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1. 发明授权

US08916226B2 Method of forming hollow tubular drug eluting medical devices 有权
标题翻译：形成中空管状药物洗脱医疗器械的方法
公开(公告)号：US08916226B2
公开(公告)日：2014-12-23
申请号：US14038300
申请日：2013-09-26
申请人： Kevin Mauch , Sean Ward , Aram Jamous
发明人： Kevin Mauch , Sean Ward , Aram Jamous
IPC分类号： B23P13/04 , A61F2/06 , A61L33/00 , A61M31/00 , A61F2/88 , A61L31/16
CPC分类号： A61M31/002 , A61F2/88 , A61F2220/0041 , A61F2220/005 , A61F2220/0058 , A61F2220/0075 , A61F2240/001 , A61F2250/0068 , A61L31/16 , Y10T29/49995
摘要： A method of a forming a hollow, drug-eluting medical device includes utilizing a hollow wire having an outer member and a lumen of the outer member, and filling the lumen with a fluid to form a supported hollow wire. The supported hollow wire is shaped into a stent pattern. Openings are formed through the outer member. The supported hollow wire is processed to remove the fluid from the lumen of the outer member without adversely affecting the outer member, leaving the hollow wire shaped into a stent pattern. The lumen is filled with a biologically or pharmacologically active substance.
摘要翻译：形成中空的药物洗脱医疗装置的方法包括利用具有外部构件的外部构件和内腔的中空丝，并且用流体填充内腔以形成支撑的中空丝。支撑的中空丝被成形为支架图案。开口通过外部构件形成。处理支撑的中空丝线以从外部构件的内腔中除去流体，而不会对外部构件产生不利影响，从而将空心线材成形为支架图案。管腔充满生物或药理活性物质。

2. 发明申请

US20140091057A1 Method of Forming Hollow Tubular Drug Eluting Medical Devices 有权
标题翻译：形成空心管状药物洗脱医疗器械的方法
公开(公告)号：US20140091057A1
公开(公告)日：2014-04-03
申请号：US14038300
申请日：2013-09-26
申请人： Kevin Mauch , Sean Ward , Aram Jamous
发明人： Kevin Mauch , Sean Ward , Aram Jamous
IPC分类号： A61M31/00
CPC分类号： A61M31/002 , A61F2/88 , A61F2220/0041 , A61F2220/005 , A61F2220/0058 , A61F2220/0075 , A61F2240/001 , A61F2250/0068 , A61L31/16 , Y10T29/49995
摘要： A method of a forming a hollow, drug-eluting medical device includes utilizing a hollow wire having an outer member and a lumen of the outer member, and filling the lumen with a fluid to form a supported hollow wire. The supported hollow wire is shaped into a stent pattern. Openings are formed through the outer member. The supported hollow wire is processed to remove the fluid from the lumen of the outer member without adversely affecting the outer member, leaving the hollow wire shaped into a stent pattern. The lumen is filled with a biologically or pharmacologically active substance.
摘要翻译：形成中空的药物洗脱医疗装置的方法包括利用具有外部构件的外部构件和内腔的中空丝，并且用流体填充内腔以形成支撑的中空丝。支撑的中空丝被成形为支架图案。开口通过外部构件形成。处理支撑的中空丝线以从外部构件的内腔中除去流体，而不会对外部构件产生不利影响，从而将空心线材成形为支架图案。管腔充满生物或药理活性物质。

3. 发明申请

US20110070358A1 Method of forming hollow tubular drug eluting medical devices 审中-公开
标题翻译：形成中空管状药物洗脱医疗器械的方法
公开(公告)号：US20110070358A1
公开(公告)日：2011-03-24
申请号：US12884551
申请日：2010-09-17
申请人： Kevin Mauch , Sean Ward , Aram Jamous
发明人： Kevin Mauch , Sean Ward , Aram Jamous
IPC分类号： B05D7/00 , B21F45/00
CPC分类号： A61M31/002 , A61F2/88 , A61F2220/0041 , A61F2220/005 , A61F2220/0058 , A61F2220/0075 , A61F2240/001 , A61F2250/0068 , A61L31/16 , Y10T29/49995
摘要： A method of a forming a hollow, drug-eluting medical device includes utilizing a hollow wire having an outer member and a lumen of the outer member, and filling the lumen with a fluid to form a supported hollow wire. The supported hollow wire is shaped into a stent pattern. Openings are formed through the outer member. The supported hollow wire is processed to remove the fluid from the lumen of the outer member without adversely affecting the outer member, leaving the hollow wire shaped into a stent pattern. The lumen is filled with a biologically or pharmacologically active substance.
摘要翻译：形成中空的药物洗脱医疗装置的方法包括利用具有外部构件的外部构件和内腔的中空丝，并且用流体填充内腔以形成支撑的中空丝。支撑的中空丝被成形为支架图案。开口通过外部构件形成。处理支撑的中空丝线以从外部构件的内腔中除去流体，而不会对外部构件产生不利影响，从而将空心线材成形为支架图案。管腔充满生物或药理活性物质。

