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1. 发明申请

US20130288351A1 CELL NUCLEUS OBSERVATION SUBSTRATE AND CELL NUCLEUS OBSERVATION APPARATUS 有权
标题翻译：细胞核观察基质和细胞核观察装置
公开(公告)号：US20130288351A1
公开(公告)日：2013-10-31
申请号：US13977417
申请日：2011-12-27
申请人： Nao Nitta
发明人： Nao Nitta
IPC分类号： G01N21/64
CPC分类号： G01N21/6486 , G01N1/30 , G01N21/6428 , G01N21/6458
摘要： To provide a technology of staining nuclei of cells, microorganisms and the like by a simple operation and observing their forms.There is provided a cell nucleus observation substrate including an introduction part into which a sample liquid containing cells is introduced and an observation area within which the cells in the sample liquid introduced from the introduction part is held, copper being disposed on a flow path of the sample liquid in the introduction part and the observation area so that the copper being capable of contacting with the sample liquid. In the cell nucleus observation substrate, the cells in the sample liquid introduced from the introduction part is contacted with copper, nucleic acids therein will emit fluorescence and is held within the observation area. Accordingly, in the cell nucleus observation substrate, the cells including the nuclei being fluorescence stained can be observed at the observation area.
摘要翻译：提供通过简单的操作和观察其形式来染色细胞，微生物等细胞核的技术。提供了一种细胞核观察基板，其包括引入部分，其中引入含有细胞的样品液体和观察区域，在该观察区域中保持从导入部分引入的样品液体中的细胞，铜布置在在引入部分和观察区域中的样品液体，使得铜能够与样品液体接触。在细胞核观察底物中，从引入部分导入的样品液中的细胞与铜接触，其中的核酸将发出荧光并保持在观察区域内。因此，在细胞核观察基板中，可以在观察区域观察包含被荧光染色的细胞核的细胞。

2. 发明申请

US20120153185A1 MICROCHIP AND PARTICULATE FRACTIONAL COLLECTION APPARATUS 有权
标题翻译：微型和颗粒状收集装置
公开(公告)号：US20120153185A1
公开(公告)日：2012-06-21
申请号：US13315052
申请日：2011-12-08
申请人： Tatsumi Ito , Masaya Kakuta , Shingo Imanishi , Nao Nitta , Koji Futamura , Toru Takashimizu , Koji Ashizaki , Motohiro Furuki
发明人： Tatsumi Ito , Masaya Kakuta , Shingo Imanishi , Nao Nitta , Koji Futamura , Toru Takashimizu , Koji Ashizaki , Motohiro Furuki
IPC分类号： G01N21/64 , G01N21/63 , G01N1/10
CPC分类号： B01L3/502776 , B01L3/502761 , B01L2200/0652 , B01L2200/0668 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2400/0418 , B01L2400/0439 , B01L2400/049 , B01L2400/0622 , G01N15/1484 , G01N2015/1409
摘要： A microchip includes a sample liquid feed channel permitting a sample liquid containing particulates to flow through, at least one pair of sheath liquid feed channels configured to merge to the sample liquid feed channel from both sides thereof for permitting a sheath liquid to flow through surrounding the sample liquid, a merging channel connected to the sample liquid feed channel and the one pair of the sheath liquid feed channels for permitting the sample liquid and the sheath liquid to merge and flow through the merging channel, a vacuum suction unit for drawing into the particulate subject to collection, connected to the merging channel, and at least one pair of discharge channels formed on both sides of the vacuum suction unit for permitting to flow through from the merging channel.
摘要翻译：微芯片包括允许含有微粒的样品液体流过的样品液体进料通道，至少一对皮肤液体进料通道，其构造成从其两侧与样品液体进料通道合并，以允许鞘液体流过围绕样品液体，连接到样品液体进料通道的合流通道和一对鞘液供给通道，用于允许样品液体和鞘液体合并并流过合流通道;真空抽吸单元，用于吸入颗粒物连接到合流通道，以及形成在真空吸引单元两侧的至少一对排出通道，用于允许从合流通道流过。

