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1. 发明公开

EP2932291A2 MOTION DETECTION AND CORRECTION METHOD FOR MAGNETIC RESONANCE DIFFUSION WEIGHTED IMAGING (DWI) 审中-公开
标题翻译：运动检测和校正算法弥散加权成像MRI（DWI）
公开(公告)号：EP2932291A2
公开(公告)日：2015-10-21
申请号：EP13818808.1
申请日：2013-12-06
申请人： Koninklijke Philips N.V. , Philips GmbH
发明人： STEHNING, Christian , PERKINS, Thomas , SENEGAS, Julien , KEUPP, Jochen
IPC分类号： G01R33/563 , G01R33/565
CPC分类号： G01R33/56341 , G01R33/4831 , G01R33/56509
摘要： A magnetic resonance imaging system (1) includes at least one processor (28) configured to receive (48) diffusion weighted imaging data based on a diffusion weighted imaging sequence with magnetic gradient fields applied in different directions and with different b-values. The at least one processor (28) is further configured to detect (50) motion corrupted data present in the received imaging data based on a comparison of data redundant in the received data, and substitute (52) alternative data for detected motion corrupted data.

2. 发明授权

EP2932291B1 MOTION DETECTION AND CORRECTION METHOD FOR MAGNETIC RESONANCE DIFFUSION WEIGHTED IMAGING (DWI) 有权
公开(公告)号：EP2932291B1
公开(公告)日：2019-11-27
申请号：EP13818808.1
申请日：2013-12-06
申请人： Koninklijke Philips N.V. , Philips GmbH
发明人： STEHNING, Christian , PERKINS, Thomas , SENEGAS, Julien , KEUPP, Jochen
IPC分类号： G01R33/563 , G01R33/565

3. 发明公开

EP2839308A1 MR IMAGING USING APT CONTRAST ENHANCEMENT AND SAMPLING AT MULTIPLE ECHO TIMES 审中-公开
标题翻译： MRBILDGEBUNG MIT APT-KONTRASTVERSTÄRKUNGUND PROBENAHME BEI MEHREREN ECHOZEITEN
公开(公告)号：EP2839308A1
公开(公告)日：2015-02-25
申请号：EP13721089.4
申请日：2013-03-21
申请人： Koninklijke Philips N.V. , Philips GmbH
发明人： EGGERS, Holger , KEUPP, Jochen
IPC分类号： G01R33/56
CPC分类号： G01R33/4828 , A61B5/055 , G01R33/243 , G01R33/5605 , G01R33/5617
摘要： The invention relates to a method of CEST or APT MR imaging of at least a portion of a body (10) placed in a main magnetic field B
0 within the examination volume of a MR device. The method of the invention comprises the following steps: • a) subjecting the portion of the body (10) to a saturation RF pulse at a saturation frequency offset; • b) subjecting the portion of the body (10) to an imaging sequence comprising at least one excitation/refocussing RF pulse and switched magnetic field gradients, whereby MR signals are acquired from the portion of the body (10) as spin echo signals; • c) repeating steps a) and b) two or more times, wherein the saturation frequency offset and/or a echo time shift in the imaging sequence are varied, such that a different combination of saturation frequency offset and echo time shift is applied in two or more of the repetitions; • d) reconstructing a MR image and/or B
0 field homogeneity corrected APT/CEST images from the acquired MR signals. Moreover, the invention relates to a MR device (1) for carrying out the method of the invention and to a computer program to be run on a MR device.
摘要翻译：本发明涉及一种放置在MR装置的检查体积内的主磁场B 0中的身体（10）的至少一部分的CEST或APT MR成像方法。本发明的方法包括以下步骤：a）使身体（10）的部分经受饱和频率偏移的饱和RF脉冲; b）使身体（10）的部分经受包括至少一个激发RF脉冲和切换磁场梯度的成像序列，从而从身体（10）的部分获取MR信号作为自旋回波信号; c）重复步骤a）和b）两次或更多次，其中成像序列中的饱和频率偏移和/或回波时间偏移被改变，使得饱和频率偏移和回波时间偏移的不同组合被应用于两个或更多的重复; d）从所获取的MR信号重建MR图像。此外，本发明涉及一种用于执行本发明的方法的MR设备（1）以及要在MR设备上运行的计算机程序。

