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1. 发明申请

WO2014154728A1 AMIDE PROTON TRANSFER (APT) AND ELECTRIC PROPERTIES TOMOGRAPHY (EPT) IMAGING IN A SINGLE MR ACQUISITION 审中-公开
标题翻译：单次MR获取中的AMAT PROTON TRANSFER（APT）和电子性质TOMOGRAPHY（EPT）成像
公开(公告)号：WO2014154728A1
公开(公告)日：2014-10-02
申请号：PCT/EP2014/056018
申请日：2014-03-26
申请人： KONINKLIJKE PHILIPS N.V. , PHILIPS DEUTSCHLAND GMBH
发明人： KATSCHER, Ulrich , DONEVA, Mariya Ivanova , STEHNING, Christian , VAN DEN BRINK, Johan Samuel , KEUPP, Jochen
IPC分类号： G01R33/48 , G01R33/56
CPC分类号： G01R33/5605 , G01R33/48 , G01R33/4828
摘要： The present invention relates to a magnetic resonance imaging, MRI, system (200) for acquiring magnetic resonance data from a target volume in a subject (218), the MRI system (200) comprising a memory (236) for storing machine executable instructions; and a processor (230) for controlling the MRI system (200), wherein execution of the machine executable instructions causes the processor (230) to use a first MRI sequence (401) containing a first selective RF pulse (413) followed by a first excitation RF pulse (415) to control the MRI system (200) to selectively excite and saturate exchangeable amide protons within a first frequency range in the target volume; irradiate said target volume with the first excitation RF pulse (415) that is adapted to excite bulk water protons in the target volume; and acquire first magnetic resonance imaging data from the target volume in response to the first excitation RF pulse (415); use a second MRI sequence (403) containing a second selective RF pulse (423) followed by a second excitation RF pulse (425) to control the MRI system (200) to selectively excite and saturate the exchangeable amide protons within a second frequency range in the target volume; irradiate said target volume with the second excitation RF pulse (425) that is adapted to excite said bulk water protons; and acquire second magnetic resonance imaging data from said target volume in response to the second excitation RF pulse (425); wherein the first MRI sequence (401) comprises gradients (417) having first gradient polarities reverse of second gradient polarities (427) of the second MRI sequence (403).
摘要翻译：本发明涉及一种用于从对象（218）中的目标体积获取磁共振数据的磁共振成像（MRI）系统（200），所述MRI系统（200）包括用于存储机器可执行指令的存储器（236）以及用于控制所述MRI系统（200）的处理器（230），其中所述机器可执行指令的执行使所述处理器（230）使用包含第一选择性RF脉冲（413）的第一MRI序列（401）激励RF脉冲（415）以控制MRI系统（200）以在目标体积的第一频率范围内选择性地激发和饱和可交换的酰胺质子; 用适于激发目标体积中的体积水质子的第一激发RF脉冲（415）照射所述目标体积; 并且响应于所述第一激发RF脉冲（415）从所述目标体积获取第一磁共振成像数据; 使用包含第二选择性RF脉冲（423）的第二MRI序列（403），随后是第二激发RF脉冲（425）以控制MRI系统（200）在第二频率范围内选择性地激发和饱和可交换的酰胺质子目标体积; 用适于激发所述主体水质子的第二激发RF脉冲（425）照射所述目标体积; 并响应于所述第二激励RF脉冲从所述目标体积获取第二磁共振成像数据（425）; 其中所述第一MRI序列（401）包括具有与所述第二MRI序列（403）的第二梯度极性（427）相反的第一梯度极性的梯度（417）。

