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1. 发明授权

US06689785B2 Epoxysuccinamide derivatives 失效
标题翻译：环氧琥珀酰胺衍生物
公开(公告)号：US06689785B2
公开(公告)日：2004-02-10
申请号：US10042994
申请日：2002-01-08
申请人： Yutaka Nomura , Toshihiro Takahashi , Yasushi Yoshino , Koichiro Nishioka
发明人： Yutaka Nomura , Toshihiro Takahashi , Yasushi Yoshino , Koichiro Nishioka
IPC分类号： A61K31497
CPC分类号： C07D405/12 , C07D303/48
摘要： Novel epoxysuccinamide derivatives represented by the general formula (1) or physiologically acceptable salts thereof, which are useful particularly as remedies for bone diseases and arthritis, wherein R1 and R3 are each hydrogen, alkyl, alkenyl, alkynyl, aryl, aralkyl, a heterocyclic group, or a heterocyclic-alkyl group; R2 is alkyl, alkenyl, alkynyl, aryl, aralkyl, a heterocyclic group, or a hetericyclic-alkyl group; X is —O— or —NR4— (wherein R4 is hydrogen, alkyl, aryl, aralkyl, a heterocyclic group, or a heterocyclic-alkyl group; Y1 is OR5, SR6, or NR7R8 (wherein each of R5, R6 and R7 is hydrogen, alkyl, aryl, aralkyl, acyl, a heterocyclic group, or a heterocyclic-alkyl group, and R8 is the same as defined for R4); and Y2 is hydrogen or alkyl, or alternatively Y1 and Y2 can be combined to form ═O, ═S, ═N—R9, or ═N—OR10 (wherein each of R9 and R10 is the same as defined for R4), provided that each of the alkyl, aryl and heterocyclic groups defined for R5 to R10 can have one or more specific substituents and that each of the group defined for R1 to R10 and Y2 is specificed in the number of carbon atoms.
摘要翻译：由通式（1）表示的新型环氧琥珀酰胺衍生物或其生理学上可接受的盐，其特别适用于骨疾病和关节炎的治疗，其中R 1和R 3各自为氢，烷基，烯基，炔基，芳基，芳烷基，杂环基或杂环烷基; R 2是烷基，烯基，炔基，芳基，芳烷基，杂环基或杂环烷基; X是-O-或-NR 4 - （其中R 4是氢，烷基，芳基，芳烷基，杂环基或杂环烷基; Y 1是OR 5，或其中R 5，R 6和R 7各自为氢，烷基，芳基，芳烷基，酰基，杂环基或杂环烷基基团和R 8与R 4中定义的相同）; Y 2是氢或烷基，或者Y 1和Y 2可以组合形成= O，= S ，= NR 9或= N-OR 10（其中R 9和R 10各自与R 4中定义的相同），条件是烷基，芳基和杂环基对R 5至R 10定义的基团可以具有一个或多个特定取代基，并且对于R 1至R 10和Y 2定义的基团中的每一个以碳原子数为特定。

2. 发明授权

US06387908B1 Epoxysuccinamide derivatives 有权
标题翻译：环氧琥珀酰胺衍生物
公开(公告)号：US06387908B1
公开(公告)日：2002-05-14
申请号：US09508026
申请日：2000-05-05
申请人： Yutaka Nomura , Toshihiro Takahashi , Yasushi Yoshino , Koichiro Nishioka
发明人： Yutaka Nomura , Toshihiro Takahashi , Yasushi Yoshino , Koichiro Nishioka
IPC分类号： A61K31336
CPC分类号： C07D405/12 , C07D303/48
摘要： Epoxysuccinamide derivatives of the formula (1): wherein R1 is hydrogen, alkyl, alkenyl, alkynyl, aryl, or aralkyl; R2 is alkyl, alkenyl, alkynyl, aryl, or aralkyl; R3 is hydrogen, alkyl, alkenyl, alkynyl, aryl, aralkyl, heterocyclic, or heterocyclic-alkyl; X is —O— or —NR4— (R4 is hydrogen, alkyl, aryl, aralkyl, heterocyclic, or heterocyclic-alkyl); Y1 is OR5, SR6, or NR7R8; and Y2 is hydrogen or alkyl. The compounds are useful as remedies for bone diseases and arthritis.
摘要翻译：式（1）的环氧琥珀酰胺衍生物：其中R1是氢，烷基，烯基，炔基，芳基或芳烷基; R2是烷基，烯基，炔基，芳基或芳烷基; R3是氢，烷基，烯基，炔基，芳基，芳烷基，杂环或杂环烷基; X是-O-或-NR 4 - （R 4是氢，烷基，芳基，芳烷基，杂环或杂环烷基）。 Y1是OR5，SR6或NR7R8; 而Y2是氢或烷基。该化合物可用作骨疾病和关节炎的补救措施。

