herath Mudiyanselage Herath , Lida Kimmel , Rajesh Parekh , David Potter , Christian Rohlff , B. Silber , Peter Snyder , Holly Soares , Thomas Stiger , P. Sunderland , Robert Townsend , W. White , Stephen Williams
IPC分类号： G01N33/68 , A61K48/00 , A61K39/00 , C07K16/40 , C12Q1/68 , G01N33/53 , G01N33/542
CPC分类号： G01N33/6896 , G01N2333/4709 , G01N2550/00 , G01N2800/2821 , G01N2800/52
摘要： The present invention provides methods and compositions for screening, diagnosis and prognosis of Alzheimer's disease, for monitoring the effectiveness of Alzheimer's disease treatment, and for drug development. Alzheimer's Disease-Associated Features (AFs), detectable by two-dimensional electrophoresis of cerebrospinal fluid, serum or plasma are described. The invention further provides Alzheimer's Disease-Associated Protein Isoforms (APIs) detectable in cerebrospinal fluid, serum or plasma, preparations comprising isolated APIs, antibodies immunospecific for APIs, pharmaceutical compositions, diagnostic and therapeutic methods, and kits comprising or based on the same.
摘要翻译：本发明提供了用于阿尔茨海默病筛选，诊断和预后的方法和组合物，用于监测阿尔茨海默病治疗的有效性和用于药物开发。描述了通过脑脊液，血清或血浆的二维电泳可检测的阿尔茨海默氏病相关特征（AF）。本发明还提供在脑脊液，血清或血浆中可检测的阿尔茨海默氏病相关蛋白质异构体（API），包含分离的API的制剂，针对API免疫特异性的抗体，药物组合物，诊断和治疗方法，以及包含或基于其的试剂盒。

2. 发明申请

US20070015217A1 Nucleic acid molecules, polypeptides and uses therefor, including diagnosis and treatment of Alzheimer's disease 审中-公开
标题翻译：核酸分子，多肽及其用途，包括阿尔茨海默病的诊断和治疗
公开(公告)号：US20070015217A1
公开(公告)日：2007-01-18
申请号：US11078000
申请日：2005-03-11
申请人： L. Durham , David Friedman , Herath Mudiyanselage Chandrasiri Herath , Lida Kimmel , Rajesh Parekh , David Potter , Christian Rohlff , B. Silber , Thomas Stiger , P. Sunderland , Robert Townsend , W. White , Stephen Williams
发明人： L. Durham , David Friedman , Herath Mudiyanselage Chandrasiri Herath , Lida Kimmel , Rajesh Parekh , David Potter , Christian Rohlff , B. Silber , Thomas Stiger , P. Sunderland , Robert Townsend , W. White , Stephen Williams
IPC分类号： G01N33/567 , G01N33/53
CPC分类号： G01N33/6896 , G01N2800/2821
摘要： The present invention provides methods and compositions for screening, diagnosis and prognosis of Alzheimer's disease, for monitoring the effectiveness of Alzheimer's disease treatment, and for drug development. Alzheimer's Disease-Associated Features (AFs), detectable by two-dimensional electrophoresis of cerebrospinal fluid, serum or plasma are described. The invention further provides Alzheimer's Disease-Associated Protein Isoforms (APIs) detectable in cerebrospinal fluid, serum or plasma, preparations comprising isolated APIs, antibodies, pharmaceutical compositions, diagnostic and therapeutic methods, and kits comprising or based on the same.
摘要翻译：本发明提供了用于阿尔茨海默病筛选，诊断和预后的方法和组合物，用于监测阿尔茨海默病治疗的有效性和用于药物开发。描述了通过脑脊液，血清或血浆的二维电泳可检测的阿尔茨海默氏病相关特征（AF）。本发明进一步提供可在脑脊液，血清或血浆中检测的阿尔茨海默氏病相关蛋白质异构体（API），包含分离的API，抗体，药物组合物，诊断和治疗方法以及包含或基于其的试剂盒。

3. 发明申请

US20210362905A1 MATERIAL HANDLING PALLET 有权
公开(公告)号：US20210362905A1
公开(公告)日：2021-11-25
申请号：US17324700
申请日：2021-05-19
申请人： Venkataramu Bangalore , David Friedman
发明人： Venkataramu Bangalore , David Friedman
IPC分类号： B65D19/00 , B65D19/38
摘要： A pallet comprises an upper load supporting surface having a peripheral edge, and a lower surface having a peripheral edge. The lower surface has substantially the same dimensions as the upper load supporting surface. A plurality of peripheral supports are provided at or near the peripheral edge of the lower surface and extend upwardly therefrom to the upper load supporting surface so that the upper load supporting surface and the lower surface are spaced from each other and define sides of the pallet. Each side of the pallet has a first opening and a second opening which are defined by the upper load supporting surface, the lower surface, and a pair of peripheral supports. Inclined surfaces are provided on the lower surface.

