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1. 发明授权

US07546166B2 Medical lead designs for lead placement through tissue 有权
标题翻译：医疗铅设计用于通过组织进行铅放置
公开(公告)号：US07546166B2
公开(公告)日：2009-06-09
申请号：US10422082
申请日：2003-04-23
申请人： Koen Michels , Nicolaas M. Lokhoff
发明人： Koen Michels , Nicolaas M. Lokhoff
IPC分类号： A61N1/05
CPC分类号： A61N1/057 , A61N1/0573
摘要： The invention is directed to medical lead designs that facilitate implantation of the leads through tissue. For example, the leads can implanted though tissue for placement of distal tips of the leads in locations on the opposing side of the tissue. The leads include fixation elements, such as flexible tines, that facilitate fixation to the tissue. The fixation elements can protrude from lead at a location more than 5 millimeters from the distal-tip of the lead such that when the distal tip has passed through the tissue, the fixation elements anchor in the tissue.
摘要翻译：本发明涉及促进引线通过组织植入的医疗引线设计。例如，引线可以通过组织植入，以将引线的远侧末端放置在组织的相对侧上的位置。引线包括便于固定到组织的固定元件，例如柔性尖齿。固定元件可以从铅的远离尖端超过5毫米的位置处从铅突出，使得当远侧末端已经穿过组织时，固定元件锚定在组织中。

2. 发明授权

US07736198B2 Method of deployable medical lead fixation 失效
标题翻译：可部署医用导线固定方法
公开(公告)号：US07736198B2
公开(公告)日：2010-06-15
申请号：US11468910
申请日：2006-08-31
申请人： Vicki L. Bjorklund , John L. Sommer , Douglas S. Hine , Charles J. Love , Douglas N. Hess , Nicolaas M. Lokhoff
发明人： Vicki L. Bjorklund , John L. Sommer , Douglas S. Hine , Charles J. Love , Douglas N. Hess , Nicolaas M. Lokhoff
IPC分类号： H01R13/24
CPC分类号： A61N1/056 , A61N1/057 , A61N2001/058
摘要： An improved medical lead assembly and method of use is provided. The lead assembly includes a lead body, and a spring member positioned adjacent to the lead body. The spring member may be deployed a selectable amount to maintain the lead body in a fixed location within a patient's body. The spring member may be an expandable coil, a mesh structure that is similar to a stent, or any other similar device that may be positioned in a low-profile state during a lead implant procedure. After the lead is positioned at a target destination, the spring member may be deployed an amount that is selected based on the characteristics of the surrounding tissue, including vessel size. According to one aspect of the invention, the lead assembly may provide means for facilitating chronic lead extraction.
摘要翻译：提供了一种改进的医疗引线组件和使用方法。引线组件包括引线体和邻近引线体定位的弹簧部件。弹簧构件可以部署可选择的量以将引线体保持在患者体内的固定位置。弹簧构件可以是可扩张线圈，类似于支架的网状结构或者在引线植入过程期间可以被定位在低轮廓状态的任何其它类似的装置。在引线定位在目标目的地之后，弹簧构件可以展开一定量，该量基于包括容器尺寸的周围组织的特性来选择。根据本发明的一个方面，引线组件可以提供用于促进慢性铅提取的装置。

3. 发明授权

US07107105B2 Deployable medical lead fixation system and method 失效
标题翻译：可部署医用铅固定系统及方法
公开(公告)号：US07107105B2
公开(公告)日：2006-09-12
申请号：US10254196
申请日：2002-09-24
申请人： Vicki L. Bjorklund , John L Sommer , Douglas S. Hine , Charles J. Love , Douglas N. Hess , Nicolaas M. Lokhoff
发明人： Vicki L. Bjorklund , John L Sommer , Douglas S. Hine , Charles J. Love , Douglas N. Hess , Nicolaas M. Lokhoff
IPC分类号： A61N1/05
CPC分类号： A61N1/056 , A61N1/057 , A61N2001/058
摘要： An improved medical lead assembly and method of use is provided. The lead assembly includes a lead body, and a spring member positioned adjacent to the lead body. The spring member may be deployed a selectable amount to maintain the lead body in a fixed location within a patient's body. The spring member may be an expandable coil, a mesh structure that is similar to a stent, or any other similar device that may be positioned in a low-profile state during a lead implant procedure. After the lead is positioned at a target destination, the spring member may be deployed an amount that is selected based on the characteristics of the surrounding tissue, including vessel size. According to one aspect of the invention, the lead assembly may provide means for facilitating chronic lead extraction.
摘要翻译：提供了一种改进的医疗引线组件和使用方法。引线组件包括引线体和邻近引线体定位的弹簧部件。弹簧构件可以部署可选择的量以将引线体保持在患者体内的固定位置。弹簧构件可以是可扩张线圈，类似于支架的网状结构或者在引线植入过程期间可以被定位在低轮廓状态的任何其它类似的装置。在引线定位在目标目的地之后，弹簧构件可以展开一定量，该量基于包括容器尺寸的周围组织的特性来选择。根据本发明的一个方面，引线组件可以提供用于促进慢性铅提取的装置。

