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1. 发明申请

US20070015217A1 Nucleic acid molecules, polypeptides and uses therefor, including diagnosis and treatment of Alzheimer's disease 审中-公开
标题翻译：核酸分子，多肽及其用途，包括阿尔茨海默病的诊断和治疗
公开(公告)号：US20070015217A1
公开(公告)日：2007-01-18
申请号：US11078000
申请日：2005-03-11
申请人： L. Durham , David Friedman , Herath Mudiyanselage Chandrasiri Herath , Lida Kimmel , Rajesh Parekh , David Potter , Christian Rohlff , B. Silber , Thomas Stiger , P. Sunderland , Robert Townsend , W. White , Stephen Williams
发明人： L. Durham , David Friedman , Herath Mudiyanselage Chandrasiri Herath , Lida Kimmel , Rajesh Parekh , David Potter , Christian Rohlff , B. Silber , Thomas Stiger , P. Sunderland , Robert Townsend , W. White , Stephen Williams
IPC分类号： G01N33/567 , G01N33/53
CPC分类号： G01N33/6896 , G01N2800/2821
摘要： The present invention provides methods and compositions for screening, diagnosis and prognosis of Alzheimer's disease, for monitoring the effectiveness of Alzheimer's disease treatment, and for drug development. Alzheimer's Disease-Associated Features (AFs), detectable by two-dimensional electrophoresis of cerebrospinal fluid, serum or plasma are described. The invention further provides Alzheimer's Disease-Associated Protein Isoforms (APIs) detectable in cerebrospinal fluid, serum or plasma, preparations comprising isolated APIs, antibodies, pharmaceutical compositions, diagnostic and therapeutic methods, and kits comprising or based on the same.
摘要翻译：本发明提供了用于阿尔茨海默病筛选，诊断和预后的方法和组合物，用于监测阿尔茨海默病治疗的有效性和用于药物开发。描述了通过脑脊液，血清或血浆的二维电泳可检测的阿尔茨海默氏病相关特征（AF）。本发明进一步提供可在脑脊液，血清或血浆中检测的阿尔茨海默氏病相关蛋白质异构体（API），包含分离的API，抗体，药物组合物，诊断和治疗方法以及包含或基于其的试剂盒。

2. 发明申请

US20050163789A9 Nucleic acid molecules, polypeptides and uses therefor, including diagnosis and treatment of Alzheimer's disease 审中-公开
标题翻译：核酸分子，多肽及其用途，包括阿尔茨海默病的诊断和治疗
公开(公告)号：US20050163789A9
公开(公告)日：2005-07-28
申请号：US10264309
申请日：2002-10-03
申请人： L. Durham , David Friedman , Herath Mudiyanselage Herath , Lida Kimmel , Rajesh Parekh , David Potter , Christian Rohlff , B. Silber , Peter Snyder , Holly Soares , Thomas Stiger , P. Sunderland , Robert Townsend , W. White , Stephen Williams
发明人： L. Durham , David Friedman , Herath Mudiyanselage Herath , Lida Kimmel , Rajesh Parekh , David Potter , Christian Rohlff , B. Silber , Peter Snyder , Holly Soares , Thomas Stiger , P. Sunderland , Robert Townsend , W. White , Stephen Williams
IPC分类号： G01N33/68 , A61K48/00 , A61K39/00 , C07K16/40 , C12Q1/68 , G01N33/53 , G01N33/542
CPC分类号： G01N33/6896 , G01N2333/4709 , G01N2550/00 , G01N2800/2821 , G01N2800/52
摘要： The present invention provides methods and compositions for screening, diagnosis and prognosis of Alzheimer's disease, for monitoring the effectiveness of Alzheimer's disease treatment, and for drug development. Alzheimer's Disease-Associated Features (AFs), detectable by two-dimensional electrophoresis of cerebrospinal fluid, serum or plasma are described. The invention further provides Alzheimer's Disease-Associated Protein Isoforms (APIs) detectable in cerebrospinal fluid, serum or plasma, preparations comprising isolated APIs, antibodies immunospecific for APIs, pharmaceutical compositions, diagnostic and therapeutic methods, and kits comprising or based on the same.
摘要翻译：本发明提供了用于阿尔茨海默病筛选，诊断和预后的方法和组合物，用于监测阿尔茨海默病治疗的有效性和用于药物开发。描述了通过脑脊液，血清或血浆的二维电泳可检测的阿尔茨海默氏病相关特征（AF）。本发明还提供在脑脊液，血清或血浆中可检测的阿尔茨海默氏病相关蛋白质异构体（API），包含分离的API的制剂，针对API免疫特异性的抗体，药物组合物，诊断和治疗方法，以及包含或基于其的试剂盒。

