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1. 发明申请

US20100021442A1 METHOD FOR PROMOTING IMMUNOTHERAPY USING AN AGENT FOR ELEVATING DENDRITIC CELL PRECURSOR LEVEL IN BLOOD 审中-公开
标题翻译：促进免疫功能的方法，用于增加血液中的细胞前体水平
公开(公告)号：US20100021442A1
公开(公告)日：2010-01-28
申请号：US12554676
申请日：2009-09-04
申请人： Kouji MATSUSHIMA , Hiroyuki Yoneyama , Yuang Zhang , Shiro Kanegasaki , Teruo Akuta
发明人： Kouji MATSUSHIMA , Hiroyuki Yoneyama , Yuang Zhang , Shiro Kanegasaki , Teruo Akuta
IPC分类号： A61K35/12 , A61P37/00
CPC分类号： A61K38/195
摘要： Although the fields of therapeutic applications of dendritic cells are now expanding, dendritic cell precursors exist only in a small amount in the peripheral blood and, therefore, it is still difficult to obtain them in a therapeutically useful amount even though they are proliferated in vitro. Therefore, it is a key point in performing a therapy with the use of dendritic cells in practice to elevate dendritic cell precursor level in the peripheral blood of a patient. The present invention provides an agent for elevating dendritic cell precursor level in the blood which comprises an agonist to a receptor expressed in immature dendritic cells or a functional derivative thereof as the active ingredient.
摘要翻译：尽管树突状细胞的治疗应用领域现在正在扩大，但是树突状细胞前体在外周血中仅存在少量，因此即使体外增殖，仍然难以以治疗有用的量获得它们。因此，在实践中使用树突状细胞进行治疗是关键点，以提高患者外周血中的树突状细胞前体水平。本发明提供了一种用于提高血液中树突状细胞前体水平的试剂，其包含对未成熟树突状细胞中表达的受体的激动剂或其功能性衍生物作为活性成分。

2. 发明申请

US20060210531A1 Agent eleveting dendritic cell precursor level in blood 审中-公开
标题翻译：代谢物提取树突状细胞前体血液中的水平
公开(公告)号：US20060210531A1
公开(公告)日：2006-09-21
申请号：US10531580
申请日：2003-10-21
申请人： Kouji Matsushima , Hiroyuki Yoneyama , Yuang Zhang , Shiro Kanegasaki , Teruo Akuta
发明人： Kouji Matsushima , Hiroyuki Yoneyama , Yuang Zhang , Shiro Kanegasaki , Teruo Akuta
IPC分类号： A61K38/19 , C07K14/52
CPC分类号： A61K38/195
摘要： Although the fields of therapeutic applications of dendritic cells are now expanding, dendritic cell precursors exist only in a small amount in the peripheral blood and, therefore, it is still difficult to obtain them in a therapeutically useful amount even though they are proliferated in vitro. Therefore, it is a key point in performing a therapy with the use of dendritic cells in practice to elevate dendritic cell precursor level in the peripheral blood of a patient. The present invention provides an agent for elevating dendritic cell precursor level in the blood which comprises an agonist to a receptor expressed in immature dendritic cells or a functional derivative thereof as the active ingredient.
摘要翻译：尽管树突状细胞的治疗应用领域现在正在扩大，但是树突状细胞前体在外周血中仅存在少量，因此即使体外增殖，仍然难以以治疗有用的量获得它们。因此，在实践中使用树突状细胞进行治疗是关键点，以提高患者外周血中的树突状细胞前体水平。本发明提供了一种用于提高血液中树突状细胞前体水平的试剂，其包含对未成熟树突状细胞中表达的受体的激动剂或其功能性衍生物作为活性成分。

