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1. 发明授权

US4245108A Process for preparing 2-thio-2-substituted-alkanoic acid derivatives 失效
标题翻译： 2-硫代-2-取代 - 链烷酸衍生物的制备方法
公开(公告)号：US4245108A
公开(公告)日：1981-01-13
申请号：US934553
申请日：1978-08-17
申请人： Kiyosi Kondo , Daiei Tunemoto , Akira Negishi , Minoru Suda
发明人： Kiyosi Kondo , Daiei Tunemoto , Akira Negishi , Minoru Suda
IPC分类号： C07D333/24 , C07C149/40
CPC分类号： C07D333/24 , C07C323/00
摘要： A process for preparing a 2-thio-2-substituted-alkanoic acid derivative represented by the formula (I) ##STR1## wherein A, R, R.sup.3 and R.sup.4 are as defined hereinafter, which comprises condensing an aldehyde compound of the formula (V)A--CHO (V)wherein A is as defined hereinafter, with a haloform of the formula CHX.sub.3 wherein X is as defined hereinafter and a mercaptan compound of the formula (IV)R.sup.3 SH (IV)wherein R.sup.3 is as defined hereinafter, in the presence of a base to produce a 2-(arylthio or alkylthio)-2-substituted-acetic acid of the formula (III) ##STR2## wherein A and R.sup.3 are as defined hereinafter, and reacting the resulting 2-(arylthio or alkylthio)-2-substituted-acetic acid of the formula (III) with an alkylating agent represented by the formula (II)RZ (II)wherein R and Z are as defined hereinafter, in the presence of at least 2 mols of a base per mol of the 2-(arylthio or alkylthio)-2-substituted-acetic acid, to form the compound of the formula (I) wherein R.sup.4 represents a hydrogen atom and, optionally, converting the resulting compound to the compound of the formula (I) wherein R.sup.4 represents an alkyl group by esterification.
摘要翻译：一种制备由式（I）表示的2-硫代-2-取代的链烷酸衍生物的方法，其中A，R，R 3和R 4如下文所定义，其中包括将式（Ⅴ）A-CHO（Ⅴ）其中A如下文定义，与式CHX 3的卤代甲基，其中X如下文所定义，和式（Ⅳ）的硫醇化合物，其中R 3如下文所定义在碱的存在下，制备式（Ⅲ）的2-（芳硫基或烷硫基）-2-取代的乙酸，其中A和R3如下文所定义，并使所得的2 式（III）的（芳硫基或烷硫基）-2-取代的乙酸与式（II）表示的烷基化剂RZ（II）其中R和Z如下文所定义，在至少2 每摩尔2-（芳硫基或烷硫基）-2-取代 - 乙酸的碱的摩尔数，形成式（I）的化合物，其中R 4表示氢原子，并且任选地将所得化合物转化为其中R 4表示烷基的式（I）化合物。

2. 发明授权

US4268442A Process for preparing aromatic acetic acid 失效
标题翻译：制备芳香乙酸的方法
公开(公告)号：US4268442A
公开(公告)日：1981-05-19
申请号：US93818
申请日：1979-11-13
申请人： Kiyosi Kondo , Tamotsu Fujimoto , Minoru Suda , Daiei Tunemoto
发明人： Kiyosi Kondo , Tamotsu Fujimoto , Minoru Suda , Daiei Tunemoto
IPC分类号： C07C29/38 , C07C51/00 , C07C51/093 , C07C57/30 , C07D207/32 , C07D207/337 , C07D307/54 , C07D317/60 , C07D333/24 , C07C53/132
CPC分类号： C07D207/337 , C07C323/00 , C07C51/093 , C07D317/60 , C07D333/24
摘要： There are disclosed processes for preparing an aromatic acetic acid by the reaction of an aromatic aldehyde with a combination of a trihalomethane and an alkanethiol, and by the reaction of an alcohol derivative (2,2,2-trihalo-1-arylethanol) with an alkanethiol, in the presence of a base in a mixed medium of water and an aprotic polar solvent.
摘要翻译：公开了通过芳族醛与三卤代甲烷和烷硫醇的组合的反应以及醇衍生物（2,2,2-三卤代-1-芳基乙醇）与在碱的存在下在水和非质子极性溶剂的混合介质中。