4. 发明申请

US20140307730A1 VOICE OVER INTERNET INTEGRATION 有权
标题翻译：语音互联网整合
公开(公告)号：US20140307730A1
公开(公告)日：2014-10-16
申请号：US13280328
申请日：2011-10-24
申请人： David Friedman , Wai Wu
发明人： David Friedman , Wai Wu
IPC分类号： H04L12/66
CPC分类号： H04M7/006 , G06Q30/0601 , G06Q30/0613 , H04L67/02 , H04M3/5183 , H04M3/523 , H04M7/003 , Y10S379/90
摘要： An Internet telephony system (ITS) comprising an enclosure, an interface to a packet switched computer network; a communications processor, configured to implement a voice over Internet Protocol communication, to execute at least a client portion of a telephony control application supporting at least a coordinated delivery of data presented to the user through a user interface and a conversation using the voice over Internet Protocol communication; and to execute a web browser; and at least one manual control input.
摘要翻译：一种互联网电话系统（ITS），包括机箱，到分组交换计算机网络的接口; 通信处理器，被配置为实现通过因特网协议通信的语音，以执行电话控制应用的至少一个客户端部分，所述电话控制应用支持通过用户界面呈现给用户的至少协调传送数据，以及使用所述互联网上的语音进行会话协议通信; 并执行网络浏览器; 和至少一个手动控制输入。

5. 发明授权

US08179882B1 Voice over internet call center integration 有权
标题翻译：语音互联网呼叫中心集成
公开(公告)号：US08179882B1
公开(公告)日：2012-05-15
申请号：US11853801
申请日：2007-09-11
申请人： David Friedman , Wai Wu
发明人： David Friedman , Wai Wu
IPC分类号： H04L12/66
CPC分类号： H04M7/006 , G06Q30/0601 , G06Q30/0613 , H04L67/02 , H04M3/5183 , H04M3/523 , H04M7/003 , Y10S379/90
摘要： An internet telephony system (ITS) comprising a browser display having a hyperlink, communicating with a server, retrieving a user's preferences, and initiating a voice communication with the user, through a communications channel defined by the user preferences. An ITS comprising a client system having an Internet browser, and a server hosting a Web site, wherein a message is transmitted from the server to the client system based on the user's status with respect to Web site, the user seeking to establish a voice communication session. A telephony server, comprising an application program communicating directly with telephony hardware, and an application programming interface, wherein the application program includes a call function to an external program. An ITS, comprising a browser display having a hyperlink, the hyperlink communicating with a server, retrieving a user-related data, and initiating a voice communication with the user, wherein the user is charged for the communication.
摘要翻译：一种互联网电话系统（ITS），包括具有超链接的浏览器显示器，通过由用户偏好定义的通信信道与服务器通信，检索用户的偏好以及发起与用户的语音通信。包括具有因特网浏览器的客户端系统和托管网站的服务器的ITS，其中基于用户关于网站的状态从服务器向客户端系统发送消息，寻求建立语音通信的用户会话一种电话服务器，包括与电话硬件直接通信的应用程序，以及应用编程接口，其中所述应用程序包括对外部程序的呼叫功能。一种ITS，包括具有超链接的浏览器显示器，与服务器通信的超链接，检索与用户相关的数据，以及发起与用户的语音通信，其中用户为该通信收费。

6. 发明申请

US20100125842A1 EFFICIENT VOLUME MANAGER HOT SWAPPING 有权
标题翻译：高效管理员热切换
公开(公告)号：US20100125842A1
公开(公告)日：2010-05-20
申请号：US12274203
申请日：2008-11-19
申请人： David Friedman , Prasad Bagal
发明人： David Friedman , Prasad Bagal
IPC分类号： G06F9/455 , G06F12/00 , G06F12/02 , G06F9/46
CPC分类号： G06F12/16 , G06F3/0631 , G06F3/0665 , G06F9/4856
摘要： Methods of hot-swapping a logical volume manager (LVM) and updating an associated extent map are presented. Methods for migrating a virtual machine running an application using an LVM from one physical machine to another physical machine are also presented. The LVM can be used by a database application or other applications in a single-node or multi-node environment. The LVM is shut down, version numbers for each segment of its associated extent map are saved, and a new LVM is started. The new LVM's extent map is compared with the old extent map, and segments in the LVM which have changed are selectively updated.
摘要翻译：介绍了热交换逻辑卷管理器（LVM）和更新相关扩展图的方法。还介绍了将使用LVM运行应用程序的虚拟机从一台物理机器迁移到另一台物理机器的方法。 LVM可以由数据库应用程序或单节点或多节点环境中的其他应用程序使用。关闭LVM，将保存其关联扩展图的每个段的版本号，并启动一个新的LVM。将新的LVM的范围图与旧的扩展图进行比较，并且LVM中已更改的段被选择性更新。

