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1. 发明授权

US5980760A System and methods for harvesting mononuclear cells by recirculation of packed red blood cells 失效
标题翻译：通过再循环包装的红细胞收获单核细胞的系统和方法
公开(公告)号：US5980760A
公开(公告)日：1999-11-09
申请号：US886780
申请日：1997-07-01
申请人： Kyungyoon Min , Richard I Brown , Daniel F Bischof , William H Cork , Robert J Cantu
发明人： Kyungyoon Min , Richard I Brown , Daniel F Bischof , William H Cork , Robert J Cantu
IPC分类号： A61M1/02 , A61M1/36 , B01D21/26 , B04B5/04 , B04B11/02 , B04B13/00
CPC分类号： B01D21/302 , A61M1/3696 , B01D21/262 , B04B13/00 , B04B5/0442 , B01D2221/10 , B04B2005/045
摘要： A blood separation system operates in a first mode to convey whole blood into the inlet region of a blood processing chamber for centrifugal separation into packed red blood cells, a plasma constituent, and an interface, which carries mononuclear cells, between the packed red blood cells and the plasma constituent. The system removes packed red blood cells and the plasma constituent from the chamber, while maintaining the interface within the chamber. The system operates in a second mode to remove the interface from the chamber by conveying packed red blood cells into the inlet region. An outlet path conveys the removed interface from the chamber. The outlet path includes a first sensing element to locate mononuclear cells in the removed interface and provide a sensed output upon locating mononuclear cells.
摘要翻译：血液分离系统以第一模式操作，以将全血输送到血液处理室的入口区域，用于离心分离成装填的红血细胞，血浆成分和携带单核细胞的界面，和等离子体成分。该系统在保持室内的界面的同时从腔室中去除填充的红细胞和等离子体成分。该系统以第二模式操作，以通过将填充的红血细胞输送到入口区域来从腔室去除界面。出口路径从腔室传送去除的界面。出口路径包括第一感测元件，以将去除界面中的单核细胞定位，并在定位单核细胞时提供感测输出。

2. 发明授权

US5961842A Systems and methods for collecting mononuclear cells employing control of packed red blood cell hematocrit 失效
标题翻译：采用控制包装的红细胞血细胞比容收集单核细胞的系统和方法
公开(公告)号：US5961842A
公开(公告)日：1999-10-05
申请号：US886350
申请日：1997-07-01
申请人： Kyungyoon Min , Richard I Brown , Robert J Cantu , Daniel F Bischof , William H Cork
发明人： Kyungyoon Min , Richard I Brown , Robert J Cantu , Daniel F Bischof , William H Cork
IPC分类号： A61M1/30 , A61M1/36 , B04B5/04 , B04B13/00 , B01D21/26
CPC分类号： B04B5/0442 , A61M1/303 , A61M1/308 , A61M1/3693 , A61M1/3696 , B04B13/00 , A61M1/30 , A61M2205/331 , B04B2005/045
摘要： Blood separation systems and methods employ a rotating chamber. The chamber includes an inlet region where whole blood enters for centrifugal separation into packed red blood cells, a plasma constituent, and an interface carrying mononuclear cells between the packed red blood cells and the plasma constituent. The packed red blood cells in the chamber have a hematocrit value H.sub.PRBC. A controller operates in a first mode to convey whole blood into the inlet region while removing packed red blood cells and the plasma constituent from the chamber and while maintaining the interface within the chamber. The controller also operates in the first mode to maintain a set H.sub.PRBC by conveying packed red blood cells into the inlet region.
摘要翻译：血液分离系统和方法采用旋转室。所述腔室包括全血进入的入口区域，用于离心分离成包装的红细胞，血浆成分，以及在填充的红细胞和血浆成分之间携带单核细胞的界面。室内包装的红细胞具有红细胞比容值HPRBC。控制器以第一模式操作，以将全血输送到入口区域，同时从室中去除填充的红细胞和等离子体成分，同时保持室内的界面。控制器还在第一模式下操作以通过将填充的红细胞输送到入口区域来维持一组HPRBC。

