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1. 发明授权

US5095034A Pharmaceutical composition for preventing and treating thrombosis 失效
标题翻译：用于预防和治疗血栓形成的药物组合物
公开(公告)号：US5095034A
公开(公告)日：1992-03-10
申请号：US515407
申请日：1990-04-27
申请人： Koichi Kato , Yukio Shimomura , Norihiko Moriya , Koichi Matsumura
发明人： Koichi Kato , Yukio Shimomura , Norihiko Moriya , Koichi Matsumura
IPC分类号： C07D307/62 , A61K31/365 , A61K31/375
CPC分类号： A61K31/365 , A61K31/375 , Y10S514/822
摘要： A pharmaceutical composition for preventing and treating thrombosis containing, as an active component, a saccharoascorbic acid derivative such as 2,3-di-O-benzyl-D-glucosaccharoascorbic acid n-octadecanethiol ester is disclosed.

2. 发明授权

US08467490B2 Communication system, receiver and reception method 失效
标题翻译：通讯系统，接收和接收方式
公开(公告)号：US08467490B2
公开(公告)日：2013-06-18
申请号：US12401657
申请日：2009-03-11
申请人： Takaaki Yamada , Hiroki Kihara , Tatsuya Sugioka , Hisashi Owa , Taichi Niki , Yukio Shimomura
发明人： Takaaki Yamada , Hiroki Kihara , Tatsuya Sugioka , Hisashi Owa , Taichi Niki , Yukio Shimomura
IPC分类号： H03D3/24
CPC分类号： H03L7/18 , H04L7/0008
摘要： A communication system includes: a transmitter adapted to transmit a synchronizing clock and serial data synchronous with the synchronizing clock over a line at low amplitude; and a receiver adapted to receive the serial data and synchronizing clock from the transmitter. The receiver includes an amplifier adapted to amplify the received synchronizing clock of low amplitude to restore the clock to its original amplitude, a latched comparator adapted to latch the received serial data in synchronism with a reproduction clock, and a phase-locked circuit.
摘要翻译：通信系统包括：发射机，适于在低幅度的线路上发送与同步时钟同步的同步时钟和串行数据; 以及适于接收串行数据并从发射机同步时钟的接收器。接收机包括放大器，其适于放大接收到的低幅度同步时钟以将时钟恢复到其原始幅度，锁存比较器适于锁存与再现时钟同步的接收串行数据，以及锁相电路。

3. 发明授权

US07115750B1 Melanin concentrating hormone antagonist 失效
标题翻译：黑色素浓缩激素拮抗剂
公开(公告)号：US07115750B1
公开(公告)日：2006-10-03
申请号：US10088771
申请日：2000-09-19
申请人： Kaneyoshi Kato , Jun Terauchi , Masaaki Mori , Nobuhiro Suzuki , Yukio Shimomura , Shiro Takekawa , Yuji Ishihara
发明人： Kaneyoshi Kato , Jun Terauchi , Masaaki Mori , Nobuhiro Suzuki , Yukio Shimomura , Shiro Takekawa , Yuji Ishihara
IPC分类号： C09B5/00 , A61K3/41 , C07D209/56 , C07D487/00 , C07D491/00
CPC分类号： C07D207/277 , C07C217/74 , C07C219/28 , C07C233/29 , C07C233/44 , C07C233/80 , C07C235/42 , C07C235/50 , C07C235/56 , C07C235/64 , C07C235/84 , C07C237/40 , C07C271/28 , C07C275/42 , C07C311/21 , C07C2602/10 , C07C2602/12 , C07D209/18 , C07D209/22 , C07D209/42 , C07D211/16 , C07D211/18 , C07D211/22 , C07D211/26 , C07D211/32 , C07D211/52 , C07D211/62 , C07D211/70 , C07D213/56 , C07D213/81 , C07D213/82 , C07D215/14 , C07D215/38 , C07D233/24 , C07D239/28 , C07D239/30 , C07D261/18 , C07D263/14 , C07D263/34 , C07D265/28 , C07D271/06 , C07D295/096 , C07D295/13 , C07D295/185 , C07D307/68 , C07D307/81 , C07D311/58 , C07D317/60 , C07D319/20 , C07D333/24 , C07D333/28 , C07D333/38 , C07D335/16 , C07D405/04 , C07D405/12 , C07D413/04 , C07D413/12 , C07D493/04
摘要： A melanin-concentrating hormone antagonist which comprises a compound of the formula: wherein Ar1 is a cyclic group which may have substituents; X is a spacer having a main chain of 1 to 6 atoms; Y is a bond or a spacer having a main chain of 1 to 6 atoms; Ar is a monocyclic aromatic ring which may be condensed with a 4 to 8 membered non-aromatic ring, and may have further substituents; R1 and R2 are independently hydrogen atom or a hydrocarbon group which may have substituents; R1 and R2, together with the adjacent nitrogen atom, may form a nitrogen-containing hetero ring which may have substituents; R2 may form a spiro ring together with Ar; or R2, together with the adjacent nitrogen atom and Y, may form a nitrogen-containing hetero ring which may have substituents; or a salt thereof; which is useful as an agent for preventing or treating obesity, etc.
摘要翻译：一种黑色素浓缩激素拮抗剂，其包含下式化合物：其中Ar 1是可以具有取代基的环状基团; X是具有1至6个原子的主链的间隔物; Y是具有1至6个原子的主链的键或间隔基; Ar是可以与4至8元非芳族环稠合的单环芳环，并且可以具有其它取代基; R 1和R 2独立地是氢原子或可以具有取代基的烃基; R 1和R 2与相邻的氮原子一起可以形成可以具有取代基的含氮杂环; R 2可以与Ar一起形成螺环; 或R 2连同相邻的氮原子和Y可以形成可具有取代基的含氮杂环; 或其盐; 其可用作预防或治疗肥胖症等的药剂。

