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1. 发明授权

US5980760A System and methods for harvesting mononuclear cells by recirculation of packed red blood cells 失效
标题翻译：通过再循环包装的红细胞收获单核细胞的系统和方法
公开(公告)号：US5980760A
公开(公告)日：1999-11-09
申请号：US886780
申请日：1997-07-01
申请人： Kyungyoon Min , Richard I Brown , Daniel F Bischof , William H Cork , Robert J Cantu
发明人： Kyungyoon Min , Richard I Brown , Daniel F Bischof , William H Cork , Robert J Cantu
IPC分类号： A61M1/02 , A61M1/36 , B01D21/26 , B04B5/04 , B04B11/02 , B04B13/00
CPC分类号： B01D21/302 , A61M1/3696 , B01D21/262 , B04B13/00 , B04B5/0442 , B01D2221/10 , B04B2005/045
摘要： A blood separation system operates in a first mode to convey whole blood into the inlet region of a blood processing chamber for centrifugal separation into packed red blood cells, a plasma constituent, and an interface, which carries mononuclear cells, between the packed red blood cells and the plasma constituent. The system removes packed red blood cells and the plasma constituent from the chamber, while maintaining the interface within the chamber. The system operates in a second mode to remove the interface from the chamber by conveying packed red blood cells into the inlet region. An outlet path conveys the removed interface from the chamber. The outlet path includes a first sensing element to locate mononuclear cells in the removed interface and provide a sensed output upon locating mononuclear cells.
摘要翻译：血液分离系统以第一模式操作，以将全血输送到血液处理室的入口区域，用于离心分离成装填的红血细胞，血浆成分和携带单核细胞的界面，和等离子体成分。该系统在保持室内的界面的同时从腔室中去除填充的红细胞和等离子体成分。该系统以第二模式操作，以通过将填充的红血细胞输送到入口区域来从腔室去除界面。出口路径从腔室传送去除的界面。出口路径包括第一感测元件，以将去除界面中的单核细胞定位，并在定位单核细胞时提供感测输出。

2. 发明授权

US5961842A Systems and methods for collecting mononuclear cells employing control of packed red blood cell hematocrit 失效
标题翻译：采用控制包装的红细胞血细胞比容收集单核细胞的系统和方法
公开(公告)号：US5961842A
公开(公告)日：1999-10-05
申请号：US886350
申请日：1997-07-01
申请人： Kyungyoon Min , Richard I Brown , Robert J Cantu , Daniel F Bischof , William H Cork
发明人： Kyungyoon Min , Richard I Brown , Robert J Cantu , Daniel F Bischof , William H Cork
IPC分类号： A61M1/30 , A61M1/36 , B04B5/04 , B04B13/00 , B01D21/26
CPC分类号： B04B5/0442 , A61M1/303 , A61M1/308 , A61M1/3693 , A61M1/3696 , B04B13/00 , A61M1/30 , A61M2205/331 , B04B2005/045
摘要： Blood separation systems and methods employ a rotating chamber. The chamber includes an inlet region where whole blood enters for centrifugal separation into packed red blood cells, a plasma constituent, and an interface carrying mononuclear cells between the packed red blood cells and the plasma constituent. The packed red blood cells in the chamber have a hematocrit value H.sub.PRBC. A controller operates in a first mode to convey whole blood into the inlet region while removing packed red blood cells and the plasma constituent from the chamber and while maintaining the interface within the chamber. The controller also operates in the first mode to maintain a set H.sub.PRBC by conveying packed red blood cells into the inlet region.
摘要翻译：血液分离系统和方法采用旋转室。所述腔室包括全血进入的入口区域，用于离心分离成包装的红细胞，血浆成分，以及在填充的红细胞和血浆成分之间携带单核细胞的界面。室内包装的红细胞具有红细胞比容值HPRBC。控制器以第一模式操作，以将全血输送到入口区域，同时从室中去除填充的红细胞和等离子体成分，同时保持室内的界面。控制器还在第一模式下操作以通过将填充的红细胞输送到入口区域来维持一组HPRBC。