3. 发明申请

US20120002043A1 OBSERVATION APPARATUS 审中-公开
标题翻译：观察装置
公开(公告)号：US20120002043A1
公开(公告)日：2012-01-05
申请号：US13256379
申请日：2010-03-16
申请人： Nao Nitta
发明人： Nao Nitta
IPC分类号： H04N7/18
CPC分类号： G01N21/6456 , G01N1/06 , G01N21/21 , G01N2001/065 , G01N2021/0339 , G06K9/00134
摘要： An observation apparatus includes a sample holder to hold a sample, a blade to cut the sample and subsequently form a new cross section, an optical system including a first objective lens and a second objective lens, and an electronic camera to capture an image of the cross section of the sample. A main controller causes the electronic camera to capture a partial image corresponding to a part of the cross section via the first objective lens. The main controller moves an XY stage to change relative positions of the sample and the optical system within an XY plane, to thereby acquire a plurality of partial images. An image processing unit generates synthesized image data obtained by synthesizing the partial images for each cross section to display it on a display unit. Accordingly, a user can observe a high-resolution image.
摘要翻译：观察装置包括用于保持样品的样品保持器，用于切割样品并随后形成新横截面的刀片，包括第一物镜和第二物镜的光学系统以及用于捕获图像的电子照相机样品的截面。主控制器使得电子照相机经由第一物镜捕获与横截面的一部分相对应的部分图像。主控制器移动XY平台以改变样品和光学系统在XY平面内的相对位置，从而获取多个部分图像。图像处理单元产生通过合成每个横截面的部分图像获得的合成图像数据，以将其显示在显示单元上。因此，用户可以观察高分辨率图像。

4. 发明申请

US20090004730A1 Cell Obsevation Aiding Instrument and Method of Cell Observation Therewith 审中-公开
标题翻译：细胞观察辅助仪器和细胞观察方法
公开(公告)号：US20090004730A1
公开(公告)日：2009-01-01
申请号：US11908980
申请日：2006-03-17
申请人： Nao Nitta , Shiro Kanegasaki , Akira Yamauchi
发明人： Nao Nitta , Shiro Kanegasaki , Akira Yamauchi
IPC分类号： C12M1/34
CPC分类号： G02B21/34 , C12N9/93
摘要： A cell observation support instrument having opposed first and second surface members 115 and 117 and stoppers that are positioned between the first and second surface members 115 and 117 in order to prevent movement of cells. The first and second surface members 115 and 117 form a cell-containing space 110 between opposed surfaces of the members 115 and 117, in order to contain a plurality of cells while allowing movement of the cells. At least one of the first and second surface members 115 and 117 is a member through which an inner side of the cell-containing space 110 can be optically observed from the outside. The stoppers are arranged in the cell-containing space 110, and the number of the stoppers is one or more.
摘要翻译：电池观察支撑器具具有相对的第一和第二表面构件115和117以及位于第一和第二表面构件115和117之间的止动件，以防止电池移动。第一和第二表面构件115和117在构件115和117的相对表面之间形成包含细胞的空间110，以便容纳多个单元，同时允许单元的移动。第一和第二表面构件115和117中的至少一个是可以从外部光学观察细胞容纳空间110的内侧的构件。止动件布置在容纳细胞的空间110中，止动件的数量为一个或多个。

5. 发明授权

US10782224B2 Spectrum analysis apparatus, fine particle measurement apparatus, and method and program for spectrum analysis or spectrum chart display 有权
公开(公告)号：US10782224B2
公开(公告)日：2020-09-22
申请号：US14342587
申请日：2012-09-12
申请人： Nao Nitta
发明人： Nao Nitta
IPC分类号： G01N33/48 , G01N33/50 , G01N15/14 , G01J3/02 , G01J3/28 , G01N21/25 , G01N15/10
摘要： Provided is a spectrum analysis apparatus including a processing unit configured to generate analysis data using an analysis function in which a linear function and a logarithmic function are included as function elements and an intensity value is set as a variable from measurement data including the intensity value of light acquired by detecting the light from a measurement target object using a plurality of light-receiving elements having different detection wavelength bands.