4. 发明授权

US08412351B2 System and method for shunting induced currents in an electrical lead 有权
标题翻译：用于在电引线中分流感应电流的系统和方法
公开(公告)号：US08412351B2
公开(公告)日：2013-04-02
申请号：US12170501
申请日：2008-07-10
申请人： Volkert A. Zeijlemaker , Nicolaas M. Lokhoff
发明人： Volkert A. Zeijlemaker , Nicolaas M. Lokhoff
IPC分类号： A61N1/05
CPC分类号： A61N1/37 , A61N1/05 , A61N1/0573 , A61N1/086 , Y10T29/49117
摘要： An implantable medical device (IMD) can include a cardiac pacemaker or an implantable cardiac defibrillator (ICD). Various portions of the IMD, such as a case or device body, the lead body, or the lead tip, can be provided to reduce or dissipate a heat production due to a current induced by various external environmental factors. According to various embodiments, features or portions can be incorporated into the lead body, the lead tip, or the IMD body to reduce the creation of an induced current, or dissipate or increase the area of dissipation of thermal energy created due to an induced current in the lead.
摘要翻译：可植入医疗装置（IMD）可以包括心脏起搏器或植入式心脏除颤器（ICD）。可以提供IMD的各个部分，例如壳体或装置主体，引线体或引线头，以减少或消散由于各种外部环境因素引起的电流引起的热量产生。根据各种实施例，可以将特征或部分结合到引线体，引线尖端或IMD体中，以减少感应电流的产生，或者消散或增加由于感应电流产生的热能耗散面积领先。

5. 发明授权

US06909920B2 System and method for positioning an implantable medical device within a body 有权
标题翻译：将可植入医疗装置定位在体内的系统和方法
公开(公告)号：US06909920B2
公开(公告)日：2005-06-21
申请号：US09844628
申请日：2001-04-27
申请人： Nicolaas M. Lokhoff , David L. Thompson
发明人： Nicolaas M. Lokhoff , David L. Thompson
IPC分类号： A61N1/05
CPC分类号： A61N1/057 , A61N2001/0585
摘要： A transvenous implantable medical device adapted for implantation in a body, and which is particularly adapted for use in a vessel such as the coronary sinus or cardiac great vein. The implantable medical device may take the form of a lead or catheter, and includes an extendable distal fixation member such as a helix. In one embodiment, the fixation member is a helix constructed of a shape memory metal or other super-elastic material. Upon deployment, the helix assumes a predetermined helix shape larger than the diameter of the lead body diameter. The helix functions to wedge or fix the lead within the vessel in a manner that does not impede the flow of blood through the vessel. The helix may be retracted for ease of repositioning and/or removal. In one embodiment of the invention, the fixation member may be advanced using a stiffening member such as a stylet. In another embodiment, the helix is coupled to a coiled conductor such that rotation of the conductor extends or retracts the helix. According to yet another aspect of the invention, a helix lumen including a flexible fluid-tight seal may be utilized to house the helix when it is in the retracted position.
摘要翻译：一种经静脉植入式医疗装置，适于植入体内，特别适用于血管如冠状窦或心脏大静脉。可植入医疗装置可以采用导联或导管的形式，并且包括可延伸的远端固定构件，例如螺旋。在一个实施例中，固定构件是由形状记忆金属或其它超弹性材料构成的螺旋。在部署时，螺旋呈现比引线体直径的直径大的预定螺旋形状。螺旋线用于以不妨碍血液通过血管的方式楔入或固定血管内的引线。螺旋可以缩回以便于重新定位和/或移除。在本发明的一个实施例中，固定构件可以使用诸如探针的加强构件前进。在另一个实施例中，螺旋连接到螺旋导体，使得导体的旋转延伸或缩回螺旋。根据本发明的另一方面，当螺旋管处于缩回位置时，可以使用包括柔性流体密封的螺旋管来容纳螺旋。