3. 发明授权

US6027657A Systems and methods for collecting diluted mononuclear cells 失效
标题翻译：用于收集稀释的单核细胞的系统和方法
公开(公告)号：US6027657A
公开(公告)日：2000-02-22
申请号：US886732
申请日：1997-07-01
申请人： Kyungyoon Min , Richard I Brown , Robert J Cantu
发明人： Kyungyoon Min , Richard I Brown , Robert J Cantu
IPC分类号： A61K35/14 , A61M1/36 , A61M1/38 , B01D21/26 , B04B5/04
CPC分类号： B01D21/302 , A61M1/3693 , A61M1/3696 , A61M1/38 , B01D21/262 , B04B5/0442 , B01D2221/10 , B04B2005/045
摘要： Systems and methods rotate a chamber, in which whole blood is centrifugally separated into packed red blood cells, a plasma constituent, and an interface between the packed red blood cells and the plasma constituent. The interface carries platelets and mononuclear cells. The systems and methods include an interface control unit. The interface control unit is operative in a first state to enable removal of platelet-poor plasma in a first container for use as a diluting liquid. In a second state, the interface control unit retains mononuclear cells in the chamber, while removing platelet-rich plasma from the chamber, bypassing the platelet-poor collection container, thereby maintaining its platelet-poor character. In a third state, the interface control unit enables the removal of mononuclear cells from the chamber in a path that leads to a second container, where the mononuclear cells are collected. The systems and methods direct platelet-poor plasma from the first container to the second container to dilute the removed mononuclear cells in the second container.
摘要翻译：系统和方法旋转室，其中全血离心分离成包装的红细胞，血浆成分以及填充的红细胞和血浆成分之间的界面。界面携带血小板和单核细胞。系统和方法包括接口控制单元。界面控制单元在第一状态下操作以使得能够在用作稀释液体的第一容器中移除贫血小血浆。在第二状态下，界面控制单元在腔室中保留单核细胞，同时从腔室中除去富含血小板的血浆，绕过血小板收集容器，从而维持其血小板减少的特征。在第三状态下，界面控制单元能够在通向收集单核细胞的第二容器的路径中从腔室去除单核细胞。系统和方法将血小板从第一容器直接引导到第二容器，以稀释第二容器中去除的单核细胞。

4. 发明授权

US6027441A Systems and methods providing a liquid-primed, single flow access chamber 失效
标题翻译：提供液体注射的单流入口室的系统和方法
公开(公告)号：US6027441A
公开(公告)日：2000-02-22
申请号：US886179
申请日：1997-07-01
申请人： Robert J Cantu , Kyungyoon Min , Douglas W Reitz
发明人： Robert J Cantu , Kyungyoon Min , Douglas W Reitz
IPC分类号： A61K35/14 , A61M1/36 , B01D21/26 , B04B9/14 , B04B11/00 , B04B11/04
CPC分类号： A61M1/3693 , A61M1/3696 , B01D21/262 , B01D21/32 , B01D21/34 , B04B9/14 , B01D2221/10 , B04B2005/045 , B04B2009/143
摘要： Blood processing systems and methods rotate a processing chamber on a rotating element. The processing chamber includes a first compartment and a second compartment. Blood is conveyed into the first compartment for centrifugal separation into components. A liquid free of blood occupies the second compartment to counter-balance the first compartment during rotation on the rotating element. In one embodiment, the second compartment is served by a single fluid flow access. Prior to use, the single access is coupled to tubing, through which a vacuum is drawn to remove air from the second compartment. While the vacuum exists, communication is opened between the tubing and a source of liquid. The vacuum draws the liquid into the second compartment through the single access, thereby priming the second compartment for use.
摘要翻译：血液处理系统和方法将处理室旋转在旋转元件上。处理室包括第一隔室和第二隔室。血液被输送到第一隔室中，用于离心分离成组分。没有血液的液体占据第二隔室，以在旋转元件旋转期间平衡第一隔间。在一个实施例中，第二隔室由单个流体流动进入。在使用之前，单个通道联接到管道，通过该管道吸入真空以从第二隔室移除空气。当存在真空时，在管道和液体源之间打开通信。真空通过单一进入将液体吸入第二隔室，从而启动第二隔间以供使用。

5. 发明授权

US06582349B1 Blood processing system 有权
标题翻译：血液处理系统
公开(公告)号：US06582349B1
公开(公告)日：2003-06-24
申请号：US09669752
申请日：2000-09-26
申请人： Robert J Cantu , Kyungyoon Min , Douglas W Reitz , Robert I Brown
发明人： Robert J Cantu , Kyungyoon Min , Douglas W Reitz , Robert I Brown
IPC分类号： B04D1100
CPC分类号： A61M1/3693 , A61M1/3696 , B01D21/262 , B01D21/32 , B01D21/34 , B01D2221/10 , B04B9/14 , B04B2005/045 , B04B2009/143
摘要： Blood processing systems and methods rotate a processing chamber on a rotating element. The processing chamber includes a first compartment and a second compartment. Blood is conveyed into the first compartment for centrifugal separation into components. A liquid free of blood occupies the second compartment to counter-balance the first compartment during rotation on the rotating element. In one embodiment, the second compartment is served by a single fluid flow access. Prior to use, the single access is coupled to tubing, through which a vacuum is drawn to remove air from the second compartment. While the vacuum exists, communication is opened between the tubing and a source of liquid. The vacuum draws the liquid into the second compartment through the single access, thereby priming the second compartment for use.
摘要翻译：血液处理系统和方法将处理室旋转在旋转元件上。处理室包括第一隔室和第二隔室。血液被输送到第一隔室中，用于离心分离成组分。没有血液的液体占据第二隔室，以在旋转元件旋转期间平衡第一隔间。在一个实施例中，第二隔室由单个流体流动进入。在使用之前，单个通道联接到管道，通过该管道吸入真空以从第二隔室移除空气。当存在真空时，在管道和液体源之间打开通信。真空通过单一进入将液体吸入第二隔室，从而启动第二隔间以供使用。

