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1. 发明授权

US06355800B1 Process for producing aminopiperazine derivatives 失效
标题翻译：制备氨基哌嗪衍生物的方法
公开(公告)号：US06355800B1
公开(公告)日：2002-03-12
申请号：US09509812
申请日：2000-04-06
申请人： Kooji Kagara , Norio Hashimoto , Atsushi Kanda , Yukihisa Baba , Tetsuo Furutera
发明人： Kooji Kagara , Norio Hashimoto , Atsushi Kanda , Yukihisa Baba , Tetsuo Furutera
IPC分类号： C07D29532
CPC分类号： C07D295/32
摘要： A new industrial process excellent in yield and purity for preparing a compound of the formula: or a salt thereof in a less number of steps with a synthetic pathway without proceeding via nitroso compounds, wherein R1 is lower aryl, ar(lower)alkoxy or heterocyclic group, each of which may be substituted with halogen, and R2 is cyclo(lower)alkyl, aryl or ar(lower)alkyl, each of which may be substituted with halogen.
摘要翻译：一种新的工业方法，其具有优良的产率和纯度，用于通过合成途径制备下式化合物或其盐在较少数量的步骤中，而不经由亚硝基化合物进行，其中R 1为低级芳基，芳（低级）烷氧基或杂环基团，其各自可以被卤素取代，并且R 2是环（低级）烷基，芳基或芳（低级）烷基，其各自可以被卤素取代。

2. 发明授权

US5361168A Lens element and lens barrel 失效
标题翻译：镜头元件和镜筒
公开(公告)号：US5361168A
公开(公告)日：1994-11-01
申请号：US874097
申请日：1992-04-27
申请人： Takashi Arai , Yukihisa Baba , Sachio Umetsu
发明人： Takashi Arai , Yukihisa Baba , Sachio Umetsu
IPC分类号： G02B7/02 , G02B9/00
CPC分类号： G02B7/022
摘要： A flow lens element is obtained by integrally molding a resin layer on a glass member. A relief portion for preventing the resin material from adhering to an outer circumferential portion of the glass member is provided between the circumferential portion and an optical portion of the glass member.
摘要翻译：通过在玻璃构件上一体地模制树脂层来获得流动透镜元件。在玻璃构件的圆周部分和光学部分之间设置有用于防止树脂材料粘附到玻璃构件的外周部分的释放部分。

3. 发明授权

US5290488A Method for molding optical elements 失效
标题翻译：光学元件成型方法
公开(公告)号：US5290488A
公开(公告)日：1994-03-01
申请号：US874099
申请日：1992-04-27
申请人： Takashi Arai , Yukihisa Baba , Sachio Umetsu
发明人： Takashi Arai , Yukihisa Baba , Sachio Umetsu
IPC分类号： B29C33/12 , B29C35/08 , B29C70/78 , B29D11/00
CPC分类号： B29C70/78 , B29C33/12 , B29D11/0073 , B29C35/0805 , B29L2011/0016
摘要： A method and apparatus for molding optical elements in which peeling between a glass member and a resin layer and between a mold member and the resin layer will not occur while at the same time it is possible to accurately bring the central axis of the glass member and the central axis of the molding surface into alignment. This is accomplished by a first step of placing the glass member upon a support portion, a second step of positioning the glass member relative to the mold means when a resin material, which has been charged into a space defined by the molding surface and the surface of the glass member, exhibits a viscosity within a predetermined range, a third step of holding the glass member at a predetermined position until the resin material cures to a predetermined ratio of polymerization, and a fourth step of releasing the glass member from the held state after the resin material has cured to the predetermined ratio of polymerization.
摘要翻译：一种用于模制光学元件的方法和装置，其中玻璃构件和树脂层之间以及模具构件与树脂层之间的剥离将不会发生，同时可以精确地使玻璃构件的中心轴线和成型面的中心轴线对齐。这是通过将玻璃构件放置在支撑部上的第一步骤，当已经装入由模制表面和表面限定的空间的树脂材料时，将玻璃构件相对于模具装置定位的第二步骤玻璃构件的粘度在预定范围内，第三步骤是将玻璃构件保持在预定位置直到树脂材料固化至预定的聚合比例，并且将玻璃构件从保持状态释放的第四步骤在树脂材料固化至预定的聚合比例之后。

