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1. 发明授权

US5843992A Epoxysuccinic acid derivatives 失效
标题翻译：环氧琥珀酸衍生物
公开(公告)号：US5843992A
公开(公告)日：1998-12-01
申请号：US930509
申请日：1997-09-29
申请人： Yutaka Nomura , Toshihiro Takahashi , Kaoru Hara , Yasushi Yoshino , Mitsuo Masaki
发明人： Yutaka Nomura , Toshihiro Takahashi , Kaoru Hara , Yasushi Yoshino , Mitsuo Masaki
IPC分类号： C07D303/48 , A61K31/335
CPC分类号： C07D303/48
摘要： An epoxysuccinic acid derivative having the following formula: ##STR1## �wherein R.sup.1 is hydrogen, alkyl, aryl, or aralkyl; each of R.sup.2 and R.sup.3 independently is aryl, aralkyl or alkyl; X is --O-- or --NR.sup.4 --; and R.sup.4 is hydrogen, alkyl, or aralkyl! is useful for prevention and treatment of bone diseases such as osteoporosis, malignant hypercalcemia and Paget's syndrome, and further useful for treatment of osteoarthritis and rheumatoid arthritis which are accompanied by abnormal enhancement of cathepsin L activity, and furthermore useful as a medicine for treating diseases in which cathepsin B and L participate, such as muscular dystrophy and muscular atrophy.
摘要翻译： PCT No.PCT / JP96 / 00889 Sec。 371日期：1997年9月29日 102（e）日期1997年9月29日PCT提交1996年4月1日PCT公布。出版物WO96 / 30354 日期：1996年10月3日具有下式的环氧琥珀酸衍生物：其中R 1是氢，烷基，芳基或芳烷基; R2和R3各自独立地为芳基，芳烷基或烷基; X是-O-或-NR4-; 和R4是氢，烷基或芳烷基]可用于预防和治疗骨质疏松症，恶性高钙血症和佩吉特综合征等骨疾病，并且还可用于治疗组织蛋白酶L活性异常增强的骨关节炎和类风湿性关节炎，并且还可用作治疗组织蛋白酶B和L参与的疾病的药物，例如肌营养不良和肌肉萎缩。

2. 再颁专利

USRE34698E Method of producing salinomycin antibiotics 失效
标题翻译：生产盐霉素抗生素的方法
公开(公告)号：USRE34698E
公开(公告)日：1994-08-16
申请号：US10786
申请日：1993-01-29
申请人： Yukio Miyazaki , Akira Shibata , Tateo Yahagi , Masayuki Hara , Kaoru Hara , Singo Yoneda , Hiroko Kasahara , Yuko Nakamura
发明人： Yukio Miyazaki , Akira Shibata , Tateo Yahagi , Masayuki Hara , Kaoru Hara , Singo Yoneda , Hiroko Kasahara , Yuko Nakamura
IPC分类号： C07D493/20 , C07H19/01 , C12P17/18 , C12N1/20 , C12N1/38
CPC分类号： C07H19/01 , C07D493/20 , C12P17/181
摘要： Polyether type antibiotics are produced by culturing a polyether type antibiotic-producing microorganism is a medium containing a fatty acid or its precursor and ammonia or an ammonium salt or urea.
摘要翻译：聚醚型抗生素通过培养聚醚型抗生素产生微生物是含有脂肪酸或其前体和氨或铵盐或尿素的培养基来生产。

3. 发明授权

US08536176B2 GPR119 agonist 失效
标题翻译： GPR119激动剂
公开(公告)号：US08536176B2
公开(公告)日：2013-09-17
申请号：US13056673
申请日：2009-07-31
申请人： Tsuyoshi Endo , Rie Takahashi , Hiroto Tanaka , Toshihiro Kunigami , Takaichi Hamano , Mai Okamura , Kaoru Hara
发明人： Tsuyoshi Endo , Rie Takahashi , Hiroto Tanaka , Toshihiro Kunigami , Takaichi Hamano , Mai Okamura , Kaoru Hara
IPC分类号： A61K31/50 , A61K31/501
CPC分类号： C07D413/14 , A61K31/454 , A61K31/4545 , A61K31/501 , A61K31/506 , C07D401/04 , C07D401/14
摘要： A cyclic amine derivative represented by the formula (II) is a GPR119 agonist, and is used as an agent for treating diabetes. wherein Ar0 is phenyl or phenyl having a substituent such as C1-8 alkylsulfonyl or the like, pyridyl, or pyridyl having a substituent such as C1-8 alkylsulfonyl; A0 is (CH2)p, O, or the like; B0 is (CH2)q, or the like, provided that B0 is neither O nor NR25 when A0 is O or NR24; one of U0 and V0 is N, and the other is N or CR26; each of X0 and Y0 is C1-3 alkylene or C1-3 alkylene having a substituent; R23 is a C1-8 alkyl group or the like; each of R21 and R22 is hydrogen, a halogen atom, or the like.
摘要翻译：由式（II）表示的环胺衍生物是GPR119激动剂，用作治疗糖尿病的药剂。其中Ar 0是苯基或具有取代基的苯基，例如C1-8烷基磺酰基等，吡啶基或具有取代基的吡啶基，例如C1-8烷基磺酰基; A 0为（CH 2）p，O等; B0为（CH2）q等，条件是当A0为O或NR24时，B0既不为O也不为NR25; U0和V0之一是N，另一个是N或CR26; X0和Y0各自为C1-3亚烷基或具有取代基的C1-3亚烷基; R 23是C 1-8烷基等; R 21和R 22各自为氢，卤素原子等。

