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1. 发明申请

WO2014147518A3 DYNAMIC MRI WITH IMAGE RECONSTRUCTION USING COMPRESSED SENSING 审中-公开
标题翻译：动态MRI与图像重建使用压缩感知
公开(公告)号：WO2014147518A3
公开(公告)日：2014-09-25
申请号：PCT/IB2014/059660
申请日：2014-03-12
申请人： KONINKLIJKE PHILIPS N.V. , PHILIPS GMBH
发明人： FUDERER, Miha , DONEVA, Mariya Ivanova
IPC分类号： G01R33/48 , G01R33/561
摘要： The invention relates to a method of MR imaging of an object (10) placed in an examination volume of a MR device (1). The method comprises the steps of: subjecting the object (10) to an imaging sequence for acquiring MR signal data, wherein the MR signal data are acquired as a function of k-space position and time by using an irregular k-space sampling pattern with sub-sampling of k-space; reconstructing MR image data from the MR signal data, which MR image data comprise spatial dimensions and a frequency dimension, sparsity of the MR image data in a transform domain being exploited for suppressing sub-sampling artefacts in the MR image data. Moreover, the invention relates to a MR device (1) and to a computer program.
摘要翻译：本发明涉及一种放置在MR设备（1）的检查体积中的物体（10）的MR成像方法。该方法包括以下步骤：使对象（10）经受用于采集MR信号数据的成像序列，其中通过使用不规则k空间采样图案来获取MR信号数据作为k空间位置和时间的函数，其中 k空间的二次采样; 根据MR信号数据重建MR图像数据，该MR图像数据包括空间维度和频率维度，变换域中的MR图像数据的稀疏性被利用来抑制MR图像数据中的子采样伪像。此外，本发明涉及MR设备（1）和计算机程序。

2. 发明公开

EP2972450A1 AUTOMATIC OPTIMIZATION OF PARALLEL IMAGING ACCELERATION PARAMETERS 有权转让
标题翻译：加速度参数的并行成像自动优化设计
公开(公告)号：EP2972450A1
公开(公告)日：2016-01-20
申请号：EP14715680.6
申请日：2014-03-12
申请人： Koninklijke Philips N.V. , Philips GmbH
发明人： BOERNERT, Peter , JURRISSEN, Michel Paul Jurriaan , DONEVA, Mariya Ivanova , DUIJNDAM, Adrianus Joseph Willibrordus , NEHRKE, Kay
IPC分类号： G01R33/561
CPC分类号： G01R33/5611 , G01R33/34092 , G01R33/5608
摘要： A parallel magnetic resonance imaging system (1) includes at least one radio frequency (RF) coil (10, 12) with a plurality of coil elements, a smart select unit (24), a parallel imaging parameter unit (28), and a sequence control (16). The smart select unit (24), from a pre-scan or prior scan of a subject with the at least one RF coil, constructs (60) a signal map and a plurality of noise maps based on different sets of reduction factors. The parallel imaging parameter unit (28) selects a set of reduction factors corresponding to a noise map which includes a highest signal-to-noise ratio (SNR). The sequence control (16) performs a magnetic resonance imaging scan of the subject based on the selected reduction factors.