6. 发明授权

US09182349B2 Cell nucleus observation substrate and cell nucleus observation apparatus 有权
标题翻译：细胞核观察底物和细胞核观察装置
公开(公告)号：US09182349B2
公开(公告)日：2015-11-10
申请号：US13977417
申请日：2011-12-27
申请人： Nao Nitta
发明人： Nao Nitta
IPC分类号： C12M1/00 , C12M3/00 , C12M1/34 , G01N21/64 , G01N1/30
CPC分类号： G01N21/6486 , G01N1/30 , G01N21/6428 , G01N21/6458
摘要： To provide a technology of staining nuclei of cells, microorganisms and the like by a simple operation and observing their forms.There is provided a cell nucleus observation substrate including an introduction part into which a sample liquid containing cells is introduced and an observation area within which the cells in the sample liquid introduced from the introduction part is held, copper being disposed on a flow path of the sample liquid in the introduction part and the observation area so that the copper being capable of contacting with the sample liquid. In the cell nucleus observation substrate, the cells in the sample liquid introduced from the introduction part is contacted with copper, nucleic acids therein will emit fluorescence and is held within the observation area. Accordingly, in the cell nucleus observation substrate, the cells including the nuclei being fluorescence stained can be observed at the observation area.
摘要翻译：提供通过简单的操作和观察其形式来染色细胞，微生物等细胞核的技术。提供了一种细胞核观察基板，其包括引入部分，其中引入含有细胞的样品液体和观察区域，在该观察区域中保持从导入部分引入的样品液体中的细胞，铜布置在在引入部分和观察区域中的样品液体，使得铜能够与样品液体接触。在细胞核观察底物中，从引入部分导入的样品液中的细胞与铜接触，其中的核酸将发出荧光并保持在观察区域内。因此，在细胞核观察基板中，可以在观察区域观察包含被荧光染色的细胞核的细胞。

7. 发明申请

US20110306086A1 CELL SEPARATING METHOD 审中-公开
标题翻译：细胞分离方法
公开(公告)号：US20110306086A1
公开(公告)日：2011-12-15
申请号：US13202719
申请日：2010-03-01
申请人： Nao Nitta
发明人： Nao Nitta
IPC分类号： C12Q1/04
CPC分类号： G01N33/52 , G01N30/00 , G01N2015/1477 , G01N2015/149
摘要： Provided is a cell separating method which suppresses physical damage to cells without using an apparatus having a complicated structure, and enables the cell separation performed by a quantitative analysis and a multi-parametric analysis and the cell separation using Hoechst staining or the like as an index.The present invention provides a cell separating method including a step (S3) of determining the characteristics of a cell labeled with a caged compound; a step (S4) of activating the caged compound labeling a target cell by emitting light only to the target cell having a predetermined characteristic; and a step (S5) of bringing cells into contact with a substance having an affinity with the activated caged compound and separating only the target cell from the cells based on the interaction between the substance and the activated caged compound.
摘要翻译：提供一种细胞分离方法，其不使用具有复杂结构的装置来抑制对细胞的物理损伤，并且能够通过定量分析和多参数分析进行细胞分离，并且使用Hoechst染色等进行细胞分离作为指标。本发明提供一种细胞分离方法，其包括：确定用笼状化合物标记的细胞的特性的步骤（S3）通过仅向具有预定特性的靶细胞发射光来激活标记化合物的靶化合物的步骤（S4）以及使细胞与活化的笼状化合物具有亲和性的物质接触的步骤（S5），并且基于物质和活化的笼状化合物之间的相互作用仅将靶细胞与细胞分离。

