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1. 发明授权

US07729783B2 Apparatus and methods for vacuum- and mechanically-assisted fixation of medical electrical leads 有权
标题翻译：用于真空和机械辅助固定医用电线的装置和方法
公开(公告)号：US07729783B2
公开(公告)日：2010-06-01
申请号：US11380228
申请日：2006-04-26
申请人： Koen Michels , Fredric W. Lindemans , Jean-Luc Jansens
发明人： Koen Michels , Fredric W. Lindemans , Jean-Luc Jansens
IPC分类号： A61N1/05
CPC分类号： A61N1/0587
摘要： A method and apparatus for providing positive fixation of medical components to a portion of pericardial tissue via both vacuum- and/or mechanically-assisted means. A source of vacuum couples via a lumen to a recessed portion of a body structure deployed into the pericardial space. The recessed portion is adapted to form a seal around its periphery with adjacent pericardial tissue so that when the recessed portion is evacuated, the tissue is drawn into the recessed portion. Then, a sharpened instrument, such as a stylet, is deployed through the lumen and pierces the tissue, thus anchoring the body structure. A source of fluid may also be included for delivery to the pericardial space (e.g., contrast media; saline solution; biological, genetic and pharmaceutical substances and the like).
摘要翻译：一种用于通过真空和/或机械辅助手段将医疗部件正向固定到心包组织的一部分的方法和装置。真空源通过内腔耦合到部署到心包空间的身体结构的凹陷部分。凹部适于围绕其周边与相邻的心包组织形成密封，使得当凹部被抽真空时，组织被拉入凹部。然后，诸如探针之类的尖锐的器械通过内腔部署并刺穿组织，从而锚固身体结构。还可以包括流体源用于递送至心包空间（例如，造影剂;盐溶液;生物，遗传和药物物质等）。

2. 发明授权

US08244379B2 Pericardium fixation concepts of epicardium pacing leads and tools 有权
标题翻译：心包起搏导联和工具的心包固定概念
公开(公告)号：US08244379B2
公开(公告)日：2012-08-14
申请号：US11380234
申请日：2006-04-26
申请人： Koen Michels , Jean-Luc Jansens , Victor Duysens , Paulus G. Adams , Paulus Van Venrooij , Markus J. C. Lazeroms , Fredric W. Lindemans
发明人： Koen Michels , Jean-Luc Jansens , Victor Duysens , Paulus G. Adams , Paulus Van Venrooij , Markus J. C. Lazeroms , Fredric W. Lindemans
IPC分类号： A61N1/05
CPC分类号： A61N1/0587
摘要： Certain aspects of the disclosure pertain to methods and apparatus for providing positive fixation of medical components to a portion of incised pericardial tissue. Accordingly, a resilient member protrudes through an incision in the pericardium and produces a positive biasing force to adjacent pericardial tissue against a side surface of an attached body structure. The resilient member can optionally be compressed during implantation and then relaxed to thereafter provide the positive biasing force. Diverse medical components can thus be safely and reliably chronically deployed into the pericardial space, including without limitation, cardiac sensing/pacing, defibrillation and/or cardioversion electrodes, mechanical and/or metabolic sensors and the like. More than one body structure can be linked to a single medical electrical lead and the medical components can couple within and/or upon a portion of the body structure, the resilient member, and the lead in myriad configurations.
摘要翻译：本公开的某些方面涉及用于向切开的心包组织的一部分提供医疗部件的正面固定的方法和装置。因此，弹性构件通过心包中的切口突出，并且相对于附接体结构的侧表面产生相邻心包组织的正偏置力。弹性构件可以可选地在植入期间被压缩，然后松弛，之后提供正的偏压力。因此，不同的医疗部件可以安全可靠地长期地部署到心包空间中，包括但不限于心脏感测/起搏，除颤和/或心脏复律电极，机械和/或代谢传感器等。多个主体结构可以连接到单个医疗电引线，并且医疗部件可以在各种构造中联接在身体结构，弹性构件和引线的一部分内和/或之内。