4. 发明公开

EP2979106A1 AMIDE PROTON TRANSFER (APT) AND ELECTRIC PROPERTIES TOMOGRAPHY (EPT) IMAGING IN A SINGLE MR ACQUISITION 审中-公开
标题翻译： AMIDPROTONENTRANSFER（APT）与电工FEATURE断层摄影（EPT）在一个单一的MR检测用摄像
公开(公告)号：EP2979106A1
公开(公告)日：2016-02-03
申请号：EP14714228.5
申请日：2014-03-26
申请人： Koninklijke Philips N.V. , Philips GmbH
发明人： KATSCHER, Ulrich , DONEVA, Mariya Ivanova , STEHNING, Christian , VAN DEN BRINK, Johan Samuel , KEUPP, Jochen
IPC分类号： G01R33/48 , G01R33/56
CPC分类号： G01R33/5605 , G01R33/48 , G01R33/4828
摘要： The present invention relates to a magnetic resonance imaging, MRI, system (200) for acquiring magnetic resonance data from a target volume in a subject (218), the MRI system (200) comprising a memory (236) for storing machine executable instructions; and a processor (230) for controlling the MRI system (200), wherein execution of the machine executable instructions causes the processor (230) to use a first MRI sequence (401) containing a first selective RF pulse (413) followed by a first excitation RF pulse (415) to control the MRI system (200) to selectively excite and saturate exchangeable amide protons within a first frequency range in the target volume; irradiate said target volume with the first excitation RF pulse (415) that is adapted to excite bulk water protons in the target volume; and acquire first magnetic resonance imaging data from the target volume in response to the first excitation RF pulse (415); use a second MRI sequence (403) containing a second selective RF pulse (423) followed by a second excitation RF pulse (425) to control the MRI system (200) to selectively excite and saturate the exchangeable amide protons within a second frequency range in the target volume; irradiate said target volume with the second excitation RF pulse (425) that is adapted to excite said bulk water protons; and acquire second magnetic resonance imaging data from said target volume in response to the second excitation RF pulse (425); wherein the first MRI sequence (401) comprises gradients (417) having first gradient polarities reverse of second gradient polarities (427) of the second MRI sequence (403).

5. 发明申请

WO2023036799A1 MECHANICAL GRADIENT MAGNETIC FIELD GENERATOR 审中-公开
公开(公告)号：WO2023036799A1
公开(公告)日：2023-03-16
申请号：PCT/EP2022/074808
申请日：2022-09-07
申请人： KONINKLIJKE PHILIPS N.V.
发明人： GLEICH, Bernhard , DUENSING, George, Randall , OVERWEG, Johannes, Adrianus , BÖRNERT, Peter, Ulrich , KEUPP, Jochen
IPC分类号： G01R33/38
摘要： Disclosed herein is a mechanical gradient magnetic field generator (100, 500, 1600. 1700, 2000, 2112) comprising a field generating element (102) comprising at least one generator layer (104). Each of the at least one generator layer comprises: a stationary divider (106); a movable divider (108) configured for moving in one (110) or two (1602) displacement directions; a mechanical element (112) configured to mechanically assist movement of the movable divider in the one or two displacement directions towards an initial position (508); and a set of rotatable magnets (114) positioned between the movable divider and the stationary divider. The set of rotatable magnets are mechanically coupled to the movable divider and to the stationary divider. The mechanical coupling of the set of rotatable magnets is such that movement of the movable divider in the one or two displacement directions causes an individual rotation of each of the set of rotatable magnets.

6. 发明申请

WO2023020901A1 MULTI-REGION MR FINGERPRINTING 审中-公开
公开(公告)号：WO2023020901A1
公开(公告)日：2023-02-23
申请号：PCT/EP2022/072390
申请日：2022-08-10
申请人： KONINKLIJKE PHILIPS N.V.
发明人： BOERNERT, Peter Ulrich , NEHRKE, Kay , AMTHOR, Thomas Erik , MEINEKE, Jan Jakob , BAUMANN, Manuel Matthias , MAZURKEWITZ, Peter Caesar , KEUPP, Jochen , DONEVA, Mariya Ivanova , VAN DEN BRINK, Johan Samuel
IPC分类号： G01R33/483 , G01R33/54 , G01R33/56 , G01R33/561 , G01R33/44 , G01R33/50 , G01R33/563
摘要： :The invention relates to a method of MR imaging of an object (10) placed in an examination volume of an MR system (1). It is an object of the invention to provide an improved quantitative MR imaging technique. The method comprises the steps of: subjecting the object (10) to an imaging sequence which generates MR signals in two or more spatially separate slices or volumes, wherein the imaging sequence is composed of a train of sequence blocks, each sequence block comprising at least one RF pulse and at least one switched readout magnetic field gradient defining a k-space sampling pattern and having associated therewith a set of acquisition parameters, acquiring the MR signals, wherein the MR signals are generated and/or manipulated in only a subset of said slices or volumes during each sequence block to acquire the MR signals in a time-multiplexed manner from all of the slices or volumes while simultaneously varying at least one acquisition parameter during the course of the imaging sequence, and reconstructing at least one MR image for each slice or volume, wherein one or more MR parameters are computed for a number of image positions from the temporal evolution of the acquired MR signals caused by the variation of the at least one acquisition parameter. Moreover, the invention relates to an MR system (1) for carrying out this method as well as to a computer program to be run on an MR system.

