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1. 发明申请

WO2010035174A1 MAGNETIC-LABEL SENSOR AND CARTRIDGE 审中-公开
标题翻译：磁性标签传感器和盒子
公开(公告)号：WO2010035174A1
公开(公告)日：2010-04-01
申请号：PCT/IB2009/054046
申请日：2009-09-16
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VAN ZON, Hans , OVSYANKO, Mikhail, M. , NIEUWENHUIS, Jeroen, H.
发明人： VAN ZON, Hans , OVSYANKO, Mikhail, M. , NIEUWENHUIS, Jeroen, H.
IPC分类号： G01N33/543 , G01N35/00
CPC分类号： G01N21/552 , G01N15/1463 , G01N2015/1493
摘要： A cartridge (1,3) for a magnetic-label sensor, in particular for a magnetic-label biosensor, comprises a sensor area (4), a fluid channel (2) in contact with said sensor area and first (A) and second (Bl, B2) reservoirs in fluid communication with said fluid channel. The first reservoir comprises a first type of magnetic particles (8) and the second reservoir comprises a second type of magnetic particles (8a). The first type of magnetic particles are functionalized for binding with said sensor area, whereas the second type of magnetic particles are non- functionalized for binding with said sensor area. The magnetic particles (8, 8a) are manipulated using magnet (13). Detection is based on frustrated total internal reflection (FTIR) is hereby light from laser/LED (II) is reflected at sensor area (4) and detected by photodetector/CCD(12).
摘要翻译：用于磁标签传感器的磁带（1,3），特别是用于磁标签生物传感器，包括传感器区域（4），与所述传感器区域接触的流体通道（2）和第一（A）和第二（B1，B2）与所述流体通道流体连通的储存器。第一储存器包括第一类型的磁性颗粒（8），第二储存器包括第二类型的磁性颗粒（8a）。第一类型的磁性颗粒被功能化用于与所述传感器区域结合，而第二类型的磁性颗粒是非功能化的，用于与所述传感器区域结合。使用磁体（13）来操纵磁性颗粒（8,8a）。检测是基于沮丧的全内反射（FTIR）因此来自激光/ LED（II）被反射在传感器区域（4）处并由光电检测器/ CCD（12）检测。

2. 发明申请

WO2009069009A1 OPTICAL DETECTION OF PARTICLES IN A MAGNETIC BIOSENSOR USING A WAVEGUIDE 审中-公开
标题翻译：使用波导的磁性生物传感器中的颗粒的光学检测
公开(公告)号：WO2009069009A1
公开(公告)日：2009-06-04
申请号：PCT/IB2008/050412
申请日：2008-02-05
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , JOHNSON, Mark, T. , IMMINK, Albert, H., J. , DE BOER, Dirk, K., G. , PRINS, Menno, W., J. , NIEUWENHUIS, Jeroen, H. , VERSCHUREN, Coen, A.
发明人： JOHNSON, Mark, T. , IMMINK, Albert, H., J. , DE BOER, Dirk, K., G. , PRINS, Menno, W., J. , NIEUWENHUIS, Jeroen, H. , VERSCHUREN, Coen, A.
IPC分类号： G01N21/55 , G01N33/543 , G01N33/487
CPC分类号： G01N27/745 , G01N21/552 , G01N21/7703 , G01N33/54333 , G01N33/54373
摘要： The present invention provides a biosensor device comprising a sensor surface and an optical wave guide having an input, an output and first and second surfaces, said optical wave guide (5) being adapted to direct light entering the optical wave guide (5) through the input (20) to the output (21) via multiple reflections on said first and second surfaces (22, 23) including at least one reflection onsaid first surface (22) under an angle fulfilling the condition of total internal reflection, wherein the sensor surface is adjacent to the first surface of total internal reflection.
摘要翻译：本发明提供了一种生物传感器装置，其包括具有输入，输出和第一和第二表面的传感器表面和光波导，所述光波导（5）适于将进入光波导（5）的光引导通过通过在所述第一和第二表面（22,23）上的多个反射将输入（20）输入（20），所述第一和第二表面（22,23）包括在满足全内反射条件的角度下的至少一个反射的第一表面（22），其中传感器表面与全内反射的第一表面相邻。