4. 发明授权

US06991908B1 Antiobestic agents methods for screening antiobestic agents and kits comprising same 失效
标题翻译：用于筛选抗生物剂的抗生物剂方法和包含其的试剂盒
公开(公告)号：US06991908B1
公开(公告)日：2006-01-31
申请号：US09869540
申请日：1999-12-27
申请人： Masaaki Mori , Yukio Shimomura , Shiro Takekawa , Tsukasa Sugo , Yoshihiro Ishibashi , Chieko Kitada , Nobuhiro Suzuki
发明人： Masaaki Mori , Yukio Shimomura , Shiro Takekawa , Tsukasa Sugo , Yoshihiro Ishibashi , Chieko Kitada , Nobuhiro Suzuki
IPC分类号： G01N33/53
CPC分类号： C07K7/08 , A61K38/10 , G01N33/74 , G01N2333/575 , G01N2333/726 , G01N2500/00 , G01N2500/02 , Y10S436/808
摘要： The present invention provides a method for screening a compound or its salt that alters the binding property between MCH or its salt and SLC-1 or its salt, characterized by using MCH or its derivative or a salt thereof and SLC-1 or its salt is useful for screening an SLC-1 agonist which can be used not only as an appetite (eating) promoting agent but also as a prophylactic/therapeutic agent for weak pains, atonic bleeding, before and after expulsion, subinvolution of uterus, cesarean section, induced abortion, galactostasis, and the like, and an SLC-1 antagonist which can be used not only as an antiobestic agents (drug), an appetite (eating) modulator, and the like, but also as a prophylactic/therapeutic agent for hyperstimulation, ankylosing uterine contractions, fetal distress, uterine rupture, cervical laceration, preterm delivery, Prader-Wili syndrome and the like.
摘要翻译：本发明提供一种筛选化合物或其盐的方法，其改变MCH或其盐与SLC-1或其盐之间的结合性质，其特征在于使用MCH或其衍生物或其盐，SLC-1或其盐是可用于筛选SLC-1激动剂，其不仅可以用作食欲（进食）促进剂，而且可用作弱疼痛，无症状出血，驱除前后，子宫切除，剖宫产，诱导流产，半乳糖淀粉酶等，以及不仅可以用作抗生素（药物），食欲调节剂等的SLC-1拮抗剂，而且可以用作过度刺激的预防/治疗剂，强直性子宫收缩，胎儿窘迫，子宫破裂，子宫颈撕裂，早产，Prader-Wili综合征等。