3. 发明授权

US08086307B2 Terminating tachyarrhythmias 有权
标题翻译：终止快速性心律失常
公开(公告)号：US08086307B2
公开(公告)日：2011-12-27
申请号：US12533650
申请日：2009-07-31
申请人： Nathalie Virag , Laurent Uldry , Fredric W. Lindemans , Lukas J. Kappenberger
发明人： Nathalie Virag , Laurent Uldry , Fredric W. Lindemans , Lukas J. Kappenberger
IPC分类号： A61N1/00
CPC分类号： A61N1/3622 , A61N1/3624 , A61N1/368
摘要： This disclosure is directed to techniques for treating tachyarrhythmias, such as atrial or ventricular fibrillation, in which a number of electrodes are employed to deliver electrical stimulation to a patient's heart in a manner designed to terminate the tachyarrhythmia episode.
摘要翻译：本公开涉及用于治疗快速性心律失常的技术，例如心房或心室颤动，其中使用多个电极以设计为终止快速性心律失常发作的方式向患者的心脏递送电刺激。

4. 发明授权

US4310000A Implantable pulse generator having separate passive sensing reference electrode 失效
标题翻译：可植入脉冲发生器具有单独的被动感应参考电极
公开(公告)号：US4310000A
公开(公告)日：1982-01-12
申请号：US114767
申请日：1980-01-23
申请人： Fredric W. Lindemans
发明人： Fredric W. Lindemans
IPC分类号： A61N1/365 , A61N1/375 , A61N1/36
CPC分类号： A61N1/375 , A61N1/365
摘要： Passive sensing reference electrode positioned on an implantable pulse generator where the electrode electrically contacts with tissue or body fluid. The electrode configuration reduces stimulation afterpotentials due to electrode polarization and output capacitor recharge by using the passive sensing reference electrode for sensing. The passive sensing reference electrode may be located adjacent the conductor sleeve, on a surface of a hermetically sealed metallic pacemaker can, or one of the surfaces of the pacemaker can may be insulated from another surface of the pacemaker can where one half of the pacemaker can may be the passive sensing reference electrode.
摘要翻译：位于可植入脉冲发生器上的被动感测参考电极，其中电极与组织或体液电接触。电极配置通过使用无源感测参考电极进行感测，减少了由于电极极化引起的电位后刺激和输出电容器再充电。无源感测参考电极可以位于导体套筒附近，在密封的金属起搏器罐的表面上，或者起搏器的一个表面可以与起搏器罐的另一个表面绝缘，其中起搏器的一半可以可以是被动感测参考电极。

5. 发明授权

US06385491B1 Temporary medical electrical lead having biodegradable electrode mounting pad loaded with therapeutic drug 失效
标题翻译：临时医用电线，具有装有治疗药物的可生物降解的电极安装垫
公开(公告)号：US06385491B1
公开(公告)日：2002-05-07
申请号：US09411837
申请日：1999-10-04
申请人： Fredric W. Lindemans , Ursula Gebhardt , Marc Hendriks
发明人： Fredric W. Lindemans , Ursula Gebhardt , Marc Hendriks
IPC分类号： A61N100
CPC分类号： A61N1/0587 , Y10T29/49147 , Y10T29/49169 , Y10T29/49174 , Y10T29/49208
摘要： A temporary cardiac electrical stimulating lead comprises a stimulating electrode mounted in or on a biodegradable electrode mounting pad disposed at a distal end of the lead. The electrode mounting pad is capable of biodegradably dissolving over time in human body fluids and is loaded with a drug for therapeutically treating a medical condition of a patient's heart. The electrode mounting pad may be loaded with any of a variety of different drugs, such anti-arrhythmia or anti-inflammatory drugs. When the lead body is pulled away from the electrode mounting pad and removed from the patient, any portion of the electrode mounting pad remaining within the patient dissolves over time and disappears.
摘要翻译：临时心电刺激引线包括安装在设置在引线的远端的可生物降解的电极安装垫中或上的刺激电极。电极安装垫能够随着时间而生物降解地溶解在人体液中，并且装载有用于治疗性地治疗患者心脏的病症的药物。电极安装垫可以装载各种不同药物中的任何一种，例如抗心律不齐或抗炎药。当引线体被拉离电极安装垫并从患者身上取下时，残留在患者内的电极安装垫的任何部分随时间而溶解并消失。