3. 发明申请

US20080124307A1 Method for promoting immunotherapy 审中-公开
标题翻译：促进免疫治疗的方法
公开(公告)号：US20080124307A1
公开(公告)日：2008-05-29
申请号：US11819147
申请日：2007-06-25
申请人： Kouji Matsushima , Hiroyuki Yoneyama , Yuang Zhang , Shiro Kanegasaki , Teruo Akuta
发明人： Kouji Matsushima , Hiroyuki Yoneyama , Yuang Zhang , Shiro Kanegasaki , Teruo Akuta
IPC分类号： A61K35/12 , A61P37/00
CPC分类号： A61K38/195
摘要： Although the fields of therapeutic applications of dendritic cells are now expanding, dendritic cell precursors exist only in a small amount in the peripheral blood and, therefore, it is still difficult to obtain them in a therapeutically useful amount even though they are proliferated in vitro. Therefore, it is a key point in performing a therapy with the use of dendritic cells in practice to elevate dendritic cell precursor level in the peripheral blood of a patient. The present invention provides an agent for elevating dendritic cell precursor level in the blood which comprises an agonist to a receptor expressed in immature dendritic cells or a functional derivative thereof as the active ingredient.
摘要翻译：尽管树突状细胞的治疗应用领域现在正在扩大，但是树突状细胞前体在外周血中仅存在少量，因此即使体外增殖，仍然难以以治疗有用的量获得它们。因此，在实践中使用树突状细胞进行治疗是关键点，以提高患者外周血中的树突状细胞前体水平。本发明提供了一种用于提高血液中树突状细胞前体水平的试剂，其包含对未成熟树突状细胞中表达的受体的激动剂或其功能性衍生物作为活性成分。

4. 发明授权

US07662781B2 Immunopotentiating agent 有权
标题翻译：免疫增强剂
公开(公告)号：US07662781B2
公开(公告)日：2010-02-16
申请号：US11883302
申请日：2005-12-20
申请人： Shiro Kanegasaki , Takuya Tamatani
发明人： Shiro Kanegasaki , Takuya Tamatani
IPC分类号： A61K38/00 , C07K5/00
CPC分类号： A61K38/195
摘要： Satisfactory effects have not always been attained by immunotherapy having been tried, and reliance upon direct attack on cells by anticancer agents, radiation, etc has been inevitable. The present invention intends to provide a therapeutic method that ensures less side effects but higher efficacy than in conventional therapeutic methods through enhancing of immune strength inherently had by living organism. Thus, the present invention relates to an immunopotentiating agent comprising MIP-1α or its functional derivative as an active ingredient.
摘要翻译：已经尝试了免疫疗法并不总是达到令人满意的效果，并且不可避免地依靠抗癌剂，辐射等对细胞的直接攻击。本发明旨在提供一种治疗方法，其通过提高活体内固有的免疫强度来确保比常规治疗方法更少的副作用，但效果更好。因此，本发明涉及包含MIP-1α或其功能性衍生物作为活性成分的免疫增强剂。

5. 发明申请

US20070145159A1 Solution temperature control device in cell observation chamber 失效
标题翻译：细胞观察室溶液温度控制装置
公开(公告)号：US20070145159A1
公开(公告)日：2007-06-28
申请号：US10572747
申请日：2004-09-13
申请人： Kouichi Noguchi , Kazuyuki Matsumura , Takesi Mitsunaga , Shiro Kanegasaki
发明人： Kouichi Noguchi , Kazuyuki Matsumura , Takesi Mitsunaga , Shiro Kanegasaki
IPC分类号： G05D23/12
CPC分类号： G02B21/34 , G02B21/30 , Y10S435/809
摘要： A solution temperature control device in a biological cell observing chamber (30) used for the detection of chemotaxis and chemotactic cell separator, comprising a first temperature controller (62) and a second temperature controller (63). The first temperature controller (62) measures the temperature of a solution filled in a pair of wells and a flow passage in the chamber and controls the temperature to a specified temperature, and the second temperature controller (63) measures the temperature of a heating part (64) which heats the chamber (30) from the outside to indirectly heat the solution filled in the pair of wells and the flow passage and controls the temperature to a specified preheat temperature. Since the state and quantity of cells moving from one well to the other through the flow passage while holding the temperature of the solution at a specified temperature can be accurately observed and measured, accuracy for controlling the temperature of the solution can be remarkably increased.
摘要翻译：用于检测趋化性和趋化细胞分离器的生物细胞观察室（30）中的溶液温度控制装置，包括第一温度控制器（62）和第二温度控制器（63）。第一温度控制器（62）测量填充在一对井中的溶液的温度和腔室中的流动通道，并将温度控制在指定温度，第二温度控制器（63）测量加热部件（64），其从外部加热所述室（30）以间接加热填充在所述一对井和所述流动通道中的溶液，并将所述温度控制到指定的预热温度。由于可以精确地观察和测量细胞在将溶液的温度保持在规定温度的同时通过流路从一个孔移动到另一个孔的状态和数量，因此可以显着提高用于控制溶液温度的精度。