3. 发明授权

US06706705B1 Quinazoline derivatives 失效
标题翻译：喹唑啉衍生物
公开(公告)号：US06706705B1
公开(公告)日：2004-03-16
申请号：US08809770
申请日：1997-03-28
申请人： Koichiro Nishioka , Toshihiro Takahashi , Yutaka Nomura
发明人： Koichiro Nishioka , Toshihiro Takahashi , Yutaka Nomura
IPC分类号： C07D23995
CPC分类号： C07D239/95
摘要： The present invention provides a new compound which shows slow and continuous blood pressure reducing action and is useful as an antihypertensive agent. The invention resides in a quinazoline derivative of the following formula (I) and its pharmaceutically acceptable salt: in which, each of R1 and R2 is H or an alkyl group of 1 to 6 carbon atoms, or R1 and R2 are combined to form an ethylene group; each of R3 and R4 is an alkyl group of 1 to 6 carbon atoms; R5 is a hydrogen atom, a hydroxyl group, an alkyl group of 1 to 6 carbon atoms, or an alkoxy group of 1 to 6 carbon atoms; each of R6 and R7 is a hydrogen atom or an alkyl group of 1 to 6 carbon atoms; and n is 2 or 3. The invention further resides in an antihypertensive agent containing the above compound.
摘要翻译：本发明提供了一种新的化合物，其显示缓慢且持续的减压作用，并且可用作抗高血压药。本发明涉及下式（I）的喹唑啉衍生物及其药学上可接受的盐：其中R 1和R 2是H或1至6个碳原子的烷基，或R 1和R 2结合形成亚乙基; R 3和R 4各自为1至6个碳原子的烷基; R 5为氢原子，羟基，碳原子数为1〜6的烷基或碳原子数1〜6的烷氧基， R 6和R 7各自为氢原子或1〜6个碳原子的烷基; 并且n为2或3.本发明还涉及含有上述化合物的抗高血压药。

4. 发明授权

US6150363A Dihydrophenazinecarboxylic acid derivatives 失效
标题翻译：二氢吩嗪酮羧酸衍生物
公开(公告)号：US6150363A
公开(公告)日：2000-11-21
申请号：US319285
申请日：1999-06-02
申请人： Toshihiro Takahashi , Yutaka Nomura , Haruo Seto , Kazuo Shin-ya
发明人： Toshihiro Takahashi , Yutaka Nomura , Haruo Seto , Kazuo Shin-ya
IPC分类号： C07D241/48 , A61K31/495 , C07D241/46
CPC分类号： C07D241/48
摘要： Dihydrophenazinecarboxylic acid derivatives of the formula (I) wherein R.sup.1 represents hydrogen, linear or branched alkyl, etc., each of R.sup.2 and R.sup.3 represents hydrogen, 3-methyl-2-butenyl, etc., and each of R.sup.4 and R.sup.5 represents hydrogen, alkyl, alkenyl, aralkyl, aryl, hydroxyl, alkoxy, aryloxy, aralkyloxy, halogen, nitro, cyano, alkylsulfonyl, arylsulfonyl, alkylcarbonyl, arylcarbonyl, etc., provided that there is no case that both of R.sup.4 and R.sup.5 are hydrogen. The dihydrophenazinecarboxylic acid derivatives are excellent in the inhibition of glutamic acid toxicity. ##STR1##
摘要翻译： PCT No.PCT / JP97 / 03674。 371日期1999年6月2日 102（e）1999年6月2日PCT 1997年10月14日提交PCT公布。出版物WO98 / 24772 日期：1998年6月11日其中R 1表示氢，直链或支链烷基等的式（I）的二氢吩嗪嗪羧酸衍生物，R 2和R 3各自表示氢，3-甲基-2-丁烯基等，R 4 并且R 5表示氢，烷基，烯基，芳烷基，芳基，羟基，烷氧基，芳氧基，芳烷氧基，卤素，硝基，氰基，烷基磺酰基，芳基磺酰基，烷基羰基，芳基羰基等。是氢。二氢吩嗪酮羧酸衍生物对谷氨酸毒性的抑制是优异的。

