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1. 发明授权

US06321998B1 Method of producing dispersions and carrying out of chemical reactions in the disperse phase 失效
标题翻译：在分散相中产生分散体并进行化学反应的方法
公开(公告)号：US06321998B1
公开(公告)日：2001-11-27
申请号：US09068264
申请日：1998-05-05
申请人： Klaus Schubert , Wilhelm Bier , Gerd Linder , Erhard Herrmann , Bernd Koglin , Thomas Menzel
发明人： Klaus Schubert , Wilhelm Bier , Gerd Linder , Erhard Herrmann , Bernd Koglin , Thomas Menzel
IPC分类号： A62C502
CPC分类号： B01F5/0256 , B01F5/0644 , B01F13/00 , B01F13/0059 , B01J19/0093 , B01J2219/00783 , B01J2219/00889 , Y10S366/03
摘要： In the process for the continuous dispersion of at least one fluid A constituting the disperse phase and at least one continuous phase constituting the enclosing phase of a fluid B, at least one fluid stream A and at least one fluid stream B are fed into a dispersion apparatus and come into contact therein in a dispersion chamber. To this end, a microstructure dispersion apparatus (1a, 1b, 3a, 3b) is used in which the fluid streams A, B are broken up into spatially separate, flowing fluid filaments by a system of microchannels (1a, 1b) associated therewith, which filaments are discharged into the dispersion chamber (4) at identical flow velocities for the particular fluid in such a manner that on discharge into the dispersion chamber (4) a fluid jet (6a) of the disperse phase is in each case immediately adjacent to a fluid jet (6b) of the continuous phase and in each case a fluid jet (6a) of the disperse phase is enclosed as it is broken up into particles in the adjacent fluid jets (6b) of the continuous phase.
摘要翻译：在构成分散相的至少一种流体A和构成流体B的封闭相的至少一个连续相的连续分散的过程中，将至少一种流体流A和至少一种流体流B进料到分散体装置并在分散室中与其接触。为此，使用通过与其相关联的微通道（1a，1b）的系统将流体流A，B分解成空间分离的流动细丝的微结构分散装置（1a，1b，3a，3b）以特定流体的相同流速将这些细丝排出到分散室（4）中，使得在排放到分散室（4）中时，分散相的流体射流（6a）在每种情况下都紧邻于在连续相的流体射流（6b）中，并且在每种情况下，分散相的流体射流（6a）被包围，因为其在连续相的相邻流体射流（6b）中被分解成颗粒。

2. 发明授权

US06264900B1 Device for carrying out chemical reactions using a microlaminar mixer 失效
标题翻译：使用微层混合器进行化学反应的装置
公开(公告)号：US06264900B1
公开(公告)日：2001-07-24
申请号：US09068322
申请日：1998-05-05
申请人： Klaus Schubert , Wilhelm Bier , Gerd Linder , Erhard Herrmann , Bernd Koglin , Thomas Menzel , Christine Maul
发明人： Klaus Schubert , Wilhelm Bier , Gerd Linder , Erhard Herrmann , Bernd Koglin , Thomas Menzel , Christine Maul
IPC分类号： B01F500
CPC分类号： B01F13/0066 , B01F5/0256 , B01F5/0644 , B01F13/0064 , B01F13/0094 , B01J19/0093 , B01J19/18 , B01J19/2415 , B01J2219/00085 , B01J2219/00164 , B01J2219/00783 , B01J2219/00873 , B01J2219/00889 , F28F2260/02 , Y10S366/03 , Y10T137/2514 , Y10T137/2516 , Y10T137/2559 , Y10T137/2562 , Y10T137/2564
摘要： A microstructures lamellae mixer comprising a guide component for supplying fluids to be mixed to a mixing chamber, the guide component being composed of a plurality of foils which are layered one above the other and into which microchannels are incorporated such that separate fluids supplied to the guide component are formed into spatially separated microstreams which then emerge adjacent to each other in a mixing chamber.
摘要翻译：一种微结构薄片混合器，包括用于供应要混合到混合室中的流体的引导部件，所述引导部件由多个彼此层叠的多个箔组成，并且微通道被并入到所述多个箔中，使得提供给所述引导件的单独流体组分形成空间分离的微流体，然后在混合室中彼此相邻出现。