2. 发明申请

WO2022194715A1 STAGED RECONSTRUCTION OF PLANNING IMAGES FOR CARDIAC MAGNETIC RESONANCE IMAGING 审中-公开
公开(公告)号：WO2022194715A1
公开(公告)日：2022-09-22
申请号：PCT/EP2022/056401
申请日：2022-03-11
申请人： KONINKLIJKE PHILIPS N.V.
发明人： KEUPP, Jochen , MEINEKE, Jan Jakob , STEHNING, Christian , SCHÜLKE, Christophe Michael Jean , DONEVA, Mariya Ivanova , BÖRNERT, Peter Ulrich
IPC分类号： G01R33/563 , G01R33/48 , A61B5/055 , G01R33/56 , G01R33/567 , A61B5/00 , G01R33/561 , A61B5/024 , A61B5/08
摘要： :Disclosed herein is a medical system (100, 300, 700) comprising a magnetic resonance imaging system (102) configured to acquire lines of k-space (144) data from a thoracic region (122) of a subject (118). Execution of machine executable instructions (140) causes a computational system (132) to: repeatedly (200) acquire the lines of k-space data by controlling the magnetic resonance imaging system with the pulse sequence commands; repeatedly (202) assemble motion resolved k-space data (146) from the lines of k-space data using at least one cardiac phase and one respiratory phase of the subject as the k-space data is acquired; retrieve (204) at least a portion (148) of the motion resolved k-space data during acquisition of the k-space data; and construct (206) a preliminary three-dimensional cardiac image (150) using at least a portion of the motion resolved k-space data before acquisition of the lines of k-space data is finished. The pulse sequence commands are according to a three-dimensional free running cardiac magnetic resonance imaging protocol.

3. 发明申请

WO2014161766A1 DETECTION OF BONE TISSUE USING MAGNETIC RESONANCE IMAGING 审中-公开
标题翻译：使用磁共振成像检测骨组织
公开(公告)号：WO2014161766A1
公开(公告)日：2014-10-09
申请号：PCT/EP2014/056145
申请日：2014-03-27
申请人： KONINKLIJKE PHILIPS N.V. , PHILIPS DEUTSCHLAND GMBH
发明人： STEHNING, Christian , SCHADEWALDT, Nicole , HELLE, Michael, Günter , RENISCH, Steffen , SCHULZ, Heinrich
IPC分类号： A61B5/055 , G01R33/48 , G06T5/00 , G06T7/00
CPC分类号： G01R33/5602 , A61B5/0035 , A61B5/055 , A61B5/4504 , A61B6/037 , A61N5/1039 , G01R33/36 , G01R33/385 , G01R33/4808 , G01R33/481 , G01R33/4816 , G01R33/4828 , G01R33/5608 , G06K9/52 , G06K9/6267 , G06T7/0012 , G06T7/11 , G06T7/35 , G06T11/003 , G06T2200/04 , G06T2207/10081 , G06T2207/10088 , G06T2207/10124 , G06T2207/20128 , G06T2207/30008
摘要： The invention provides for a medical apparatus (300, 400, 500) comprising: a magnetic resonance imaging system (302) for acquiring magnetic resonance data (342) from an imaging zone (308); a processor (330) for controlling the medical apparatus; a memory (336) storing machine executable instructions (350, 352, 354, 356). Execution of the instructions causes the processor to: acquire (100, 200) the magnetic resonance data using a pulse sequence (340) which specifies an echo time greater than 400 μβ; reconstruct (102, 202) a magnetic resonance image using the magnetic resonance data; generate (104, 204) a thresholded image (346) by thresholding the magnetic resonance image to emphasize bone structures and suppressing tissue structures in the magnetic resonance image; and generate (106, 206) a bone-enhanced image by applying a background removal algorithm to the thresholded image.
摘要翻译：本发明提供一种医疗设备（300,400,500），包括：用于从成像区域（308）获取磁共振数据（342）的磁共振成像系统（302）。用于控制医疗装置的处理器（330）存储器（336），用于存储机器可执行指令（350,352,354,356）。执行指令使处理器：使用指定大于400μs的回波时间的脉冲序列（340）获取（100,200）磁共振数据; 使用磁共振数据重建（102,202）磁共振图像; 通过阈值化磁共振图像来产生（104,204）阈值图像（346），以强调骨结构并抑制磁共振图像中的组织结构; 并通过将背景去除算法应用于阈值图像来生成（106,206）骨骼增强图像。