3. 发明公开

EP2979106A1 AMIDE PROTON TRANSFER (APT) AND ELECTRIC PROPERTIES TOMOGRAPHY (EPT) IMAGING IN A SINGLE MR ACQUISITION 审中-公开
标题翻译： AMIDPROTONENTRANSFER（APT）与电工FEATURE断层摄影（EPT）在一个单一的MR检测用摄像
公开(公告)号：EP2979106A1
公开(公告)日：2016-02-03
申请号：EP14714228.5
申请日：2014-03-26
申请人： Koninklijke Philips N.V. , Philips GmbH
发明人： KATSCHER, Ulrich , DONEVA, Mariya Ivanova , STEHNING, Christian , VAN DEN BRINK, Johan Samuel , KEUPP, Jochen
IPC分类号： G01R33/48 , G01R33/56
CPC分类号： G01R33/5605 , G01R33/48 , G01R33/4828
摘要： The present invention relates to a magnetic resonance imaging, MRI, system (200) for acquiring magnetic resonance data from a target volume in a subject (218), the MRI system (200) comprising a memory (236) for storing machine executable instructions; and a processor (230) for controlling the MRI system (200), wherein execution of the machine executable instructions causes the processor (230) to use a first MRI sequence (401) containing a first selective RF pulse (413) followed by a first excitation RF pulse (415) to control the MRI system (200) to selectively excite and saturate exchangeable amide protons within a first frequency range in the target volume; irradiate said target volume with the first excitation RF pulse (415) that is adapted to excite bulk water protons in the target volume; and acquire first magnetic resonance imaging data from the target volume in response to the first excitation RF pulse (415); use a second MRI sequence (403) containing a second selective RF pulse (423) followed by a second excitation RF pulse (425) to control the MRI system (200) to selectively excite and saturate the exchangeable amide protons within a second frequency range in the target volume; irradiate said target volume with the second excitation RF pulse (425) that is adapted to excite said bulk water protons; and acquire second magnetic resonance imaging data from said target volume in response to the second excitation RF pulse (425); wherein the first MRI sequence (401) comprises gradients (417) having first gradient polarities reverse of second gradient polarities (427) of the second MRI sequence (403).

4. 发明公开

EP2976654A2 MR IMAGE RECONSTRUCTION USING COMPRESSED SENSING 审中-公开
标题翻译：与压缩传感MR图像重建
公开(公告)号：EP2976654A2
公开(公告)日：2016-01-27
申请号：EP14720249.3
申请日：2014-03-12
申请人： Koninklijke Philips N.V. , Philips GmbH
发明人： FUDERER, Miha , DONEVA, Mariya Ivanova
IPC分类号： G01R33/48 , G01R33/561
CPC分类号： G01R33/4824 , G01R33/4828 , G01R33/561 , G01R33/5611 , G01R33/56545
摘要： The invention relates to a method of MR imaging of an object (10) placed in an examination volume of a MR device (1). The method comprises the steps of: subjecting the object (10) to an imaging sequence for acquiring MR signal data, wherein the MR signal data are acquired as a function of k-space position and time by using an irregular k-space sampling pattern with sub-sampling of k-space; reconstructing MR image data from the MR signal data, which MR image data comprise spatial dimensions and a frequency dimension, sparsity of the MR image data in a transform domain being exploited for suppressing sub-sampling artefacts in the MR image data. Moreover, the invention relates to a MR device (1) and to a computer program.

5. 发明申请

WO2023020901A1 MULTI-REGION MR FINGERPRINTING 审中-公开
公开(公告)号：WO2023020901A1
公开(公告)日：2023-02-23
申请号：PCT/EP2022/072390
申请日：2022-08-10
申请人： KONINKLIJKE PHILIPS N.V.
发明人： BOERNERT, Peter Ulrich , NEHRKE, Kay , AMTHOR, Thomas Erik , MEINEKE, Jan Jakob , BAUMANN, Manuel Matthias , MAZURKEWITZ, Peter Caesar , KEUPP, Jochen , DONEVA, Mariya Ivanova , VAN DEN BRINK, Johan Samuel
IPC分类号： G01R33/483 , G01R33/54 , G01R33/56 , G01R33/561 , G01R33/44 , G01R33/50 , G01R33/563
摘要： :The invention relates to a method of MR imaging of an object (10) placed in an examination volume of an MR system (1). It is an object of the invention to provide an improved quantitative MR imaging technique. The method comprises the steps of: subjecting the object (10) to an imaging sequence which generates MR signals in two or more spatially separate slices or volumes, wherein the imaging sequence is composed of a train of sequence blocks, each sequence block comprising at least one RF pulse and at least one switched readout magnetic field gradient defining a k-space sampling pattern and having associated therewith a set of acquisition parameters, acquiring the MR signals, wherein the MR signals are generated and/or manipulated in only a subset of said slices or volumes during each sequence block to acquire the MR signals in a time-multiplexed manner from all of the slices or volumes while simultaneously varying at least one acquisition parameter during the course of the imaging sequence, and reconstructing at least one MR image for each slice or volume, wherein one or more MR parameters are computed for a number of image positions from the temporal evolution of the acquired MR signals caused by the variation of the at least one acquisition parameter. Moreover, the invention relates to an MR system (1) for carrying out this method as well as to a computer program to be run on an MR system.