4. 发明授权

US6147079A N-(4-acetyl-1-piperazinyl)-4-fluorobenzamide hydrate 失效
标题翻译： N-（4-乙酰基-1-哌嗪基）-4-氟苯甲酰胺水合物
公开(公告)号：US6147079A
公开(公告)日：2000-11-14
申请号：US319271
申请日：1999-06-14
申请人： Satoshi Kitamura , Hisashi Mimura , Hiroshi Yamasaki , Yukihisa Baba
发明人： Satoshi Kitamura , Hisashi Mimura , Hiroshi Yamasaki , Yukihisa Baba
IPC分类号： C07D295/22 , A61K31/495 , A61P25/28 , A61P43/00 , C07D295/32 , C07D241/04
CPC分类号： C07D295/32
摘要： Hydrates of N-(4-acetyl-1-piperazinyl)-4-fluorobenzamide, which are stable against heat, light, and humidity, are described. The material is easy to handle under ordinary interior humidity conditions. N-(4-acetyl-1-piperazinyl)-4-fluorobenzamide hydrate is useful as a medicament in the treatment of amnesia and senile dementia.
摘要翻译： PCT No.PCT / JP97 / 04451 Sec。 371日期1999年6月14日第 102（e）1999年6月14日PCT 1997年12月5日PCT公布。第WO98 / 25914号公报日期1998年6月18日描述了对热，光和湿度稳定的N-（4-乙酰基-1-哌嗪基）-4-氟苯甲酰胺的水合物。该材料在普通内部湿度条件下易于处理。 N-（4-乙酰基-1-哌嗪基）-4-氟苯甲酰胺水合物可用作治疗遗忘和老年痴呆的药物。

5. 发明授权

US5269978A Method of manufacturing optical element 失效
标题翻译：制造光学元件的方法
公开(公告)号：US5269978A
公开(公告)日：1993-12-14
申请号：US844776
申请日：1992-03-02
申请人： Sachio Umetsu , Takashi Arai , Yukihisa Baba
发明人： Sachio Umetsu , Takashi Arai , Yukihisa Baba
IPC分类号： C03B11/02 , B29C31/00 , B29C43/08 , B29D11/00 , G02B3/00 , B29C35/08
CPC分类号： B29C43/021 , B29C31/00 , B29C43/08 , B29D11/00865 , B29C2043/3411 , B29C2043/3689 , B29L2011/00 , B29L2011/0016
摘要： A plurality of mold members are disposed on an index table to be intermittently rotatably driven. Energy sources for curing the activation energy curable resin at positions to which the mold members are intermittently moved, a first robot for supplying a molding parent material to the mold member, a second robot for taking out an optical element after molding from the mold member, and a third robot for supplying the activation energy curable resin before supplying the molding parent material to the mold member are disposed proximate to the index table. The operations of each robot are performed together at each moved position of the mold member.
摘要翻译：多个模具构件设置在分度台上以间歇地旋转驱动。用于在模具构件间歇移动的位置处固化活化能固化树脂的能量源，用于将模塑母材供给到模具构件的第一机器人，用于从模具构件取出模制后的光学元件的第二机器人，并且在将成型母材料供给到模具构件之前提供活化能固化树脂的第三机器人设置在靠近分度台。每个机器人的操作在模具构件的每个移动位置一起执行。