4. 发明申请

US20150230859A1 BI-DIRECTIONAL DEPLOYMENT OF NEUROMODULATION DEVICES AND ASSOCIATED SYSTEMS AND METHODS 审中-公开
标题翻译：神经修复装置和相关系统和方法的双向部署
公开(公告)号：US20150230859A1
公开(公告)日：2015-08-20
申请号：US14183669
申请日：2014-02-19
申请人： Kevin Mauch
发明人： Kevin Mauch
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B2018/00214 , A61B2018/00267 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00791 , A61B2018/00875 , A61B2018/0091 , A61B2018/1435 , A61B2018/1467
摘要： Methods for treating a patient using therapeutic renal neuromodulation and associated devices, systems, and methods are disclosed herein. One aspect of the present technology, for example, is directed to bi-directional control of helical- or spiral-shaped neuromodulation devices. A system can include, for example, a catheter having an elongated shaft and a treatment assembly at a distal portion of the elongated shaft. The catheter can further include a first control member configured to deploy a distal region of the treatment assembly and a second control member configured to deploy a proximal region of the treatment assembly. The proximal and distal regions of the treatment assembly are selectively transformable independent of each other.
摘要翻译：本文公开了使用治疗性肾神经调节和相关联的装置，系统和方法治疗患者的方法。例如，本技术的一个方面涉及螺旋形或螺旋状神经调节装置的双向控制。系统可以包括例如具有细长轴的导管和在细长轴的远侧部分处的治疗组件。导管还可包括构造成展开处理组件的远侧区域的第一控制构件和构造成展开处理组件的近侧区域的第二控制构件。处理组件的近端区域和远端区域彼此独立地选择性地变换。

5. 发明申请

US20120143293A1 CATHETER APPARATUSES HAVING MULTI-ELECTRODE ARRAYS FOR RENAL NEUROMODULATION AND ASSOCIATED SYSTEMS AND METHODS 有权
公开(公告)号：US20120143293A1
公开(公告)日：2012-06-07
申请号：US13281395
申请日：2011-10-25
申请人： Kevin Mauch , Mario Alvarado , Robert Beetel , William Chang , Justin Goshgarian , Leonila Rivera , Sukyoung Shin , Michele Silver , Sina Som , Andrew Wu , Denise Zarins , Juanita Sanchez-Cole , Maria G. Aboytes
发明人： Kevin Mauch , Mario Alvarado , Robert Beetel , William Chang , Justin Goshgarian , Leonila Rivera , Sukyoung Shin , Michele Silver , Sina Som , Andrew Wu , Denise Zarins , Juanita Sanchez-Cole , Maria G. Aboytes
IPC分类号： A61N1/18 , A61F7/12
CPC分类号： A61B18/1492 , A61B2018/00023 , A61B2018/00404 , A61B2018/00434 , A61B2018/00505 , A61B2018/00511 , A61B2018/00577 , A61B2018/1435 , A61B2018/1467 , A61M25/0041 , A61M25/0074 , A61M25/0133 , A61M25/0138 , A61M25/0147
摘要： Catheter apparatuses, systems, and methods for achieving renal neuromodulation by intravascular access are disclosed herein. One aspect of the present technology, for example, is directed to a treatment device having a multi-electrode array configured to be delivered to a renal blood vessel. The array is selectively transformable between a delivery or low-profile state (e.g., a generally straight shape) and a deployed state (e.g., a radially expanded, generally helical shape). The multi-electrode array is sized and shaped so that the electrodes or energy delivery elements contact an interior wall of the renal blood vessel when the array is in the deployed (e.g., helical) state. The electrodes or energy delivery elements are configured for direct and/or indirect application of thermal and/or electrical energy to heat or otherwise electrically modulate neural fibers that contribute to renal function or of vascular structures that feed or perfuse the neural fibers.

