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1. 发明授权

US06180626B2 Vascular-permeability suppressants 失效
标题翻译：血管通透性抑制剂
公开(公告)号：US06180626B2
公开(公告)日：2001-01-30
申请号：US09051086
申请日：1998-04-13
申请人： Kyoichi Shimomura , Toshitaka Manda , Fusako Nishigaki
发明人： Kyoichi Shimomura , Toshitaka Manda , Fusako Nishigaki
IPC分类号： A61K31535
CPC分类号： C07D303/22 , A61K31/336
摘要： A vascular permeability suppressant includes an oxaspirooctane derivative of the general formula (I): [wherein, R1 represents, for example, lower alkylcarbamoyl group or protected carbamoyl group, R2 represents lower alkoxyl group, and R3 represents the formula: or a pharmaceutically acceptable salt thereof, together with a pharmaceutically acceptable carrier. Particularly, for example, an agent that can prevent retention of carcinomatous pleural effusion or carcinomatous ascites.
摘要翻译：血管渗透性抑制剂包括通式（I）的氧杂辛烷衍生物：[其中，R 1表示例如低级烷基氨基甲酰基或被保护的氨基甲酰基，R 2表示低级烷氧基，R 3表示下式：或其药学上可接受的盐与药学上可接受的载体一起。特别是，例如可以防止癌性胸腔积液或癌性腹水保留的药剂。

2. 发明申请

US20060199832A1 Use of non-immunosupressive pipecolic acid derivatives for inducing chondrogenic differentiation 审中-公开
标题翻译：使用非免疫抑制性哌醋酸衍生物诱导软骨形成分化
公开(公告)号：US20060199832A1
公开(公告)日：2006-09-07
申请号：US10547782
申请日：2004-03-01
申请人： Fusako Nishigaki , Susumu Miyata
发明人： Fusako Nishigaki , Susumu Miyata
IPC分类号： A61K31/4745
CPC分类号： A61K31/436 , A61K31/00
摘要： A non-immunosuppressive pipecolic acid derivative having an affinity for FKBP-type immunophilins is provided for inducing chondrogenic differentiation. Composition containing such compounds is also disclosed.
摘要翻译：提供对FKBP型免疫亲和素具有亲和力的非免疫抑制性哌耳酸衍生物用于诱导软骨形成分化。还公开了含有这些化合物的组合物。

3. 发明申请

US20110152268A1 NOVEL PHARMACEUTICAL COMPOSITION FOR TREATING NOCICEPTIVE PAIN 审中-公开
标题翻译：用于治疗疼痛的新型药物组合物
公开(公告)号：US20110152268A1
公开(公告)日：2011-06-23
申请号：US13061219
申请日：2009-09-10
申请人： Nobuaki Takeshita , Fusako Nishigaki , Toshiaki Aoki , Seiji Tamura , Kazumi Kikuchi , Akio Kuroda
发明人： Nobuaki Takeshita , Fusako Nishigaki , Toshiaki Aoki , Seiji Tamura , Kazumi Kikuchi , Akio Kuroda
IPC分类号： A61K31/5375 , C07D265/30 , A61P29/00
CPC分类号： C07D265/30 , A61K31/5375
摘要： The present invention relates to a pharmaceutical composition for treating nociceptive pain, containing a morpholine derivative or a pharmaceutically acceptable salt thereof, as an active ingredient. The present invention is useful in providing an excellent pharmaceutical composition for treating nociceptive pain. In addition, the present invention is particularly useful in providing a pharmaceutical composition for treating pain accompanying a disease selected from the group consisting of rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, spondylosis deformans, gouty arthritis, juvenile arthritis, scapulohumeral periarthritis, and cervical syndrome, lumbago, lumbago accompanying spondylosis deformans, menalgia, pain and tumentia after inflammation, operation or injury, pain after odontectomy, and cancer pain. In addition, the present invention is particularly useful for alleviating pain in a damaged cartilage region, and is particularly useful for osteoarthritis in which NSAIDs are not effective.
摘要翻译：本发明涉及用于治疗伤害性疼痛的药物组合物，其含有吗啉衍生物或其药学上可接受的盐作为活性成分。本发明可用于提供用于治疗伤害性疼痛的优异药物组合物。此外，本发明特别可用于提供用于治疗伴随选自以下的疾病的药物组合物：选自类风湿性关节炎，类风湿性脊椎炎，骨关节炎，变形性椎关节强硬症，痛风性关节炎，幼年型关节炎，肩周炎性关节炎和子宫颈综合征，腰痛，腰痛伴椎关节僵硬，麻痹症，炎症，手术或损伤后疼痛，咽后切除术后的疼痛，以及癌症疼痛。此外，本发明特别可用于缓解软骨损伤区域的疼痛，特别适用于NSAIDs无效的骨关节炎。