4. 发明申请

WO2014060863A1 MR RECEIVE COIL LOCALIZATION AND MR-BASED ATTENUATION CORRECTION 审中-公开
标题翻译：接收线圈定位和基于MR的衰减校正
公开(公告)号：WO2014060863A1
公开(公告)日：2014-04-24
申请号：PCT/IB2013/056522
申请日：2013-08-09
申请人： KONINKLIJKE PHILIPS N.V. , PHILIPS DEUTSCHLAND GMBH
发明人： STEHNING, Christian , RENISCH, Steffen , DAHNKE, Hannes , HU, Zhiqiang
IPC分类号： A61B6/03 , A61B6/00 , A61B5/055 , G01R33/48 , G01R33/56 , G01T1/16 , G01R33/565
CPC分类号： A61B5/055 , A61B5/0035 , A61B5/06 , A61B6/037 , A61B6/4417 , A61B6/501 , A61B6/5247 , A61B6/5258 , A61N5/1039 , G01R33/287 , G01R33/481 , G01R33/4828 , G01R33/5608 , G01R33/5616 , G01T1/1603
摘要： A system (10) and method generate one or more MR data sets of an imaging volume (16) using an MR scanner (14). The imaging volume (16) includes one or more of a region of interest (ROI), the ROI including a metal element, and a local receive coil (18) of the MR scanner (14). At least one of an attenuation, confidence or density map accounting for the metal element is generated and the location of the local receive coil (18) within the imaging volume (16) is determined. The generating includes identification of the metal element within the ROI based on a phase map of the ROI generated from the MR data sets. The determining includes registering a known sensitivity profile of the local receive coil (18) to a sensitivity map of the local receive coil (18) generated from the MR data sets.
摘要翻译：系统（10）和方法使用MR扫描器（14）生成成像体积（16）的一个或多个MR数据集。成像体积（16）包括感兴趣区域（ROI）中的一个或多个，ROI包括金属元件和MR扫描器（14）的局部接收线圈（18）。产生对金属元件的衰减，置信度或密度图中的至少一个，并且确定成像体积（16）内的局部接收线圈（18）的位置。该生成包括基于从MR数据集生成的ROI的相位图来识别ROI内的金属元素。确定包括将本地接收线圈（18）的已知灵敏度分布记录到从MR数据集生成的本地接收线圈（18）的灵敏度映射。

5. 发明申请

WO2018115179A1 MRI METHOD FOR T1 MAPPING OF THE HEART USING A MAXIMUM LIKELIHOOD RECONSTRUCTION IN K-SPACE 审中-公开
公开(公告)号：WO2018115179A1
公开(公告)日：2018-06-28
申请号：PCT/EP2017/083917
申请日：2017-12-20
申请人： KONINKLIJKE PHILIPS N.V.
发明人： STEHNING, Christian , BÖRNERT, Peter , AMTHOR, Thomas, Erik , DONEVA, Mariya, Ivanova , SMINK, Jouke , KOUWENHOVEN, Marc
IPC分类号： G01R33/50 , G01R33/54 , G01R33/56 , G01R33/561 , G01R33/567 , A61B5/055 , A61B5/00
摘要： The invention provides for a magnetic resonance imaging system (100) for acquiring magnetic resonance data (146) from a subject (118) from a region of interest (109) within an imaging zone (108). The magnetic resonance imaging system comprises a memory (134) for storing machine executable instructions (140) and pulse sequence commands (142). The pulse sequence commands are configured for controlling the magnetic resonance imaging system to perform magnetization preparation pulses which causes magnetization inversion within the region of interest and initiates a T1 relaxation process. The pulse sequence commands are configured for acquiring portions of the magnetic resonance data as discrete units during a rest and relaxation interval of a heart phase of the subject. The magnetic resonance imaging system further comprises a processor (130) for controlling the magnetic resonance imaging system. Execution of the machine executable instructions causes the processor to repeatedly: receive (202) an ECG signal (124) descriptive of the heart phase of the subject; detect (204) an onset of the rest and relaxation interval of the heart phase using the ECG signal; acquire (206) a portion (146) of the magnetic resonance data a predetermined delay after the onset of the rest and relaxation interval by controlling (200) the magnetic resonance imaging system with the pulse sequence commands, wherein the portion of the magnetic resonance data undersamples k-space; determine (208) an inversion delay (308, 502) for the portion of the magnetic resonance data using a timing of the magnetization preparation pulses and the onset of the rest and relaxation interval. Execution of the machine executable instructions further causes the processor to calculate a T1 map (150) of the region of interest using a maximum likelihood reconstruction that uses the magnetic resonance data and the inversion delay for each portion of the magnetic resonance data.