6. 发明申请

WO2014141086A1 AUTOMATIC OPTIMIZATION OF PARALLEL IMAGING ACCELERATION PARAMETERS 审中-公开
标题翻译：并行成像加速度参数的自动优化
公开(公告)号：WO2014141086A1
公开(公告)日：2014-09-18
申请号：PCT/IB2014/059667
申请日：2014-03-12
申请人： KONINKLIJKE PHILIPS N.V. , PHILIPS DEUTSCHLAND GMBH
发明人： BOERNERT, Peter , JURRISSEN, Michel Paul Jurriaan , DONEVA, Mariya Ivanova , DUIJNDAM, Adrianus Joseph Willibrordus , NEHRKE, Kay
IPC分类号： G01R33/561
CPC分类号： G01R33/5611 , G01R33/34092 , G01R33/5608
摘要： A parallel magnetic resonance imaging system (1) includes at least one radio frequency (RF) coil (10, 12) with a plurality of coil elements, a smart select unit (24), a parallel imaging parameter unit (28), and a sequence control (16). The smart select unit (24), from a pre-scan or prior scan of a subject with the at least one RF coil, constructs (60) a signal map and a plurality of noise maps based on different sets of reduction factors. The parallel imaging parameter unit (28) selects a set of reduction factors corresponding to a noise map which includes a highest signal-to-noise ratio (SNR). The sequence control (16) performs a magnetic resonance imaging scan of the subject based on the selected reduction factors.
摘要翻译：平行磁共振成像系统（1）包括具有多个线圈元件的至少一个射频（RF）线圈（10,12），智能选择单元（24），并行成像参数单元（28）和序列控制（16）。智能选择单元（24）从具有至少一个RF线圈的对象的预扫描或先前扫描构造（60）基于不同的缩减因子集合的信号图和多个噪声图。并行成像参数单元（28）选择与包括最高信噪比（SNR）的噪声映射对应的一组减少因子。序列控制（16）基于所选择的缩小因子执行对象的磁共振成像扫描。

7. 发明申请

WO2022008329A1 MAGNETIC RESONANCE FINGERPRINTING QUALITY ASSURANCE 审中-公开
公开(公告)号：WO2022008329A1
公开(公告)日：2022-01-13
申请号：PCT/EP2021/068112
申请日：2021-07-01
申请人： KONINKLIJKE PHILIPS N.V.
发明人： AMTHOR, Thomas Erik , DONEVA, Mariya Ivanova , KOKEN, Peter , NEHRKE, Kay
IPC分类号： G01R33/56 , G01R33/561
摘要： Disclosed herein is a medical system (100, 300) comprising a memory (110) storing machine executable instructions (120) and an MRF scoring module (122). The MRF scoring module is configured for outputting an MRF quality score (126) in response to receiving MRF data (124) as input. The medical system further comprises a computational system (106) configured for controlling the medical system, wherein execution of the machine executable instructions causes the computational system to: receive (200) the MRF data; receive (202) the MRF quality score in response to inputting the MRF data into an MRF scoring module; append (206) the MRF quality score to the MRF data if the MRF quality score is within a predetermined range (128); and provide (208) a signal (132) if the MRF quality score is outside of the predetermined range.