3. 发明授权

US06299657B1 Process for carrying out chemical reactions using a microlaminar mixer 失效
标题翻译：使用微层混合器进行化学反应的方法
公开(公告)号：US06299657B1
公开(公告)日：2001-10-09
申请号：US09419457
申请日：1999-10-15
申请人： Klaus Schubert , Wilhelm Bier , Gerd Linder , Erhard Herrmann , Bernd Koglin , Thomas Menzel , Christine Maul
发明人： Klaus Schubert , Wilhelm Bier , Gerd Linder , Erhard Herrmann , Bernd Koglin , Thomas Menzel , Christine Maul
IPC分类号： B01F302
CPC分类号： B01F13/0066 , B01F5/0256 , B01F5/0644 , B01F13/0064 , B01F13/0094 , B01J19/0093 , B01J19/18 , B01J19/2415 , B01J2219/00085 , B01J2219/00164 , B01J2219/00783 , B01J2219/00873 , B01J2219/00889 , F28F2260/02 , Y10S366/03 , Y10T137/2514 , Y10T137/2516 , Y10T137/2559 , Y10T137/2562 , Y10T137/2564
摘要： In the reaction process, at least two educts A, B are divided by a system, assigned to each of them, of slit-like microchannels 1a, 1b into spatially separate fluid lamellae, which then emerge into a common mixing and reaction space 4. The fluid lamellae here have a thickness
摘要翻译：在反应过程中，至少两个喷射管A，B被分配给它们中的每一个的狭缝状微通道1a，1b的系统划分成空间上分开的流体薄片，然后出现在共同的混合和反应空间4中。这里的流体薄片的厚度<1,000μm，优选<100μm，宽度厚度比至少为10.这里重要的是，喷射A，B可以作为薄的液体薄片6a，6b出现到混合/反应空间如图4所示，喷射管A的每个流体薄片6a被引导到混合/反应空间4中，紧邻另一个喷射B的流体薄片6b。然后相邻的流体薄片6a，6b然后通过扩散和/或湍流混合。结果，与常规反应器相比，混合操作大大加快。在快速化学反应的情况下，以这种方式大大地防止了不期望的副产物或二次产物的形成。

4. 发明授权

US6082891A Static micromixer 失效
标题翻译：静态微混合器
公开(公告)号：US6082891A
公开(公告)日：2000-07-04
申请号：US62074
申请日：1998-04-17
申请人： Klaus Schubert , Wilhelm Bier , Erhard Herrmann , Thomas Menzel , Gerd Linder
发明人： Klaus Schubert , Wilhelm Bier , Erhard Herrmann , Thomas Menzel , Gerd Linder
IPC分类号： B01F5/00 , B01F5/02 , B01F5/06 , B01F13/00 , B01J19/00 , B01J19/24 , B01L3/00
CPC分类号： B01J19/0093 , B01F13/0064 , B01F13/0066 , B01F13/0094 , B01F5/0256 , B01F5/0644 , B01J2219/00783 , B01J2219/00822 , B01J2219/00889 , B01L3/5027 , Y10S366/03
摘要： In a static micromixer a flow guide structure consisting of a stack of foils provided with passages formed into alternate foils so as to extend between a mixing chamber at one end of the flow guide structure and different admission chambers at the opposite end of the flow guide structure, the passages are curved so that they are all parallel at their exit ends adjacent the mixing chamber and, at their entrance ends, the flow guide structure has face areas which are inclined with respect to the exit end face of the flow guide structure at such an angle that the curved passages have all about the same length.
摘要翻译：在静态微型混合器中，流动引导结构由一叠箔组成，其中提供有形成为交替箔片的通道，以便在流动引导结构的一端处的混合室与流动引导结构的相对端处的不同入口室之间延伸通道是弯曲的，使得它们在邻近混合室的出口端处都是平行的，并且在其入口端处，流动引导结构具有相对于流动引导结构的出口端面倾斜的面部区域弯曲通道具有大约相同长度的角度。