6. 发明授权

US06168561A Blood processing chamber counter-balanced with blood-free liquid 失效
标题翻译：血液处理室与无血液反应
公开(公告)号：US06168561A
公开(公告)日：2001-01-02
申请号：US09377339
申请日：1999-08-19
申请人： Robert J Cantu , Kyungyoon Min , Douglas W Reitz
发明人： Robert J Cantu , Kyungyoon Min , Douglas W Reitz
IPC分类号： B01D2126
CPC分类号： A61M1/3693 , A61M1/3696 , B01D21/262 , B01D21/32 , B01D21/34 , B01D2221/10 , B04B9/14 , B04B2005/045 , B04B2009/143
摘要： Blood processing systems and methods rotate a processing chamber on a rotating element. The processing chamber includes a first compartment and a second compartment. Blood is conveyed into the first compartment for centrifugal separation into components. A liquid free of blood occupies the second compartment to counter-balance the first compartment during rotation on the rotating element. In one embodiment, the second compartment is served by a single fluid flow access. Prior to use, the single access is coupled to tubing, through which a vacuum is drawn to remove air from the second compartment. While the vacuum exists, communication is opened between the tubing and a source of liquid. The vacuum draws the liquid into the second compartment through the single access, thereby priming the second compartment for use.
摘要翻译：血液处理系统和方法将处理室旋转在旋转元件上。处理室包括第一隔室和第二隔室。血液被输送到第一隔室中，用于离心分离成组分。没有血液的液体占据第二隔室，以在旋转元件旋转期间平衡第一隔间。在一个实施例中，第二隔室由单个流体流动进入。在使用之前，单个通道联接到管道，通过该管道吸入真空以从第二隔室移除空气。当存在真空时，在管道和液体源之间打开通信。真空通过单一进入将液体吸入第二隔室，从而启动第二隔间以供使用。

7. 发明申请

US20140043930A1 PLATELET RESUSPENSION METHOD AND APPARATUS 审中-公开
公开(公告)号：US20140043930A1
公开(公告)日：2014-02-13
申请号：US14113077
申请日：2012-05-02
申请人： Fletcher C. Belt , Michael J. Kast , Kyungyoon Min , Katherine Radwanski , William H. Cork
发明人： Fletcher C. Belt , Michael J. Kast , Kyungyoon Min , Katherine Radwanski , William H. Cork
IPC分类号： A61M1/02
CPC分类号： A61M1/025 , A61M1/0281 , A61M1/3693 , A61M1/3696
摘要： A method is disclosed for resuspending a concentrated blood component collected in a single-use processing chamber that is mounted to a rotatable support of a centrifugal collection system. A resuspension solution is introduced to the single-use processing chamber constraining the concentrated blood component. The rotatable support with the single-use processing chamber mounted thereto is removed from the centrifugal collection system and mounted to a resuspension device. The device is then activated for a period of time sufficient to resuspend the concentrated blood component in the resuspension solution. In another aspect, the resuspension device is configured to impart a reciprocating arcuate motion to the support and its associated single-use processing chamber. A frequency of approximately 300 to 325 rpm over a period of time of approximately 1.5 to 2.5 minutes has been found effective for resuspending platelets. Reciprocation through an arc of less than 200° is provided.
摘要翻译：公开了一种用于将收集在一次性处理室中的浓缩血液成分重新悬浮的方法，所述一次性处理室安装在离心收集系统的可旋转支撑件上。将再悬浮溶液引入约束浓缩血液成分的一次性加工室中。安装在其上的一次性处理室的可旋转支撑件从离心收集系统中移除并安装到再悬挂装置。然后将该装置激活足以将浓缩血液成分重悬于再悬浮液中的一段时间。在另一方面，再悬浮装置被配置为向支撑件及其相关联的一次性使用处理室施加往复的弓形运动。发现在约1.5至2.5分钟的时间段内约300至325rpm的频率已经被有效用于重悬血小板。提供通过小于200°的弧的往复运动。

