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1. 发明授权

US07468161B2 Automated high volume slide processing system 有权
标题翻译：自动化大容量幻灯片处理系统
公开(公告)号：US07468161B2
公开(公告)日：2008-12-23
申请号：US11116676
申请日：2005-04-27
申请人： Kurt Reinhardt , Charles D. Lemme , Glen Ward , William L. Richards , Wayne Showalter , Brandon Ambler , Austin Ashby , Chris Borchert , Devon C. Campbell , Kimberly Christensen , Matthew Freeman , Andrew Ghusson , Rick Griebel , Kendall B. Hendrick , Miroslav Holubec , Parula Mehta , Vince Rizzo
发明人： Kurt Reinhardt , Charles D. Lemme , Glen Ward , William L. Richards , Wayne Showalter , Brandon Ambler , Austin Ashby , Chris Borchert , Devon C. Campbell , Kimberly Christensen , Matthew Freeman , Andrew Ghusson , Rick Griebel , Kendall B. Hendrick , Miroslav Holubec , Parula Mehta , Vince Rizzo
IPC分类号： G01N1/28 , G01N35/00 , G01N1/36
CPC分类号： G01N35/00029 , B01L9/52 , B01L2300/0822 , G01N1/30 , G01N1/312 , G01N1/36 , G01N35/00732 , G01N35/0099 , G01N2035/00039 , G01N2035/00138 , Y10T436/11 , Y10T436/112499 , Y10T436/25 , Y10T436/2575
摘要： An automated system is provided for performing slide processing operations on slides bearing biological samples. In one embodiment, the disclosed system includes a slide tray holding a plurality of slides in a substantially horizontal position and a workstation that receives the slide tray. In a particular embodiment, a workstation delivers a reagent to slide surfaces without substantial transfer of reagent (and reagent borne contaminants such as dislodged cells) from one slide to another. A method for automated processing of slides also is provided.
摘要翻译：提供了一种自动化系统，用于对载有生物样品的载玻片进行滑动加工操作。在一个实施例中，所公开的系统包括容纳大致水平位置的多个滑块的滑动盘和接收滑动盘的工作站。在一个具体实施方案中，工作站递送试剂以滑动表面，而不会将试剂（和试剂携带的污染物，例如脱落的细胞）基本上从一个载玻片转移到另一个载体。还提供了一种用于自动处理幻灯片的方法。

2. 发明授权

US08663991B2 Automated high volume slide processing system 有权
标题翻译：自动化大容量幻灯片处理系统
公开(公告)号：US08663991B2
公开(公告)日：2014-03-04
申请号：US11181625
申请日：2005-07-13
申请人： Kurt Reinhardt , Charles D. Lemme , Glen Ward , William L. Richards , Wayne Showalter , Brandon Ambler , Austin Ashby , Chris Borchert , Devon C. Campbell , Kimberly Christensen , Matthew Freeman , Andrew Ghusson , Rick Griebel , Kendall B. Hendrick , Miroslav Holubec , Parula Mehta , Vince Rizzo
发明人： Kurt Reinhardt , Charles D. Lemme , Glen Ward , William L. Richards , Wayne Showalter , Brandon Ambler , Austin Ashby , Chris Borchert , Devon C. Campbell , Kimberly Christensen , Matthew Freeman , Andrew Ghusson , Rick Griebel , Kendall B. Hendrick , Miroslav Holubec , Parula Mehta , Vince Rizzo
IPC分类号： G01N35/00
CPC分类号： G01N35/00029 , B01L9/52 , B01L2300/0822 , G01N1/30 , G01N1/312 , G01N1/36 , G01N35/00732 , G01N35/0099 , G01N2035/00039 , G01N2035/00138 , Y10T436/11 , Y10T436/112499 , Y10T436/25 , Y10T436/2575
摘要： An automated system is provided for performing slide processing operations on slides bearing biological samples. In one embodiment, the disclosed system includes a slide tray holding a plurality of slides in a substantially horizontal position and a workstation that receives the slide tray. In a particular embodiment, a workstation delivers a reagent to slide surfaces without substantial transfer of reagent (and reagent borne contaminants such as dislodged cells) from one slide to another. A method for automated processing of slides also is provided.
摘要翻译：提供了一种自动化系统，用于对载有生物样品的载玻片进行滑动加工操作。在一个实施例中，所公开的系统包括容纳大致水平位置的多个滑块的滑动盘和接收滑动盘的工作站。在一个具体实施方案中，工作站递送试剂以滑动表面，而不会将试剂（和试剂携带的污染物，例如脱落的细胞）基本上从一个载玻片转移到另一个载体。还提供了一种用于自动处理幻灯片的方法。