3. 发明授权

US4238396A 1-Hydrocarbyl-pyrrole-2-acetic acid derivatives and their production 失效
标题翻译： 1-烃基 - 吡咯-2-乙酸衍生物及其制备
公开(公告)号：US4238396A
公开(公告)日：1980-12-09
申请号：US963673
申请日：1978-11-27
申请人： Kiyosi Kondo , Minoru Suda , Daiei Tunemoto
发明人： Kiyosi Kondo , Minoru Suda , Daiei Tunemoto
IPC分类号： C07D207/32 , C07D207/33 , C07D207/337 , C07D207/34
CPC分类号： C07D207/33 , C07D207/337 , C07D207/34
摘要： 5-Cyano-1-hydrocarbylpyrrole-2-acetic acid is converted to 5-acyl-1-hydrocarbylpyrrole-2-acetic acid by reaction with a Grignard reagent followed by hydrolysis. The cyano compound, novel per se, is produced by reacting 1-hydrocarbyl-2-(2',2',2'-trihalo-1'-hydroxyethyl)pyrrole with a cyanating reagent under basic conditions. The latter pyrrole is in turn formed by reacting 1-hydrocarbylpyrrole with trihaloacetaldehyde such as chloral, preferably in the presence of added organic acid catalyst.
摘要翻译： 5-氰基-1-烃基吡咯-2-乙酸通过与格氏试剂反应然后水解转化为5-酰基-1-烃基吡咯-2-乙酸。氰基化合物本身是通过在碱性条件下使1-烃基-2-（2'，2'，2'-三卤代-1'-羟乙基）吡咯与氰化试剂反应制备的。后者的吡咯又通过1-烃基吡咯与三卤代乙醛如氯醛反应形成，优选在加入的有机酸催化剂存在下形成。

4. 发明授权

US3988380A Process for preparing 1,2-disubstituted-trans-olefins 失效
标题翻译： 1,2-二取代 - 反式 - 烯烃的制备方法
公开(公告)号：US3988380A
公开(公告)日：1976-10-26
申请号：US529083
申请日：1974-12-03
申请人： Kiyosi Kondo , Akira Negishi , Daiei Tunemoto
发明人： Kiyosi Kondo , Akira Negishi , Daiei Tunemoto
IPC分类号： C07C1/32 , C07D309/12 , C07F9/40 , C07C29/10
CPC分类号： C07C1/324 , C07D309/12 , C07F9/4015
摘要： A new process for preparing 1,2-disubstituted-trans-olefins selectively by reacting specific 2-alkenyl phosphonic acid derivatives with metal hydrides, and a new process for producing the specific 2-alkenylphosphonic acid derivatives. The 1,2-disubstituted-trans-olefins are useful as precursors for synthesis of insect pheromones.
摘要翻译：通过使特定的2-烯基膦酸衍生物与金属氢化物反应选择性地制备1,2-二取代的 - 反式烯烃的新方法，以及用于制备特定的2-链烯基膦酸衍生物的新方法。 1,2-二取代的 - 反式 - 烯烃可用作合成昆虫信息素的前体。

5. 发明授权

US4163758A 2-Nitroethylcyclopentane compounds and process for preparing the same 失效
标题翻译： 2-硝基乙基环戊烷化合物及其制备方法
公开(公告)号：US4163758A
公开(公告)日：1979-08-07
申请号：US939937
申请日：1978-09-06
申请人： Kiyosi Kondo , Daiei Tunemoto , Teruo Umemoto
发明人： Kiyosi Kondo , Daiei Tunemoto , Teruo Umemoto
IPC分类号： C07C45/51 , C07C45/67 , C07C405/00 , C07C49/46
CPC分类号： C07C405/0041 , C07C45/511 , C07C45/673 , Y02P20/55
摘要： 2-Nitroethylcyclopentane compounds represented by the formula (I) ##STR1## wherein X represents a ##STR2## R and R.sup.1 each represents a hydrogen atom or a protective group for a hydroxy group, R.sup.2 represents an unsubstituted or substituted alkyl group having 1 to 8 carbon atoms and R.sup.5 represents a hydrogen atom or an alkyl group havng 1 to 4 carbon atoms, which are useful as intermediates for the synthesis of prostaglandin compounds, and a process for preparing the 2-nitroethylcyclopentane compounds of the formula (I).
摘要翻译：由式（I）表示的2-硝基乙基环戊烷化合物其中X表示R 1和R 1各自表示氢原子或羟基的保护基，R 2表示未取代或取代的烷基，其具有 1〜8个碳原子，R 5表示氢原子或1〜4个碳原子的烷基，可用作合成前列腺素化合物的中间体，以及制备式（I）的2-硝基乙基环戊烷化合物的方法，。