3. 发明申请

WO2010035204A1 DETECTION SYSTEM AND METHOD 审中-公开
标题翻译：检测系统和方法
公开(公告)号：WO2010035204A1
公开(公告)日：2010-04-01
申请号：PCT/IB2009/054123
申请日：2009-09-21
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , WIMBERGER-FRIEDL, Reinhold , NIEUWENHUIS, Jeroen, H. , SCHLEIPEN, Johannes, J., H., B.
发明人： WIMBERGER-FRIEDL, Reinhold , NIEUWENHUIS, Jeroen, H. , SCHLEIPEN, Johannes, J., H., B.
IPC分类号： G01N21/64 , G01N21/77 , G01N33/543
CPC分类号： G01N21/6428 , G01N21/648
摘要： A detection system combines an excitation radiation source (18) providing excitation radiation (10) to an analysis region of a sample (14) within a substrate (16) having a detection surface, a detector (22) for detecting radiation collected from the analysis region comprising the detection surface of the sample resulting from the excitation, and a magnet arrangement (24) beneath the analysis region of the sample, and stationary with respect to the excitation radiation source and light coupling arrangement, for attracting magnetic beads (15) within the sample to the substrate surface The detection radiation is collected from the detection surface of the substrate, to give an enhanced surface specificity The invention combines the advantages of surface detection with a simple low cost magnetic system for bringing the target to the surface
摘要翻译：检测系统将提供激发辐射（10）的激发辐射源（18）组合到具有检测表面的衬底（16）内的样品（14）的分析区域，用于检测从分析中收集的辐射的检测器（22）包括由激发产生的样品的检测表面的区域和在样品的分析区域下方的磁体布置（24），并且相对于激发辐射源和光耦合装置固定，用于吸引在其内部的磁珠（15）样品到基板表面检测辐射是从基板的检测表面收集的，以提供更好的表面特性本发明将表面检测的优点与简单的低成本磁性系统相结合，使目标达到表面

4. 发明申请

WO2009144660A1 DEVICE AND METHODS FOR DETECTING ANALYTES IN SALIVA 审中-公开
标题翻译：用于检测SALIVA中分析物的装置和方法
公开(公告)号：WO2009144660A1
公开(公告)日：2009-12-03
申请号：PCT/IB2009/052196
申请日：2009-05-26
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , COZART BIOSCIENCE LIMITED , NIEUWENHUIS, Jeroen, H. , JEHANLI, Ahmed, M., T. , DE THEIJE, Femke, K. , PELSSERS, Eduard, G., M.
发明人： NIEUWENHUIS, Jeroen, H. , JEHANLI, Ahmed, M., T. , DE THEIJE, Femke, K. , PELSSERS, Eduard, G., M.
IPC分类号： G01N33/543
CPC分类号： G01N33/9486 , B01L3/502753 , G01N27/745 , G01N33/54326 , G01N33/54393 , G01N33/946
摘要： The invention provides a device for detecting drugs of abuse or other compounds in saliva. The invention thus provides a device for detecting the preence of on e or more analytes in a saliva sample, comprising: (a) One or more pre-treatment regions for specifically or non-specifically removing at least a part of the fraction of the saliva sample interfering with detection of the one or more analytes; and (b) A detection region comprising a biosensor surface, the surface comprising: molecules capable of specifically binding the one or more analytes; or the one ormore analytes and/or analyte analogues.
摘要翻译：本发明提供了一种用于检测唾液中的药物或其他化合物的装置。因此，本发明提供了一种用于检测唾液样品中e或更多分析物的优先性的装置，其包括：（a）用于特异性或非特异性地去除唾液部分的至少一部分的一个或多个预处理区域样品干扰一种或多种分析物的检测; 和（b）包含生物传感器表面的检测区域，所述表面包括：能够特异性结合所述一种或多种分析物的分子; 或一种或多种分析物和/或分析物类似物。