4. 发明申请

US20110137032A1 GPR119 AGONIST 失效
公开(公告)号：US20110137032A1
公开(公告)日：2011-06-09
申请号：US13056673
申请日：2009-07-31
申请人： Tsuyoshi Endo , Rie Takahashi , Hiroto Tanaka , Toshihiro Kunigami , Takaichi Hamano , Mai Okamura , Kaoru Hara
发明人： Tsuyoshi Endo , Rie Takahashi , Hiroto Tanaka , Toshihiro Kunigami , Takaichi Hamano , Mai Okamura , Kaoru Hara
IPC分类号： C07D401/04 , C07D413/14 , C07D401/14
CPC分类号： C07D413/14 , A61K31/454 , A61K31/4545 , A61K31/501 , A61K31/506 , C07D401/04 , C07D401/14
摘要： A cyclic amine derivative represented by the formula (II) is a GPR119 agonist, and is used as an agent for treating diabetes. wherein Ar0 is phenyl or phenyl having a substituent such as C1-8 alkylsulfonyl or the like, pyridyl, or pyridyl having a substituent such as C1-8 alkylsulfonyl;A0 is (CH2)p, O, or the like;B0 is (CH2)q, or the like, provided that B0 is neither O nor NR25 when A0 is O or NR24;one of U0 and V0 is N, and the other is N or CR26;each of X0 and Y0 is C1-3 alkylene or C1-3 alkylene having a substituent;R23 is a C1-8 alkyl group or the like;each of R21 and R22 is hydrogen, a halogen atom, or the like.
摘要翻译：由式（II）表示的环胺衍生物是GPR119激动剂，用作治疗糖尿病的药剂。其中Ar 0是苯基或具有取代基的苯基，例如C1-8烷基磺酰基等，吡啶基或具有取代基的吡啶基，例如C1-8烷基磺酰基; A 0为（CH 2）p，O等; B0为（CH2）q等，条件是当A0为O或NR24时，B0既不为O也不为NR25; U0和V0之一是N，另一个是N或CR26; X0和Y0各自为C1-3亚烷基或具有取代基的C1-3亚烷基; R 23是C 1-8烷基等; R 21和R 22各自为氢，卤素原子等。

5. 发明授权

US5824964A Circuit board for a semiconductor device and method of making the same 失效
标题翻译：一种用于半导体器件的电路板及其制造方法
公开(公告)号：US5824964A
公开(公告)日：1998-10-20
申请号：US834480
申请日：1997-04-11
申请人： Yoshiji Kasai , Kaoru Hara , Misao Aruga
发明人： Yoshiji Kasai , Kaoru Hara , Misao Aruga
IPC分类号： H01L23/13 , H01L23/31 , H01L23/367 , H01L25/065 , H05K3/00 , H05K1/00
CPC分类号： H01L24/32 , H01L23/13 , H01L23/3121 , H01L23/3675 , H01L24/97 , H01L25/0655 , H05K3/0052 , H01L2224/16225 , H01L2224/27013 , H01L2224/32225 , H01L2224/48091 , H01L2224/48227 , H01L2224/73204 , H01L2224/73265 , H01L2224/83051 , H01L2224/97 , H01L24/48 , H01L2924/00014 , H01L2924/01023 , H01L2924/01029 , H01L2924/01033 , H01L2924/14 , H01L2924/15153 , H01L2924/15159 , H01L2924/1517 , H01L2924/15312 , H01L2924/1532 , H01L2924/181 , H05K2201/09036 , H05K2201/0909 , H05K2201/09827 , H05K3/0061 , Y10T29/4913 , Y10T29/49155
摘要： In the circuit board of the present invention, a base board has a first face and a second face, in which a plurality of sets of wire patterns, to which semiconductor chips are respectively connected, are printed on the first face. A metal plate for radiating heat is fixed on the second face of the base board. The base board includes a V-notch being formed along a border between the sets of wire patterns, and the metal plate includes a V-notch being formed to correspond to the V-notch of the base board, whereby the circuit board is divided into a plurality of circuit units, which are mutually connected by a thin section corresponding to the V-notches of the metal plate.
摘要翻译：在本发明的电路板中，基板具有第一面和第二面，其中在第一面上印刷有分别连接有半导体芯片的多组线图案。用于散热的金属板固定在基板的第二面上。基板包括沿着线图案组之间的边界形成的V形凹口，并且金属板包括形成为对应于基板的V形凹口的V形凹口，由此将电路板分成多个电路单元，其通过与金属板的V形凹口对应的薄部分相互连接。

6. 发明授权

US4212942A Method of producing salinomycin antibiotics 失效
标题翻译：生产盐霉素抗生素的方法
公开(公告)号：US4212942A
公开(公告)日：1980-07-15
申请号：US911231
申请日：1978-05-31
申请人： Yukio Miyazaki , Akira Shibata , Tateo Yahagi , Masayuki Hara , Kaoru Hara , Singo Yoneda , Hiroko Kasahara , Yuko Nakamura
发明人： Yukio Miyazaki , Akira Shibata , Tateo Yahagi , Masayuki Hara , Kaoru Hara , Singo Yoneda , Hiroko Kasahara , Yuko Nakamura
IPC分类号： C07D493/20 , C07H19/01 , C12P17/18
CPC分类号： C07H19/01 , C07D493/20 , C12P17/181
摘要： Polyether type antibiotics are produced by culturing a polyether type antibiotic-producing microorganism in a medium containing a fatty acid or its precursor and ammonia or an ammonium salt or urea.
摘要翻译：聚醚型抗生素通过在含有脂肪酸或其前体和氨或铵盐或尿素的培养基中培养聚醚型抗生素生产微生物来制备。

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