8. 发明申请

US20130345674A1 MEMBRANE SEPARATION DEVICES, SYSTEMS AND METHODS EMPLOYING SAME, AND DATA MANAGEMENT SYSTEMS AND METHODS 审中-公开
公开(公告)号：US20130345674A1
公开(公告)日：2013-12-26
申请号：US14003284
申请日：2012-03-09
申请人： Benjamin E. Kusters , Christopher J. Wegener , Daniel R. Boggs , Kyungyoon Min , William H. Cork , Daryl R. Calhoun , Bryan Blickhan , Daniel Lynn
发明人： Benjamin E. Kusters , Christopher J. Wegener , Daniel R. Boggs , Kyungyoon Min , William H. Cork , Daryl R. Calhoun , Bryan Blickhan , Daniel Lynn
IPC分类号： A61M1/36 , A61M1/38
CPC分类号： A61M1/34 , A61M1/0272 , A61M1/0281 , A61M1/265 , A61M1/3403 , A61M1/3496 , A61M1/3633 , A61M1/3687 , A61M1/3692 , A61M1/38 , A61M2205/3331 , A61M2205/50 , A61M2205/60 , B01D61/18 , B01D63/06 , B01D63/16 , B01D2313/08 , B01D2313/20 , B01D2315/02 , G16H10/40
摘要： A membrane separation device is disclosed along with systems and methods employing the device in blood processing procedures. In one embodiment, a spinning membrane separator is provided in which at least two zones or regions are created in the gap between the membrane and the shell, such that mixing of the fluid between the two regions is inhibited by a radial rib associated with the membrane that decreases the gap between the membrane and the shell to define two fluid regions, the ridge isolating the fluid in the two regions to minimize mixing between the two. Automated systems and methods are disclosed for separating a unit of previously collected whole blood into components, such as concentrated red cells and plasma, for collecting red cells and plasma directly from a donor in a single pass, and for cell washing. Data management systems and methods and priming methods are also disclosed.

9. 发明授权

US08448992B2 Sterile docking device, medical fluid flow system with sterile docking device and method of using same 有权
标题翻译：无菌对接装置，具有无菌对接装置的医用流体流动系统及其使用方法
公开(公告)号：US08448992B2
公开(公告)日：2013-05-28
申请号：US13028372
申请日：2011-02-16
申请人： Kyungyoon Min , William H. Cork
发明人： Kyungyoon Min , William H. Cork
IPC分类号： F16L35/00 , B32B38/04
CPC分类号： A61M39/143 , F04C2270/0421 , F16L29/005 , F16L47/02 , F16L2201/44
摘要： Method and apparatus are disclosed for forming a sealed communication between conduits or conduit subassemblies, each of which has a wall with an exterior surface, and at least one of the walls includes an electrically conductive portion. The exterior surfaces may be brought into a facing relationship, and each conductive portion is heated sufficiently to sterilize the exterior surfaces of the walls by generating electrical current in the conductive portion, such as by application of a voltage or by induction. An aperture is then provided, as by an aperture-forming member, through the facing walls to provide communication between the conduits or conduit subassemblies.
摘要翻译：公开了用于在导管或导管子组件之间形成密封连接的方法和装置，每个管子组件具有带有外表面的壁，并且至少一个壁包括导电部分。外表面可以处于面对的关系，并且每个导电部分被充分加热以通过在导电部分中产生电流来消除（例如通过施加电压或通过感应）的电流。然后，通过孔形成构件，通过面向壁提供孔，以在导管或导管组件之间提供连通。

10. 发明授权

US11462321B2 Mobile applications for blood centers 有权
公开(公告)号：US11462321B2
公开(公告)日：2022-10-04
申请号：US13209161
申请日：2011-08-12
申请人： Brian C. Case , Jonathan Prendergast , John W. Barry, Jr. , Kyungyoon Min , William H. Cork , Daryl Richard Calhoun , Christie Larson , Robert Bronersky
发明人： Brian C. Case , Jonathan Prendergast , John W. Barry, Jr. , Kyungyoon Min , William H. Cork , Daryl Richard Calhoun , Christie Larson , Robert Bronersky
IPC分类号： G06Q10/08 , G16H40/63 , G06T11/20 , G16H10/60 , G16H40/67 , G06Q10/10
摘要： Certain examples provide systems, methods, and apparatus to provide information regarding blood collection instruments via a mobile device. An example method for blood collection instrument management includes providing a graphical representation of one or more blood collection instruments with a visual indication of a status for each instrument. The graphical representation is to visually convey information regarding each of the one or more blood collection instruments and is selectable by a user to provide additional information regarding each of the one or more blood collection instruments. The method includes facilitating access to troubleshoot and interact with the one or more blood collection instruments via the mobile device. The method includes dynamically updating the status for each instrument via communication between the mobile device and one or more blood collection facilities at which the one or more blood collection instruments are located.

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