5. 发明申请

WO2008075285A1 MEASURING AGGLUTINATION PARAMETERS 审中-公开
标题翻译：测量参数
公开(公告)号：WO2008075285A1
公开(公告)日：2008-06-26
申请号：PCT/IB2007/055195
申请日：2007-12-18
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , DITTMER, Wendy, U. , DE KIEVIT, Peggy , NIEUWENHUIS, Jeroen, H. , PRINS, Menno, W., J. , VAN IJZENDOORN, Leonardus, J. , JANSSEN, Xander, J., A.
发明人： DITTMER, Wendy, U. , DE KIEVIT, Peggy , NIEUWENHUIS, Jeroen, H. , PRINS, Menno, W., J. , VAN IJZENDOORN, Leonardus, J. , JANSSEN, Xander, J., A.
IPC分类号： G01N15/02 , G01N33/543 , G01R33/12
CPC分类号： G01N15/0266 , B82Y25/00 , G01N27/745 , G01N33/54333 , G01N2015/0092 , G01R33/093 , G01R33/1269 , Y10S436/806
摘要： A method and system are described for measuring agglutination in a target- induced agglutination assay with one or more magnetic particles performed in a reaction chamber. After the magnetic particles (3, 15), which are capable of binding to a target (5) are provided in the assay, an agglutination process resulting in agglutinated particles (100) comprising at least one magnetic particle is performed. The method then further comprises applying an alternating current magnetic field (H AC ) to the assay and- measuring an effect of the H AC on the one or more magnetic particles (3,15) unattached to any surface. The measured effect is indicative of one or more agglutination parameters.
摘要翻译：描述了用于在反应室中进行的一种或多种磁性颗粒测量靶诱导的凝集测定中的凝集的方法和系统。在测定中提供能够结合靶（5）的磁性颗粒（3,15）之后，进行产生包含至少一个磁性颗粒的凝集颗粒（100）的凝集过程。该方法然后还包括向测定中施加交流磁场（H SUB AC），并且测量一个或多个磁性颗粒（3）上的H AC的影响，15）不附着在任何表面上。测量的效果表示一个或多个凝集参数。

6. 发明申请

WO2009013662A1 MAGNETIC SENSOR DEVICE 审中-公开
标题翻译：磁传感器装置
公开(公告)号：WO2009013662A1
公开(公告)日：2009-01-29
申请号：PCT/IB2008/052818
申请日：2008-07-14
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PRINS, Menno, W., J. , DITTMER, Wendy, U. , NIEUWENHUIS, Jeroen, H.
发明人： PRINS, Menno, W., J. , DITTMER, Wendy, U. , NIEUWENHUIS, Jeroen, H.
IPC分类号： G01N33/543
CPC分类号： G01N33/54333 , G01N27/745
摘要： The present invention provides a sensor device (20) and a method for determining the presence and/or amount of target moieties (22) in a sample fluid (27), the target moieties (22) being labeled with magnetic or magnetizable objects (23). The sensor device (20) comprises a magnetic field generating means adapted for applying a retention field for retaining the labeled target moieties (22, 23) to the sensor surface (24) during fluid manipulations. Through this the binding between the labeled target moieties (22, 23) and the sensor surface (24) and/or the magnetic particles (23) and the target moieties (22) is substantially not disturbed during these fluid manipulations. This leads to a reliable and accurate sensor device (20).
摘要翻译：本发明提供一种传感器装置（20）和用于确定样品流体（27）中目标部分（22）的存在和/或数量的方法，目标部分（22）用磁性或可磁化物体（23）标记）。传感器装置（20）包括磁场产生装置，其适于在流体操纵期间施加用于将标记的目标部分（22,23）保持到传感器表面（24）的保持场。通过这一点，标记的目标部分（22,23）和传感器表面（24）和/或磁性颗粒（23）和目标部分（22）之间的结合在这些流体操纵过程中基本上不受干扰。这导致可靠且准确的传感器装置（20）。