7. 发明授权

US07694021B1 Firewall for gateway network elements between IP based networks 有权
标题翻译：基于IP的网络之间的网关网元的防火墙
公开(公告)号：US07694021B1
公开(公告)日：2010-04-06
申请号：US10690182
申请日：2003-10-21
申请人： Lee Shombert , Stephen James , Jennifer Carle , David Friedman
发明人： Lee Shombert , Stephen James , Jennifer Carle , David Friedman
IPC分类号： G06F15/16
CPC分类号： H04L63/00
摘要： Techniques for implementing a firewall in a gateway network element between two IP based networks is provided. Packets can be filtered out that specify the gateway network element as the source, where the packet comes from the network that is not visible to the other network. For example, if a packet on DCC going to the gateway network element specifies the gateway network element as the source, the packet can be discarded.
摘要翻译：提供了在两个基于IP的网络之间的网关网元中实现防火墙的技术。可以过滤掉可以将网关网元指定为源的数据包，其中数据包来自网络，对另一个网络不可见。例如，如果DCC上的到达网关网元的数据包将网关网元指定为源，则可以丢弃该数据包。

8. 发明申请

US20060021989A1 Beverage container for immersing food 审中-公开
标题翻译：用于浸泡食物的饮料容器
公开(公告)号：US20060021989A1
公开(公告)日：2006-02-02
申请号：US10901805
申请日：2004-07-29
申请人： David Friedman
发明人： David Friedman
IPC分类号： A47G19/22
CPC分类号： A47G19/22
摘要： A beverage container for immersing food including an open container, a holder defining an area adapted to hold food and a handle. The holder fits within the open container and has a first magnetic portion such that when the holder is in the container, the first magnetic portion is adjacent an interior part of the walls of the container. The handle has a second magnetic portion such that when the second magnetic portion of the handle is placed adjacent an exterior part of the walls of the container near the first magnetic portion of the holder, a magnetic bond formed between the first and second magnetic portions permits movement of the handle to control movement of the holder. The holder can take many forms such as a basket. Channels and/or tracks may be added to guide the holder and/or handle during movement. A retrofit kit is also claimed.
摘要翻译： 1.一种用于浸渍食物的饮料容器，包括开放的容器，限定适于保持食物的区域的保持器和手柄。保持器安装在敞开的容器内并且具有第一磁性部分，使得当保持器位于容器中时，第一磁性部分邻近容器的壁的内部。手柄具有第二磁性部分，使得当手柄的第二磁性部分靠近容器的第一磁性部分的容器的壁的外部部分附近放置时，形成在第一和第二磁性部分之间的磁性粘合允许手柄的运动来控制支架的运动。持有人可以采取许多形式，如篮子。可以添加通道和/或轨道以在运动期间引导保持器和/或手柄。还要求改装套件。

9. 外观设计

USD250518S Jewelry medallion or similar article 失效
公开(公告)号：USD250518S
公开(公告)日：1978-12-12
申请号：US711524
申请日：1976-08-04
申请人： David Friedman
设计人： David Friedman

10. 发明公开

US20230227206A1 MATERIAL HANDLING PALLET 审中-公开
公开(公告)号：US20230227206A1
公开(公告)日：2023-07-20
申请号：US18068688
申请日：2022-12-20
申请人： Venkataramu Bangalore , David Friedman
发明人： Venkataramu Bangalore , David Friedman
IPC分类号： B65D19/00 , B65D19/38
CPC分类号： B65D19/0046 , B65D19/38 , B65D2203/10 , B65D2519/00363 , B65D2519/00288 , B65D2519/00308 , B65D2519/00323 , B65D2519/00273
摘要： A pallet comprises an upper load supporting surface having a peripheral edge, and a lower surface having a peripheral edge. The lower surface has substantially the same dimensions as the upper load supporting surface. A plurality of peripheral supports are provided at or near the peripheral edge of the lower surface and extend upwardly therefrom to the upper load supporting surface so that the upper load supporting surface and the lower surface are spaced from each other and define sides of the pallet. Each side of the pallet has a first opening and a second opening which are defined by the upper load supporting surface, the lower surface, and a pair of peripheral supports. Inclined surfaces are provided on the lower surface.

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