7. 发明申请

WO2021204619A1 MEASUREMENT OF INTRA-CELLULAR CONDUCTIVITY USING MAGNETIC RESONANCE IMAGING 审中-公开
公开(公告)号：WO2021204619A1
公开(公告)日：2021-10-14
申请号：PCT/EP2021/058416
申请日：2021-03-31
申请人： KONINKLIJKE PHILIPS N.V.
发明人： KATSCHER, Ulrich, Wolfgang , KEUPP, Jochen
IPC分类号： A61B5/0536 , G01R33/56 , G01R33/563 , G01R33/44
摘要： Disclosed herein is a method of medical imaging. The method comprises: receiving (200) a first electrical properties tomography conductivity map (122) for a first radio frequency value, receiving (202) a second electrical properties tomography conductivity map (124), calculating (204) a low frequency conductivity map (126) using the first electrical properties tomography conductivity map and the second electrical properties tomography conductivity map, calculating (208) an intra-cellular volume map (130) and an extra-cellular volume map (131) by performing an optimization of a two-term exponential model to the multi-b diffusion weighted magnetic resonance imaging signal spectra map, calculating (210) an intra-cellular volume fraction map (132) by performing a voxel wise division of the intra-cellular volume map by the voxel wise sum of the extra-cellular volume map plus the intra-cellular volume map, and calculating (212) an intra-cellular conductivity map (134) by performing a voxel wise division of an intermediate mapping by the intra-cellular volume fraction map.

8. 发明申请

WO2019086284A1 DEEP-LEARNING BASED PROCESSING OF MOTION ARTIFACTS IN MAGNETIC RESONANCE IMAGING DATA 审中-公开
公开(公告)号：WO2019086284A1
公开(公告)日：2019-05-09
申请号：PCT/EP2018/078863
申请日：2018-10-22
申请人： KONINKLIJKE PHILIPS N.V.
发明人： SOMMER, Karsten , BROSCH, Tom , HARDER, Tim, Philipp , KEUPP, Jochen , GRAESSLIN, Ingmar , WIEMKER, Rafael , SAALBACH, Axel
IPC分类号： G06T5/00 , G01R33/565
CPC分类号： G06T5/003 , G01R33/56509 , G06T2207/10076 , G06T2207/20081 , G06T2207/20084
摘要： The invention relates to a magnetic resonance imaging data processing system (126) for processing motion artifacts in magnetic resonance imaging data sets using a deep learning network (146, 502, 702) trained for the processing of motion artifacts in magnetic resonance imaging data sets. The magnetic resonance imaging data processing system (126) comprises a memory (134, 136) storing machine executable instructions (161, 164) and the trained deep learning network (146, 502, 702). Furthermore, the magnetic resonance imaging data processing system (126) comprises a processor (130) for controlling the magnetic resonance imaging data processing system. Execution of the machine executable instructions (161, 164) causes the processor (130) to control the magnetic resonance imaging data processing system (126) to: receive a magnetic resonance imaging data set (144, 500, 800), apply the received magnetic resonance imaging data set (144, 500, 800) as an input to the trained deep learning network (146, 502, 702), process one or more motion artifacts present in the received magnetic resonance imaging data set (144, 500, 800) using the trained deep learning network (146, 502, 702).