8. 发明申请

WO2014147508A2 A METHOD FOR K-SPACE SAMPLING 审中-公开
标题翻译： K空间采样的方法
公开(公告)号：WO2014147508A2
公开(公告)日：2014-09-25
申请号：PCT/IB2014/059513
申请日：2014-03-07
申请人： KONINKLIJKE PHILIPS N.V. , PHILIPS DEUTSCHLAND GMBH
发明人： DONEVA, Mariya Ivanova , HELLE, Michael Günter , BOERNERT, Peter
IPC分类号： G01R33/561
CPC分类号： G01R33/5611 , G01R33/4818
摘要： The present invention relates to a magnetic resonance imaging MRI system (100) for acquiring magnetic resonance data from a target volume in a subject (118), the magnetic resonance imaging system (100) comprises: a memory (136) for storing machine executable instructions; and a processor (130) for controlling the MRI system (100), wherein execution of the machine executable instructions causes the processor (130) to: determine an energy distribution (301-305) over a k-space domain of the target volume; receive a reduction factor representing a degree of under-sampling of the k-space domain; derive from the energy distribution (301-305) and the received reduction factor a sampling density function; derive from the sampling density function an energy dependent sampling pattern of the k-space domain; control the MRI system (100) to acquire under-sampled k-space data using a pulse sequence that samples the k-space domain along the derived sampling pattern; apply a compressed sensing reconstruction to the acquired under-sampled data to reconstruct an image of the target volume.
摘要翻译：磁共振成像系统（100）包括：存储器（136），用于存储机器可执行指令 ; 以及用于控制所述MRI系统（100）的处理器（130），其中所述机器可执行指令的执行使所述处理器（130）确定所述目标体积的k空间域上的能量分布（301-305）接收表示k空间域的低采样度的缩小因子; 从能量分布（301-305）和收到的减少因子得出采样密度函数; 从采样密度函数导出k空间域的能量相关采样模式; 控制MRI系统（100）使用沿着导出的采样模式对k-空间域进行采样的脉冲序列来获取欠采样的k空间数据; 对所获取的未采样数据应用压缩感测重建以重建目标体积的图像。

9. 发明申请

WO2016074946A1 MAGNETIC RESONANCE FINGERPRINTING IN SLICES ALONG A ONE-DIMENSIONAL EXTENSION 审中-公开
标题翻译：在一维延伸中指向单曲的磁共振
公开(公告)号：WO2016074946A1
公开(公告)日：2016-05-19
申请号：PCT/EP2015/075194
申请日：2015-10-30
申请人： KONINKLIJKE PHILIPS N.V.
发明人： AMTHOR, Thomas Erik , DONEVA, Mariya Ivanova , KOKEN, Peter , KEUPP, Jochen , BOERNERT, Peter
IPC分类号： G01R33/483 , G01R33/50 , A61B5/055 , G01R33/30 , G01R33/48 , G01R33/54
CPC分类号： A61B5/055 , A61B5/4872 , G01R33/307 , G01R33/4828 , G01R33/4835 , G01R33/50 , G01R33/54 , G01R33/563
摘要： The invention provides for a magnetic resonance imaging system (100) which comprise a magnet (104) and a magnetic field gradient generator (110, 112) for generating a gradient magnetic field within an imaging zone (108). The gradient magnetic field is aligned with a predetermined direction. The magnetic resonance imaging system further comprise a memory (134, 136) for storing machine executable instructions (150, 152, 154), a pre-calculated magnetic resonance fingerprinting dictionary (144), and pulse sequence instructions (140). The pulse sequence instructions cause the magnetic resonance imaging system to acquire the magnetic resonance data according to a magnetic resonance fingerprinting technique. The magnetic resonance fingerprinting technique encodes the magnetic resonance data as slices (125). The pre-calculated magnetic resonance fingerprinting dictionary contains a listing of calculated magnetic resonance signals in response to execution of the pulse sequence instructions for a set of predetermined substances. Execution of the machine executable instructions causes a processor (130) controlling the magnetic resonance imaging system to: acquire (300) the magnetic resonance data by controlling the magnetic resonance imaging system with pulse sequence instructions; divide (302) the magnetic resonance data into a set of slices; calculate (304) the abundance of each of the set of predetermined substances within each of the set of slices by comparing the magnetic resonance data for each of the set of slices with the pre-calculated magnetic resonance fingerprinting dictionary; and calculate (306) amagnetic resonance fingerprint chart by plotting abundance of each of the set of predetermined substances within each of the set of slicesas a function of position along the predetermined direction.
摘要翻译：本发明提供一种磁共振成像系统（100），其包括用于在成像区域（108）内产生梯度磁场的磁体（104）和磁场梯度发生器（110,112）。梯度磁场与预定方向对齐。磁共振成像系统还包括用于存储机器可执行指令（150,152,154），预先计算的磁共振指纹词典（144）和脉冲序列指令（140）的存储器（134,136）。脉冲序列指令使得磁共振成像系统根据磁共振指纹技术获取磁共振数据。磁共振指纹技术将磁共振数据编码为片（125）。预先计算的磁共振指纹词典包含响应于一组预定物质的脉冲序列指令的执行而计算的磁共振信号的列表。执行机器可执行指令使得控制磁共振成像系统的处理器（130）通过用脉冲序列指令控制磁共振成像系统来获取（300）磁共振数据; 将（302）磁共振数据划分成一组切片; 通过将所述一组切片中的每一个的磁共振数据与所述预先计算的磁共振指纹词典进行比较，来计算（304）所述一组切片中的每组中的所述一组预定物质的丰度; 并且通过绘制在所述一组切片中的每组中的所述一组预定物质中的每一个的丰度作为沿着所述预定方向的位置的函数来计算（306）磁共振指纹图。