6. 发明授权

US4169199A Precursors for prostaglandin analogue and process for preparing the same 失效
标题翻译：前列腺素类似物的前体及其制备方法
公开(公告)号：US4169199A
公开(公告)日：1979-09-25
申请号：US862328
申请日：1977-12-20
申请人： Kiyosi Kondo , Daiei Tunemoto , Yuriko Takahatake
发明人： Kiyosi Kondo , Daiei Tunemoto , Yuriko Takahatake
IPC分类号： C07C405/00 , C07D309/10
CPC分类号： C07C405/0033
摘要： Bicyclolactone compounds represented by the formula (I) ##STR1## wherein R.sup.1 represents an alkyl group having 1 to 4 carbon atoms, R.sup.2 represents a substituted or unsubstituted alkyl group having 1 to 8 carbon atoms and R.sup.3 represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms;.gamma.-lactone sulfide or sulfoxide compounds represented by the formula (II) ##STR2## wherein R.sup.2 and R.sup.3 are as defined above, R.sup.4 represents a hydrogen atom or a --COOR.sup.1 group wherein R.sup.1 is as defined above, R.sup.5 represents a hydrogen atom or a --CH.sub.2 --Y--(CH.sub.2).sub.n --COOR.sup.6 group wherein Y represents a --CH.sub.2 CH.sub.2 -- group or a --CH.dbd.CH-- group, R.sup.6 represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms and n is an integer of 0 to 6, R.sup.7 represents an alkyl group having 1 to 4 carbon atoms or an aryl group and m is 0 or 1, useful as precursors for prostaglandin analogues; and process for preparing the same.
摘要翻译：由式（I）表示的双环内酯化合物其中R 1表示具有1至4个碳原子的烷基，R 2表示取代或未取代的碳原子数1〜8的烷基，R 3表示氢原子或具有1至4个碳原子的烷基; （II）表示的γ-LACTON硫化物或硫化物化合物其中R 2和R 3如上所定义，R 4表示氢原子或-COOR 1基团，其中R 1如上所定义，R 5表示氢原子或-CH 2 -Y-（CH 2）n -COOR 6基团，其中Y表示-CH 2 CH 2 - 基或-CH = CH-基，R 6表示氢原子或具有1至4个碳原子的烷基，n为 0〜6的整数，R7表示碳原子数为1〜4的烷基或芳基，m为0或1，可用作前列腺素类似物的前体; 及其制备方法。