3. 发明授权

US6027657A Systems and methods for collecting diluted mononuclear cells 失效
标题翻译：用于收集稀释的单核细胞的系统和方法
公开(公告)号：US6027657A
公开(公告)日：2000-02-22
申请号：US886732
申请日：1997-07-01
申请人： Kyungyoon Min , Richard I Brown , Robert J Cantu
发明人： Kyungyoon Min , Richard I Brown , Robert J Cantu
IPC分类号： A61K35/14 , A61M1/36 , A61M1/38 , B01D21/26 , B04B5/04
CPC分类号： B01D21/302 , A61M1/3693 , A61M1/3696 , A61M1/38 , B01D21/262 , B04B5/0442 , B01D2221/10 , B04B2005/045
摘要： Systems and methods rotate a chamber, in which whole blood is centrifugally separated into packed red blood cells, a plasma constituent, and an interface between the packed red blood cells and the plasma constituent. The interface carries platelets and mononuclear cells. The systems and methods include an interface control unit. The interface control unit is operative in a first state to enable removal of platelet-poor plasma in a first container for use as a diluting liquid. In a second state, the interface control unit retains mononuclear cells in the chamber, while removing platelet-rich plasma from the chamber, bypassing the platelet-poor collection container, thereby maintaining its platelet-poor character. In a third state, the interface control unit enables the removal of mononuclear cells from the chamber in a path that leads to a second container, where the mononuclear cells are collected. The systems and methods direct platelet-poor plasma from the first container to the second container to dilute the removed mononuclear cells in the second container.
摘要翻译：系统和方法旋转室，其中全血离心分离成包装的红细胞，血浆成分以及填充的红细胞和血浆成分之间的界面。界面携带血小板和单核细胞。系统和方法包括接口控制单元。界面控制单元在第一状态下操作以使得能够在用作稀释液体的第一容器中移除贫血小血浆。在第二状态下，界面控制单元在腔室中保留单核细胞，同时从腔室中除去富含血小板的血浆，绕过血小板收集容器，从而维持其血小板减少的特征。在第三状态下，界面控制单元能够在通向收集单核细胞的第二容器的路径中从腔室去除单核细胞。系统和方法将血小板从第一容器直接引导到第二容器，以稀释第二容器中去除的单核细胞。

4. 发明授权

US06183651B2 Blood processing systems and methods which optically monitor plasma opacity 有权
标题翻译：血液处理系统和光学监测等离子体不透明度的方法
公开(公告)号：US06183651B2
公开(公告)日：2001-02-06
申请号：US09382893
申请日：1999-08-25
申请人： Richard I Brown , John T Foley , Kyungyoon Min , Mark Sahlin
发明人： Richard I Brown , John T Foley , Kyungyoon Min , Mark Sahlin
IPC分类号： B01D1712
CPC分类号： B01D17/0217 , A61M1/3693 , A61M1/3696 , A61M2202/0427 , A61M2205/331 , B01D21/003 , B01D21/2405 , B01D21/245 , B01D21/26 , B01D21/262 , B01D21/32 , B01D2221/10 , B04B5/0442 , B04B13/00 , A61M2202/0071
摘要： Blood processing systems and methods separate blood into constituents including a plasma constituent that includes a platelet volume. The systems and methods detect the optical density of the plasma constituent and generate a first output indicative of the optical density. A processing element integrates the first output relative to the volume of plasma constituent and generates an integrated output. The integrated output correlates to the platelet volume. A second processing element generates a third output based, at least in part, upon the integrated output, which comprises parameters for storing the platelet volume.
摘要翻译：血液处理系统和方法将血液分成包括血小板体积的血浆成分的成分。系统和方法检测等离子体成分的光密度并产生表示光密度的第一输出。处理元件将第一输出相对于等离子体成分的体积积分并产生积分输出。综合输出与血小板体积相关。第二处理元件至少部分地基于集成输出产生第三输出，其包括用于存储血小板体积的参数。

5. 发明授权

US5958250A Blood processing systems and methods which optically derive the volume of platelets contained in a plasma constituent 失效
标题翻译：血液处理系统和光学导出血浆成分中所含的血小板体积的方法
公开(公告)号：US5958250A
公开(公告)日：1999-09-28
申请号：US896665
申请日：1997-07-18
申请人： Richard I Brown , John T Foley , Kyungyoon Min , Mark Sahlin
发明人： Richard I Brown , John T Foley , Kyungyoon Min , Mark Sahlin
IPC分类号： G01N33/49 , A61B5/145 , A61K35/14 , A61M1/02 , A61M1/36 , A61P7/00 , B01D17/02 , B01D17/12 , B01D21/24 , B01D21/26 , B04B5/04 , B04B13/00 , G01N21/35
CPC分类号： B01D17/0217 , A61M1/3693 , A61M1/3696 , B01D21/003 , B01D21/2405 , B01D21/245 , B01D21/262 , B01D21/32 , B04B13/00 , B04B5/0442 , A61M2202/0427 , A61M2205/331 , B01D2221/10
摘要： Blood processing systems and methods separate blood into constituents including a plasma constituent that includes a platelet volume. The systems and methods detect the optical density of the plasma constituent and generate a first output indicative of the optical density. A processing element integrates the first output relative to the volume of plasma constituent and generates an integrated output. The integrated output correlates to the platelet volume. A second processing element generates a third output based, at least in part, upon the integrated output, which comprises parameters for storing the platelet volume.
摘要翻译：血液处理系统和方法将血液分成包括血小板体积的血浆成分的成分。系统和方法检测等离子体成分的光密度并产生表示光密度的第一输出。处理元件将第一输出相对于等离子体成分的体积积分并产生积分输出。综合输出与血小板体积相关。第二处理元件至少部分地基于集成输出产生第三输出，其包括用于存储血小板体积的参数。

