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1. 发明授权

US08981103B2 Stable crystal of 4-oxoquinoline compound 有权
标题翻译：稳定的4-氧代喹啉化合物
公开(公告)号：US08981103B2
公开(公告)日：2015-03-17
申请号：US12538694
申请日：2009-08-10
申请人： Koji Ando , Koji Matsuda , Shuji Miyake , Hideto Uehara
发明人： Koji Ando , Koji Matsuda , Shuji Miyake , Hideto Uehara
IPC分类号： C07D215/00 , C07D215/56
CPC分类号： C07D215/56
摘要： Provision of a stabilized crystal of 6-(3-chloro-2-fluorobenzyl)-1-[(S)-1-hydroxymethyl-2-methylpropyl]-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (compound A). A crystal of compound A, which shows a particular X-ray powder diffraction pattern of a characteristic diffraction peaks at diffraction angles 2θ(°) as measured by X-ray powder diffractometry.
摘要翻译：提供6-（3-氯-2-氟苄基）-1 - [（S）-1-羟甲基-2-甲基丙基] -7-甲氧基-4-氧代-1,4-二氢喹啉-3-酮的稳定结晶，羧酸（化合物A）。化合物A的晶体，其显示了通过X射线粉末衍射测量的衍射角2θ时的特征衍射峰的特定X射线粉末衍射图案（°）。

2. 发明授权

US07635704B2 Stable crystal of 4-oxoquinoline compound 有权
标题翻译：稳定的4-氧代喹啉化合物
公开(公告)号：US07635704B2
公开(公告)日：2009-12-22
申请号：US11133471
申请日：2005-05-20
申请人： Motohide Satoh , Takahisa Motomura , Takashi Matsuda , Kentaro Kondo , Koji Ando , Koji Matsuda , Shuji Miyake , Hideto Uehara
发明人： Motohide Satoh , Takahisa Motomura , Takashi Matsuda , Kentaro Kondo , Koji Ando , Koji Matsuda , Shuji Miyake , Hideto Uehara
IPC分类号： A61K31/4704 , C07D215/36
CPC分类号： C07D215/56
摘要： Provision of a stabilized crystal of 6-(3-chloro-2-fluorobenzyl)-1-[(S)-1-hydroxymethyl-2-methylpropyl]-7-methoxy-4-oxo-1, 4-dihydroquinoline-3-carboxylic acid (compound A). A crystal of compound A, which shows a particular X-ray powder diffraction pattern of a characteristic diffraction peaks at diffraction angles 2θ(°) as measured by X-ray powder diffractmetry.
摘要翻译：提供6-（3-氯-2-氟苄基）-1 - [（S）-1-羟甲基-2-甲基丙基] -7-甲氧基-4-氧代-1,4-二氢喹啉-3-酮的稳定结晶，羧酸（化合物A）。表示化合物A的晶体，其显示了通过X射线粉末衍射测量法测得的衍射角2θ（°）的特征衍射峰的特定X射线粉末衍射图。

3. 发明申请

US20060030710A1 Stable crystal of 4-oxoquinoline compound 有权
标题翻译：稳定的4-氧代喹啉化合物
公开(公告)号：US20060030710A1
公开(公告)日：2006-02-09
申请号：US11133471
申请日：2005-05-20
申请人： Motohide Satoh , Takahisa Motomura , Takashi Matsuda , Kentaro Kondo , Koji Ando , Koji Matsuda , Shuji Miyake , Hideto Uehara
发明人： Motohide Satoh , Takahisa Motomura , Takashi Matsuda , Kentaro Kondo , Koji Ando , Koji Matsuda , Shuji Miyake , Hideto Uehara
IPC分类号： C07D215/36 , A61K31/4704
CPC分类号： C07D215/56
摘要： Provision of a stabilized crystal of 6-(3-chloro-2-fluorobenzyl)-1-[(S)-1-hydroxymethyl-2-methylpropyl]-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (compound A). A crystal of compound A, which shows a particular X-ray powder diffraction pattern of a characteristic diffraction peaks at diffraction angles 2θ(°) as measured by X-ray powder diffractmetry.
摘要翻译：提供6-（3-氯-2-氟苄基）-1 - [（S）-1-羟基甲基-2-甲基丙基] -7-甲氧基-4-氧代-1,4-二氢喹啉-3-酮的稳定结晶，羧酸（化合物A）。表示化合物A的晶体，其显示了通过X射线粉末衍射测量法测得的衍射角2θ（°）的特征衍射峰的特定X射线粉末衍射图。