6. 发明申请

US20110319952A1 TERMINATING TACHYARRHYTHMIAS 有权
标题翻译：终止TACHYARRHYTHMIAS
公开(公告)号：US20110319952A1
公开(公告)日：2011-12-29
申请号：US12826010
申请日：2010-06-29
申请人： Nathalie Virag , Laurent Uldry , Fredric W. Lindemans , Lukas J. Kappenberger
发明人： Nathalie Virag , Laurent Uldry , Fredric W. Lindemans , Lukas J. Kappenberger
IPC分类号： A61N1/365
CPC分类号： A61N1/3622 , A61B5/046 , A61B5/0464 , A61N1/3624 , A61N1/37264 , A61N1/37282
摘要： This disclosure is directed to techniques for treating tachyarrhythmias, such as atrial or ventricular fibrillation, in which a number of electrodes are employed to deliver electrical stimulation to a patient's heart in a manner designed to terminate the tachyarrhythmia episode.
摘要翻译：本公开涉及用于治疗快速性心律失常的技术，例如心房或心室颤动，其中使用多个电极以设计为终止快速性心律失常发作的方式向患者的心脏递送电刺激。

7. 发明授权

US06748653B2 Method of making a temporary medical lead having biodegradable electrode mounting pad loaded with therapeutic drug 失效
标题翻译：制造具有装有治疗药物的可生物降解电极安装垫的临时医用引线的方法
公开(公告)号：US06748653B2
公开(公告)日：2004-06-15
申请号：US09947433
申请日：2001-09-07
申请人： Fredric W. Lindemans , Ursula Gebhardt , Marc Hendriks
发明人： Fredric W. Lindemans , Ursula Gebhardt , Marc Hendriks
IPC分类号： H05K1300
CPC分类号： A61N1/0587 , Y10T29/49147 , Y10T29/49169 , Y10T29/49174 , Y10T29/49208
摘要： A method of making a temporary medical electrical lead for pacing or defibrillating a heart of a patient. The method comprises providing at least one electrical conductor having proximal and distal ends; providing an insulating sheath formed of biocompatible material extending over and covering at least portions of the at least one electrical conductor, attaching an electrical connector assembly to the proximal end of the at least one electrical conductor for attachment to a device capable of providing pacing or defibrillation pulses; providing an electrode mounting pad in the form of a cast matrix structure made of a biodegradable, biocompatible material soluble in human body fluids and having an outer heart non-contacting surface and an inner heart contacting surface, the outer surface being less permeable to passage of body fluids than the inner surface and wherein the inner surface of the pad has larger interstices and is less dense than the outer surface; providing a drug for treating for treating a medical condition of the patient's heart; loading the drug into the matrix of the pad; and attaching at least portions of the distal end of the at least one electrical conductor or of the electrode member to the electrode mounting pad.
摘要翻译：制造用于起搏或除颤患者心脏的临时医用电线的方法。该方法包括提供至少一个具有近端和远端的电导体; 提供由生物相容性材料形成的绝缘护套，所述绝缘护套由所述至少一个电导体的至少一部分延伸并覆盖所述至少一个电导体的至少一部分，将电连接器组件附接到所述至少一个电导体的近端以附接到能够提供起搏或除颤的装置脉冲提供由可溶于人体液体的可生物降解的生物相容性材料制成的铸造基质结构形式的电极安装垫，并且具有外部心脏非接触表面和内部心脏接触表面，所述外部表面对于通过体液比内表面多，并且其中垫的内表面具有较大的间隙并且密度小于外表面; 提供用于治疗患者心脏的医疗状况的药物; 将药物加载到垫的基质中; 以及将所述至少一个电导体或所述电极构件的远端的至少一部分附接到所述电极安装垫。