7. 发明申请

WO2009013658A3 MICROFLUIDIC METHODS AND SYSTEMS FOR USE IN DETECTING ANALYTES 审中-公开
公开(公告)号：WO2009013658A3
公开(公告)日：2009-01-29
申请号：PCT/IB2008/052803
申请日：2008-07-11
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VERHOECKX, Godefridus, J. , VAN DAMME, Hendrik, S. , NIEUWENHUIS, Jeroen, H. , SHULEPOV, Sergei , WEEKAMP, Johannes, W. , SIJBERS, Mara, J., J. , BRANS, Harold, J., A. , DE THEIJE, Femke, K. , IMMINK, Albert, H, .J.
发明人： VERHOECKX, Godefridus, J. , VAN DAMME, Hendrik, S. , NIEUWENHUIS, Jeroen, H. , SHULEPOV, Sergei , WEEKAMP, Johannes, W. , SIJBERS, Mara, J., J. , BRANS, Harold, J., A. , DE THEIJE, Femke, K. , IMMINK, Albert, H, .J.
IPC分类号： B01L3/00
摘要： A microfluidic reactor arrangement (100) for use in detecting an analyte in a fluid sample (106) is described. The reactor arrangement is provided with a reagent providing means such that the reagent can be introduced after assembly of the reactor arrangement. The latter can be performed by introducing the reagent in the form of a solution or a dispersion and fixing it on a holding means (118) by removal of the liquid, i.e. by drying, the holding means comprising the reagent in a solid version in the detector chamber. Prior to the introduction of the reagent, components of the reactor arrangement already present, such as the sample inlet can be hydrophilised by a wetting hydrophilising technique. The invention relates to a manufacturing technique as well as to the resulting product. The invention furthermore relates to functionalizing of the reactor arrangement with a particular reagent for particular applications. The latter can be performed well after fabrication and assembly of the major reactor arrangement components.

8. 发明申请

WO2010049883A1 BIOSENSOR WITH MULTI-CHAMBER CARTRIDGE 审中-公开
标题翻译：生物传感器与多个盒子
公开(公告)号：WO2010049883A1
公开(公告)日：2010-05-06
申请号：PCT/IB2009/054740
申请日：2009-10-27
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , NEIJZEN, Jacobus, H., M. , WIMBERGER-FRIEDL, Reinhold , MAAS, Joost, H. , NIEUWENHUIS, Jeroen, H. , BRULS, Dominique, M. , IMMINK, Albert, H., J. , OVSYANKO, Mikhail, M.
发明人： NEIJZEN, Jacobus, H., M. , WIMBERGER-FRIEDL, Reinhold , MAAS, Joost, H. , NIEUWENHUIS, Jeroen, H. , BRULS, Dominique, M. , IMMINK, Albert, H., J. , OVSYANKO, Mikhail, M.
IPC分类号： G01N33/543 , G01N35/00 , G01R33/00
CPC分类号： G01N33/54326 , B01L3/502761 , B82Y25/00 , G01N27/745 , G01R33/093 , G01R33/1269
摘要： The present invention provides a biosensor comprising a cartridge for accommodating a fluid sample, the cartridge comprising at least two chambers, wherein each chamber comprises a sensor surface with one or more binding sites. The biosensor further comprises means for generating a magnetic field at the binding sites of the sensor surfaces of the at least two chambers. The biosensor also comprises means for detecting particles accumulated at/and or proximate the binding sites of the sensor surfaces of the at least two chambers. Therein, the magnetic field at the binding sites has a sufficiently large gradient to actuate magnetic label particles towards the binding sites.
摘要翻译：本发明提供了一种生物传感器，其包括用于容纳流体样品的盒，所述盒包括至少两个室，其中每个室包括具有一个或多个结合位点的传感器表面。生物传感器还包括用于在至少两个室的传感器表面的结合位置处产生磁场的装置。生物传感器还包括用于检测在至少两个室的传感器表面的结合位点处和/或附近堆积的颗粒的装置。其中，结合位点处的磁场具有足够大的梯度以朝向结合位点致动磁性标记颗粒。