4. 发明授权

US08420821B2 Process for production of 4-oxoquinoline compound 有权
标题翻译： 4-氧代喹啉化合物的制备方法
公开(公告)号：US08420821B2
公开(公告)日：2013-04-16
申请号：US12281921
申请日：2007-03-06
申请人： Koji Matsuda , Koji Ando , Shigeji Ohki , Takahiro Yamasaki , Jun-ichi Hoshi
发明人： Koji Matsuda , Koji Ando , Shigeji Ohki , Takahiro Yamasaki , Jun-ichi Hoshi
IPC分类号： C07D215/233
CPC分类号： C07C229/30 , C07C65/21 , C07C69/716 , C07C229/34 , C07D215/233 , C07D215/56 , C07F7/1804 , Y02P20/55
摘要： The present invention provides a compound useful as a synthetic intermediate for an anti-HIV agent having an integrase inhibitory activity, a production method thereof, and a production method of an anti-HIV agent using the synthetic intermediate. Specifically, the present invention provides, for example, compounds represented by the formulas (6), (7-1), (7-2) and (8): wherein R is a fluorine atom or a methoxy group, R1 is a C1-C4 alkyl group, R2 is a hydroxyl-protecting group, and X2 is a halogen atom, a production method thereof, and a production method of an anti-HIV agent using the synthetic intermediate.
摘要翻译：本发明提供了可用作具有整合酶抑制活性的抗HIV剂的合成中间体的化合物，其制备方法和使用该合成中间体的抗HIV药物的制备方法。具体地说，本发明提供例如由式（6），（7-1），（7-2）和（8）表示的化合物：其中R是氟原子或甲氧基，R1是C1 -C4烷基，R2为羟基保护基，X2为卤素原子，其制造方法以及使用该合成中间体的抗HIV剂的制造方法。

5. 发明授权

US08383819B2 Method for producing 4-oxoquinoline compound 有权
标题翻译： 4-氧代喹啉化合物的制备方法
公开(公告)号：US08383819B2
公开(公告)日：2013-02-26
申请号：US12281889
申请日：2007-03-06
申请人： Koji Matsuda , Koji Ando , Shigeji Ohki , Jun-ichi Hoshi , Takahiro Yamasaki
发明人： Koji Matsuda , Koji Ando , Shigeji Ohki , Jun-ichi Hoshi , Takahiro Yamasaki
IPC分类号： C07D215/00
CPC分类号： C07C229/30 , C07C43/215 , C07C57/72 , C07C57/76 , C07C61/40 , C07C67/333 , C07C67/343 , C07C69/708 , C07C69/716 , C07C69/738 , C07C69/92 , C07C69/94 , C07C229/34 , C07D215/56
摘要： The present invention provides a compound useful as a synthetic intermediate for an anti-HIV agent having an integrase inhibitory activity, and a production method thereof, and a production method of an anti-HIV agent using the synthetic intermediate. Specifically, for example, a compound represented by the formula (2′): wherein R is a fluorine atom or a methoxy group, and R400 is a hydrogen atom or a C1-C4 alkyl group, or a salt thereof, and a production method thereof, and a production method of an anti-HIV agent using the synthetic intermediate.
摘要翻译：本发明提供了可用作具有整合酶抑制活性的抗HIV剂的合成中间体的化合物及其制备方法，以及使用该合成中间体的抗HIV剂的制备方法。具体而言，例如，式（2'）表示的化合物或其盐，其中R为氟原子或甲氧基，R400为氢原子或C1-C4烷基，以及使用该合成中间体的抗HIV剂的制造方法。