3. 发明申请

US20050113302A1 A3 receptor-mediated cardioprotective proteins and therapeutic and diagnostic methods of use 审中-公开
标题翻译： A3受体介导的心脏保护蛋白和治疗和诊断方法的使用
公开(公告)号：US20050113302A1
公开(公告)日：2005-05-26
申请号：US10652779
申请日：2003-08-29
申请人： John Thompson , David Potter , Delvin Knight , Antonio Gualberto , Katherine Landschulz , Herath Mudiyenselage Chandrasiri Herath , Christian Rohlff
发明人： John Thompson , David Potter , Delvin Knight , Antonio Gualberto , Katherine Landschulz , Herath Mudiyenselage Chandrasiri Herath , Christian Rohlff
IPC分类号： A61K20060101 , A61K38/00 , A61K38/08 , A61K38/10 , A61K38/17 , C07K7/06 , C07K7/08 , C07K14/47 , G01N33/68
CPC分类号： C07K14/47 , A61K38/00 , G01N33/6893 , G01N2500/04 , G01N2500/10 , G01N2500/20
摘要： Proteins are identified that exhibit an altered expression in mammalian cardiac tissue in response to A3 agonist infusion. These proteins are termed A3 receptor-mediated cardioprotective proteins (A3Ps) and protein isoforms (A3PIs) and are useful as pharmaceuticals and as targets in screening methods for identifying an agent capable of modulating the expression of one or more A3P and/or A3PI.
摘要翻译：鉴定出响应于A 3 N激动剂输注在哺乳动物心脏组织中表现出改变的蛋白质。这些蛋白质被称为Aβ受体介导的心脏保护性蛋白（A 3 S Ps）和蛋白质同种型（Aβ3β），并且可用作药物以及作为用于鉴定能够调节一个或多个A 3 P和/或A 3 PI的表达的试剂的筛选方法中的靶标。

4. 发明授权

US09447178B2 Therapeutic and diagnostic target 有权
标题翻译：治疗和诊断目标
公开(公告)号：US09447178B2
公开(公告)日：2016-09-20
申请号：US14127788
申请日：2012-06-28
申请人： Christian Rohlff , Alasdair Stamps
发明人： Christian Rohlff , Alasdair Stamps
IPC分类号： A61K39/395 , C07K16/18 , A61K39/00 , C07K16/00 , C07K16/28 , C07K16/30 , C12Q1/68 , G01N33/574 , C07K14/435 , G01N33/566
CPC分类号： C07K16/18 , A61K39/0011 , C07K14/435 , C07K16/005 , C07K16/2896 , C07K16/30 , C07K2317/55 , C07K2317/732 , C07K2317/77 , C12Q1/6886 , C12Q2600/158 , G01N33/566 , G01N33/57426 , G01N2500/04 , H01M2/0473 , H01M2/263 , H01M2/30 , H01M10/058
摘要： The present invention provides methods and compositions for treatment, screening, diagnosis and prognosis of acute myeloid leukemia (AML), B-cell chronic lymphocytic leukemia, breast cancer, colorectal cancer, kidney cancer, head and neck cancer, lung cancer, ovarian cancer or pancreatic cancer, for monitoring the effectiveness of acute myeloid leukemia (AML), B-cell chronic lymphocytic leukemia, breast cancer, colorectal cancer, kidney cancer, head and neck cancer, lung cancer, ovarian cancer or pancreatic cancer treatment, and for drug development. The present invention also provides methods and compositions for depletion of immune cells to treat inflammatory diseases.
摘要翻译：本发明提供急性骨髓性白血病（AML），B细胞慢性淋巴细胞白血病，乳腺癌，结肠直肠癌，肾癌，头颈癌，肺癌，卵巢癌或卵巢癌的治疗，筛选，诊断和预后的方法和组合物胰腺癌，用于监测急性骨髓性白血病（AML），B细胞慢性淋巴细胞白血病，乳腺癌，结肠直肠癌，肾癌，头颈癌，肺癌，卵巢癌或胰腺癌治疗的有效性，以及药物开发。本发明还提供用于消除免疫细胞以治疗炎性疾病的方法和组合物。

