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1. 发明授权

US08736170B1 Stable cold field emission electron source 有权
标题翻译：稳定的冷场发射电子源
公开(公告)号：US08736170B1
公开(公告)日：2014-05-27
申请号：US13032488
申请日：2011-02-22
申请人： Kun Liu , Gregory A. Schwind
发明人： Kun Liu , Gregory A. Schwind
IPC分类号： H01J25/50 , H01J23/06
CPC分类号： H01J23/06 , H01J37/063 , H01J37/073 , H01J2237/022
摘要： A cold field emission (CFE) electron source for a focused electron beam system such as a transmission electron microscope (TEM), scanning transmission electron microscope (STEM), or scanning electron microscope (SEM) is disclosed. The source employs an emitter enclosure electrode behind the CFE tip which, in conjunction with the extractor electrode, defines a closed volume that can be thoroughly cleaned by electron impact desorption (EID) and radiative heating from a heated filament located between the emitter enclosure electrode and extractor electrode. The extractor electrode may have a counterbore which restricts backscattered electrons generated at the extractor from reaching portions of the source and gun which have not been cleaned by EID. Pre-cleaning of the emitter enclosure electrode and extractor electrode prior to cold field emission substantially improves both source emission stability and frequency noise characteristics, enabling source operation over time intervals adequate for application to TEMs, STEMs, and SEMs.
摘要翻译：公开了透射电子显微镜（TEM），扫描透射电子显微镜（STEM）或扫描电子显微镜（SEM）等聚焦电子束系的冷场发射（CFE）电子源。该源在CFE尖端之后采用发射器外壳电极，其与提取器电极结合，限定可通过电子轰击解吸（EID）彻底清洁的封闭体积，以及位于发射体外壳电极和提取电极。提取器电极可以具有沉孔，其限制在提取器处产生的反向散射电子到达未被EID清洁的源和枪的部分。在冷场发射之前预先清洁发射器外壳电极和提取器电极大大改善了源发射稳定性和频率噪声特性，从而能够实现源于在适用于TEM，STEM和SEM的时间间隔的源操作。

2. 发明申请

US20200277252A1 NOVEL SUBSTITUTED CYCLOBUTYLBENZENE COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE (IDO) INHIBITORS 审中-公开
公开(公告)号：US20200277252A1
公开(公告)日：2020-09-03
申请号：US16753035
申请日：2018-10-04
申请人： Meredeth Ann McGowan , Abdelghani Achab , Xavier Fradera , Yongxin Han , Derun Li , Jongwon Lim , Kun Liu , Nunzio Sciammetta , Catherine M. White , Wensheng Yu , Hongjun Zhang , Hua Zhou , MERCK SHARP & DOHME CORP.
发明人： Meredeth Ann McGowan , Abdelghani Achab , Xavier Fradera , Yongxin Han , Derun Li , Jongwon Lim , Kun Liu , Nunzio Sciammetta , Catherine M. White , Wensheng Yu , Hongjun Zhang , Hua Zhou
IPC分类号： C07C237/42 , C07D241/24 , C07D213/82 , C07D233/90 , C07D263/34 , C07D231/14 , C07D277/56 , C07D239/28 , C07D213/75 , C07D309/14 , C07D237/20 , C07D307/14 , C07D205/04 , C07D285/06 , C07D487/04
摘要： Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof: (Formula (I)). Also disclosed herein are uses of a compound disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of a composition in the potential treatment or prevention of an IDO-associated disease or disorder.

3. 发明授权

US08885750B2 Method and system for transmitting data using collaborative multiple input multiple output beamforming 有权
标题翻译：使用协同多输入多输出波束形成传输数据的方法和系统
公开(公告)号：US08885750B2
公开(公告)日：2014-11-11
申请号：US13522456
申请日：2010-01-27
申请人： Huahua Xiao , Dengkui Zhu , Zhaohua Lu , Kun Liu
发明人： Huahua Xiao , Dengkui Zhu , Zhaohua Lu , Kun Liu
IPC分类号： H04B7/02 , H04B7/06 , H04B7/10 , H04L1/00 , H04B7/04
CPC分类号： H04B7/024 , H04B7/0434 , H04B7/0465 , H04B7/0617 , H04B7/0632 , H04B7/0636 , H04B7/0689 , H04B7/0697 , H04B7/10 , H04L1/0001 , H04L1/0026
摘要： The present invention discloses a method and a system for transmitting data using the collaborative multiple input multiple output (MIMO) beamforming. The method comprises: selecting an MIMO mode according to channel quality information (CQI) (S502); performing the MIMO encoding on a data stream according to the selected MIMO mode, and distributing the encoded data stream to a plurality of transmitting ends which are mutual collaborative (S504); and transmitting, by the plurality of transmitting ends, the encoded data stream (S506). The present invention solves the problem in the relevant art of reducing the system performance and the flexibility, which is caused by adopting the fixed MIMO mode when the system carries out the encoding and the transmission, which is capable of improving the system performance.
摘要翻译：本发明公开了一种使用协同多输入多输出（MIMO）波束形成来发送数据的方法和系统。该方法包括：根据信道质量信息（CQI）选择MIMO模式（S502）; 根据所选择的MIMO模式对数据流执行MIMO编码，并将编码数据流分配到相互协作的多个发送端（S504）; 以及由所述多个发送端发送所述编码数据流（S506）。本发明解决了当系统进行编码和传输时采用固定MIMO模式，从而提高系统性能的相关技术中降低系统性能和灵活性的问题。