5. 发明授权

US5843992A Epoxysuccinic acid derivatives 失效
标题翻译：环氧琥珀酸衍生物
公开(公告)号：US5843992A
公开(公告)日：1998-12-01
申请号：US930509
申请日：1997-09-29
申请人： Yutaka Nomura , Toshihiro Takahashi , Kaoru Hara , Yasushi Yoshino , Mitsuo Masaki
发明人： Yutaka Nomura , Toshihiro Takahashi , Kaoru Hara , Yasushi Yoshino , Mitsuo Masaki
IPC分类号： C07D303/48 , A61K31/335
CPC分类号： C07D303/48
摘要： An epoxysuccinic acid derivative having the following formula: ##STR1## �wherein R.sup.1 is hydrogen, alkyl, aryl, or aralkyl; each of R.sup.2 and R.sup.3 independently is aryl, aralkyl or alkyl; X is --O-- or --NR.sup.4 --; and R.sup.4 is hydrogen, alkyl, or aralkyl! is useful for prevention and treatment of bone diseases such as osteoporosis, malignant hypercalcemia and Paget's syndrome, and further useful for treatment of osteoarthritis and rheumatoid arthritis which are accompanied by abnormal enhancement of cathepsin L activity, and furthermore useful as a medicine for treating diseases in which cathepsin B and L participate, such as muscular dystrophy and muscular atrophy.
摘要翻译： PCT No.PCT / JP96 / 00889 Sec。 371日期：1997年9月29日 102（e）日期1997年9月29日PCT提交1996年4月1日PCT公布。出版物WO96 / 30354 日期：1996年10月3日具有下式的环氧琥珀酸衍生物：其中R 1是氢，烷基，芳基或芳烷基; R2和R3各自独立地为芳基，芳烷基或烷基; X是-O-或-NR4-; 和R4是氢，烷基或芳烷基]可用于预防和治疗骨质疏松症，恶性高钙血症和佩吉特综合征等骨疾病，并且还可用于治疗组织蛋白酶L活性异常增强的骨关节炎和类风湿性关节炎，并且还可用作治疗组织蛋白酶B和L参与的疾病的药物，例如肌营养不良和肌肉萎缩。

6. 发明申请

US20090056881A1 Device for Adhering Together Continuous Sheets of Paper 有权
标题翻译：连续使用纸张的设备
公开(公告)号：US20090056881A1
公开(公告)日：2009-03-05
申请号：US12281817
申请日：2007-05-11
申请人： Toshihiro Takahashi , Toshihiro Takahashi
发明人： Toshihiro Takahashi , Toshihiro Takahashi
IPC分类号： B29C65/52 , B29C65/48
CPC分类号： B65H37/04 , B65H23/1886 , B65H39/16 , B65H2301/4148 , Y10T156/1317 , Y10T156/1712 , Y10T156/1722 , Y10T156/1727
摘要： A working apparatus for pasting two continuous paper webs together having patterns is provided which can be made small as a whole and whose pasting processing treatment reduces a paper loss occurring when the apparatus starts to operate.To this end, the apparatus which has an upper paper line 1 along which a continuous upper paper web 2 having a pattern printed thereon is driven to travel by a drive unit, a lower paper line 3 along which a continuous lower paper 4 web having a pattern printed thereon is driven to travel by a drive unit, a pasting unit 5 for pasting the upper and lower paper webs together into a combined paper web 7 while registering the patterns on them with each other, a combined paper line 6 along which the combined paper web 7 is driven to travel by a drive unit and a processing unit disposed in each corresponding one of the lines upstream and downstream of the pasting unit for processing the paper web traveling along the corresponding line, comprises: a paste applying unit 23 disposed in the lower paper line upstream of the pasting unit and whose paste applying operation can be turned on and off; an upper paper winding unit 31 disposed downstream of the pasting unit for winding up the upper paper web passed through the pasting unit; and a drive source provided for each corresponding one of the drive and processing units and operable individually.
摘要翻译：提供一种用于将两个连续纸幅粘合在一起的图案的工作装置，其可以整体变小，并且其糊化处理处理减少了装置开始操作时发生的纸张损失。为此，具有上部纸线1的装置沿着该上部纸张线1驱动具有印刷在其上的图案的连续的上部纸幅2，由驱动单元驱动，下部纸张3沿着连续的下部纸4网具有印刷在其上的图案被驱动单元驱动，粘贴单元5用于将上纸和下纸幅粘合在一起成为组合纸幅7，同时将图案彼此对准，组合纸线6，其组合纸幅7通过驱动单元和处理单元被驱动，该处理单元布置在粘贴单元的上游和下游的每个相应的一行中，用于处理沿着相应的行行进的纸幅，包括：糊料施加单元23，设置在可以打开和关闭粘贴单元上游的下部纸线，并且其糊状施加操作可以被打开和关闭; 布置在粘贴单元下游的上部纸张卷绕单元31，用于卷绕通过粘贴单元的上部纸幅; 以及为驱动和处理单元中的每个相应的一个提供的驱动源，并且可单独操作。