5. 发明申请

US20120114672A1 Antibodies Specific to Cadherin-17 有权
标题翻译：卡介素-17特异性抗体
公开(公告)号：US20120114672A1
公开(公告)日：2012-05-10
申请号：US13265517
申请日：2010-04-20
申请人： Christian Rohlff , Jonathan Alexander Terrett
发明人： Christian Rohlff , Jonathan Alexander Terrett
IPC分类号： A61K39/395 , C12N15/13 , C12N15/63 , C12N1/19 , C12P21/02 , A61P35/00 , C12N1/21 , C07K16/18 , C12N5/10
CPC分类号： C07K16/28 , A61K39/00 , A61K47/6817 , A61K47/6849 , A61K47/6851 , C07K2317/51 , C07K2317/515 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/77 , C07K2317/80
摘要： The present disclosure provides antibodies, including isolated monoclonal antibodies, which specifically bind to Cadherin-17 with high affinity. Nucleic acid molecules encoding Cadherin-17 antibodies, expression vectors, host cells and methods for expressing the Cadherin-17 antibodies are also provided. Bispecific molecules and pharmaceutical compositions comprising the Cadherin-17 antibodies are also provided. Methods for detecting Cadherin-17, as well as methods for treating various cancers, including colorectal cancer, are disclosed.
摘要翻译：本公开提供了抗体，包括分离的单克隆抗体，其以高亲和力特异性结合钙粘着蛋白-17。还提供了编码钙粘蛋白-17抗体的核酸分子，表达载体，宿主细胞和用于表达钙粘着蛋白-17抗体的方法。还提供了包含钙黏着蛋白-17抗体的双特异性分子和药物组合物。公开了用于检测Cadherin-17的方法，以及用于治疗各种癌症的方法，包括结肠直肠癌。

6. 发明申请

US20100285017A1 MATRIPTASE PROTEIN AND USES THEREOF 有权
标题翻译： MATRIPTASE蛋白及其用途
公开(公告)号：US20100285017A1
公开(公告)日：2010-11-11
申请号：US12701566
申请日：2010-02-07
申请人： Christian Rohlff , Jonathan Alexander Terrett
发明人： Christian Rohlff , Jonathan Alexander Terrett
IPC分类号： A61K39/395 , C07K16/30 , C07K14/435 , A61P35/00 , C07H21/04 , C12N15/63 , C12P21/08 , G01N33/573 , A61K38/17 , C12N5/10 , C12Q1/02 , C12Q1/68
CPC分类号： G01N33/573 , C12Q1/37 , G01N33/574 , G01N2333/96433
摘要： The present invention provides methods and compositions for treatment, screening, diagnosis, prognosis and therapy of breast cancer, colorectal cancer, esophageal cancer, gastric cancer, prostate cancer and uterine cancer, for monitoring the effectiveness of breast cancer, colorectal cancer, esophageal cancer, gastric cancer, prostate cancer and uterine cancer treatment, and for drug development.
摘要翻译：本发明提供乳腺癌，结肠直肠癌，食管癌，胃癌，前列腺癌和子宫癌的治疗，筛选，诊断，预后和治疗的方法和组合物，用于监测乳腺癌，结肠直肠癌，食管癌，胃癌，前列腺癌和子宫癌治疗，以及药物开发。