7. 发明授权

US4540794A Method for preparing 5-mercapto-1,2,3-thiadiazole salts 失效
标题翻译： 5-巯基-1,2,3-噻二唑盐的制备方法
公开(公告)号：US4540794A
公开(公告)日：1985-09-10
申请号：US532922
申请日：1983-09-16
申请人： Kunikazu Sakai , Daiei Tunemoto , Takeo Kobori , Kiyosi Kondo
发明人： Kunikazu Sakai , Daiei Tunemoto , Takeo Kobori , Kiyosi Kondo
IPC分类号： C07D249/04 , C07D249/06 , C07D285/06
CPC分类号： C07D285/06 , C07D249/04 , C07D249/06
摘要： A method for preparing a 5-mercapto-1,2,3-thiadiazole salt represented by the general formula (I) is disclosed: ##STR1## the method comprises the steps of: providing a sulfonylhydrazone derivative represented by the general formula (II): ##STR2## providing a sulfide represented by the general formula (III):M--S--M' (III)(wherein R is an aryl group, X is a chlorine or bromine atom, M is an alkali metal atom and M' is a hydrogen atom or an alkali metal atom);combining the sulfonylhydrazone derivative represented by the general formula (II) and the sulfide represented by the general formula (III) and allowing a reaction to occur; andobtaining the 5-mercapto-1,2,3-thiadiazole salt represented by the general formula (I).
摘要翻译：公开了制备由通式（I）表示的5-巯基-1,2,3-噻二唑盐的方法：（I）该方法包括以下步骤：提供由通式（I）表示的磺酰腙衍生物（II）：提供由通式（III）表示的硫化物的化合物（II）：MS-M'（III）（其中R是芳基，X是氯或溴原子，M是碱金属原子和M'是氢原子或碱金属原子）; 将由通式（II）表示的磺酰腙衍生物与由通式（III）表示的硫化物组合并进行反应; 得到通式（I）表示的5-巯基-1,2,3-噻二唑盐。

8. 发明授权

US4749407A N-propargyl-N-(2-trifluoromethylbenzoyl)-3-substituted benzenesulfonamide and selective herbicide containing the same as an active ingredient 失效
标题翻译： N-炔丙基-N-（2-三氟甲基苯甲酰基）-3-取代苯磺酰胺和含有其作为活性成分的选择性除草剂
公开(公告)号：US4749407A
公开(公告)日：1988-06-07
申请号：US877380
申请日：1986-06-23
申请人： Daiei Tunemoto , Hideko Sakai , Kiyosi Kondo , Kaoru Mori , Masahiro Watanabe , Takeo Komata , Kenji Motojima
发明人： Daiei Tunemoto , Hideko Sakai , Kiyosi Kondo , Kaoru Mori , Masahiro Watanabe , Takeo Komata , Kenji Motojima
IPC分类号： A01N41/06 , C07C67/00 , C07C301/00 , C07C311/51 , A01N9/16 , C07C143/78
CPC分类号： A01N41/06
摘要： There are disclosed an N-propargyl-N-(2-trifluoromethylbenzoyl)-3-substituted benzenesulfonamide represented by the general formula: ##STR1## wherein R.sup.1 represents a halogen atom, a lower alkyl group, a lower alkoxy group, a perfluoro-lower alkyl group having 1 to 4 carbon atoms, a nitro group, a cyano group, a carboxyl group or a lower alkoxycarbonyl group; and R.sup.2 represents a hydrogen atom, a halogen atom, a lower alkyl group, a perfluoro-lower alkyl group having 1 to 4 carbon atoms, a lower alkoxy group, a nitro group, a cyano group, a carboxyl group or a lower alkoxycarbonyl group, and a selective herbicide containing the same as an active ingredient.
摘要翻译：公开了由以下通式表示的N-炔丙基-N-（2-三氟甲基苯甲酰基）-3-取代的苯磺酰胺：其中R 1表示卤素原子，低级烷基，低级烷氧基，全氟低级具有1至4个碳原子的烷基，硝基，氰基，羧基或低级烷氧基羰基; R 2表示氢原子，卤素原子，低级烷基，碳原子数1〜4的全氟低级烷基，低级烷氧基，硝基，氰基，羧基或低级烷氧基羰基，以及含有与活性成分相同的选择性除草剂。