4. 发明授权

US08871759B2 Inhibitors of hepatitis C virus replication 有权
标题翻译：丙型肝炎病毒复制抑制剂
公开(公告)号：US08871759B2
公开(公告)日：2014-10-28
申请号：US13260684
申请日：2010-03-25
申请人： Craig A. Coburn , Steven W. Ludmerer , Kun Liu , Hao Wu , Richard Soll , Bin Zhong , Jian Zhu
发明人： Craig A. Coburn , Steven W. Ludmerer , Kun Liu , Hao Wu , Richard Soll , Bin Zhong , Jian Zhu
IPC分类号： A61K31/5365 , C07D413/14
CPC分类号： C07D498/04 , A61K31/4025 , A61K31/404 , A61K31/4178 , A61K31/4184 , A61K31/423 , A61K31/437 , A61K31/4439 , A61K31/4985 , A61K31/506 , A61K31/5365 , A61K31/5377 , A61K31/5383 , A61K31/553 , A61K38/05 , A61K38/06 , A61K45/06 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D471/04 , C07D487/04 , C07D498/10 , C07K5/06 , C07K5/08
摘要： The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.
摘要翻译：本发明涉及可用作丙型肝炎病毒（HCV）NS5A抑制剂，这种化合物的合成以及这些化合物用于抑制HCV NS5A活性用于治疗或预防HCV感染的用途的式（I）化合物和抑制基于细胞的系统中的HCV病毒复制和/或病毒生产。

5. 发明申请

US20140206665A1 SELECTIVE GLYCOSIDASE INHIBITORS AND USES THEREOF 有权
标题翻译：选择性糖苷酶抑制剂及其用途
公开(公告)号：US20140206665A1
公开(公告)日：2014-07-24
申请号：US14238481
申请日：2012-08-10
申请人： Harold G. Selnick , Kun Liu , Ernest J. McEachern , Yuanxi Zhou , Yongbao Zhu
发明人： Harold G. Selnick , Kun Liu , Ernest J. McEachern , Yuanxi Zhou , Yongbao Zhu
IPC分类号： C07D263/58 , C07D413/04 , C07D417/04 , C07D277/60
CPC分类号： C07D263/58 , A61K31/423 , A61K31/428 , C07D277/60 , C07D277/82 , C07D413/04 , C07D417/04
摘要： The invention is directed to compounds for selectively inhibiting glycosidases, uses of the compounds and pharmaceutical compositions including the compounds, and methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, and/or accumulation or deficiency of O-GlcNAc.
摘要翻译：本发明涉及用于选择性抑制糖苷酶的化合物，化合物的用途和包括该化合物的药物组合物，以及治疗与O-GlcNAC的缺乏或过量表达有关的疾病和障碍和/或O-GlcNAc的积累或缺陷的方法。

6. 发明申请

US20140107044A1 SELECTIVE GLYCOSIDASE INHIBITORS AND USES THEREOF 有权
标题翻译：选择性糖苷酶抑制剂及其用途
公开(公告)号：US20140107044A1
公开(公告)日：2014-04-17
申请号：US14006888
申请日：2012-03-16
申请人： Ernest J. McEachern , David J. Vocadlo , Yuanxi Zhou , Craig A. Coburn , Kun Liu , Harold G. Selnick
发明人： Ernest J. McEachern , David J. Vocadlo , Yuanxi Zhou , Craig A. Coburn , Kun Liu , Harold G. Selnick
IPC分类号： C07H9/06 , C12Q1/34
CPC分类号： C07H9/06 , C07H13/04 , C12Q1/34 , G01N2333/924 , G01N2500/04
摘要： The invention provides compounds for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc.
摘要翻译：本发明提供了用于选择性抑制糖苷酶，化合物前药和包含化合物的化合物或前药的药物组合物的化合物。本发明还提供了治疗与O-GlcNAcase的缺乏或过度表达相关的疾病和障碍的方法，O-GlcNAc的积累或缺乏。