3. 发明授权

US08883509B2 Apparatus and method for biological sample processing 有权
标题翻译：用于生物样品处理的装置和方法
公开(公告)号：US08883509B2
公开(公告)日：2014-11-11
申请号：US12167459
申请日：2008-07-03
申请人： Charles D. Lemme , William Richards , Glen Ward , Austin Ashby , Andrew Ghusson , Lisa Jensen-Long , Kevin Knapp , Rodney Kugizaki , Alain Larson , Paul Richards , Wayne Showalter , Chad Wilkinson
发明人： Charles D. Lemme , William Richards , Glen Ward , Austin Ashby , Andrew Ghusson , Lisa Jensen-Long , Kevin Knapp , Rodney Kugizaki , Alain Larson , Paul Richards , Wayne Showalter , Chad Wilkinson
IPC分类号： G01N1/28 , G01N35/02 , G01N35/10 , G01N35/00 , G01N1/31 , G01N35/04
CPC分类号： G01N1/312 , G01N1/06 , G01N35/00029 , G01N35/0092 , G01N35/1002 , G01N35/1011 , G01N35/1081 , G01N2035/00039 , G01N2035/00049 , G01N2035/00138 , G01N2035/00346 , G01N2035/00376 , G01N2035/0453 , Y10T436/112499 , Y10T436/25 , Y10T436/2575
摘要： An apparatus and method are described that achieve independent and simultaneous processing of a plurality of substrate-supported biological samples. In one embodiment, substrate holders arranged in a minor arc are independently moveable between a processing position and an access position, and reagents are delivered to substrates held in the substrate holders through a nozzle plate that moves along the arc of substrate holders. The disclosed apparatus and method are particularly suited for implementation of lean processing of biological samples.
摘要翻译：描述了实现多个基板支持的生物样品的独立且同时处理的装置和方法。在一个实施例中，布置成小弧的衬底保持器可以在处理位置和访问位置之间独立地移动，并且试剂通过沿着衬底保持器的弧移动的喷嘴板被传送到保持在衬底保持器中的衬底。所公开的装置和方法特别适合于实施生物样品的精益加工。

4. 发明申请

US20090017491A1 APPARATUS AND METHOD FOR BIOLOGICAL SAMPLE PROCESSING 有权
标题翻译：用于生物样品处理的装置和方法
公开(公告)号：US20090017491A1
公开(公告)日：2009-01-15
申请号：US12167459
申请日：2008-07-03
申请人： Charles D. Lemme , William Richards , Glen Ward , Austin Ashby , Andrew Ghusson , Lisa Jensen-Long , Kevin Knapp , Rodney Kugizaki , Alain Larson , Paul Richards , Wayne Showalter , Chad Wilkinson
发明人： Charles D. Lemme , William Richards , Glen Ward , Austin Ashby , Andrew Ghusson , Lisa Jensen-Long , Kevin Knapp , Rodney Kugizaki , Alain Larson , Paul Richards , Wayne Showalter , Chad Wilkinson
IPC分类号： G01N1/30 , B01J19/00 , G01N1/28 , G05B11/00 , G01N25/00
CPC分类号： G01N1/312 , G01N1/06 , G01N35/00029 , G01N35/0092 , G01N35/1002 , G01N35/1011 , G01N35/1081 , G01N2035/00039 , G01N2035/00049 , G01N2035/00138 , G01N2035/00346 , G01N2035/00376 , G01N2035/0453 , Y10T436/112499 , Y10T436/25 , Y10T436/2575
摘要： An apparatus and method are described that achieve independent and simultaneous processing of a plurality of substrate-supported biological samples. In one embodiment, substrate holders arranged in a minor arc are independently moveable between a processing position and an access position, and reagents are delivered to substrates held in the substrate holders through a nozzle plate that moves along the arc of substrate holders. The disclosed apparatus and method are particularly suited for implementation of lean processing of biological samples.
摘要翻译：描述了实现多个基板支持的生物样品的独立且同时处理的装置和方法。在一个实施例中，布置成小弧的衬底保持器可以在处理位置和访问位置之间独立地移动，并且试剂通过沿着衬底保持器的弧移动的喷嘴板被传送到保持在衬底保持器中的衬底。所公开的装置和方法特别适合于实施生物样品的精益加工。