5. 发明申请

US20070173498A1 Melanin concentrating hormone antagonist 审中-公开
标题翻译：黑色素浓缩激素拮抗剂
公开(公告)号：US20070173498A1
公开(公告)日：2007-07-26
申请号：US11224744
申请日：2005-09-12
申请人： Kaneyoshi Kato , Jun Terauchi , Masaaki Mori , Nobuhiro Suzuki , Yukio Shimomura , Shiro Takekawa , Yuji Ishihara
发明人： Kaneyoshi Kato , Jun Terauchi , Masaaki Mori , Nobuhiro Suzuki , Yukio Shimomura , Shiro Takekawa , Yuji Ishihara
IPC分类号： A61K31/538 , A61K31/4706 , A61K31/40 , A61K31/165 , A61K31/353
CPC分类号： C07D207/277 , C07C217/74 , C07C219/28 , C07C233/29 , C07C233/44 , C07C233/80 , C07C235/42 , C07C235/50 , C07C235/56 , C07C235/64 , C07C235/84 , C07C237/40 , C07C271/28 , C07C275/42 , C07C311/21 , C07C2602/10 , C07C2602/12 , C07D209/18 , C07D209/22 , C07D209/42 , C07D211/16 , C07D211/18 , C07D211/22 , C07D211/26 , C07D211/32 , C07D211/52 , C07D211/62 , C07D211/70 , C07D213/56 , C07D213/81 , C07D213/82 , C07D215/14 , C07D215/38 , C07D233/24 , C07D239/28 , C07D239/30 , C07D261/18 , C07D263/14 , C07D263/34 , C07D265/28 , C07D271/06 , C07D295/096 , C07D295/13 , C07D295/185 , C07D307/68 , C07D307/81 , C07D311/58 , C07D317/60 , C07D319/20 , C07D333/24 , C07D333/28 , C07D333/38 , C07D335/16 , C07D405/04 , C07D405/12 , C07D413/04 , C07D413/12 , C07D493/04
摘要： A melanin-concentrating hormone antagonist which comprises a compound of the formula: wherein Ar1 is a cyclic group which may have substituents; X is a spacer having a main chain of 1 to 6 atoms; Y is a bond or a spacer having a main chain of 1 to 6 atoms; Ar is a monocyclic aromatic ring which may be condensed with a 4 to 8 membered non-aromatic ring, and may have further substituents; R1 and R2 are independently hydrogen atom or a hydrocarbon group which may have substituents; R1 and R2, together with the adjacent nitrogen atom, may form a nitrogen-containing hetero ring which may have substituents; R2 may form a spiro ring together with Ar; or R2, together with the adjacent nitrogen atom and Y, may form a nitrogen-containing hetero ring which may have substituents; or a salt thereof; which is useful as an agent for preventing or treating obesity, etc.
摘要翻译：一种黑色素浓缩激素拮抗剂，其包含下式化合物：其中Ar 1是可以具有取代基的环状基团; X是具有1至6个原子的主链的间隔物; Y是具有1至6个原子的主链的键或间隔基; Ar是可以与4至8元非芳族环稠合的单环芳环，并且可以具有其它取代基; R 1和R 2独立地是氢原子或可以具有取代基的烃基; R 1和R 2与相邻的氮原子一起可以形成可以具有取代基的含氮杂环; R 2可以与Ar一起形成螺环; 或R 2连同相邻的氮原子和Y可以形成可具有取代基的含氮杂环; 或其盐; 其可用作预防或治疗肥胖症等的药剂。