8. 发明授权

US4402330A Body implantable lead 失效
标题翻译：身体可植入铅
公开(公告)号：US4402330A
公开(公告)日：1983-09-06
申请号：US261718
申请日：1981-05-08
申请人： Fredric W. Lindemans
发明人： Fredric W. Lindemans
IPC分类号： A61N1/05 , A61N1/04
CPC分类号： A61N1/056
摘要： A lead for a body implantable electrical stimulation system including at least one electrical conductor and electrical insulation which together define a flexible lead body. A stiffening system, in the form of a member coiled about a portion of the lead body, is provided to enhance the ability of that lead body portion to maintain its orientation in the presence of external forces, including forces imparted to the lead by movement of the body as well as gravity. Preferably, the coiled member is a multifilar member and, in a preferred embodiment, is a close wound trifilar member. The desired lead body orientation may be a straight or curved configuration and, in the latter instance, the lead body may be provided with a lumen such that the curve is extended or straightened on insertion of a stylet of sufficient stiffness. A body compatible material may overlie the coiled member to provide a smooth exterior surface at the stiffened lead body portion and, in a preferred embodiment, extends beyond the lead body portion to provide a stiffness transition region adjacent the coiled member.
摘要翻译：一种用于身体可植入电刺激系统的引线，包括至少一个电导体和电绝缘，其一起限定柔性引线体。提供卷绕在引线主体的一部分上的部件的形式的加强系统，以增强引线本体部分在存在外力的情况下保持其取向的能力，包括通过运动引起的引导力身体以及重力。优选地，螺旋构件是多面构件，并且在优选实施例中是闭合缠绕的三面构件。期望的铅体取向可以是直的或弯曲的构造，并且在后一种情况下，引线主体可以设置有内腔，使得在插入足够刚度的探针时，曲线被延伸或拉直。身体相容的材料可以覆盖在线圈构件上，以在加强的引线主体部分处提供光滑的外表面，并且在优选实施例中，延伸超出引线本体部分以提供邻近线圈构件的刚度过渡区域。

9. 发明授权

US08812107B2 Terminating tachyarrhythmias 有权
标题翻译：终止快速性心律失常
公开(公告)号：US08812107B2
公开(公告)日：2014-08-19
申请号：US12826010
申请日：2010-06-29
申请人： Nathalie Virag , Laurent Uldry , Fredric W. Lindemans , Lukas J. Kappenberger
发明人： Nathalie Virag , Laurent Uldry , Fredric W. Lindemans , Lukas J. Kappenberger
IPC分类号： A61N1/365
CPC分类号： A61N1/3622 , A61B5/046 , A61B5/0464 , A61N1/3624 , A61N1/37264 , A61N1/37282
摘要： This disclosure is directed to techniques for treating tachyarrhythmias, such as atrial or ventricular fibrillation, in which a number of electrodes are employed to deliver electrical stimulation to a patient's heart in a manner designed to terminate the tachyarrhythmia episode.
摘要翻译：本公开涉及用于治疗快速性心律失常的技术，例如心房或心室颤动，其中使用多个电极以设计为终止快速性心律失常发作的方式向患者的心脏递送电刺激。

10. 发明申请

US20110029033A1 TERMINATING TACHYARRHYTHMIAS 有权
公开(公告)号：US20110029033A1
公开(公告)日：2011-02-03
申请号：US12533650
申请日：2009-07-31
申请人： Nathalie Virag , Laurent Uldry , Fredric W. Lindemans , Lukas J. Kappenberger
发明人： Nathalie Virag , Laurent Uldry , Fredric W. Lindemans , Lukas J. Kappenberger
IPC分类号： A61N1/368
CPC分类号： A61N1/3622 , A61N1/3624 , A61N1/368
摘要： This disclosure is directed to techniques for treating tachyarrhythmias, such as atrial or ventricular fibrillation, in which a number of electrodes are employed to deliver electrical stimulation to a patient's heart in a manner designed to terminate the tachyarrhythmia episode.

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