5. 发明授权

US07303725B2 Automated high volume slide staining system 有权
标题翻译：自动化大容量载玻片染色系统
公开(公告)号：US07303725B2
公开(公告)日：2007-12-04
申请号：US10414804
申请日：2003-04-15
申请人： Kurt Reinhardt , Charles D. Lemme , Glen Ward , William Richards , Wayne Showalter
发明人： Kurt Reinhardt , Charles D. Lemme , Glen Ward , William Richards , Wayne Showalter
IPC分类号： G01N1/28 , G01N1/36 , G01N35/00
CPC分类号： B01L9/52 , B01L2300/0822 , G01N1/312 , G01N1/36 , Y10T436/11 , Y10T436/112499 , Y10T436/25
摘要： An automated slide processing apparatus includes a plurality of work stations arranged in a stack, and a transport/elevator for transporting slides between the various work stations.
摘要翻译：一种自动滑块处理装置，包括以堆叠方式布置的多个工作站，以及用于在各个工作站之间运送滑块的运输/升降机。

6. 发明授权

US08048373B2 Automated high volume slide staining system 有权
标题翻译：自动化大容量载玻片染色系统
公开(公告)号：US08048373B2
公开(公告)日：2011-11-01
申请号：US11876059
申请日：2007-10-22
申请人： Kurt Reinhardt , Charles D. Lemme , Glen Ward , William Richards , Wayne Showalter
发明人： Kurt Reinhardt , Charles D. Lemme , Glen Ward , William Richards , Wayne Showalter
IPC分类号： G01N1/28
CPC分类号： B01L9/52 , B01L2300/0822 , G01N1/312 , G01N1/36 , Y10T436/11 , Y10T436/112499 , Y10T436/25
摘要： An automated slide processing apparatus includes a plurality of work stations arranged in a stack, and a transport/elevator for transporting slides between the various work stations.
摘要翻译：一种自动滑块处理装置，包括以堆叠方式布置的多个工作站，以及用于在各个工作站之间运送滑块的运输/升降机。

7. 发明授权

US06403931B1 Slide heater calibrator and temperature converter apparatus and method 失效
标题翻译：滑动式加热器校准器和温度变换装置及方法
公开(公告)号：US06403931B1
公开(公告)日：2002-06-11
申请号：US09415026
申请日：1999-10-07
申请人： Wayne Showalter , William L. Richards , Charles D. Lemme
发明人： Wayne Showalter , William L. Richards , Charles D. Lemme
IPC分类号： H05B102
CPC分类号： G01N1/312 , B01L7/00 , G01N2035/00079 , G01N2035/00356 , G05D23/19 , Y10S435/809
摘要： Apparatus and methods for controlling heaters in an automated biological apparatus are provided. The heating system has a conversion buffer in between the desired temperature generator and the heating controller. The heating controller is in communication with a slide temperature sensor, which provides feedback to the heating controller, and a heater. Because the slide temperature sensor may inaccurately reflect the actual temperature on the slide, the heating controller may inaccurately heat the slide to an undesired temperature. Thus, the conversion buffer compensates for potential inaccuracies of the heating controller. The desired temperature generator sends the “desired temperature” for the slide to the conversion buffer. The conversion buffer converts the “desired temperature” to an “adjusted temperature” and sends it to the heating controller. The heating controller then controls the heater based upon the “adjusted temperature” and the heating sensor. The conversion buffer may be generated during calibration of the machine. Similarly, the temperature, which is sensed from the slide temperature sensor, may be adjusted to reflect the actual temperature for the slide.
摘要翻译：提供了一种用于在自动生物装置中控制加热器的装置和方法。加热系统在期望的温度发生器和加热控制器之间具有转换缓冲器。加热控制器与滑动温度传感器连通，该温度传感器向加热控制器和加热器提供反馈。因为滑块温度传感器可能不准确地反映滑块上的实际温度，所以加热控制器可能不准确地将滑块加热到不期望的温度。因此，转换缓冲器补偿了加热控制器的潜在不准确。所需的温度发生器将幻灯片的“所需温度”发送到转换缓冲区。转换缓冲器将“所需温度”转换为“调节温度”，并将其发送到加热控制器。然后，加热控制器基于“调节温度”和加热传感器控制加热器。转换缓冲器可能在校准机器期间产生。类似地，可以调节从滑动温度传感器感测的温度以反映滑块的实际温度。