6. 发明授权

US07521227B2 Cell observation chamber 失效
标题翻译：细胞观察室
公开(公告)号：US07521227B2
公开(公告)日：2009-04-21
申请号：US10572746
申请日：2004-09-13
申请人： Kazuyuki Matsumura , Shiro Kanegasaki
发明人： Kazuyuki Matsumura , Shiro Kanegasaki
IPC分类号： C12M3/00
CPC分类号： C12M41/46 , B01L3/502761 , B01L2200/0668 , B01L2300/14 , Y10T436/25
摘要： A biological cell observing chamber (30), wherein an intermediate support body (32) forming a skeleton outer shell structural part is mounted on a bottom support body (31) and a cover block body (33) is mounted on the bottom support body (31) on which the intermediate support body (32) is mounted by using lever mechanisms (36) and (37) incorporating a cam mechanism and a clamp mechanism so that the contact faces thereof can be pressed against each other in the vertical direction. The cam mechanism comprises cam grooves (36b) and (37b) formed in both leg part inner surfaces of U-shaped levers (36) and (37) rotatably supported on the bottom support body (31) and pins (40) and (41) slidably moving in the cam grooves and built in the outer peripheral surfaces of the intermediate support body (32) and the cover block body (33) at corresponding two points. Thus, in the biological cell observing chamber used for the detection of cell chemotaxis and chemotactic cell separator, the assembly and disassembly operations for the intermediate support body forming the skeleton outer shell structural part and the cover block body can be facilitated, and the operability of the chamber can be increased.
摘要翻译：一种生物细胞观察室（30），其中形成骨架外壳结构部分的中间支撑体（32）安装在底部支撑体（31）上并且盖块体（33）安装在底部支撑体 31），其中通过使用具有凸轮机构和夹紧机构的杠杆机构（36）和（37）来安装中间支撑体（32），使得其接触面可以在垂直方向上彼此挤压。凸轮机构包括形成在可旋转地支撑在底部支撑体（31）和销（40）和（41）上的U形杆（36）和（37）的两个腿部内表面中的凸轮槽（36b）和（37b））可滑动地移动到凸轮槽中并且在对应的两个点处内置在中间支撑体（32）和盖块体（33）的外周表面中。因此，在用于检测细胞趋化性和趋化性细胞分离器的生物细胞观察室中，能够促进构成骨架外壳结构部分和盖体的中间支撑体的组装和拆卸操作，可以增加房间。

7. 发明申请

US20060121600A1 Apparatus for detecting cell chemotaxis 失效
标题翻译：用于检测细胞趋化性的装置
公开(公告)号：US20060121600A1
公开(公告)日：2006-06-08
申请号：US10542189
申请日：2004-04-08
申请人： Shiro Kanegasaki
发明人： Shiro Kanegasaki
IPC分类号： C12M1/34
CPC分类号： B01L3/50273 , B01L3/502738 , B01L2200/0647 , B01L2300/049 , B01L2300/0816 , B01L2300/0822 , B01L2300/0864 , B01L2400/0487 , G01N15/1484 , G01N2015/1486
摘要： The present invention relates to an improvement in an apparatus for detecting chemotaxis of cells. It aims at providing a structure for detecting chemotaxis of cells at an elevated accuracy with the use of a microquantity of cells. That is to say, an object of the present invention is to provide an apparatus for detecting chemotaxis of cells by which cell injection and position control can be easily carried out while ensuring the prevention of unexpected migration of the cells definitely positioned in a well or the injected sample so that a stable concentration gradient due to the diffusion of the specimen can be maintained and which ensures further automated operation and controlling. Namely, an apparatus for detecting chemotaxis of cells with a structure wherein two wells are connected to each other via a channel having resistance to the passage of cells and each well has an opening for injecting cells or a specimen, characterized by having (1) a means of transporting a liquid and a means of stopping the transportation after the injection or the aspiration discharge of the liquid and (2) a means of sealing the opening(s) in one or both of the cell-injection side and the specimen-injection side.
摘要翻译：本发明涉及用于检测细胞趋化性的装置的改进。其目的在于提供一种以高精度检测细胞趋化性的结构，使用微量的细胞。也就是说，本发明的目的是提供一种用于检测细胞的趋化性的装置，通过该装置可以容易地进行细胞注射和位置控制，同时确保防止绝对定位在孔中的细胞的意外迁移或注入样品，从而可以保持由于样品扩散而产生的稳定的浓度梯度，并确保进一步的自动化操作和控制。也就是说，一种用于检测细胞的趋化性的装置，其中两个孔通过具有对细胞通过的通道和每个孔的通道彼此连接，具有用于注入细胞或样本的开口，其特征在于具有（1）运送液体的方法和在液体的注射或抽吸排出之后停止运输的装置和（2）在细胞注射侧和样品注射中的一个或两个中密封开口的装置侧。