6. 发明申请

US20090318702A1 PROCESS FOR PRODUCTION OF 4-OXOQUINOLINE COMPOUND 有权
标题翻译： 4-氧杂环戊烯化合物的生产方法
公开(公告)号：US20090318702A1
公开(公告)日：2009-12-24
申请号：US12281921
申请日：2007-03-06
申请人： Koji Matsuda , Koji Ando , Shigeji Ohki , Takahiro Yamasaki , Jun-ichi Hoshi
发明人： Koji Matsuda , Koji Ando , Shigeji Ohki , Takahiro Yamasaki , Jun-ichi Hoshi
IPC分类号： C07D215/233 , C07C229/34 , C07C69/612 , C07C49/303
CPC分类号： C07C229/30 , C07C65/21 , C07C69/716 , C07C229/34 , C07D215/233 , C07D215/56 , C07F7/1804 , Y02P20/55
摘要： The present invention provides a compound useful as a synthetic intermediate for an anti-HIV agent having an integrase inhibitory activity, a production method thereof, and a production method of an anti-HIV agent using the synthetic intermediate. Specifically, the present invention provides, for example, compounds represented by the formulas (6), (7-1), (7-2) and (8): wherein R is a fluorine atom or a methoxy group, R1 is a C1-C4 alkyl group, R2 is a hydroxyl-protecting group, and X2 is a halogen atom, a production method thereof, and a production method of an anti-HIV agent using the synthetic intermediate.
摘要翻译：本发明提供了可用作具有整合酶抑制活性的抗HIV剂的合成中间体的化合物，其制备方法和使用该合成中间体的抗HIV药物的制备方法。具体地说，本发明提供例如由式（6），（7-1），（7-2）和（8）表示的化合物：其中R是氟原子或甲氧基，R1是C1 -C4烷基，R2为羟基保护基，X2为卤素原子，其制造方法以及使用该合成中间体的抗HIV剂的制造方法。

7. 发明申请

US20090036684A1 METHOD FOR PRODUCING 4-OXOQUINOLINE COMPOUND 有权
标题翻译：生产4-氧杂环戊烯化合物的方法
公开(公告)号：US20090036684A1
公开(公告)日：2009-02-05
申请号：US12281889
申请日：2007-03-06
申请人： Koji Matsuda , Koji Ando , Shigeki Ohki , Jun-ichi Hoshi , Takahiro Yamasaki
发明人： Koji Matsuda , Koji Ando , Shigeki Ohki , Jun-ichi Hoshi , Takahiro Yamasaki
IPC分类号： C07D215/00 , C07C69/76 , C07C65/00 , C07C49/105
CPC分类号： C07C229/30 , C07C43/215 , C07C57/72 , C07C57/76 , C07C61/40 , C07C67/333 , C07C67/343 , C07C69/708 , C07C69/716 , C07C69/738 , C07C69/92 , C07C69/94 , C07C229/34 , C07D215/56
摘要： The present invention provides a compound useful as a synthetic intermediate for an anti-HIV agent having an integrase inhibitory activity, and a production method thereof, and a production method of an anti-HIV agent using the synthetic intermediate. Specifically, for example, a compound represented by the formula (2′): wherein R is a fluorine atom or a methoxy group, and R400 is a hydrogen atom or a C1-C4 alkyl group, or a salt thereof, and a production method thereof, and a production method of an anti-HIV agent using the synthetic intermediate.
摘要翻译：本发明提供了可用作具有整合酶抑制活性的抗HIV剂的合成中间体的化合物及其制备方法，以及使用该合成中间体的抗HIV剂的制备方法。具体而言，例如，式（2'）表示的化合物或其盐，其中R为氟原子或甲氧基，R400为氢原子或C1-C4烷基，以及使用该合成中间体的抗HIV剂的制造方法。

8. 发明授权

US08949515B2 Storage device and memory controller 有权
标题翻译：存储设备和存储控制器
公开(公告)号：US08949515B2
公开(公告)日：2015-02-03
申请号：US13512958
申请日：2010-12-01
申请人： Masataka Nishi , Ryo Fujita , Ryoichi Inada , Takuma Nishimura , Masahiro Shiraishi , Koji Matsuda
发明人： Masataka Nishi , Ryo Fujita , Ryoichi Inada , Takuma Nishimura , Masahiro Shiraishi , Koji Matsuda
IPC分类号： G06F12/02
CPC分类号： G06F12/0246 , G06F2212/7203
摘要： Disclosed is a storage device using non-volatile semiconductor memory that achieves high performance and long life for the device. When managing the non-volatile semiconductor memory (2), physical blocks are classified into three types: scratch blocks (22), data blocks (23), and erased blocks (24). Data writing from a host device (3) is performed on the scratch blocks. When the number of empty pages within a scratch block becomes less than a predetermined number or no longer exists, the block is treated thereafter as a data block, and one of the erased blocks is newly assigned as a scratch block. If there are insufficient erased blocks, a block with relatively less valid data is selected from among the data blocks. After copying all valid data included in the block to a scratch block, the block is erased, and thus an erased block is acquired.
摘要翻译：公开了一种使用非易失性半导体存储器的存储装置，其实现了该装置的高性能和长寿命。当管理非易失性半导体存储器（2）时，物理块被分为三种类型：暂存块（22），数据块（23）和擦除块（24）。在暂存块上执行来自主机（3）的数据写入。当暂存块内的空页数少于预定数量或不再存在时，该块被当作数据块处理，并且其中一个擦除块被新分配为暂存块。如果擦除块不足，则从数据块中选择具有相对较少有效数据的块。将块中包含的所有有效数据复制到暂存块后，块被擦除，从而获取被擦除的块。