9. 发明申请

WO2009115951A1 CARTRIDGE FOR ASSAYS WITH MAGNETIC PARTICLES 审中-公开
标题翻译：用于磁性颗粒测定的盒子
公开(公告)号：WO2009115951A1
公开(公告)日：2009-09-24
申请号：PCT/IB2009/051021
申请日：2009-03-11
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , SIJBERS, Mara, J., J. , VAN LANKVELT, Petrus, J., W. , DE THEIJE, Femke, K. , NIEUWENHUIS, Jeroen, H.
发明人： SIJBERS, Mara, J., J. , VAN LANKVELT, Petrus, J., W. , DE THEIJE, Femke, K. , NIEUWENHUIS, Jeroen, H.
IPC分类号： G01N33/53
CPC分类号： G01N33/54333 , B03C1/282 , B03C1/288 , B03C2201/18 , B03C2201/26 , G01N27/745 , G01N33/54373 , G01N33/946 , G01N33/948 , G01N33/9486
摘要： The invention relates to a cartridge (100) and a corresponding sensor device for the detection of target components in a liquid sample. The cartridge (100) comprises a sample chamber(SC), at least two reservoirs(131, 132) that can be furnished with magnetic particles(MP, MP'), and at least two corresponding sensitive zones (121, 122) in which solved magnetic particles and/or target components can be detected. When a magnetic actuation field(B) of a given configuration is established in the sample chamber, the magnetic particles of different reservoirs migrate predominantly to different sensitive zones. Thus a mixing of magnetic particles can be avoided.
摘要翻译：本发明涉及一种用于检测液体样品中的目标组分的盒（100）和相应的传感器装置。盒（100）包括样品室（SC），至少两个可以配备有磁性颗粒（MP，MP'）和至少两个对应的敏感区域（121,122）的储存器（131,132），其中可以检测到溶解的磁性颗粒和/或目标成分。当在样品室中建立给定构造的磁致动场（B）时，不同储层的磁性颗粒主要迁移到不同的敏感区域。因此，可以避免磁性颗粒的混合。

10. 发明申请

WO2009013668A2 SENSOR CARTRIDGE 审中-公开
标题翻译：传感器盒
公开(公告)号：WO2009013668A2
公开(公告)日：2009-01-29
申请号：PCT/IB2008/052844
申请日：2008-07-16
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , IMMINK, Albert, H., J. , DE THEIJE, Femke, K. , PRINS, Menno, W., J. , DITTMER, Wendy, U. , NIEUWENHUIS, Jeroen, H.
发明人： IMMINK, Albert, H., J. , DE THEIJE, Femke, K. , PRINS, Menno, W., J. , DITTMER, Wendy, U. , NIEUWENHUIS, Jeroen, H.
IPC分类号： G01R33/09
CPC分类号： G01R33/1269
摘要： The present invention provides a sensor cartridge (10) for distinctively determining at least two different target moieties in a fluid sample. The sensor cartridge (10) comprises a reaction chamber (1) and at least a first and second region (2, 3) distinct from each other. The first region (2) comprises magnetic or magnetizable objects (4a) labelled with a first type of probes for specifically binding a first type of target moieties and the second region (3) comprises magnetic or magnetizable objects (4b) labelled with a second type of probes for specifically binding a second type of target moieties, the magnetic or magnetizable objects (4a, 4b) in the first and second region (2, 3) being directly contactable by the sample fluid. The present invention also provides a method for the manufacturing of such sensor devices (10) and a method for determining the presence and/or amount of at least two different target moieties in a sample fluid using such sensor cartridge (10).
摘要翻译：本发明提供一种用于区别地确定流体样品中至少两个不同靶部分的传感器盒（10）。传感器盒（10）包括反应室（1）和至少彼此不同的第一和第二区域（2,3）。第一区域（2）包括用第一类型的探针标记的磁性或可磁化物体（4a），用于特异性地结合第一类型的靶部分，第二区域（3）包括用第二类型标记的磁性或可磁化物体（4b）的用于特异性结合第二类型的靶部分的探针，第一和第二区域（2,3）中的磁性或可磁化物体（4a，4b）可由样品流体直接接触。本发明还提供了用于制造这种传感器装置（10）的方法以及使用这种传感器盒（10）确定样品流体中至少两种不同靶部分的存在和/或量的方法。

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