6. 发明授权

US06899666B2 Blood processing systems and methods 失效
标题翻译：血液处理系统和方法
公开(公告)号：US06899666B2
公开(公告)日：2005-05-31
申请号：US10337486
申请日：2003-01-07
申请人： Richard I Brown
发明人： Richard I Brown
IPC分类号： A61M1/02 , A61M1/30 , A61M1/36 , B01D17/02 , B01D21/24 , B01D21/26 , B04B5/04 , B04B7/08 , B04B13/00
CPC分类号： B04B13/00 , A61M1/025 , A61M1/30 , A61M1/302 , A61M1/303 , A61M1/308 , A61M1/3603 , A61M1/3693 , A61M1/3696 , A61M2202/0427 , A61M2205/331 , A61M2205/3344 , A61M2205/3351 , A61M2205/3355 , A61M2205/3393 , B01D17/0217 , B01D21/0003 , B01D21/2405 , B01D21/245 , B01D21/26 , B01D21/262 , B01D21/32 , B01D21/34 , B01D2221/10 , B04B5/0442 , B04B7/08 , B04B2005/045 , A61M2202/0071
摘要： Systems and methods centrifugally separate whole blood into red blood cells, plasma, and a platelet concentrate. The systems and methods rotate a first rotating separation zone about a rotational axis, to separate whole blood into red blood cells and plasma constituent carrying platelets. Red blood cells separated are directed in a first circumferential flow direction toward a terminal wall, where blood flow is halted. Surface hematocrit is successively increased in the first circumferential flow direction by separating the plasma constituent from the red blood cells. Separated red blood cells are directed from the first rotating separation zone through a path where the surface hematocrit is the most. Plasma constituent separated is directed in a second circumferential flow direction opposite to the first circumferential flow direction toward a different region in the first rotating separation zone, where the surface hematocrit is the least. The systems and methods separate the plasma constituent into platelet concentrate and plasma in a second rotating separation zone.
摘要翻译：系统和方法将全血离心分离成红细胞，血浆和血小板浓缩物。系统和方法围绕旋转轴旋转第一旋转分离区，以将全血分离成红细胞和携带血小板的血浆成分。分离的红细胞在朝向终止壁的第一周向流动方向上被引导，其中血液流动停止。通过将等离子体成分与红细胞分离，在第一周向流动方向上依次增加表面血细胞比容。分离的红细胞从第一旋转分离区通过表面血细胞比容最多的路径引导。分离的等离子体成分在与第一圆周流动方向相反的第二圆周流动方向上朝向第一旋转分离区中的不同区域，其中表面血细胞比容最小。系统和方法在第二旋转分离区中将等离子体成分分离成血小板浓缩物和血浆。

7. 发明授权

US06296450B1 Systems and methods for control of pumps employing gravimetric sensing 有权
标题翻译：使用重力感应控制泵的系统和方法
公开(公告)号：US06296450B1
公开(公告)日：2001-10-02
申请号：US09390269
申请日：1999-09-03
申请人： Tom Westberg , Richard E Mullen , Clement Lim Yu , Richard I Brown
发明人： Tom Westberg , Richard E Mullen , Clement Lim Yu , Richard I Brown
IPC分类号： F04B4900
CPC分类号： F04B49/06 , F04B49/12 , F04B2205/09
摘要： Systems and related methods pump fluid through a pump having a stroke volume. The systems and methods employ gravimetric control measures to monitor fluid flow through the pump. An actuator interacts with the pump during a stroke interval (TStroke) to pump fluid through the pump. The systems and methods couple a receptacle to the pump, to either dispense fluid into the pump or to receive fluid from the pump. The systems and methods detect changes in weight of the receptacle over a sample time period. The systems and methods achieve a desired flow rate (QDesired) by deriving an actual flow rate (QActual) by sensing changes in weight of the receptacle over the sample time period, taking into account the density of the fluid, and adjusting the stroke interval based upon QActual so that QDesired is achieved.
摘要翻译：系统和相关方法通过具有行程体积的泵来泵送流体。系统和方法采用重力控制措施来监测通过泵的流体流量。执行器在行程间隔（TStroke）期间与泵相互作用以泵送流体通过泵。系统和方法将容器连接到泵，以将流体分配到泵中或从泵接收流体。系统和方法在一个采样时间段内检测容器的重量变化。系统和方法通过在考虑到流体的密度的基础上感测容器在采样时间段内的重量变化并通过调节基于行程间隔的方式获得实际流量（QActual）来实现期望的流量（QDesire）在QActual上实现QDesired。