7. 发明授权

US08356650B2 Working apparatus for pasting continuous paper webs together 有权
标题翻译：将连续纸幅粘贴在一起的工作装置
公开(公告)号：US08356650B2
公开(公告)日：2013-01-22
申请号：US12281817
申请日：2007-05-11
申请人： Toshihiro Takahashi , Toshihiro Takahashi
发明人： Toshihiro Takahashi , Toshihiro Takahashi
IPC分类号： B32B37/00 , B32B38/04
CPC分类号： B65H37/04 , B65H23/1886 , B65H39/16 , B65H2301/4148 , Y10T156/1317 , Y10T156/1712 , Y10T156/1722 , Y10T156/1727
摘要： A working apparatus for pasting two continuous paper webs together having patterns is provided which can be made small as a whole and whose pasting processing treatment reduces a paper loss occurring when the apparatus starts to operate.To this end, the apparatus which has an upper paper line 1 along which a continuous upper paper web 2 having a pattern printed thereon is driven to travel by a drive unit, a lower paper line 3 along which a continuous lower paper 4 web having a pattern printed thereon is driven to travel by a drive unit, a pasting unit 5 for pasting the upper and lower paper webs together into a combined paper web 7 while registering the patterns on them with each other, a combined paper line 6 along which the combined paper web 7 is driven to travel by a drive unit and a processing unit disposed in each corresponding one of the lines upstream and downstream of the pasting unit for processing the paper web traveling along the corresponding line, comprises: a paste applying unit 23 disposed in the lower paper line upstream of the pasting unit and whose paste applying operation can be turned on and off; an upper paper winding unit 31 disposed downstream of the pasting unit for winding up the upper paper web passed through the pasting unit; and a drive source provided for each corresponding one of the drive and processing units and operable individually.
摘要翻译：提供一种用于将两个连续纸幅粘合在一起的图案的工作装置，其可以整体变小，并且其糊化处理处理减少了装置开始操作时发生的纸张损失。为此，具有上部纸线1的装置沿着该上部纸张线1驱动具有印刷在其上的图案的连续的上部纸幅2，由驱动单元驱动，下部纸张3沿着连续的下部纸4网具有印刷在其上的图案被驱动单元驱动，粘贴单元5用于将上纸和下纸幅粘合在一起成为组合纸幅7，同时将图案彼此对准，组合纸线6，其组合纸幅7通过驱动单元和处理单元被驱动，该处理单元布置在粘贴单元的上游和下游的每个相应的一行中，用于处理沿着相应的行行进的纸幅，包括：糊料施加单元23，其设置在可以打开和关闭粘贴单元上游的下部纸线，并且其糊状施加操作可以被打开和关闭; 布置在粘贴单元下游的上部纸张卷绕单元31，用于卷绕通过粘贴单元的上部纸幅; 以及为驱动和处理单元中的每个相应的一个提供的驱动源，并且可单独操作。

8. 发明授权

US09145009B2 Print label producing apparatus and cutting blade receiving member 有权
标题翻译：打印标签产生装置和切割刀片接收部件
公开(公告)号：US09145009B2
公开(公告)日：2015-09-29
申请号：US13929339
申请日：2013-06-27
申请人： Toshihiro Takahashi
发明人： Toshihiro Takahashi
IPC分类号： B41J11/00 , B41J11/70 , B26D1/08 , B26D3/08 , B26D3/12 , B26D5/10 , B26D7/20 , B26D7/00
CPC分类号： B41J11/70 , B26D1/085 , B26D3/085 , B26D3/12 , B26D5/10 , B26D7/20 , B26D2007/005 , B41J11/703
摘要： This disclosure discloses a print label producing apparatus comprising an apparatus main body, and a cutting blade receiving member, the apparatus main body comprising a feeder, a printing head, a cutting blade configured to press and cut a print-receiving tape, and a holding portion configured to attach and detach the cutting blade receiving member, and the cutting blade receiving member comprises a first cutting blade receiving member comprising at least one concave portion configured to receive at least a part of the print-receiving tape, and a first contact portion configured to receive and stop the cutting blade, disposed at the adjacent position from the concave portion, and a second cutting blade receiving member comprising a second contact portion configured to receive and stop contact of the cutting blade, and the holding portion is configured to permit selective mounting of one of the first and second cutting blade receiving member.
摘要翻译：本公开公开了一种包括设备主体和切割刀片接收部件的打印标签产生设备，该设备主体包括馈送器，打印头，被配置为按压和切割打印接收带的切割刀片，以及保持被配置为附接和拆卸切割刀片接收构件的部分，并且切割刀片接收构件包括第一切割刀片接收构件，该第一切割刀片接收构件包括构造成容纳打印接收带的至少一部分的至少一个凹部，以及第一接触部被配置为接收和停止设置在与所述凹部相邻的位置处的所述切割刀片;以及第二切割刀片接收部件，所述第二切割刀片接收部件包括被配置为接收和停止所述切割刀片的接触的第二接触部分，并且所述保持部分被配置为允许选择性地安装第一和第二切割刀片接收构件中的一个。