6. 发明申请

US20110155149A1 Percutanous Methods for Creating Native Tissue Venous Valves 审中-公开
标题翻译：用于创建本土组织静脉瓣的经皮方法
公开(公告)号：US20110155149A1
公开(公告)日：2011-06-30
申请号：US13041182
申请日：2011-03-04
申请人： Kevin Mauch
发明人： Kevin Mauch
IPC分类号： A61B17/00
CPC分类号： A61F2/2475 , A61F2/958
摘要： Percutaneous methods of forming a venous valve from autologous tissue are disclosed. The methods include percutaneously creating one or two subintimal dissections for forming one or two flaps of intimal tissue. In one method, a puncture element is delivered by a catheter based delivery system to a treatment site where a new venous valve is to be created. The puncture element is deployed to gain access to a subintimal layer of the vein wall. A dilation balloon is than positioned and inflated within the subintimal layer to create a flap and corresponding pocket/sinus in the vein, which than acts as a one-way monocuspid valve in the manner of a native venous valve. In a similar manner, methods of forming new bicuspid venous valves by subintimal dissections are also disclosed.
摘要翻译：公开了从自体组织形成静脉瓣的经皮方法。所述方法包括经皮创建一个或两个内膜消融以形成一个或两个内膜组织瓣。在一种方法中，穿刺元件通过基于导管的递送系统递送到将要创建新的静脉瓣的治疗部位。部分穿刺元件以进入静脉壁的内膜层。扩张气囊不是在内膜层内定位和充气，以在静脉中产生瓣和相应的口袋/窦，其以天然静脉瓣的方式用作单向单瓣阀。以类似的方式，还公开了通过底内夹层形成新的二尖瓣静脉瓣的方法。

7. 发明申请

US20090182361A1 Obstruction Removal System 失效
标题翻译：阻塞移除系统
公开(公告)号：US20090182361A1
公开(公告)日：2009-07-16
申请号：US11972743
申请日：2008-01-11
申请人： Dustin Thompson , D.H. Perkins , Jeremy Johnson , Michele Silver , Kevin Mauch
发明人： Dustin Thompson , D.H. Perkins , Jeremy Johnson , Michele Silver , Kevin Mauch
IPC分类号： A61B17/22
CPC分类号： A61B17/320758 , A61B10/0266 , A61B17/32002 , A61B17/320708 , A61B17/320725 , A61B2010/0225 , A61B2017/00345 , A61B2017/00867 , A61B2017/320008 , A61B2017/320012 , A61B2017/32006 , A61B2017/320064 , A61B2017/320741
摘要： An obstruction removal system for percutaneous removal of clots or obstructions within the vascular system is disclosed. The obstruction removal system includes a multi-lumen catheter with a plurality of circulating capture devices occurring along a drive belt. The plurality of capture devices may be basket-like devices attached to the drive belt, or may be formed by integral coiled or protuberant sections of the drive belt. The circulating capture or interference devices affect removal of the clot or obstruction bit-by-bit through a series of passes.
摘要翻译：公开了一种用于经皮去除血管系统内的血块或障碍物的阻塞去除系统。阻塞移除系统包括具有多个沿传动带发生的循环捕获装置的多腔导管。多个捕获装置可以是连接到驱动带的篮状装置，或者可以由驱动带的一体的卷绕的或突出的部分形成。循环捕获或干扰装置通过一系列通路影响凝块的清除或逐位阻塞。

8. 发明授权

US08177802B2 Apparatus for percutaneously creating native tissue venous valves 有权
标题翻译：用于经皮创建天然组织静脉瓣的装置
公开(公告)号：US08177802B2
公开(公告)日：2012-05-15
申请号：US12335804
申请日：2008-12-16
申请人： Kevin Mauch , Maria Arreguin
发明人： Kevin Mauch , Maria Arreguin
IPC分类号： A61B17/32 , A61B17/22 , A61M29/00 , A61M29/02
CPC分类号： A61B17/320016 , A61B2017/22044 , A61B2017/22048 , A61B2017/22061 , A61B2017/22072 , A61F2/2412 , A61F2/2415 , A61F2/2475 , A61M25/1002 , A61M25/1011 , A61M2025/0034 , A61M2025/0037 , A61M2025/1045 , A61M2025/1047 , A61M2025/1081 , A61M2025/1093
摘要： Percutaneous apparatus for forming a bicuspid venous valve from autologous tissue are disclosed. A multilumen catheter is disclosed that includes a delivery shaft positioned on either side of the balloon. When the balloon is inflated within the vein at a treatment location where a bicuspid valve is to be created, the delivery shafts are pressed into the wall of the vein by the inflated balloon so that exit ports in the delivery shafts are at diametrically opposed locations. The delivery shafts may than be used to deliver puncture elements through the exit ports and into the vessel wall to gain access to a subintimal layer of the vein wall. In this manner, the inventive multilumen catheter aids in making properly positioned flaps of venous tissue for creating a bicuspid venous valve from autologous tissue.
摘要翻译：公开了用于从自体组织形成双尖静脉瓣的经皮装置。公开了一种多腔导管，其包括位于气囊两侧的输送轴。当气囊在要产生二尖瓣的治疗位置在静脉内膨胀时，输送轴通过膨胀的气囊被压入静脉的壁中，使得输送轴中的出口处于直径相对的位置。输送轴可以不用于将穿刺元件通过出口端口输送到血管壁中，以进入静脉壁的内膜层。以这种方式，本发明的多腔导管有助于制造适当定位的静脉组织瓣，用于从自体组织产生二尖瓣静脉瓣。