4. 发明授权

US08524727B2 Pyrimidine compound 有权
标题翻译：嘧啶化合物
公开(公告)号：US08524727B2
公开(公告)日：2013-09-03
申请号：US12933137
申请日：2010-03-29
申请人： Yuji Matsushima , Hirokazu Kubota , Hisao Hamaguchi , Yoshinori Okamoto , Takeshi Hondo , Fusako Nishigaki
发明人： Yuji Matsushima , Hirokazu Kubota , Hisao Hamaguchi , Yoshinori Okamoto , Takeshi Hondo , Fusako Nishigaki
IPC分类号： A01N43/54 , A61K31/505
CPC分类号： C07D239/42 , C07D239/34 , C07D239/38 , C07D239/48 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/06 , C07D451/04 , C07D453/02 , C07D491/107 , C07D493/08
摘要： A novel and excellent method for preventing and/or treating diseases related to a cannabinoid type 2 receptor, based on an agonistic action on a cannabinoid type 2 receptor. It was found that a hetero ring derivative mainly having two substituents, for example, a pyrimidine-5-carboxamide derivative having a substituent amino group at the 2-position, exhibits a potent agonistic action on a cannabinoid type 2 receptor, and can be an agent for preventing and/or treating diseases related to a cannabinoid type 2 receptor such as inflammatory diseases, pain, and the like.
摘要翻译：基于对大麻素2型受体的激动作用，预防和/或治疗与大麻素2型受体相关的疾病的新颖且优异的方法。发现主要具有两个取代基的杂环衍生物，例如2-位具有取代基氨基的嘧啶-5-甲酰胺衍生物对大麻素2型受体表现出强烈的激动作用，并且可以是用于预防和/或治疗与大麻素2型受体相关的疾病如炎性疾病，疼痛等的药剂。

5. 发明申请

US20110053912A1 PYRIMIDINE COMPOUND 有权
标题翻译：吡嗪化合物
公开(公告)号：US20110053912A1
公开(公告)日：2011-03-03
申请号：US12933137
申请日：2010-03-29
申请人： Yuji Matsushima , Hirokazu Kubota , Hisao Hamaguchi , Yoshinori Okamoto , Takeshi Hondo , Fusako Nishigaki
发明人： Yuji Matsushima , Hirokazu Kubota , Hisao Hamaguchi , Yoshinori Okamoto , Takeshi Hondo , Fusako Nishigaki
IPC分类号： A61K31/55 , C07D405/12 , A61K31/506 , A61P29/00 , C07D413/12 , A61K31/5377 , C07D417/12 , A61K31/541 , C07D491/107 , C07D417/14
CPC分类号： C07D239/42 , C07D239/34 , C07D239/38 , C07D239/48 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/06 , C07D451/04 , C07D453/02 , C07D491/107 , C07D493/08
摘要： A novel and excellent method for preventing and/or treating diseases related to a cannabinoid type 2 receptor, based on an agonistic action on a cannabinoid type 2 receptor. It was found that a hetero ring derivative mainly having two substituents, for example, a pyrimidine-5-carboxamide derivative having a substituent amino group at the 2-position, exhibits a potent agonistic action on a cannabinoid type 2 receptor, and can be an agent for preventing and/or treating diseases related to a cannabinoid type 2 receptor such as inflammatory diseases, pain, and the like.
摘要翻译：基于对大麻素2型受体的激动作用，预防和/或治疗与大麻素2型受体相关的疾病的新颖且优异的方法。发现主要具有两个取代基的杂环衍生物，例如2-位具有取代基氨基的嘧啶-5-甲酰胺衍生物对大麻素2型受体表现出强烈的激动作用，并且可以是用于预防和/或治疗与大麻素2型受体相关的疾病如炎性疾病，疼痛等的药剂。

6. 发明授权

US06489340B1 Macrolide compounds for inducing chondrogenic differentiation 失效
标题翻译：用于诱导软骨形成分化的大环内酯类化合物
公开(公告)号：US06489340B1
公开(公告)日：2002-12-03
申请号：US09926700
申请日：2001-12-04
申请人： Fusako Nishigaki , Susumu Miyata
发明人： Fusako Nishigaki , Susumu Miyata
IPC分类号： A61K3133
CPC分类号： A61K31/407 , A61K31/436
摘要： Chondrogenic differentiations is induced by administering a macrocyclic lactone to mammals to prevent or treat damage to cartilage.
摘要翻译：通过向哺乳动物施用大环内酯以预防或治疗软骨损伤来诱导软骨形成分化。

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