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1. 发明申请

WO2015040120A1 MR-BASED ATTENUATION CORRECTION IN PET/MR IMAGING WITH DIXON PULSE SEQUENCE 审中-公开
标题翻译：用DIXON脉冲序列进行PET / MR成像的基于MR的衰减校正
公开(公告)号：WO2015040120A1
公开(公告)日：2015-03-26
申请号：PCT/EP2014/069910
申请日：2014-09-18
申请人： KONINKLIJKE PHILIPS N.V.
发明人： STEHNING, Christian , EGGERS, Holger , BÖRNERT, Peter , HU, Lingzhi , HU, Zhiqiang
IPC分类号： G01R33/48 , G01R33/561 , G01R33/56
CPC分类号： G01R33/481 , G01R33/4816 , G01R33/4828 , G01R33/5608 , G01R33/5615 , G01R33/5616
摘要： A medical imaging system (10) includes a nuclear imaging system (62), a timing optimization unit (40), a magnetic resonance (MR) scanner (12), an MR reconstruction unit (38), and an attenuation map unit (50). The nuclear imaging system (62) receives nuclear decay data and generates at least one nuclear image (64) of a first resolution based on the received nuclear decay data of an imaged subject (16) and an attenuation map (52). The timing optimization unit (40) which selects a first and a second echo time for a modified Dixon (mDixon) pulse sequence and a sufficient number of repetition times (TRs) to generate an image of the subject (16) of at least a first resolution, with the phase angle difference between water and fat at the first and the second echo time being unequal to 0° and 180°. The MR scanner (12) applies the sequence to the subject (16) and receives MR data (32) from the subject. The MR reconstruction unit (38) reconstructs at least one MR image (44) based on the MR data (32). The attenuation map unit (50) constructs the attenuation map (52) based on the reconstructed MR image (44).
摘要翻译：医疗成像系统（10）包括核成像系统（62），定时优化单元（40），磁共振（MR）扫描器（12），MR重建单元（38）和衰减映射单元）。核成像系统（62）接收核衰变数据，并基于所接收的成像对象（16）的核衰减数据和衰减图（52）产生第一分辨率的至少一个核图像（64）。定时优化单元（40），其针对修改的Dixon（mDixon）脉冲序列选择第一和第二回波时间以及足够数量的重复次数（TR），以产生至少第一个分辨率，第一和第二回波时间的水和脂肪之间的相位角差不等于0°和180°。 MR扫描器（12）将序列应用于对象（16）并从对象接收MR数据（32）。 MR重建单元（38）基于MR数据（32）重建至少一个MR图像（44）。衰减映射单元（50）基于重建的MR图像构造衰减图（52）（44）。

2. 发明申请

WO2016092394A1 SYSTEMS AND METHODS FOR TRANSLATION OF MEDICAL IMAGING USING MACHINE LEARNING 审中-公开
标题翻译：使用机器学习翻译医学成像的系统和方法
公开(公告)号：WO2016092394A1
公开(公告)日：2016-06-16
申请号：PCT/IB2015/058995
申请日：2015-11-20
申请人： KONINKLIJKE PHILIPS N.V. , CASE WESTERN RESERVE UNIVERSITY , UNIVERSITY HOSPITALS MEDICAL GROUP, INC.
发明人： HU, Lingzhi , SHAO, Lingxiong , MUZIC, Raymond Frank , SU, Kuan-Hao , QIAN, Pengjiang
IPC分类号： G06T11/00
CPC分类号： G06T11/006 , G06T5/007 , G06T2207/10081 , G06T2207/10088 , G06T2207/10104 , G06T2207/20081 , G06T2207/20221
摘要： A medical image(24) with contrast of one imaging modality is emulated from images with other contrast characteristics. A plurality of input images (20) of a region of interest with the other contrast characteristics is received. A transform (22) which was generated by machine learning is applied to the corresponding plurality of input images (20) to generate a scalar value (38) or a vector value (38') representing the corresponding voxel (36ʹ) of the medical image (24) to be evaluated.
摘要翻译：具有一种成像模式的对比度的医学图像（24）从具有其他对比度特征的图像中模拟。接收具有其他对比度特性的感兴趣区域的多个输入图像（20）。将通过机器学习产生的变换（22）应用于对应的多个输入图像（20），以生成表示医学图像的相应体素（36'）的标量值（38）或矢量值（38'）（24）进行评估。

3. 发明申请

WO2015011584A3 DIFFERENTIATING TISSUES WITH MRI USING MULTI-ECHO ULTRA-SHORT TE (UTE) WITH MDIXON PULSE SEQUENCE 审中-公开
公开(公告)号：WO2015011584A3
公开(公告)日：2015-01-29
申请号：PCT/IB2014/062787
申请日：2014-07-02
申请人： KONINKLIJKE PHILIPS N.V.
发明人： HU, Lingzhi , STEHNING, Christian , HU, Zhiqiang , SHAO, Lingxiong
IPC分类号： G01R33/48 , G01R33/56
摘要： A medical imaging system (10) includes a magnetic resonance (MR) scanner (12), and a MR reconstruction unit (34). The MR scanner (12) applies a multi-echo ultra-short TE (UTE) with mDixon pulse sequence to a subject (16) and receives MR data (33) representing at least a portion of the subject. The MR reconstruction unit (34) reconstructs a Free Induction Decay (FID) image (120), and one or more echo magnitude images (122), one or more phase images (39), an in-phase image (39), a water image (39), and a fat image (39) from the received MR data (33).