9. 发明授权

US4212984A Prostaglandin precursors 失效
标题翻译：前列腺素前体
公开(公告)号：US4212984A
公开(公告)日：1980-07-15
申请号：US862329
申请日：1977-12-20
申请人： Kiyosi Kondo , Daiei Tunemoto , Teruo Umemoto
发明人： Kiyosi Kondo , Daiei Tunemoto , Teruo Umemoto
IPC分类号： C07C29/14 , C07C405/00 , C07F7/18 , C07C177/00
CPC分类号： C07C321/00 , C07C405/0033 , C07F7/1856 , Y02P20/55
摘要： 4-Oxy-6-alkenyl-bicyclo[3.1.0]hexan-2-one compounds represented by the formula (I) ##STR1## wherein R represents a hydrogen atom or a protective group for a hydroxy group, R.sup.1 represents an alkyl group having 1 to 4 carbon atoms or an aryl group, R.sup.2 represents a substituted or unsubstituted alkyl group having 1 to 8 carbon atoms and R.sup.3 represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms;4-oxycyclopentanone compounds represented by the formula (II) ##STR2## wherein R, R.sup.2 and R.sup.3 are as defined above, R.sup.4 represents a hydroxymethyl group, a methylene group (.dbd.CH.sub.2) or a --COOR.sup.1 group wherein R.sup.1 is as defined above, and R.sup.5 represents an alkyl group having 1 to 4 carbon atoms or an aryl group, useful as prostaglandin precursors; and processes for preparing the same.
摘要翻译：由式（I）表示的4-氧基-6-烯基 - 双环[3.1.0]己-2-酮化合物其中R表示氢原子或羟基保护基，R 1表示具有1〜4个碳原子的烷基或芳基，R 2表示取代或未取代的碳原子数1〜8的烷基，R 3表示氢原子或碳原子数1〜4的烷基。由式（II）表示的4-羟基环戊酮化合物其中R，R 2和R 3如上所定义，R 4表示羟甲基，亚甲基（= CH 2）或-COOR 1基团，其中R 1为 R5代表具有1-4个碳原子的烷基或芳基，可用作前列腺素前体; 及其制备方法。

10. 发明授权

US4163106A Prostaglandin precursors and processes for preparing the same 失效
标题翻译：前列腺素前体及其制备方法
公开(公告)号：US4163106A
公开(公告)日：1979-07-31
申请号：US772053
申请日：1977-02-25
申请人： Kiyosi Kondo , Daiei Tunemoto
发明人： Kiyosi Kondo , Daiei Tunemoto
IPC分类号： C07C405/00 , C07C177/00 , C07C147/14
CPC分类号： C07C405/0033 , C07C67/00 , C07C2102/18
摘要： 6-Alkenyl-bicyclo[3.1.0]hexanone compounds represented by the formula (I) ##STR1## wherein R.sup.1 represents an alkyl group having 1 to 4 carbon atoms or an aryl group, and R.sup.2 represents a substituted or unsubstituted alkyl group having 1 to 8 carbon atoms;Cyclopentanone compounds represented by the formula (II) ##STR2## wherein R.sup.2 is as defined above, R.sup.3 represents a hydrogen atom or a --COOR.sup.1 group wherein R.sup.1 is as defined above, R.sup.4 represents a hydrogen atom or a --CH.sub.2 --Y--(CH.sub.2).sub.n --COOR.sup.6 wherein Y represents a --CH.sub.2 CH.sub.2 -- group or a --CH.dbd.CH-- group, R.sup.6 represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, and n is an integer of 0 to 6, R.sup.5 represents a --S--R.sup.7 group or a --SO--R.sup.7 group wherein R.sup.7 represents an alkyl group having 1 to 4 carbon atoms or an aryl group, with the proviso that R.sup.3 and R.sup.4 cannot be hydrogen atoms at the same time, useful as prostaglandin precursors; andProcesses for preparing the same.
摘要翻译：由式（I）表示的6-烯基 - 双环[3.1.0]己酮化合物其中R 1表示具有1至4个碳原子的烷基或芳基，R 2表示取代或未取代的烷基具有1至8个碳原子的基团; 式（II）表示的环戊烷酮化合物其中R 2如上所定义，R 3表示氢原子或-COOR 1基团，其中R 1如上所定义，R 4表示氢原子或-CH 2 -Y - （CH 2）n -COOR 6其中Y表示-CH 2 CH 2 - 基或-CH = CH-基，R 6表示氢原子或碳原子数1〜4的烷基，n表示0〜6的整数， R5表示-S-R7基或-SO-R7基，其中R7表示具有1-4个碳原子的烷基或芳基，条件是R3和R4不能同时为氢原子，可用作前列腺素前体; 及其制备方法。

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