6. 发明申请

WO2015011584A3 DIFFERENTIATING TISSUES WITH MRI USING MULTI-ECHO ULTRA-SHORT TE (UTE) WITH MDIXON PULSE SEQUENCE 审中-公开
公开(公告)号：WO2015011584A3
公开(公告)日：2015-01-29
申请号：PCT/IB2014/062787
申请日：2014-07-02
申请人： KONINKLIJKE PHILIPS N.V.
发明人： HU, Lingzhi , STEHNING, Christian , HU, Zhiqiang , SHAO, Lingxiong
IPC分类号： G01R33/48 , G01R33/56
摘要： A medical imaging system (10) includes a magnetic resonance (MR) scanner (12), and a MR reconstruction unit (34). The MR scanner (12) applies a multi-echo ultra-short TE (UTE) with mDixon pulse sequence to a subject (16) and receives MR data (33) representing at least a portion of the subject. The MR reconstruction unit (34) reconstructs a Free Induction Decay (FID) image (120), and one or more echo magnitude images (122), one or more phase images (39), an in-phase image (39), a water image (39), and a fat image (39) from the received MR data (33).

7. 发明申请

WO2014091374A2 MOTION DETECTION AND CORRECTION METHOD FOR MAGNETIC RESONANCE DIFFUSION WEIGHTED IMAGING (DWI) 审中-公开
标题翻译：磁共振扩散加权成像（DWI）的运动检测和校正方法
公开(公告)号：WO2014091374A2
公开(公告)日：2014-06-19
申请号：PCT/IB2013/060691
申请日：2013-12-06
申请人： KONINKLIJKE PHILIPS N.V. , PHILIPS DEUTSCHLAND GMBH
发明人： STEHNING, Christian , PERKINS, Thomas , SENEGAS, Julien , KEUPP, Jochen
IPC分类号： G01R33/563
CPC分类号： G01R33/56341 , G01R33/4831 , G01R33/56509
摘要： A magnetic resonance imaging system (1) includes at least one processor (28) configured to receive (48) diffusion weighted imaging data based on a diffusion weighted imaging sequence with magnetic gradient fields applied in different directions and with different b-values. The at least one processor (28) is further configured to detect (50) motion corrupted data present in the received imaging data based on a comparison of data redundant in the received data, and substitute (52) alternative data for detected motion corrupted data.
摘要翻译：磁共振成像系统（1）包括至少一个处理器（28），其被配置为基于具有在不同方向上施加的磁梯度场的扩散加权成像序列来接收（48）扩散加权成像数据，以及具有不同的b值。所述至少一个处理器（28）还被配置为基于所接收的数据中的冗余数据的比较来检测（50）存在于所接收的成像数据中的运动损坏的数据，并且用替代（52）用于检测到的运动损坏的数据的替代数据。

8. 发明申请

WO2019238462A1 POSITION FEED BACK INDICATOR FOR MEDICAL IMAGING 审中-公开
公开(公告)号：WO2019238462A1
公开(公告)日：2019-12-19
申请号：PCT/EP2019/064404
申请日：2019-06-04
申请人： KONINKLIJKE PHILIPS N.V.
发明人： KRUEGER, Sascha , STEHNING, Christian , MAZURKEWITZ, Peter
IPC分类号： A61B6/00 , A61B5/11 , G06T7/20 , G06T7/30 , A61B5/055 , G01R33/48
摘要： The invention provides for a medical instrument (100, 300, 400, 500, 600) comprising a camera system (102, 102', 102'') for imaging a portion (418) of a subject (108) reposing on a subject support (106). The medical instrument further comprises a display system (104) for rendering a position feedback indicator (130, 900). The display system is configured such that the position feedback indicator is visible to the subject when the subject is reposing on the subject support. The execution of the machine executable instructions (120) causes a processor (114) controlling the medical instrument to: acquire (200) a base position image (122) using the camera system; repeatedly (202) acquire a subsequent image (124) using the camera system; repeatedly (204) calculate an image transformation (126) from voxels of at least a portion of the base position image to voxels of the subsequent image by inputting the base position image and the subsequent image into an image transformation algorithm (128); and repeatedly (206) render a position feedback indicator (130, 900) on the display, wherein the position feedback indicator is controlled by the image transformation.