8. 发明申请

US20060141510A1 Method for information processing with nucleic acid molecules 审中-公开
标题翻译：用核酸分子进行信息处理的方法
公开(公告)号：US20060141510A1
公开(公告)日：2006-06-29
申请号：US11290259
申请日：2005-11-30
申请人： Akira Suyama , Nao Nitta
发明人： Akira Suyama , Nao Nitta
IPC分类号： C12Q1/68 , G06F19/00
CPC分类号： G06N3/123 , B82Y10/00
摘要： The present invention is directed to provide an information processing method using autonomously workable nucleic acids, and a molecular computer to carry out operations with the method. Objectives above mentioned may be achieved with following method. The present invention provides an information processing method carrying out operations with functions receiving an argument and returning a return value through chemical reactions of molecules, comprising (a) inputting a first encoded nucleic acid defined in correspondence to a first degradable single stranded nucleic acid as an argument (b) carrying out an operation with functions defined in correspondence to chemical reactions of operator nucleic acids based on the argument (c) obtaining a second encoded nucleic acid defined in correspondence to a second single stranded nucleic acid as a return value. Furthermore, the invention provides a molecular computer designed on the basis of the method.
摘要翻译：本发明旨在提供一种使用自主可行的核酸的信息处理方法和分子计算机来执行该方法的操作。上述目的可以通过以下方法实现。本发明提供了一种执行具有接收参数并通过分子的化学反应返回返回值的功能的信息处理方法，包括：（a）将与第一可降解单链核酸相对应地定义的第一编码核酸输入为（b）基于参数（c）获得对应于第二单链核酸定义的第二编码核酸作为返回值，执行与操作者核酸的化学反应相对应地定义的功能的操作。此外，本发明提供了一种基于该方法设计的分子计算机。

9. 发明授权

US09459213B2 Method of detecting nucleic acids, method of optically observing sample and fluorescent substance 有权
标题翻译：检测核酸的方法，光学观察样品和荧光物质的方法
公开(公告)号：US09459213B2
公开(公告)日：2016-10-04
申请号：US13882909
申请日：2011-11-04
申请人： Nao Nitta
发明人： Nao Nitta
IPC分类号： C12Q1/68 , G01N33/00 , G01N21/64
CPC分类号： C12Q1/6825 , C12Q1/6816 , C12Q1/6827 , G01N21/6486 , G01N2021/6421 , G01N2201/12 , Y10T436/143333 , C12Q2563/137
摘要： [Object] A method of detecting nucleic acids easily without requiring complicated operations such as mixing of liquids and cleaning within micro-scale flow channels.[Solving Means] A method of detecting nucleic acids including the steps of bringing a sample containing the nucleic acids into contact with copper, and detecting fluorescence emitted from the sample is provided. According to the method of detecting nucleic acids, only by bringing the sample containing nucleic acids into contact with copper, the fluorescence derived from the composite of the nucleic acids and copper can be easily detected.
摘要翻译： [解决方案]提供了检测核酸的方法，包括使含有核酸的样品与铜接触并检测从样品发出的荧光的步骤。根据检测核酸的方法，仅通过使含有核酸的样品与铜接触，可以容易地检测到来自核酸和铜的复合物的荧光。

10. 发明授权

US08816311B2 Fine particle measuring apparatus 有权
标题翻译：细颗粒测量仪
公开(公告)号：US08816311B2
公开(公告)日：2014-08-26
申请号：US13605256
申请日：2012-09-06
申请人： Nao Nitta
发明人： Nao Nitta
IPC分类号： G01N23/04
CPC分类号： G01N21/6486 , G01N15/1429 , G01N15/1434 , G01N15/1459 , G01N21/274 , G01N21/64 , G01N21/645 , G01N2015/0065 , G01N2015/1006 , G01N2021/6417 , G01N2201/06113
摘要： A fine particle measuring apparatus is provided. The fine particle measuring apparatus includes a detection unit configured to detect light emitted from a fine particle and a processing unit having a memory device storing instructions which when executed by the processing unit, cause the processing unit to calculate a corrected intensity value of the detected light and generate spectrum data based on the corrected intensity value.
摘要翻译：提供了一种微粒测量装置。微粒测量装置包括：检测单元，其被配置为检测从微粒发射的光;以及处理单元，具有存储指令的处理单元，所述指令在由所述处理单元执行时使所述处理单元计算所检测的光的校正强度值并且基于校正的强度值生成频谱数据。

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