6. 发明授权

US08043126B2 Deployable medical lead fixation system and method 有权
标题翻译：可部署医用铅固定系统及方法
公开(公告)号：US08043126B2
公开(公告)日：2011-10-25
申请号：US12816020
申请日：2010-06-15
申请人： Vicki L. Bjorklund , John L. Sommer , Douglas S. Hine , Charles J. Love , Douglas N. Hess , Nicolaas M. Lokhoff
发明人： Vicki L. Bjorklund , John L. Sommer , Douglas S. Hine , Charles J. Love , Douglas N. Hess , Nicolaas M. Lokhoff
IPC分类号： H01R13/24
CPC分类号： A61N1/056 , A61N1/057 , A61N2001/058
摘要： An improved medical lead assembly and method of use is provided. The lead assembly includes a lead body, and a spring member positioned adjacent to the lead body. The spring member may be deployed a selectable amount to maintain the lead body in a fixed location within a patient's body. The spring member may be an expandable coil, a mesh structure that is similar to a stent, or any other similar device that may be positioned in a low-profile state during a lead implant procedure. After the lead is positioned at a target destination, the spring member may be deployed an amount that is selected based on the characteristics of the surrounding tissue, including vessel size. According to one aspect of the invention, the lead assembly may provide means for facilitating chronic lead extraction.
摘要翻译：提供了一种改进的医疗引线组件和使用方法。引线组件包括引线体和邻近引线体定位的弹簧部件。弹簧构件可以部署可选择的量以将引线体保持在患者体内的固定位置。弹簧构件可以是可扩张线圈，类似于支架的网状结构或者在引线植入过程期间可以被定位在低轮廓状态的任何其它类似的装置。在引线定位在目标目的地之后，弹簧构件可以展开一定量，该量基于包括容器尺寸的周围组织的特性来选择。根据本发明的一个方面，引线组件可以提供用于促进慢性铅提取的装置。

7. 发明申请

US20110024186A1 LEAD APPARATUS 有权
标题翻译：铅装置
公开(公告)号：US20110024186A1
公开(公告)日：2011-02-03
申请号：US12795236
申请日：2010-06-07
申请人： Rogier Receveur , Jean Joseph Gerardus Rutten , Karel F.A.A. Smits , Nicolaas M. Lokhoff , Sylvia Weijzen-Engels , Didier Billy , Tim Dirk Jan Jongen , Lilian Kornet
发明人： Rogier Receveur , Jean Joseph Gerardus Rutten , Karel F.A.A. Smits , Nicolaas M. Lokhoff , Sylvia Weijzen-Engels , Didier Billy , Tim Dirk Jan Jongen , Lilian Kornet
IPC分类号： H01B5/00 , H01R43/00
CPC分类号： A61N1/056 , A61N1/3756
摘要： A lead including one or more electrodes (e.g., electrodes, such as those having circuitry associated therewith).
摘要翻译：包括一个或多个电极（例如，电极，例如具有与其相关联的电路的电极）的引线。