6. 发明授权

US5264160A Method of molding optical elements 失效
标题翻译：光学元件成型方法
公开(公告)号：US5264160A
公开(公告)日：1993-11-23
申请号：US874087
申请日：1992-04-27
申请人： Takashi Arai , Yukihisa Baba , Sachio Umetsu
发明人： Takashi Arai , Yukihisa Baba , Sachio Umetsu
IPC分类号： B29C31/04 , B29C43/18 , B29C43/34 , B29C70/78 , B29D11/00 , B29C35/08
CPC分类号： B29C43/021 , B29C31/044 , B29C43/18 , B29C43/34 , B29C70/78 , B29D11/0073 , B29C2043/3433 , B29C2043/3618 , B29K2101/12 , B29L2011/0016
摘要： A method of molding an optical element in which a required amount of a resin material can be accurately supplied without air bubbles becoming entrapped in the resin material when it is supplied. The method includes a first step of making a tip of resin material supply means approach a molding surface until the tip is a predetermined distance away from the molding surface, a second step of discharging a predetermined amount of the resin material from the tip of the supply means while the tip of the supply means is the predetermined distance away from the molding surface, and a third step of discharging the resin material from the tip at a predetermined discharge rate, until a required amount of the resin has been supplied, while the tip of the supply means is moved in a direction away from the molding surface as the lower end of the resin material discharged from the tip is maintained in contact with the molding surface.
摘要翻译：一种成型光学元件的方法，其中可以准确地供应所需量的树脂材料，而在供应时没有气泡被夹在树脂材料中。该方法包括：第一步骤，使树脂材料供给装置的尖端接近模制表面，直到尖端距离模制表面预定距离;第二步骤，从供给的尖端排出预定量的树脂材料意味着供给装置的前端距离模制表面预定距离，第三步骤以预定的排出速率从尖端排出树脂材料，直到提供所需量的树脂，同时尖端的供给装置沿着离开模制表面的方向移动，因为从尖端排出的树脂材料的下端保持与模制表面接触。

7. 发明授权

US5675011A Process for producing pyrrolidine derivative and salt thereof 失效
标题翻译：制备吡咯烷衍生物及其盐的方法
公开(公告)号：US5675011A
公开(公告)日：1997-10-07
申请号：US487521
申请日：1995-06-07
申请人： Kohji Kagara , Shunsuke Goto , Satoshi Yonishi , Muneharu Ikushima , Yukihisa Baba , Haruo Horiai
发明人： Kohji Kagara , Shunsuke Goto , Satoshi Yonishi , Muneharu Ikushima , Yukihisa Baba , Haruo Horiai
IPC分类号： C07D207/14 , C07D401/06
CPC分类号： C07D401/06 , C07D207/14
摘要： A process for producing a compound of the general formula: ##STR1## wherein R.sup.1 is heterocyclic(lower)alkyl, R.sup.2 is acyl, and R.sup.3 is carboxy(lower)alkyl or protected carboxy(lower)alkyl, which is useful as a medicament or a salt thereof.
摘要翻译：制备通式如下的化合物的方法：其中R 1为杂环（低级）烷基，R 2为酰基，且R 3为羧基（低级）烷基或被保护的羧基（低级）烷基，其可用作药物或其盐。

8. 发明授权

US5292457A Method for molding optical elements 失效
标题翻译：光学元件成型方法
公开(公告)号：US5292457A
公开(公告)日：1994-03-08
申请号：US874100
申请日：1992-04-27
申请人： Takashi Arai , Yukihisa Baba
发明人： Takashi Arai , Yukihisa Baba
IPC分类号： B29C33/14 , B29C33/12 , B29C35/08 , B29C39/10 , B29C39/26 , B29C70/78 , B29D11/00 , B29K105/20 , B29K105/32 , B29L9/00 , B29L11/00 , G02B3/00
CPC分类号： B29C70/78 , B29C33/12 , B29D11/0073 , B29C35/0805 , B29L2011/0016
摘要： A method and apparatus for molding optical elements in which a resin layer is accurately formed on a surface of a desired shape without the occurrence of peeling between a glass member and a resin layer and between a mold member and the resin layer when the resin layer is molded. This is accomplished by a first step of placing the glass member upon a supporting member, a second step of holding the glass member in a state in which the surface thereof is spaced away from the molding surface of the mold member by a predetermined distance, and a third step of moving the mold member and the supporting member relative to each other, after the resin material, which has been charged into a space defined by the molding surface and the surface of the glass member, has cured to a predetermined ratio of polymerization, in such a manner that glass member is supported on the resin layer independently.
摘要翻译：一种用于模制光学元件的方法和装置，其中当树脂层是树脂层时，在所需形状的表面上精确地形成树脂层而不会在玻璃构件和树脂层之间以及模具构件和树脂层之间发生剥离模制。这是通过将玻璃构件放置在支撑构件上的第一步骤，将玻璃构件保持在与模具构件的模制表面间隔开预定距离的状态的第二步骤来实现的，以及在被填充到由模制表面和玻璃构件的表面限定的空间中的树脂材料固化到预定的聚合比例之后，使模具构件和支撑构件相对移动的第三步骤以玻璃构件独立地支撑在树脂层上的方式。