9. 发明申请

WO2013111101A1 TUMOR SEGMENTATION AND TISSUE CLASSIFICATION IN 3D MULTI-CONTRAST 审中-公开
标题翻译： 3D多对象中的肿瘤分类和组织分类
公开(公告)号：WO2013111101A1
公开(公告)日：2013-08-01
申请号：PCT/IB2013/050644
申请日：2013-01-25
申请人： KONINKLIJKE PHILIPS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH
发明人： FRANZ, Astrid Ruth , REMMELE, Stefanie , STEHNING, Christian , KEUPP, Jochen
IPC分类号： G06T7/00
CPC分类号： G06T7/11 , A61B5/0042 , A61B5/055 , A61B5/742 , A61B6/037 , A61B6/461 , A61B6/481 , A61B6/5211 , G01R33/4808 , G01R33/5601 , G01R33/563 , G06T7/0012 , G06T7/174 , G06T7/187 , G06T15/08 , G06T2207/10088 , G06T2207/10104 , G06T2207/20016 , G06T2207/20092 , G06T2207/20168 , G06T2207/30016 , G06T2207/30096
摘要： A medical imaging system (5) includes a workstation (20), a coarse segmenter (30), a fine segmenter (32), and an enclosed tissue identification module (34). The workstation (20) includes at least one input device (22) for receiving a selected location as a seed in a first contrasted tissue type and a display device (26) which displays a diagnostic image delineating a first segmented region of a first tissue type and a second segmented region of a second contrasted tissue type and identified regions which include regions fully enclosed by the first segmented region as a third tissue type. The coarse segmenter (30) grows a coarse segmented region of coarse voxels for each contrasted tissue type from the seed location based on a first growing algorithm and a growing fraction for each contrasted tissue type. The seed location for growing the second contrasted tissue type includes the first coarse segmented region and any fully enclosed coarse voxels, and each coarse voxel includes an aggregation of voxels and a maximum and a minimum of the voxel intensities. The fine segmenter (32) grows a segmented region of voxels for each contrasted tissue type from the seed location and bounded by the second coarse segmented region based on a second growing algorithm and a growing fraction for each contrasted tissue type initially set to the growing fraction for the corresponding region. The seed location for growing the second contrasted tissue type includes the first segmented region and any identified regions. The enclosed tissue identification module (34) identifies any regions of voxels fully enclosed by the first segmented region as being of the third tissue type. The coarse segmenter, the fine segmenter, and the enclosed tissue identification module are implemented by an electronic data processing device.
摘要翻译：医疗成像系统（5）包括工作站（20），粗分割器（30），精细分割器（32）和封闭的组织识别模块（34）。工作站（20）包括至少一个输入装置（22），用于以第一对比组织类型的种子的形式接收所选择的位置，以及显示装置（26），其显示描绘第一组织类型的第一分割区域以及第二对比组织类型的第二分割区域和被识别的区域，其包括由第一分割区域完全包围的区域作为第三组织类型。粗分割器（30）基于第一生长算法和每个对比组织类型的生长部分，从种子位置为每个对比组织类型生长粗体素的粗分割区域。用于生长第二对比组织类型的种子位置包括第一粗分段区域和任何完全封闭的粗体素，并且每个粗体素包括体素的聚集和体素强度的最大和最小值。细分割器（32）基于第二种生长算法，从种子位置生长每个对比组织类型的分形区域，并由第二粗分段区域生长，并且对于初始设置为生长部分的每个对比组织类型的生长部分对于相应的区域。用于生长第二对比组织类型的种子位置包括第一分割区域和任何识别的区域。封闭的组织识别模块（34）将由第一分段区域完全包围的体素的任何区域识别为第三组织类型。粗分割器，精细分割器和封闭组织识别模块由电子数据处理装置实现。

10. 发明申请

WO2013108142A1 MULTI-RESONANT T/R ANTENNA FOR MR IMAGE GENERATION 审中-公开
标题翻译：用于MR图像生成的多谐振T / R天线
公开(公告)号：WO2013108142A1
公开(公告)日：2013-07-25
申请号：PCT/IB2013/050041
申请日：2013-01-03
申请人： KONINKLIJKE PHILIPS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH
发明人： LEUSSLER, Christoph , MAZURKEWITZ, Peter , KEUPP, Jochen
IPC分类号： G01R33/36
CPC分类号： G01R33/3635 , G01R33/34 , G01R33/34092 , G01R33/3628 , G01R33/3642 , G01R33/446
摘要： A dual- or multi-resonant RF/MR transmit and/or receive antenna (1, 2) especially in the form of a planar antenna or a volume array antenna (also called antenna array) is disclosed for MR image generation of at least two different nuclei like e.g. 1 H, 19 F, 3 He, 13 C, 23 Na or other nuclei having different Larmor frequencies. Basically, the antenna is coupled by means of an inductive coupling device (LI) with related transmit/receive channels (T/R). By such an inductive coupling, the tuning and matching of the antenna at the different resonant frequencies is easier to be obtained than in case of a galvanic connection. Further, the invention relates to an MR imaging apparatus comprising such a dual- or multi-resonant RF/MR transmit and/or receive antenna.
摘要翻译：公开了特别是平面天线或体积阵列天线（也称为天线阵列）形式的双或多谐振RF / MR发射和/或接收天线（1,2），用于至少两个不同的核，例如 1H，19F，3He，13C，23Na或具有不同拉莫尔频率的其他核。基本上，天线通过具有相关发射/接收信道（T / R）的感应耦合装置（LI）耦合。通过这种电感耦合，天线在不同谐振频率下的调谐和匹配比电流连接的情况更容易得到。此外，本发明涉及包括这种双谐振或多谐振RF / MR发射和/或接收天线的MR成像设备。

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