9. 发明申请

US20120116383A1 CATHETER APPARATUSES HAVING MULTI-ELECTRODE ARRAYS FOR RENAL NEUROMODULATION AND ASSOCIATED SYSTEMS AND METHODS 有权
标题翻译：具有多极电极阵列用于肾神经调节和相关系统和方法的导管装置
公开(公告)号：US20120116383A1
公开(公告)日：2012-05-10
申请号：US13281361
申请日：2011-10-25
申请人： Kevin Mauch , William Chang , Justin Goshgarian , Leonila Rivera , Martin Rothman
发明人： Kevin Mauch , William Chang , Justin Goshgarian , Leonila Rivera , Martin Rothman
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B2018/00023 , A61B2018/00404 , A61B2018/00434 , A61B2018/00505 , A61B2018/00511 , A61B2018/00577 , A61B2018/1435 , A61B2018/1467 , A61M25/0041 , A61M25/0074 , A61M25/0133 , A61M25/0138 , A61M25/0147
摘要： Catheter apparatuses, systems, and methods for achieving renal neuromodulation by intravascular access are disclosed herein. One aspect of the present technology, for example, is directed to a treatment device having a multi-electrode array configured to be delivered to a renal blood vessel. The array is selectively transformable between a delivery or low-profile state (e.g., a generally straight shape) and a deployed state (e.g., a radially expanded, generally helical shape). The multi-electrode array is sized and shaped so that the electrodes or energy delivery elements contact an interior wall of the renal blood vessel when the array is in the deployed (e.g., helical) state. The electrodes or energy delivery elements are configured for direct and/or indirect application of thermal and/or electrical energy to heat or otherwise electrically modulate neural fibers that contribute to renal function or of vascular structures that feed or perfuse the neural fibers.
摘要翻译：本文公开了通过血管内通路实现肾脏神经调节的导管装置，系统和方法。例如，本技术的一个方面涉及具有被配置为输送到肾血管的多电极阵列的治疗装置。阵列可以在传送或低轮廓状态（例如，大致直线形状）和展开状态（例如，径向膨胀，大致螺旋形状）之间选择性地变换。多电极阵列的尺寸和形状使得当阵列处于部署（例如螺旋状态）时，电极或能量递送元件接触肾血管的内壁。电极或能量输送元件构造成用于直接和/或间接施加热和/或电能以加热或以其他方式电调节有助于肾功能的神经纤维或者供给或灌注神经纤维的血管结构。

10. 发明申请

US20110301625A1 Hydrodynamic Thrombectomy Catheter 审中-公开
标题翻译：流体动力学血栓切除术导管
公开(公告)号：US20110301625A1
公开(公告)日：2011-12-08
申请号：US13211419
申请日：2011-08-17
申请人： Kevin Mauch , Maria Arreguin
发明人： Kevin Mauch , Maria Arreguin
IPC分类号： A61B17/22
CPC分类号： A61B17/22 , A61B2017/00539 , A61B2017/22034 , A61B2017/2212 , A61B2017/2215
摘要： A catheter apparatus for removing an obstruction within a body lumen includes an elongate tubular shaft defining a lumen and a flexible membrane that fluidly seals the distal end of the tubular shaft. At least one cutting element or tool is attached to and distally extends from the flexible membrane. An actuating mechanism is operatively connected to a proximal end of the tubular shaft. The actuating mechanism displaces a fluid disposed within the lumen of the tubular shaft in such a manner that the fluid oscillates the flexible membrane and the cutting element attached thereto. Accordingly, the catheter apparatus uses pulsatile fluid flow through the tubular shaft to transmit energy from the driving mechanical at the proximal end of the catheter apparatus to the flexible membrane at the distal end of the catheter apparatus. The transmitted energy causes the cutting element to oscillate and break up a target blood clot.
摘要翻译：用于去除体腔内的梗阻的导管装置包括限定内腔的细长管状轴和流体地密封管状轴的远端的柔性膜。至少一个切割元件或工具附接到柔性膜并且从柔性膜向远侧延伸。致动机构可操作地连接到管状轴的近端。致动机构使配置在管状轴的内腔内的流体以这样的方式移动，使得流体使柔性膜和连接到其上的切割元件摆动。因此，导管装置使用穿过管状轴的脉动流体流将导管装置的近端处的机械驱动能量传导到导管装置的远端处的柔性膜。所传输的能量导致切割元件振荡并破坏目标血块。

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