9. 发明授权

US4734419A Quinazoline derivatives, compositions thereof and their use in treating diabetic complications 失效
标题翻译：喹唑啉衍生物，其组合物及其在治疗糖尿病并发症中的用途
公开(公告)号：US4734419A
公开(公告)日：1988-03-29
申请号：US908005
申请日：1986-09-16
申请人： Masashi Hashimoto , Teruo Oku , Yoshikuni Ito , Takayuki Namiki , Kozo Sawada , Chiyoshi Kasahara , Yukihisa Baba
发明人： Masashi Hashimoto , Teruo Oku , Yoshikuni Ito , Takayuki Namiki , Kozo Sawada , Chiyoshi Kasahara , Yukihisa Baba
IPC分类号： C12N9/99 , A61K31/505 , A61K31/517 , A61K31/54 , A61K31/5415 , A61P1/16 , A61P3/08 , A61P3/10 , A61P13/02 , A61P15/00 , A61P25/00 , A61P27/02 , A61P27/12 , A61P43/00 , C07D239/80 , C07D239/91 , C07D239/93 , C07D239/95 , C07D239/96 , C07D265/26 , C07D285/24 , C07D401/06 , C07D409/06 , C07D521/00
CPC分类号： C07D401/06 , C07D239/95 , C07D239/96 , C07D285/24 , C07D409/06
摘要： The invention relates to compounds of the formula: ##STR1## in which R.sup.1 and R.sup.2 are each hydrogen, halogen, lower alkoxy or halo(lower)alkyl,R.sup.3 is dihalophenyl, naphthyl(lower)alkyl, phenyl(lower)alkyl substituted by one or two substituent(s) selected from the group consisting of halogen, lower alkoxy, halo(lower)alkyl and lower alkyl, or thienyl(lower)alkyl,R.sup.4 is carboxy or protected carboxy,Y is carbonyl, thiocarbonyl or sulfonyl andZ is lower alkylene, and pharmaceutically acceptable salts thereof, useful in the treatment of diabetic complications.
摘要翻译：本发明涉及下式的化合物：其中R 1和R 2各自为氢，卤素，低级烷氧基或卤代（低级）烷基，R 3为二卤代苯基，萘基（低级）烷基，苯基（低级）烷基）或低级烷基，或噻吩基（低级）烷基，R4为羧基或被保护的羧基，Y为羰基，硫代羰基或磺酰基，Z为低级亚烷基及其药学上可接受的盐，可用于治疗糖尿病并发症。

10. 发明授权

US5543525A Process for producing pyrrolidine derivative and salt thereof 失效
标题翻译：制备吡咯烷衍生物及其盐的方法
公开(公告)号：US5543525A
公开(公告)日：1996-08-06
申请号：US360679
申请日：1994-12-30
申请人： Kohji Kagara , Shunsuke Goto , Satoshi Yonishi , Muneharu Ikushima , Yukihisa Baba , Haruo Horiai
发明人： Kohji Kagara , Shunsuke Goto , Satoshi Yonishi , Muneharu Ikushima , Yukihisa Baba , Haruo Horiai
IPC分类号： C07D207/14 , C07D401/06
CPC分类号： C07D401/06 , C07D207/14
摘要： A process for producing a compound of the general formula: ##STR1## wherein R.sup.1 is heterocyclic(lower)alkyl,R.sup.2 is acyl, andR.sup.3 is carboxy(lower)alkyl orprotected carboxy (lower) alkyl, which is useful as a medicament or a salt thereof.
摘要翻译： PCT No.PCT / JP93 / 00886 Sec。 371日期1994年12月30日第 102（e）日期1994年12月30日PCT提交1993年6月29日PCT公布。出版物WO94 / 01400 日本1994年1月20日制备通式如下的化合物的方法：其中R1是杂环（低级）烷基，R2是酰基，R3是羧基（低级）烷基或保护的羧基（低级）烷基，其是可用作药物或其盐。

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