8. 发明授权

US07022516B2 Well unit for detecting cell chemotaxis and separating chemotactic cells 失效
公开(公告)号：US07022516B2
公开(公告)日：2006-04-04
申请号：US10181708
申请日：2001-12-06
申请人： Shiro Kanegasaki , Yuji Kikuchi , Hiroko Kikuchi
发明人： Shiro Kanegasaki , Yuji Kikuchi , Hiroko Kikuchi
IPC分类号： C12M1/34
CPC分类号： G01N33/5302 , B01L3/5027 , B01L3/502761 , B01L2300/0861 , B01L2400/086 , C12M41/46 , G01N15/1456 , G01N33/5005 , G01N2015/1486 , G01N2015/1493
摘要： The present invention aims at providing a well unit to be used in fabricating an apparatus whereby movements of cells based on their own actions can be accurately and easily detected, in detecting the chemotaxis of cells due to a chemotactic factor or the inhibition of the chemotaxis of cells by an inhibitor.Accordingly, the present invention provides a well unit to be used in an apparatus for detecting chemotaxis of cells and separating cells characterized in that a plural number of wells, in which a liquid sample can be held in a resting state, are connected to each other via a channel, the channel is provided with a bank, and, in the upper part of the bank, barriers constituting one or more grooves having a width and/or a depth fit for the diameter or deformability of cells are provided or a plane is provided so as to give a gap having a depth fit for the diameter or deformability of cells between the plane and the glass substrate.

9. 发明申请

US20090004730A1 Cell Obsevation Aiding Instrument and Method of Cell Observation Therewith 审中-公开
标题翻译：细胞观察辅助仪器和细胞观察方法
公开(公告)号：US20090004730A1
公开(公告)日：2009-01-01
申请号：US11908980
申请日：2006-03-17
申请人： Nao Nitta , Shiro Kanegasaki , Akira Yamauchi
发明人： Nao Nitta , Shiro Kanegasaki , Akira Yamauchi
IPC分类号： C12M1/34
CPC分类号： G02B21/34 , C12N9/93
摘要： A cell observation support instrument having opposed first and second surface members 115 and 117 and stoppers that are positioned between the first and second surface members 115 and 117 in order to prevent movement of cells. The first and second surface members 115 and 117 form a cell-containing space 110 between opposed surfaces of the members 115 and 117, in order to contain a plurality of cells while allowing movement of the cells. At least one of the first and second surface members 115 and 117 is a member through which an inner side of the cell-containing space 110 can be optically observed from the outside. The stoppers are arranged in the cell-containing space 110, and the number of the stoppers is one or more.
摘要翻译：电池观察支撑器具具有相对的第一和第二表面构件115和117以及位于第一和第二表面构件115和117之间的止动件，以防止电池移动。第一和第二表面构件115和117在构件115和117的相对表面之间形成包含细胞的空间110，以便容纳多个单元，同时允许单元的移动。第一和第二表面构件115和117中的至少一个是可以从外部光学观察细胞容纳空间110的内侧的构件。止动件布置在容纳细胞的空间110中，止动件的数量为一个或多个。

10. 发明授权

US07259008B2 Microsample treatment apparatus 失效
标题翻译：微型样品处理装置
公开(公告)号：US07259008B2
公开(公告)日：2007-08-21
申请号：US10181707
申请日：2001-12-06
申请人： Shiro Kanegasaki , Yuji Kikuchi
发明人： Shiro Kanegasaki , Yuji Kikuchi
IPC分类号： C12M1/34
CPC分类号： B01L3/502715 , B01L3/502746 , B01L2200/027 , B01L2300/0816 , B01L2400/086 , G01N15/1456 , G01N2015/1486
摘要： A microsample treatment apparatus and an apparatus for detecting chemotaxis of cells and separating chemotactic cells includes a number of wells that are connected to each other via a part having resistance to fluids. The wells are each provided with tubes for injecting/sucking a sample and, if necessary, tubes for relieving pressure changes at the injection/suction. The tubes have a space in common at the top ends thereof in which a liquid can be held.
摘要翻译：用于检测细胞的趋化性和分离趋化细胞的微量样品处理装置和装置包括通过具有耐流体性的部分彼此连接的多个孔。每个井都设有用于注入/吸取样品的管子，如果需要的话，管子用于在注入/抽吸时减轻压力变化。管在其顶端具有共同的空间，其中可以保持液体。

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