9. 发明申请

WO2018114554A1 DIXON-TYPE WATER/FAT SEPARATION MR IMAGING 审中-公开
公开(公告)号：WO2018114554A1
公开(公告)日：2018-06-28
申请号：PCT/EP2017/082736
申请日：2017-12-14
申请人： KONINKLIJKE PHILIPS N.V.
发明人： EGGERS, Holger , STEHNING, Christian , BECK, Gabriele, Marianne , VAN IJPEREN, Gerrit, Hendrik
IPC分类号： G01R33/48 , G01R33/54 , G01R33/561
CPC分类号： G01R33/4828 , G01R33/4824 , G01R33/543 , G01R33/5618
摘要： The invention relates to a method of Dixon-type MR imaging. The method comprises the steps of: subjecting the object (10) to an imaging sequence (31) comprising a series of refocusing RF pulses, wherein two echo signals are generated in each time interval between two consecutive refocusing RF pulses, acquiring the echo signals from the object (10) using a bipolar pair of readout magnetic field gradients, wherein the two readout magnetic field gradients have different strengths such that the corresponding two echo signals are acquired at different receive bandwidths, and reconstructing a MR image from the acquired echo signals, whereby signal contributions from water protons and fat protons are separated. Moreover the invention relates to a MR device (1) and to a computer program to be run on a MR device (1).

10. 发明申请

WO2017157879A1 ELECTROMAGNETIC DRIVABLE INSERTS 审中-公开
标题翻译：电磁驱动器
公开(公告)号：WO2017157879A1
公开(公告)日：2017-09-21
申请号：PCT/EP2017/055895
申请日：2017-03-14
申请人： KONINKLIJKE PHILIPS N.V.
发明人： GLEICH, Bernhard , SCHMALE, Ingo , STEHNING, Christian , RAHMER, Jürgen Erwin , MAZURKEWITZ, Peter , BONTUS, Claas , WIRTZ, Daniel , BORGERT, Jörn
IPC分类号： A61N5/10
CPC分类号： A61N5/1001 , A61B17/861 , A61B17/8685 , A61B17/8875 , A61B2017/00411 , A61N2005/1024 , A61N2005/109 , A61N2005/1094
摘要： The present invention relates to magnetically activatable inserts. In order to provide improved ways of controlling, a radiation providing seed (10) for use in radiotherapy is provided. The seed comprises a seed core (12) that is configured to generate radiation, a casing (14) providing a cavity (16), and a movable (18) insert which is guided inside the cavity. The seed core is attached to the movable insert, which is configured as a magnetic insert, such that upon applying a magnetic field with a moving component, the insert is movable relative to the casing. The insert is movable between a first position (P1) and a second position (P2). In the first position, the seed core is in a shielded arrangement within the casing, and in the second position, the seed core is in an exposed arrangement, such that in the second position, the seed provides more radiation than in the first position. The movable insert is configured to cause a movement between the first and the second position upon being moved relative to the casing. Further, the insert is a screw insert (20) that is movably hold by a threaded connection arranged along a thread axis. The screw insert is rotatable relative to the casing to cause a screw motion resulting in a movement along the thread axis. And the screw insert has a magnetization component (24) arranged transverse to the thread axis, such that upon applying a magnetic field with a rotational component, the screw insert is rotatable relative to the casing.
摘要翻译：本发明涉及可磁性激活的插入件。为了提供改进的控制方式，提供了用于放射治疗的辐射提供种子（10）。种子包括构造成产生辐射的种子核心（12），提供空腔（16）的壳体（14）以及在空腔内引导的可移动（18）插入件。种芯被附接到构造为磁性插入件的可移动插入件，使得在用移动部件施加磁场时，插入件能够相对于壳体移动。插入件可在第一位置（P1）和第二位置（P2）之间移动。在第一位置中，种子核心在壳体内处于屏蔽布置中，并且在第二位置中，种子核心处于暴露布置，使得在第二位置中，种子提供比在第一位置更多的辐射。可移动插入件构造成在第一位置和第二位置相对于壳体移动时引起移动。此外，插入件是螺纹插入件（20），其通过沿着螺纹轴布置的螺纹连接而可移动地保持。螺钉插件可相对于壳体旋转以引起螺纹运动，导致沿螺纹轴线的移动。并且螺钉插入件具有横向于螺纹轴布置的磁化部件（24），使得在施加具有旋转部件的磁场时，螺钉插入件能够相对于壳体旋转。

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