7. 发明申请

US20130211906A1 Measuring and Utilizing The Effect of Social Sharing In Online Advertising 审中-公开
标题翻译：衡量和利用社会分享在线广告中的作用
公开(公告)号：US20130211906A1
公开(公告)日：2013-08-15
申请号：US13397417
申请日：2012-02-15
申请人： Ashish Sumant , Lei Tang , Kun Liu , Wanlin Pang
发明人： Ashish Sumant , Lei Tang , Kun Liu , Wanlin Pang
IPC分类号： G06Q30/02
CPC分类号： G06Q50/01 , G06Q30/02
摘要： The present invention provides techniques for use in measuring effects of social sharing, and social sharing user characteristics, on advertisement effectiveness. Measurement information can be used in many ways, such as in optimizing advertisement campaigns and advertisement targeting. Techniques are provided in which bucket testing experiments are utilized. Advertisement performance may be tracked, including downstream advertisement performance, which may follow social sharing, in measuring differences in advertisement performance between content sharing users and content non-sharing users. Techniques are provided in which user social graph information may be used in determining downstream advertisement performance, even without information regarding specific sharing instances.
摘要翻译：本发明提供了用于测量社会共享效果和社会共享用户特征对广告效果的技术。测量信息可以以许多方式使用，例如优化广告活动和广告定位。提供了使用桶测试实验的技术。可以跟踪广告效果，包括可能遵循社交共享的下游广告演出，衡量内容共享用户与内容非共享用户之间的广告效果差异。提供了技术，其中用户社交图信息可以用于确定下游广告表现，即使没有关于特定共享实例的信息。

8. 外观设计

USD687787S1 Keyless entry remote 有权
公开(公告)号：USD687787S1
公开(公告)日：2013-08-13
申请号：US29419230
申请日：2012-04-26
申请人： Ching-Tang Chin , Kun Liu , Hong-Xiu Luo , Ho-Chyuan Su , Ching-Chang Ni , Tzu-Cheng Yu
设计人： Ching-Tang Chin , Kun Liu , Hong-Xiu Luo , Ho-Chyuan Su , Ching-Chang Ni , Tzu-Cheng Yu

9. 外观设计

USD680092S1 Mobile phone 有权
公开(公告)号：USD680092S1
公开(公告)日：2013-04-16
申请号：US29419547
申请日：2012-04-30
申请人： Cheng-Chieh Tsai , Tzu-Cheng Yu , Po-Ching Huang , Kun Liu , Hong-Xiu Luo
设计人： Cheng-Chieh Tsai , Tzu-Cheng Yu , Po-Ching Huang , Kun Liu , Hong-Xiu Luo

10. 发明申请

US20130067243A1 Secure Data Synchronization 有权
标题翻译：安全数据同步
公开(公告)号：US20130067243A1
公开(公告)日：2013-03-14
申请号：US13230121
申请日：2011-09-12
申请人： Matthew Z. Tamayo-Rios , Saurav Sinha , Ruslan Ovechkin , Gopinathan Kannan , Vijay G. Bharadwaj , Christopher R. Macaulay , Eric Fleischman , Nathan J. Ide , Kun Liu
发明人： Matthew Z. Tamayo-Rios , Saurav Sinha , Ruslan Ovechkin , Gopinathan Kannan , Vijay G. Bharadwaj , Christopher R. Macaulay , Eric Fleischman , Nathan J. Ide , Kun Liu
IPC分类号： G06F12/14
CPC分类号： G06F21/6218 , G06F21/44 , G06F21/6245 , G06F21/6272 , G06F2221/2107 , H04L63/0428 , H04L63/062 , H04L67/1095 , H04L67/1097
摘要： Techniques for secure data synchronization are described. In one or more implementations, techniques may be employed to conserve high cost data storage by storing larger portions of encrypted data in low cost storage, while storing relatively smaller encryption keys in higher cost storage. A device that is granted access to the encryption keys can retrieve the encrypted data from the low cost storage and use the encryption keys to decrypt the encrypted data.
摘要翻译：描述了用于安全数据同步的技术。在一个或多个实现中，可以采用技术来通过将较大部分的加密数据存储在低成本存储中，同时在较高成本存储中存储相对较小的加密密钥来节省高成本数据存储。授权访问加密密钥的设备可以从低成本存储中检索加密数据，并使用加密密钥对加密数据进行解密。

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