6. 发明申请

US20050048605A1 Novel polypeptide dna thereof and use of the same 失效
标题翻译：新型多肽dna及其用途
公开(公告)号：US20050048605A1
公开(公告)日：2005-03-03
申请号：US10489537
申请日：2002-09-13
申请人： Masaaki Mori , Kozo Hayashi , Hiroyuki Miya , Shuji Sato , Chieko Kitada , Hirokazu Matsumoto , Toshimi Nagi , Yukio Shimomura
发明人： Masaaki Mori , Kozo Hayashi , Hiroyuki Miya , Shuji Sato , Chieko Kitada , Hirokazu Matsumoto , Toshimi Nagi , Yukio Shimomura
IPC分类号： A61K38/00 , A61K48/00 , C07K14/705 , C12N15/12 , C12P21/08 , C07H21/04 , C07K14/47
CPC分类号： C07K14/705 , A61K38/00 , A61K48/00
摘要： The present invention aims at providing a novel polypeptide, a receptor, a DNA thereof, and the like. Specifically, the present invention provides a polypeptide having a binding ability to the protein represented by SEQ ID NO: 1 or SEQ ID NO: 3, or its amide, its ester or its salt, a polynucleotide encoding the polypeptide, an antisense polynucleotide or an antibody to the polypeptide, a screening of agent for prevention and/or treatment of cancer, obesity, etc., which comprises using the above, and the like. The polypeptide, receptor, polynucleotide, antisense polynucleotide, antibody and the like are useful for an agent of prevention and/or treatment of cancer, obesity and the like. Further, they are useful for a screening of an agent for prevention and/or treatment of cancer, obesity and the like.
摘要翻译：本发明的目的在于提供新的多肽，受体及其DNA等。具体地说，本发明提供了具有与SEQ ID NO：1或SEQ ID NO：3所代表的蛋白结合能力的多肽或其酰胺，其酯或其盐，编码多肽的多核苷酸，反义多核苷酸或对多肽的抗体，筛选用于预防和/或治疗癌症，肥胖症等的药剂，其包括使用上述方法等。多肽，受体，多核苷酸，反义多核苷酸，抗体等可用于预防和/或治疗癌症，肥胖症等。此外，它们可用于筛选用于预防和/或治疗癌症，肥胖症等的药剂。

7. 发明授权

US08817929B2 Transmission circuit and communication system 有权
标题翻译：传输电路和通信系统
公开(公告)号：US08817929B2
公开(公告)日：2014-08-26
申请号：US13137261
申请日：2011-08-02
申请人： Yukio Shimomura
发明人： Yukio Shimomura
IPC分类号： H04L7/00
CPC分类号： H04J3/0685 , H03M9/00 , H04J3/047
摘要： A transmission circuit includes: a plurality of lane blocks arranged in parallel to each other configured to convert parallel data supplied from a corresponding lane into serial data and output the serial data; and a clock enabler block including at least one clock enabler for outputting a drive clock phase-locked with a reference clock to the plurality of lane blocks after a plurality of cycles of the drive clock in response to an enable signal. Each of the plurality of lane blocks has a divider for dividing the drive clock supplied from the clock enabler block to generate a divide clock and a load signal, and a parallel-to-serial converter for converting parallel data supplied from the corresponding lane into serial data in synchronization with the divide clock and the load signal generated by the divider and the drive clock generated by the clock enabler block.
摘要翻译：传输电路包括：多个并行布置的多个通道块，配置成将从相应通道提供的并行数据转换为串行数据并输出串行数据; 以及时钟使能器块，其包括至少一个时钟使能器，用于响应于使能信号，在所述驱动时钟的多个周期之后，将与参考时钟锁相的驱动时钟输出到所述多个通道块。多个通道块中的每一个具有用于分割从时钟使能器块提供的驱动时钟以产生除法时钟和负载信号的分频器，以及用于将从相应通道提供的并行数据转换成串行的并行转换器数据与分频时钟同步，由分频器产生的负载信号和由时钟使能器模块产生的驱动时钟。

8. 发明申请

US20120306462A1 Electricity Generation Device and Permanent-Magnet Electric Generator 有权
标题翻译：发电装置和永磁发电机
公开(公告)号：US20120306462A1
公开(公告)日：2012-12-06
申请号：US13485727
申请日：2012-05-31
申请人： Hitoshi Oyori , Yukio Shimomura
发明人： Hitoshi Oyori , Yukio Shimomura
IPC分类号： G05F1/455
CPC分类号： H02P9/006 , H02P9/10 , H02P29/02
摘要： An electricity generation device includes a permanent-magnet electric generator with three or more phase windings each having an output terminal and connected to a neutral point, and bidirectional semiconductor switching circuits capable of interrupting connections between the respective phase windings and the neutral point. Each switching circuit allows current to flow in both directions. A gate signal generation circuit outputs to one of the switching circuits during a period including the time at which the AC voltage excited in the corresponding phase winding turns from positive to negative and during a period including the time at which the AC voltage excited in the corresponding phase winding turns from negative to positive. A startup gate signal output circuit outputs a startup gate signal to all of the bidirectional semiconductor switching circuits when the permanent-magnet electric generator is to be started.
摘要翻译：发电装置包括具有三个或更多个相绕组的永磁式发电机，每个相绕组具有输出端并连接到中性点，以及能够中断各相绕组和中性点之间的连接的双向半导体开关电路。每个开关电路允许电流在两个方向上流动。在包括在相应相绕组中激发的交流电压从正变为负的时间和包括在相应的相位绕组中激发的交流电压的时间的时段期间，门信号产生电路输出到一个开关电路相绕组从负变为正。当要启动永久磁铁发电机时，启动门信号输出电路向所有双向半导体开关电路输出启动门信号。