8. 发明授权

US5980757A Interface detection and control systems and method 失效
标题翻译：接口检测和控制系统及方法
公开(公告)号：US5980757A
公开(公告)日：1999-11-09
申请号：US922880
申请日：1997-09-03
申请人： Richard I Brown , John T Foley , Kyungoon Min , Mark Sahlin
发明人： Richard I Brown , John T Foley , Kyungoon Min , Mark Sahlin
IPC分类号： B01D21/26 , B04B5/04 , B04B13/00 , G01F23/292 , B01D17/12 , B04B15/00 , G01N21/00
CPC分类号： B01D21/262 , B04B13/00 , B04B5/0442 , G01F23/292 , B01D2221/08 , B01D2221/10 , B04B2013/006
摘要： A viewing area in a blood separation chamber is monitored for the presence of an interface region between plasma and cellular blood components. Sensed optical density values for the viewing area are compared to a calibrated threshold value to generate a time pulse output. A calibration element derives the calibrated threshold value based upon either (i) a comparison of a sensed reference optical density value in the viewing area to an expected optical density value for the reference material, or (ii) a sensed optical density value of plasma exiting the blood separation chamber, or both.
摘要翻译：监测血液分离室中的观察区域是否存在血浆和细胞血液成分之间的界面区域。将观察区域的感测光密度值与校准的阈值进行比较以产生时间脉冲输出。校准元件基于（i）将观察区域中的感测参考光密度值与参考材料的预期光密度值进行比较，或（ii）等离子体出射的感测光密度值血液分离室，或两者。

9. 发明授权

US06984218B2 Systems and methods for control of pumps employing electrical field sensing 有权
公开(公告)号：US06984218B2
公开(公告)日：2006-01-10
申请号：US10153165
申请日：2002-05-21
申请人： Abinash Nayak , James Jacobson , Tom Westberg , William E Brach , Richard I Brown
发明人： Abinash Nayak , James Jacobson , Tom Westberg , William E Brach , Richard I Brown
IPC分类号： A61M37/00 , C02F1/00
CPC分类号： F04B43/026 , A61M1/1006 , A61M1/1037 , A61M1/1053 , A61M1/1062 , A61M1/30 , A61M1/302 , A61M1/303 , A61M1/308 , A61M1/3696 , A61M2205/128 , A61M2205/331 , A61M2205/3393 , F04B13/02 , F04B49/065 , F04B2205/09
摘要： Systems and related methods pump fluid through a pump. The pump comprises a pump chamber, which is responsive to applied pressures to convey fluid. The systems and methods place an electrode in electrical conductive contact with fluid in the pump chamber which, in use, is coupled to an electrical source. The electrode generates an electrical field in the pump chamber that varies according volume of fluid in the pump chamber. The systems and methods register variations in the electrical field as fluid is conveyed through the pump chamber.

10. 发明授权

US06312607B1 Blood processing systems and methods which optically monitor incremental platelet volumes in a plasma constituent 有权
标题翻译：血液处理系统和光学监测血浆成分中血小板增加量的方法
公开(公告)号：US06312607B1
公开(公告)日：2001-11-06
申请号：US09419727
申请日：1999-10-16
申请人： Richard I Brown , John T Foley , Timothy J Patno
发明人： Richard I Brown , John T Foley , Timothy J Patno
IPC分类号： B01D1712
CPC分类号： B01D21/26 , A61M1/30 , A61M1/302 , A61M1/303 , A61M1/308 , A61M1/3693 , A61M1/3696 , A61M2202/0427 , A61M2205/331 , A61M2205/50 , B01D17/0217 , B01D21/0003 , B01D21/2405 , B01D21/245 , B01D21/262 , B01D21/32 , B01D2221/08 , B01D2221/10 , B04B5/0442 , B04B13/00 , A61M2202/0071
摘要： Blood processing systems and methods separate blood into constituents including a plasma constituent that includes a platelet volume. The systems and methods detect the optical density of the plasma constituent and generate a first output indicative of the optical density. A processing element integrates the first output relative to the volume of plasma constituent and generates an integrated output. The integrated output correlates to the platelet volume. A second processing element generates an output based, at least in part, upon the integrated output, which comprises a value indicating a blood volume that needs be processed to obtain a desired platelet volume.
摘要翻译：血液处理系统和方法将血液分成包括血小板体积的血浆成分的成分。系统和方法检测等离子体成分的光密度并产生表示光密度的第一输出。处理元件将第一输出相对于等离子体成分的体积积分并产生积分输出。综合输出与血小板体积相关。第二处理元件至少部分地基于积分输出生成输出，其包括指示需要处理以获得期望的血小板体积的血液体积的值。

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