5. 发明授权

US06305834B1 Method and device for producing a dispersed mixture via crossing partial flows 有权
标题翻译：通过部分流动产生分散混合物的方法和装置
公开(公告)号：US06305834B1
公开(公告)日：2001-10-23
申请号：US09355638
申请日：1999-08-02
申请人： Klaus Schubert , Wilhelm Bier , Gerd Linder , Erhard Herrmann , Bernd Klinksiek , Bernd Krumbach
发明人： Klaus Schubert , Wilhelm Bier , Gerd Linder , Erhard Herrmann , Bernd Klinksiek , Bernd Krumbach
IPC分类号： B01F506
CPC分类号： B01J19/0093 , B01J19/2415 , B01J19/26 , B01J2219/00074 , B01J2219/00103 , B01J2219/00783 , B01J2219/00873 , B01J2219/00889 , F28F2260/02
摘要： A method and a device for producing a dispersed mixture from at least two phases. To do this, the first and the second phase are subdivided into split streams so that the split streams from the first phase are located on a first flat layer and the split streams from the second phase are located on a second flat layer, the split streams of the first phase inside the flat layer being fed onto the split streams of the second phase at an angle in order to bring about a dispersion and mixing process, wherein the flat layers are directly arranged on top of each other, and parallel to each other. The device consists of at least one base unit containing two foils into which a parallel assembly of grooves is inserted on one side of each foil. Both foils are configured in the base unit such that the sides of the foils fitted with grooves lie on top of each other and form an angle with each other.
摘要翻译：一种用于从至少两相制备分散混合物的方法和装置。为此，第一和第二阶段被细分为分流，使得来自第一阶段的分流被定位在第一平坦层上，并且来自第二相的分离流位于第二平坦层上，分离流的第一相内的第一相被以一定的角度供给到第二相的分流上，以便实现分散和混合过程，其中平坦层直接布置在彼此的顶部上并且彼此平行。该装置包括至少一个包含两个箔片的基座单元，每个箔片的一侧上插入有平行的凹槽组件。两个箔被配置在基部单元中，使得装配有凹槽的箔的侧面彼此顶部并且彼此形成一个角度。

6. 发明授权

US5803600A Static micromixer with heat exchanger 失效
标题翻译：具有热交换器的静态微混合器
公开(公告)号：US5803600A
公开(公告)日：1998-09-08
申请号：US728344
申请日：1996-10-09
申请人： Klaus Schubert , Wilhelm Bier , Gerd Linder , Dieter Seidel
发明人： Klaus Schubert , Wilhelm Bier , Gerd Linder , Dieter Seidel
IPC分类号： B01F5/00 , B01F5/02 , B01F5/04 , B01F5/06 , B01F13/00 , B01J19/00 , B01J19/24 , F28D9/00 , F28F3/04 , B01F15/06
CPC分类号： B01F13/0066 , B01F13/0064 , B01F13/0093 , B01F13/0096 , B01F5/0256 , B01F5/0644 , B01J19/0093 , B01J19/2415 , F28D9/0037 , F28F3/048 , B01J2219/00121 , B01J2219/00159 , B01J2219/00783 , B01J2219/00873 , B01J2219/00889 , F28F2260/02 , Y10S366/03
摘要： In a static micromixer for mixing at least two fluids including a flow guide structure having a longitudinal axis extending in the general flow direction of the fluids through the guide structure, separate fluid admission areas disposed at the entrance end of the flow guide structure and a mixing chamber disposed at the exit end of the flow guide structure, the flow guide structure is formed by foils of a thickness of about 100 .mu.m disposed on top of each other and having parallel grooves extending in one foil from one of the fluid admission areas at an angle with respect to the general fluid flow direction through the flow guide structure to the mixing chamber and in an adjacent foil from another of the fluid admission areas to the mixing chamber such that in the mixing chamber the fluid exits of different foils are disposed adjacent each other, the grooves having a width of less than 250 .mu.m and being spaced from each other by less than 70 .mu.m to provide for the fluid flow filaments entering the mixing chamber at different angles and closely adjacent each other.
摘要翻译：在用于混合至少两种流体的静态微混合器中，包括具有在流体的一般流动方向上延伸通过引导结构的纵向轴线的流动引导结构，设置在流动引导结构的入口端处的单独的流体入口区域和混合设置在流动引导结构的出口端的腔室，流动引导结构由彼此顶部设置的约100μm的厚度的箔形成，并且具有在一个箔中从一个流体入口区域延伸的平行凹槽相对于通过流动引导结构到混合室的一般流体流动方向的角度以及从另一个流体入口区域到混合室的相邻箔片的角度，使得在混合室中，不同箔片的流体离开设置在相邻彼此之间的沟槽宽度小于250μm，彼此间隔小于70μm以提供流体流动的纤维 ts以不同的角度进入混合室并且紧密相邻。