9. 发明授权

US08948439B2 Acoustic conversion device and acoustic conversion device assembly method 有权
标题翻译：声转换装置和声转换装置组装方法
公开(公告)号：US08948439B2
公开(公告)日：2015-02-03
申请号：US13110100
申请日：2011-05-18
申请人： Tsutomu Nagumo , Koji Matsuda , Koji Nageno , Takeshi Hara , Takahiro Suzuki , Takayuki Ishii , Kenji Hiraiwa
发明人： Tsutomu Nagumo , Koji Matsuda , Koji Nageno , Takeshi Hara , Takahiro Suzuki , Takayuki Ishii , Kenji Hiraiwa
IPC分类号： H04R1/00 , H04R9/06 , H04R11/02 , H04R25/00 , H04R9/08 , H04R11/04 , H04R17/02 , H04R19/04 , H04R21/02
CPC分类号： H04R11/02
摘要： An acoustic conversion device includes: a driving unit including a pair of magnets disposed so as to face each other, a yoke to which the pair of magnets are attached, a coil to which driving current is supplied, a vibrating portion which vibrates when driving current is supplied to the coil, and an armature disposed between the pair of magnets with the vibrating portion being passed through the coil; and a diaphragm unit including a diaphragm, and a beam portion for propagating the vibration of the vibrating portion to the diaphragm; with a coil attachment portion to which the coil is attached, located in a state in parallel with the vibrating portion, being provided to the armature.
摘要翻译：一种声转换装置，包括：驱动单元，包括一对彼此相对配置的磁体;一对磁体附接的磁轭;供给驱动电流的线圈;驱动电流时振动的振动部; 设置在所述一对磁体之间的电枢，所述振动部分通过所述线圈; 以及包括隔膜的隔膜单元和用于将振动部分的振动传播到隔膜的梁部分; 其中线圈附接部分位于与振动部分平行的状态下，被设置在电枢上。

10. 发明申请

US20110311090A1 ACOUSTIC CONVERSION DEVICE 有权
标题翻译：声音转换装置
公开(公告)号：US20110311090A1
公开(公告)日：2011-12-22
申请号：US13108489
申请日：2011-05-16
申请人： Tsutomu Nagumo , Koji Matsuda , Kenji Hiraiwa , Takayuki Ishii , Koji Nageno , Takeshi Hara , Takahiro Suzuki
发明人： Tsutomu Nagumo , Koji Matsuda , Kenji Hiraiwa , Takayuki Ishii , Koji Nageno , Takeshi Hara , Takahiro Suzuki
IPC分类号： H04R1/00
CPC分类号： H04R11/02
摘要： An acoustic conversion device includes: a driving unit including a pair of magnets disposed so as to face each other, a yoke to which the pair of magnets are attached, a coil to which driving current is supplied, a vibrating portion which vibrates when driving current is supplied to the coil, and an armature disposed between the pair of magnets with the vibrating portion passed through the coil; and a diaphragm unit including a holding frame having an opening, a resin film adhered to the holding frame in a state covering the opening of the holding frame, a diaphragm held on the inner side of the holding frame in a state adhered to the resin film, and a beam portion of which the tip portion formed integrally with the diaphragm is combined with the vibrating portion of the armature, for propagating the vibration of the vibrating portion to the diaphragm.
摘要翻译：一种声转换装置，包括：驱动单元，包括一对彼此相对配置的磁体;一对磁体附接的磁轭;供给驱动电流的线圈;驱动电流时振动的振动部; 设置在所述一对磁体之间的电枢，所述振动部通过所述线圈; 以及膜片单元，其包括具有开口的保持框架，在覆盖所述保持框架的开口的状态下粘附到所述保持框架的树脂膜，以与所述树脂膜粘附的状态保持在所述保持框架的内侧的隔膜并且将与隔膜一体形成的前端部的梁部与电枢的振动部结合，将振动部的振动传播到振动膜。

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