9. 发明申请

US20140224865A1 Base 审中-公开
标题翻译：基础
公开(公告)号：US20140224865A1
公开(公告)日：2014-08-14
申请号：US14080882
申请日：2013-11-15
申请人： Toshihiro Takahashi , Teruo Imamaki
发明人： Toshihiro Takahashi , Teruo Imamaki
IPC分类号： B65D5/18
CPC分类号： B65D5/18 , B29C65/224 , B29C65/4815 , B29C65/5057 , B29C65/7841 , B29C65/787 , B29C66/1122 , B29C66/53461 , B29C66/7486 , B29C66/81463 , B29C66/8167 , B29C66/8222 , B29C66/8322 , B29C66/849 , B29C66/87445 , B65B11/08 , B65B11/58 , B65B51/18 , B65D5/4608
摘要： A base includes a main plate-shaped portion including a first plate-shaped portion and a pair of second plate-shaped portions, a first folding portion provided on a first virtual line, a second folding portion provided on a second virtual line, two first bottom surface portions that are each provided, in the main plate-shaped portion, between a central position of the first virtual line and each of two intersection points, two second bottom surface portions that are each provided, in the main plate-shaped portion, between a central position of the second virtual line and each of two intersection points, a first side surface portion provided between the two first bottom surface portions, on the first virtual line in the main plate-shaped portion, and a second side surface portion provided between the two second bottom surface portions, on the second virtual line in the main plate-shaped portion.
摘要翻译：基座包括主板形部分，其包括第一板状部分和一对第二板状部分，设置在第一假想线上的第一折叠部分，设置在第二假想线上的第二折叠部分，在主板状部分中，设置在主板状部分中的第一虚拟线的中心位置和两个交点之间的两个第二底面部分的底表面部分，在第二虚拟线的中心位置和两个交点之间，设置在两个第一底面部之间的第一侧面部，位于主板状部的第一假想线上，第二侧面部设置在两个第二底面部之间，位于主板状部分的第二假想线上。

10. 发明申请

US20140135190A1 Base 审中-公开
标题翻译：基础
公开(公告)号：US20140135190A1
公开(公告)日：2014-05-15
申请号：US14080872
申请日：2013-11-15
申请人： Toshihiro Takahashi , Teruo Imamaki , Naoki Tanjima
发明人： Toshihiro Takahashi , Teruo Imamaki , Naoki Tanjima
IPC分类号： B65B5/02
CPC分类号： B65B5/024 , B65B5/04 , B65B23/00
摘要： A base includes a substantially rectangular plate-shaped portion including a first set and a second set, a first folding portion on a first virtual line, a second folding portion on a second virtual line, a plurality of first bottom surface portions each provided in the vicinity of each of two intersection points at which the first virtual line and each of two sides of the first set intersect, a plurality of second bottom surface portions each provided in the vicinity of each of two intersection points at which the second virtual line and each of the two sides of the first set intersect, a first side surface portion provided substantially in the center, in a reference direction, of the first virtual line on the plate-shaped portion, and a second side surface portion provided substantially in the center, in the reference direction, of the second virtual line on the plate-shaped portion.
摘要翻译：底座包括基本上矩形的板状部分，其包括第一组和第二组，第一虚拟线上的第一折叠部分，第二假想线上的第二折叠部分，多个第一底部表面部分所述第一虚拟线和所述第一组的两侧中的每一个相交的两个交点中的每一个相邻的多个第二底面部分分别设置在所述第二虚拟线和每个所述两个交点的每个交点附近所述第一组的两侧相交，所述第一侧面部分大致位于所述板状部分上的所述第一假想线的基准方向的中心，以及设置在所述中心的第二侧面部，在该板状部分上的第二虚拟线的参考方向。

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