7. 发明授权

US5249359A Process for manufacturing finely structured bodies such as heat exchangers 失效
标题翻译：用于制造诸如热交换器的精细结构体的方法
公开(公告)号：US5249359A
公开(公告)日：1993-10-05
申请号：US854065
申请日：1992-03-19
申请人： Klaus Schubert , Wilhelm Bier , Gerd Linder , Peter Schmid , Peter Bichler , Winfried Brunner , Wolfgang Simon
发明人： Klaus Schubert , Wilhelm Bier , Gerd Linder , Peter Schmid , Peter Bichler , Winfried Brunner , Wolfgang Simon
IPC分类号： B01D25/00 , B01J19/00 , B01J35/04 , B23B1/00 , B23C3/00 , B23P15/26 , C02F3/10 , F28D9/00 , G02B5/18 , B23D15/00
CPC分类号： G02B5/1852 , B01D25/001 , B01J19/0093 , B01J35/04 , B23B1/00 , B23C3/00 , B23P15/26 , F28D9/00 , F28D9/0037 , F28F13/185 , B01D2201/46 , C02F3/101 , F28F2260/00 , Y02W10/15 , Y10T29/301 , Y10T29/307 , Y10T29/4935 , Y10T29/49366 , Y10T29/49826
摘要： A method of producing a finely structured body which includes a plurality of stacked, cut sections of foil at least one of which is provided with grooves in a selected groove direction on at least one surface thereof, and which has a plurality of closely juxtaposed, channel-like perforations with high shape accuracy, true dimensions and high surface quality. The method includes: a. providing a vacuum clamping means comprised of a ground, sintered metal plate which is connected to a vacuum source and which is positioned on a work table which is movable in two mutually perpendicular directions X and Y; b. positioning a machinable foil on the ground, sintered metal plate and clamping the machinable foil thereto by applying an effective amount of vacuum; c. cutting a plurality of parallel grooves into the surface of the machinable foil by means of at least one shaping diamond positioned on a cutting spindle and adjustable in a direction Z, each groove of the plurality of grooves having a groove length, a groove width, and a cross-sectional shape that is constant over the groove length and freely selectable; d. cutting the grooved machinable foil into cut sections having selected lengths and widths; and e. stacking the cut sections, wherein the plurality of grooves have a form precision such that, for groove lengths of more than 1000 .mu.m, the groove width has an accuracy of about +1 .mu.m for land widths which equal or exceed about 15 .mu.m.
摘要翻译：一种制造精细结构体的方法，其包括多个层叠的切割部分的箔，其至少一个在其至少一个表面上沿选定的凹槽方向设置有凹槽，并且具有多个紧密并置的通道类似的穿孔具有高的形状精度，真实的尺寸和高的表面质量。该方法包括：a。提供真空夹紧装置，其包括接地的烧结金属板，该金属板连接到真空源并且位于可在两个相互垂直的方向X和Y上移动的工作台上; b。将可机加工的箔定位在地面上，烧结金属板，并通过施加有效量的真空将可机加工的箔夹紧在其上; C。通过位于切割轴上的至少一个成形金刚石将多个平行凹槽切割成可加工箔的表面，并且可沿方向Z调节，多个凹槽中的每个凹槽具有凹槽长度，凹槽宽度和在槽长度上恒定的横截面形状并且可自由选择; d。将切槽的可加工箔切割成具有选定长度和宽度的切割部分; 和e。堆叠切割部分，其中多个凹槽具有形状精度，使得对于大于1000μm的凹槽长度，对于等于或超过约15μm的凹槽宽度，凹槽宽度具有约+1μm的精度。