4. 发明公开

EP3230954A1 SYSTEMS AND METHODS FOR TRANSLATION OF MEDICAL IMAGING USING MACHINE LEARNING 审中-公开
标题翻译：用机器学习翻译医学成像的系统和方法
公开(公告)号：EP3230954A1
公开(公告)日：2017-10-18
申请号：EP15807698.4
申请日：2015-11-20
申请人： Koninklijke Philips N.V. , Case Western Reserve University , University Hospitals Medical Group, Inc.
发明人： HU, Lingzhi , SHAO, Lingxiong , MUZIC, Raymond Frank , SU, Kuan-Hao , QIAN, Pengjiang
IPC分类号： G06T11/00
CPC分类号： G06T11/006 , G06T5/007 , G06T2207/10081 , G06T2207/10088 , G06T2207/10104 , G06T2207/20081 , G06T2207/20221
摘要： A medical image (24) with contrast of one imaging modality is emulated from images with other contrast characteristics. A plurality of input images (20) of a region of interest with the other contrast characteristics is received. A transform (22) which was generated by machine learning is applied to the corresponding plurality of input images (20) to generate a scalar value (38) or a vector value (38′) representing the corresponding voxel (36′) of the medical image (24) to be evaluated.
摘要翻译：具有其他对比度特征的图像仿真具有一种成像模态的对比度的医学图像（24）。接收具有其他对比度特性的感兴趣区域的多个输入图像（20）。通过机器学习生成的变换（22）被应用于对应的多个输入图像（20）以生成表示医学图像的对应体素（36'）的标量值（38）或向量值（38'）（24）进行评估。

5. 发明公开

EP3025163A2 DIFFERENTIATING TISSUES WITH MR IMAGING 审中-公开
标题翻译：与磁共振成像组织分化
公开(公告)号：EP3025163A2
公开(公告)日：2016-06-01
申请号：EP14755143.6
申请日：2014-07-02
申请人： Koninklijke Philips N.V.
发明人： HU, Lingzhi , STEHNING, Christian , HU, Zhiqiang , SHAO, Lingxiong
IPC分类号： G01R33/48 , G01R33/56
CPC分类号： G01R33/4816 , G01R33/481 , G01R33/4828 , G01R33/5608 , G01R33/58
摘要： A medical imaging system (10) includes a magnetic resonance (MR) scanner (12), and a MR reconstruction unit (34). The MR scanner (12) applies a multi-echo ultra-short TE (UTE) with mDixon pulse sequence to a subject (16) and receives MR data (33) representing at least a portion of the subject. The MR reconstruction unit (34) reconstructs a Free Induction Decay (FID) image (120), and one or more echo magnitude images (122), one or more phase images (39), an in-phase image (39), a water image (39), and a fat image (39) from the received MR data (33).

6. 发明公开

EP3049818A1 MR-BASED ATTENUATION CORRECTION IN PET/MR IMAGING WITH DIXON PULSE SEQUENCE 有权转让
标题翻译： MR BASED衰减校正IN有狄克松脉冲序列PET / MR成像
公开(公告)号：EP3049818A1
公开(公告)日：2016-08-03
申请号：EP14767008.7
申请日：2014-09-18
申请人： Koninklijke Philips N.V.
发明人： STEHNING, Christian , EGGERS, Holger , BÖRNERT, Peter , HU, Lingzhi , HU, Zhiqiang
IPC分类号： G01R33/48 , G01R33/561 , G01R33/56
CPC分类号： G01R33/481 , G01R33/4816 , G01R33/4828 , G01R33/5608 , G01R33/5615 , G01R33/5616
摘要： A medical imaging system (10) includes a nuclear imaging system (62), a timing optimization unit (40), a magnetic resonance (MR) scanner (12), an MR reconstruction unit (38), and an attenuation map unit (50). The nuclear imaging system (62) receives nuclear decay data and generates at least one nuclear image (64) of a first resolution based on the received nuclear decay data of an imaged subject (16) and an attenuation map (52). The timing optimization unit (40) which selects a first and a second echo time for a modified Dixon (mDixon) pulse sequence and a sufficient number of repetition times (TRs) to generate an image of the subject (16) of at least a first resolution, with the phase angle difference between water and fat at the first and the second echo time being unequal to 0° and 180°. The MR scanner (12) applies the sequence to the subject (16) and receives MR data (32) from the subject. The MR reconstruction unit (38) reconstructs at least one MR image (44) based on the MR data (32). The attenuation map unit (50) constructs the attenuation map (52) based on the reconstructed MR image (44).

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