8. 发明申请

US20110168744A1 METHOD AND APPARATUS FOR MODIFYING PRESSURE WITHIN A FLUID DISPENSER 有权
标题翻译：用于在流体分配器中调节压力的方法和装置
公开(公告)号：US20110168744A1
公开(公告)日：2011-07-14
申请号：US13050707
申请日：2011-03-17
申请人： Charles D. Lemme , Vincent R. Rizzo, JR. , Bobbi Druyor-Sanchez , Anthony Ford , Bronwen Heilman , Darin McDaniel , Brian McGraw , Stephen Mead , William Richards , Wayne Showalter
发明人： Charles D. Lemme , Vincent R. Rizzo, JR. , Bobbi Druyor-Sanchez , Anthony Ford , Bronwen Heilman , Darin McDaniel , Brian McGraw , Stephen Mead , William Richards , Wayne Showalter
IPC分类号： B67D7/06
CPC分类号： G01N1/312 , G01N35/1002 , G01N35/1016 , G01N2001/317 , G01N2035/1034
摘要： A fluid dispenser comprising a barrel having a reservoir chamber, the barrel having an upper portion, a cap connected to the reservoir chamber, the cap having a surface with at least one hole therethrough, a valve comprising a biasing member and a hole sealer, the valve being adjacent to the reservoir chamber, a coupler having a dispense chamber, and a vent located between the cap and the reservoir chamber, the vent including a vent opening and a vent material composed of oliophobic material.
摘要翻译：一种流体分配器，包括具有储存室的桶，所述桶具有上部，连接到储存室的盖，所述盖具有带有至少一个孔的表面，包括偏置构件和孔封闭器的阀，阀邻近储存室，具有分配室的联接器和位于盖和储存室之间的通风口，排气口包括通气口和由矾土材料构成的排气材料。

9. 发明授权

US07404927B2 Automated molecular pathology apparatus having fixed slide platforms 有权
标题翻译：具有固定滑动平台的自动分子病理装置
公开(公告)号：US07404927B2
公开(公告)日：2008-07-29
申请号：US11293489
申请日：2005-12-02
申请人： Charles D. Lemme , William Richards , Wayne Showalter
发明人： Charles D. Lemme , William Richards , Wayne Showalter
IPC分类号： G01N21/00
CPC分类号： G01N1/312 , Y10T436/112499 , Y10T436/2575
摘要： Apparatus and methods for automatically staining or treating multiple tissue samples mounted on slides are provided, in which the slides and reagent bottles are held in fixed position, and the reagent and wash solutions brought to the slides.
摘要翻译：提供了用于自动染色或处理安装在载玻片上的多个组织样品的装置和方法，其中载玻片和试剂瓶保持在固定位置，并将试剂和洗涤液带到载玻片上。

10. 发明授权

US07270785B1 Automated molecular pathology apparatus having fixed slide platforms 有权
标题翻译：具有固定滑动平台的自动分子病理装置
公开(公告)号：US07270785B1
公开(公告)日：2007-09-18
申请号：US10283639
申请日：2002-10-30
申请人： Charles D. Lemme , William Richards , Wayne Showalter
发明人： Charles D. Lemme , William Richards , Wayne Showalter
IPC分类号： B32B5/02
CPC分类号： G01N1/312 , Y10T436/112499 , Y10T436/2575
摘要： Apparatus and methods for automatically staining or treating multiple tissue samples mounted on slides are provided, in which the slides and reagent bottles are held in fixed position, and the reagent and wash solutions brought to the slides.
摘要翻译：提供了用于自动染色或处理安装在载玻片上的多个组织样品的装置和方法，其中载玻片和试剂瓶保持在固定位置，并将试剂和洗涤溶液带到载玻片上。

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