8. 发明授权

US5152060A Process for manufacturing fine-structured bodies 失效
标题翻译：制造精细结构体的方法
公开(公告)号：US5152060A
公开(公告)日：1992-10-06
申请号：US708818
申请日：1991-05-31
申请人： Klaus Schubert , Wilhelm Bier , Gerd Linder , Peter Schmid , Peter Bichler , Winfried Brunner , Wolfgang Simon
发明人： Klaus Schubert , Wilhelm Bier , Gerd Linder , Peter Schmid , Peter Bichler , Winfried Brunner , Wolfgang Simon
IPC分类号： B01D25/00 , B01J19/00 , B01J35/04 , B23B1/00 , B23C3/00 , B23D1/00 , B23P15/00 , B23P15/16 , B23P15/26 , C02F3/10 , F28D9/00 , G02B5/18
CPC分类号： G02B5/1852 , B01D25/001 , B01J19/0093 , B01J35/04 , B23B1/00 , B23C3/00 , B23P15/26 , C02F3/101 , F28D9/00 , F28D9/0037 , B01D2201/46 , B01J2219/00783 , B01J2219/00833 , B01J2219/00835 , B01J2219/00873 , F28F2260/02 , Y02W10/15 , Y10T29/49366 , Y10T29/5183 , Y10T82/10 , Y10T82/266
摘要： A method of producing a finely structured body comprised of a plurality of stacked, cut sections of foil at least one of which is provided with grooves. A machinable foil is wrapped around a cylindrical mandrel of a lathe to overlap opposing edges. The overlapped edges are clamped into an axial recess of the cylindrical mandrel by means of a clamping means and a plurality of grooves cut into the surface of the foil by means of at least one shaping diamond positioned in a feed which is finely adjustable. The plurality of grooves each have a groove length, a groove width, and a cross-sectional shape that is constant over the groove length and is freely selectable. Then, the grooved machinable foil is cut into cut sectoins and the cut sections are stacked. The plurality of grooves have a form precision such that, for groove lengths of more than 1000 .mu.m, the groove width has an accuracy of about .+-.1 .mu.m for land widths which equal or exceed about 15 .mu.m. Alternately, the machinable foil may be stretched over a vacuum clamping means comprised of a ground, sintered metal plate positioned on a work table which is movable in two mutually perpendicular directions X and Y and a plurality of grooves cut into the surface of the machinable foil by means of at least one shaping diamond positioned on a cutting spindle and adjustable in a direction Z.
摘要翻译：一种制造精细结构的主体的方法，其包括多个层叠的切割部分的箔片，其中至少一个设置有凹槽。可机加工的箔被卷绕在车床的圆柱形心轴上以与相对的边缘重叠。重叠的边缘通过夹紧装置夹紧到圆柱形心轴的轴向凹槽中，并且通过至少一个定位在可精细调节的进给中的成形金刚石切割成箔的表面的多个凹槽。多个槽各自具有在槽长度上恒定的槽长度，槽宽度和横截面形状，并且可自由选择。然后，将开槽的可机加工的箔切割成切割部分，并且切割部分被堆叠。多个凹槽的形状精度使得对于大于1000μm的凹槽长度，槽宽度对于等于或超过约15μm的平面宽度具有大约+/-1μm的精度。或者，可加工箔可以在真空夹紧装置上拉伸，该真空夹紧装置包括位于工作台上的接地烧结金属板，其可沿两个相互垂直的方向X和Y移动，并且多个槽切割成可加工箔的表面通过至少一个定位在切割主轴上并可在Z方向上调节的成形金刚石。