7. 发明申请

US20090258376A1 Protein isoforms and uses thereof 审中-公开
标题翻译：蛋白质同种型及其用途
公开(公告)号：US20090258376A1
公开(公告)日：2009-10-15
申请号：US12322714
申请日：2009-02-05
申请人： Christian Rohlff
发明人： Christian Rohlff
IPC分类号： G01N33/53
CPC分类号： G01N33/6896 , G01N2800/2821 , G01N2800/285
摘要： There is provided a method for screening for or, diagnosis or prognosis of a neurological disorder in a subject, for determining the stage or severity of such a neurological disorder in a subject, for identifying a subject at risk of developing such a neurological disorder, or for monitoring the effect of therapy administered to a subject having such a neurological disorder, said method comprising: (a) analyzing a test sample of body fluid or tissue from the subject said sample comprising at least one Protein Isoform selected from one of the following Protein Isoform Families: PIF-1 and PIF-2; and (b) comparing the abundance of said Protein Isoform(s) in the test sample with the abundance of said Protein Isoform(s) in a test sample from one or more persons free from neurological disorder, or with a previously determined reference range for that Protein Isoform in subjects free from neurological disorder, wherein a diagnosis of or a positive result in screening for or a prognosis of a more advanced condition of said neurological disorder is indicated by an increased abundance of said Protein Isoform(s) in the test sample relative to the abundance of said Protein Isoform(s) in the test sample from one or more persons free from neurological disorder, or with the previously determined reference range for that Protein Isoform in subjects free from neurological disorder.
摘要翻译：提供了用于筛选受试者神经障碍的诊断或预后的方法，用于确定受试者中这种神经障碍的阶段或严重程度，用于鉴定发生这种神经障碍风险的受试者，或用于监测施用于具有这种神经障碍的受试者的治疗效果，所述方法包括：（a）从受试者分析体液或组织的测试样品，所述样品包含至少一种选自以下蛋白质之一的蛋白质异构体异构体家族：PIF-1和PIF-2; 和（b）将来自测试样品中的所述蛋白质同种型的丰度与来自一个或多个没有神经障碍的人的测试样品中的所述蛋白质异构体的丰度进行比较，或者与先前确定的参考范围所述免疫神经障碍的受试者中的蛋白质异构体，其中所述神经系统疾病的更晚期状态的筛查或预后的诊断或阳性表现为所述测试样品中所述蛋白质同种型的丰度增加相对于来自一个或多个没有神经障碍的人的测试样品中所述蛋白质同种型的丰度，或者与免疫神经障碍的受试者中该蛋白质同种型的先前确定的参考范围相关。

8. 发明申请

US20090208507A1 PROTEIN ISOFORMS AND USES THEREOF 审中-公开
标题翻译：蛋白质ISOFORMS及其用途
公开(公告)号：US20090208507A1
公开(公告)日：2009-08-20
申请号：US12359265
申请日：2009-01-23
申请人： Christian Rohlff
发明人： Christian Rohlff
IPC分类号： A61K39/395 , C07K16/18 , G01N33/53 , C07K14/00 , A61K31/7088 , A61P9/00
CPC分类号： G01N33/6896 , A61K38/00 , C07K14/47 , G01N2800/2814
摘要： There is provided, inter alia, a method of diagnosing MCI in a subject, differentiating MCI from AD in a subject, guiding therapy in a subject suffering from MCI, or assigning a prognostic risk of one or more future clinical outcomes to a subject suffering from MCI, the method comprising: (a) performing assays configured to detect a polypeptide derived from a protein selected from the list consisting of proteins defined by SEQ ID Nos 1-18 as a marker in one or more samples obtained from said subject; and (b) correlating the results of said assay(s) to the presence or absence of MCI and AD in the subject, to a therapeutic regimen to be used in the subject, or to the prognostic risk of one or more clinical outcomes for the subject suffering from MCI.
摘要翻译：特别地，提供了诊断受试者中MCI的方法，区分受试者中的MCI与AD，指导患有MCI的受试者的治疗，或将一种或多种未来临床结果的预后风险指定给患有 MCI，所述方法包括：（a）进行配置以检测来源于选自SEQ ID No.1-18所定义的蛋白质的蛋白质的多肽的测定作为从所述受试者获得的一个或多个样品中的标记物; 和（b）将所述测定的结果与受试者中MCI和AD的存在或不存在相关，以用于受试者中使用的治疗方案，或将所述测定的一个或多个临床结果的预后风险与受试者患有MCI。