10. 发明申请

WO2015159172A1 METHOD OF IMPROVED MULTIPLE-PHASE DYNAMIC CONTRAST-ENHANCED MAGNETIC RESONANCE IMAGING 审中-公开
标题翻译：改进的多相动态对比增强磁共振成像方法
公开(公告)号：WO2015159172A1
公开(公告)日：2015-10-22
申请号：PCT/IB2015/052354
申请日：2015-03-31
申请人： KONINKLIJKE PHILIPS N.V. , THE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER
发明人： GDANIEC, Nadine , BOERNERT, Peter , DONEVA, Mariya Ivanova , PEDROSA, Ivan
IPC分类号： A61B5/00 , A61B5/055 , A61B6/00
CPC分类号： A61B5/055 , A61B5/4869 , A61B5/4872 , A61B5/7207 , G01R33/4828 , G01R33/5601 , G06T7/0012 , G06T7/30 , G06T2207/10088 , G06T2207/30096
摘要： A method of operating a magnetic resonance imaging system (10) with regard to acquiring multiple-phase dynamic contrast-enhanced magnetic resonance images, the method comprising steps of acquiring (48) a first set of magnetic resonance image data (x pre ) prior to administering a contrast agent to the subject of interest (20), by employing a water/fat magnetic resonance signal separation technique, determining (52) a first image of the spatial distribution of fat (I pre ) of at least the portion of the subject of interest (20), acquiring (50) at least a second set of magnetic resonance image data (x 2) of at least the portion of the subject of interest (20) after administering the contrast agent to the subject of interest (20), by employing a water/fat magnetic resonance signal separation technique, determining (54) at least a second image of the spatial distribution of fat (I 2 ph ) of at least the portion of the subject of interest (20), applying (56) an image registration method to the second image of the spatial distribution of fat (I 2 ph ) with reference to the first image of the spatial distribution of fat (I pre ) for correcting a potential motion of the subject of interest (20); and a magnetic resonance imaging system (10) having a control unit (26) that is configured to carry out steps (56-64) of such a method; and a software module (44) for carrying out such a method, wherein the method steps (56-64) to be conducted are converted into a program code that is implementable in a memory unit (30) and is executable by a processor unit (32) of the magnetic resonance imaging system (10).
摘要翻译：一种在获取多相动态对比度增强磁共振图像时操作磁共振成像系统（10）的方法，所述方法包括以下步骤：在施用之前获取（48）第一组磁共振图像数据（xpre）通过使用水/脂肪磁共振信号分离技术来确定（52）至少感兴趣的对象的部分的脂肪（Ipre）的空间分布的第一图像（52）和感兴趣对象（20）的造影剂（20），通过采用（50）至少所述感兴趣对象的部分（20）的至少第二组磁共振图像数据（x2），将所述造影剂施用于感兴趣对象（20）水分/脂肪磁共振信号分离技术，确定（54）至少所述感兴趣对象部分（20）的脂肪空间分布（I2 ph）的至少第二图像，应用（56）图像配准方法到秒参考脂肪空间分布的第一个图像（Ipre），用于校正感兴趣对象的潜在运动（20）的脂肪空间分布（I2 ph）的图像。以及具有控制单元（26）的磁共振成像系统（10），所述控制单元被配置为执行这种方法的步骤（56-64）; 以及用于执行这种方法的软件模块（44），其中要执行的方法步骤（56-64）被转换成可在存储器单元（30）中实现的程序代码，并且可由处理器单元 32）的磁共振成像系统（10）。

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