9. 发明授权

US5253409A Method of manufacturing a plastic article having micro-openings defined therein 失效
标题翻译：制造具有限定在其中的微孔的塑料制品的方法
公开(公告)号：US5253409A
公开(公告)日：1993-10-19
申请号：US964026
申请日：1992-10-21
申请人： Wilhelm Bier , Thomas Schaller , Klaus Schubert
发明人： Wilhelm Bier , Thomas Schaller , Klaus Schubert
IPC分类号： B23P13/02 , B01D39/16 , B23P15/16 , B23P17/04 , B23Q3/08 , B29C33/00 , B29D28/00 , G02B5/18 , B23P17/00
CPC分类号： B23P15/16 , B01D39/16 , B01D39/1692 , B23Q3/08 , B29C33/0033 , G02B5/1847 , Y10T29/4981 , Y10T29/49812
摘要： A method of manufacturing a plastic article having micro-openings defined therein by working a semi-finished plastic structure having microrecesses defined on one side thereof, the method including, in the order recited, providing a semi-finished plastic structure having opposing first and second sides, wherein the first side of the opposing sides has microrecesses defined therein; filling the semi-finished plastic structure to cover the microrecesses with a substance which is hardenable and selectively removable; hardening the substance; machining the surface of the hardened substance to smooth it; clamping the semi-finished plastic structure onto a vacuum tensioning device with the smoothed surface of the hardened substance in contact with the vacuum tensioning device; machining the second side of the opposing sides of the semi-finished plastic structure until the microrecesses of the first side are at least partially exposed thereby defining micro-openings in the structure; and removing the hardened substance selectively from the microrecesses.
摘要翻译：一种制造具有限定在其中具有微孔的塑料制品的方法，其特征在于，通过加工具有限定在其一侧上的微细加工的半成品塑料结构，所述方法包括按所述顺序提供半成品塑料结构，其具有相对的第一和第二侧面，其中相对侧的第一侧具有限定在其中的微孔; 填充半成品塑料结构以用可硬化和可选择性去除的物质覆盖微组织; 硬化物质; 加工硬化物质的表面使其光滑; 将半成品塑料结构夹紧到真空拉紧装置上，使硬化物质的平滑表面与真空张紧装置接触; 加工半成品塑料结构的相对侧面的第二面，直到第一侧面的微观形状至少部分地露出，从而限定结构中的微孔; 并从微量去除选择性地去除硬化物质。

10. 发明授权

US5792653A Substrate for cell structures 失效
标题翻译：基质用于细胞结构
公开(公告)号：US5792653A
公开(公告)日：1998-08-11
申请号：US201183
申请日：1994-01-31
申请人： Karl Friedrich Weibezahn , Gudrun Knedlitschek , Hermann Dertinger , Klaus Schubert , Thomas Schaller , Wilhelm Bier
发明人： Karl Friedrich Weibezahn , Gudrun Knedlitschek , Hermann Dertinger , Klaus Schubert , Thomas Schaller , Wilhelm Bier
IPC分类号： C12M1/00 , B01L3/00 , C12M3/00 , C12M3/06 , C12N5/00 , C12N5/06
CPC分类号： B01L3/5085 , C12M23/34 , C12M25/02 , C12M29/04 , C12N5/0068 , C12N2533/30 , C12N2535/10
摘要： In an apparatus for culturing cells which comprises a plate-like body with a lattice structure having openings separated from one another by sidewalls and a bottom disposed on one side of the lattice structure and having passages permeable for liquids but not for cells so as to form, with the lattice structure, cavities for receiving cells to be grown therein, the cavities have a clear width of between 50 .mu.m and 1000 .mu.m and the bottom consists of a material to which cells placed into the cavities will not easily attach so that the cells grow from the side walls of the cavities causing them to form a three-dimensional cell structure.
摘要翻译：在用于培养细胞的装置中，该装置包括具有格子结构的板状体，该板状体具有通过侧壁彼此分开的开口的平板状体和设置在格子结构的一侧上的底部，并且具有可渗透液体而不是细胞的通道，从而形成具有晶格结构的用于接收细胞的空腔用于生长在其中，空腔具有在50μm和1000μm之间的清晰宽度，并且底部由放置到空腔中的细胞将不容易附着的材料组成，使得细胞从腔的侧壁生长，使得它们形成三维细胞结构。

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