9. 发明授权

US09181339B2 Antibodies specific to cadherin-17 有权
标题翻译：对cadherin-17特异的抗体
公开(公告)号：US09181339B2
公开(公告)日：2015-11-10
申请号：US13265517
申请日：2010-04-20
申请人： Christian Rohlff , Jonathan Alexander Terrett
发明人： Christian Rohlff , Jonathan Alexander Terrett
IPC分类号： C07K16/28 , C07K16/30 , A61K39/00 , A61K47/48
CPC分类号： C07K16/28 , A61K39/00 , A61K47/6817 , A61K47/6849 , A61K47/6851 , C07K2317/51 , C07K2317/515 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/77 , C07K2317/80
摘要： The present disclosure provides antibodies, including isolated monoclonal antibodies, which specifically bind to Cadherin-17 with high affinity. Nucleic acid molecules encoding Cadherin-17 antibodies, expression vectors, host cells and methods for expressing the Cadherin-17 antibodies are also provided. Bispecific molecules and pharmaceutical compositions comprising the Cadherin-17 antibodies are also provided. Methods for detecting Cadherin-17, as well as methods for treating various cancers, including colorectal cancer, are disclosed.
摘要翻译：本公开提供了抗体，包括分离的单克隆抗体，其以高亲和力特异性结合钙粘着蛋白-17。还提供了编码钙粘蛋白-17抗体的核酸分子，表达载体，宿主细胞和用于表达钙粘着蛋白-17抗体的方法。还提供了包含钙黏着蛋白-17抗体的双特异性分子和药物组合物。公开了用于检测Cadherin-17的方法，以及用于治疗各种癌症的方法，包括结肠直肠癌。

10. 发明申请

US20130251723A1 ANTI-ROR1 ANTIBODIES 有权
标题翻译：抗ROR1抗体
公开(公告)号：US20130251723A1
公开(公告)日：2013-09-26
申请号：US13823999
申请日：2011-10-03
申请人： Christian Rohlff , Alasdair Stamps , Jonathan Alexander Terrett
发明人： Christian Rohlff , Alasdair Stamps , Jonathan Alexander Terrett
IPC分类号： C07K16/40
CPC分类号： C07K16/40 , C07K16/005 , C07K16/2803 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/73 , C07K2317/77
摘要： The invention provides antibodies which bind to the extracellular domain of the Tyrosine-protein kinase transmembrane receptor ROR1. Nucleic acid molecules encoding the antibodies, expression vectors, host cells and methods for expressing the antibodies are also provided. The antibodies may be used for the treatment of cancer, including non-small cell lung carcinoma, B-cell chronic lymphocytic leukemia and colon cancer.
摘要翻译：本发明提供结合酪氨酸 - 蛋白激酶跨膜受体ROR1的细胞外结构域的抗体。还提供了编码抗体的核酸分子，表达载体，宿主细胞和用于表达抗体的方法。抗体可用于治疗癌症，包括非小细胞肺癌，B细胞慢性淋巴细胞白血病和结肠癌。

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