9. 发明申请

US20120033748A1 Transmission circuit and communication system 有权
标题翻译：传输电路和通信系统
公开(公告)号：US20120033748A1
公开(公告)日：2012-02-09
申请号：US13137261
申请日：2011-08-02
申请人： Yukio Shimomura
发明人： Yukio Shimomura
IPC分类号： H04L27/00
CPC分类号： H04J3/0685 , H03M9/00 , H04J3/047
摘要： A transmission circuit includes: a plurality of lane blocks arranged in parallel to each other configured to convert parallel data supplied from a corresponding lane into serial data and output the serial data; and a clock enabler block including at least one clock enabler for outputting a drive clock phase-locked with a reference clock to the plurality of lane blocks after a plurality of cycles of the drive clock in response to an enable signal. Each of the plurality of lane blocks has a divider for dividing the drive clock supplied from the clock enabler block to generate a divide clock and a load signal, and a parallel-to-serial converter for converting parallel data supplied from the corresponding lane into serial data in synchronization with the divide clock and the load signal generated by the divider and the drive clock generated by the clock enabler block.
摘要翻译：传输电路包括：多个并行布置的多个通道块，配置成将从相应通道提供的并行数据转换为串行数据并输出串行数据; 以及时钟使能器块，其包括至少一个时钟使能器，用于响应于使能信号，在所述驱动时钟的多个周期之后，将与参考时钟锁相的驱动时钟输出到所述多个通道块。多个通道块中的每一个具有用于分割从时钟使能器块提供的驱动时钟以产生除法时钟和负载信号的分频器，以及用于将从相应通道提供的并行数据转换成串行的并行转换器数据与分频时钟同步，由分频器产生的负载信号和由时钟使能器模块产生的驱动时钟。

10. 发明授权

US07323541B2 Polypeptide DNA thereof and use of the same 失效
标题翻译：其多肽DNA及其用途
公开(公告)号：US07323541B2
公开(公告)日：2008-01-29
申请号：US10489537
申请日：2002-09-13
申请人： Masaaki Mori , Kozo Hayashi , Hiroyuki Miya , Shuji Sato , Chieko Kitada , Hirokazu Matsumoto , Toshimi Nagi , Yukio Shimomura
发明人： Masaaki Mori , Kozo Hayashi , Hiroyuki Miya , Shuji Sato , Chieko Kitada , Hirokazu Matsumoto , Toshimi Nagi , Yukio Shimomura
IPC分类号： A61K38/04
CPC分类号： C07K14/705 , A61K38/00 , A61K48/00
摘要： The present invention aims at providing a novel polypeptide, a receptor, a DNA thereof, and the like. Specifically, the present invention provides a polypeptide having a binding ability to the protein represented by SEQ ID NO: 1 or SEQ ID NO: 3, or its amide, its ester or its salt, a polynucleotide encoding the polypeptide, an antisense polynucleotide or an antibody to the polypeptide, a screening of agent for prevention and/or treatment of cancer, obesity, etc., which comprises using the above, and the like.The polypeptide, receptor, polynucleotide, antisense polynucleotide, antibody and the like are useful for an agent of prevention and/or treatment of cancer, obesity and the like. Further, they are useful for a screening of an agent for prevention and/or treatment of cancer, obesity and the like.
摘要翻译：本发明的目的在于提供新的多肽，受体及其DNA等。具体地说，本发明提供了具有与SEQ ID NO：1或SEQ ID NO：3所代表的蛋白结合能力的多肽或其酰胺，其酯或其盐，编码多肽的多核苷酸，反义多核苷酸或对多肽的抗体，筛选用于预防和/或治疗癌症，肥胖症等的药剂，其包括使用上述方法等。多肽，受体，多核苷酸，反义多核苷酸，抗体等可用于预防和/或治疗癌症，肥胖症等。此外，它们可用于筛选用于预防和/或治疗癌症，肥胖症等的药剂。

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