8. 发明申请

US20100256719A1 DEPLOYABLE MEDICAL LEAD FIXATION SYSTEM AND METHOD 有权
标题翻译：可配置医疗铅固定系统和方法
公开(公告)号：US20100256719A1
公开(公告)日：2010-10-07
申请号：US12816020
申请日：2010-06-15
申请人： Vicki L. Bjorklund , John L. Sommer , Douglas S. Hine , Charles J. Love , Douglas N. Hess , Nicolaas M. Lokhoff
发明人： Vicki L. Bjorklund , John L. Sommer , Douglas S. Hine , Charles J. Love , Douglas N. Hess , Nicolaas M. Lokhoff
IPC分类号： A61N1/05
CPC分类号： A61N1/056 , A61N1/057 , A61N2001/058
摘要： An improved medical lead assembly and method of use is provided. The lead assembly includes a lead body, and a spring member positioned adjacent to the lead body. The spring member may be deployed a selectable amount to maintain the lead body in a fixed location within a patient's body. The spring member may be an expandable coil, a mesh structure that is similar to a stent, or any other similar device that may be positioned in a low-profile state during a lead implant procedure. After the lead is positioned at a target destination, the spring member may be deployed an amount that is selected based on the characteristics of the surrounding tissue, including vessel size. According to one aspect of the invention, the lead assembly may provide means for facilitating chronic lead extraction.
摘要翻译：提供了一种改进的医疗引线组件和使用方法。引线组件包括引线体和邻近引线体定位的弹簧部件。弹簧构件可以部署可选择的量以将引线体保持在患者体内的固定位置。弹簧构件可以是可扩张线圈，类似于支架的网状结构或者在引线植入过程期间可以被定位在低轮廓状态的任何其它类似的装置。在引线定位在目标目的地之后，弹簧构件可以展开一定量，该量基于包括容器尺寸的周围组织的特性来选择。根据本发明的一个方面，引线组件可以提供用于促进慢性铅提取的装置。

9. 发明申请

US20090240296A1 SYSTEM AND METHOD FOR SHUNTING INDUCED CURRENTS IN AN ELECTRICAL LEAD 有权
标题翻译：用于在电气引线中调谐感应电流的系统和方法
公开(公告)号：US20090240296A1
公开(公告)日：2009-09-24
申请号：US12170501
申请日：2008-07-10
申请人： VOLKERT A. ZEIJLEMAKER , Nicolaas M. Lokhoff
发明人： VOLKERT A. ZEIJLEMAKER , Nicolaas M. Lokhoff
IPC分类号： A61N1/05 , A61N1/39
CPC分类号： A61N1/37 , A61N1/05 , A61N1/0573 , A61N1/086 , Y10T29/49117
摘要： An implantable medical device (IMD) can include a cardiac pacemaker or an implantable cardiac defibrillator (ICD). Various portions of the IMD, such as a case or device body, the lead body, or the lead tip, can be provided to reduce or dissipate a heat production due to a current induced by various external environmental factors. According to various embodiments, features or portions can be incorporated into the lead body, the lead tip, or the IMD body to reduce the creation of an induced current, or dissipate or increase the area of dissipation of thermal energy created due to an induced current in the lead.
摘要翻译：可植入医疗装置（IMD）可以包括心脏起搏器或植入式心脏除颤器（ICD）。可以提供IMD的各个部分，例如壳体或装置主体，引线体或引线头，以减少或消散由于各种外部环境因素引起的电流引起的热量产生。根据各种实施例，可以将特征或部分结合到引线体，引线尖端或IMD体中，以减少感应电流的产生，或者消散或增加由于感应电流产生的热能耗散面积领先。

10. 发明授权

US07251532B2 Medical lead fixation 有权
标题翻译：医用铅固定
公开(公告)号：US07251532B2
公开(公告)日：2007-07-31
申请号：US10688229
申请日：2003-10-17
申请人： Douglas N. Hess , Nicolaas M. Lokhoff , Michael A. Ruff , Richard D. Sandstrom , Timothy G. Laske
发明人： Douglas N. Hess , Nicolaas M. Lokhoff , Michael A. Ruff , Richard D. Sandstrom , Timothy G. Laske
IPC分类号： A61N1/05
CPC分类号： A61N1/0575 , A61N1/0565
摘要： A distal tip coupled to a body of an implantable medical device includes a canted passageway extending distally from a lumen of the body and an opening terminating the passageway and positioned in proximity to a distal end of the distal tip; a helical fixation element coupled to an elongated member extending within the lumen of the body is adapted to deflect along the canted passageway of the distal tip. The elongated member is adapted to move the helical member through the passageway of the distal tip and out from the opening and to rotate the helical element thereby affixing the helical element into an implant site.
摘要翻译：联接到可植入医疗装置的主体的远侧末端包括从主体的内腔向远端延伸的倾斜通道和终止该通道并且定位在远侧末端的远端附近的开口; 耦合到在主体的内腔内延伸的细长构件的螺旋固定元件适于沿着远端尖端的倾斜通道偏转。细长构件适于将螺旋构件移动通过远侧尖端的通道并从开口移出并旋转螺旋元件，从而将螺旋元件固定到植入位置。

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