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1. 发明申请

US20150230859A1 BI-DIRECTIONAL DEPLOYMENT OF NEUROMODULATION DEVICES AND ASSOCIATED SYSTEMS AND METHODS 审中-公开
标题翻译：神经修复装置和相关系统和方法的双向部署
公开(公告)号：US20150230859A1
公开(公告)日：2015-08-20
申请号：US14183669
申请日：2014-02-19
申请人： Kevin Mauch
发明人： Kevin Mauch
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B2018/00214 , A61B2018/00267 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00791 , A61B2018/00875 , A61B2018/0091 , A61B2018/1435 , A61B2018/1467
摘要： Methods for treating a patient using therapeutic renal neuromodulation and associated devices, systems, and methods are disclosed herein. One aspect of the present technology, for example, is directed to bi-directional control of helical- or spiral-shaped neuromodulation devices. A system can include, for example, a catheter having an elongated shaft and a treatment assembly at a distal portion of the elongated shaft. The catheter can further include a first control member configured to deploy a distal region of the treatment assembly and a second control member configured to deploy a proximal region of the treatment assembly. The proximal and distal regions of the treatment assembly are selectively transformable independent of each other.
摘要翻译：本文公开了使用治疗性肾神经调节和相关联的装置，系统和方法治疗患者的方法。例如，本技术的一个方面涉及螺旋形或螺旋状神经调节装置的双向控制。系统可以包括例如具有细长轴的导管和在细长轴的远侧部分处的治疗组件。导管还可包括构造成展开处理组件的远侧区域的第一控制构件和构造成展开处理组件的近侧区域的第二控制构件。处理组件的近端区域和远端区域彼此独立地选择性地变换。

2. 发明申请

US20140091057A1 Method of Forming Hollow Tubular Drug Eluting Medical Devices 有权
标题翻译：形成空心管状药物洗脱医疗器械的方法
公开(公告)号：US20140091057A1
公开(公告)日：2014-04-03
申请号：US14038300
申请日：2013-09-26
申请人： Kevin Mauch , Sean Ward , Aram Jamous
发明人： Kevin Mauch , Sean Ward , Aram Jamous
IPC分类号： A61M31/00
CPC分类号： A61M31/002 , A61F2/88 , A61F2220/0041 , A61F2220/005 , A61F2220/0058 , A61F2220/0075 , A61F2240/001 , A61F2250/0068 , A61L31/16 , Y10T29/49995
摘要： A method of a forming a hollow, drug-eluting medical device includes utilizing a hollow wire having an outer member and a lumen of the outer member, and filling the lumen with a fluid to form a supported hollow wire. The supported hollow wire is shaped into a stent pattern. Openings are formed through the outer member. The supported hollow wire is processed to remove the fluid from the lumen of the outer member without adversely affecting the outer member, leaving the hollow wire shaped into a stent pattern. The lumen is filled with a biologically or pharmacologically active substance.
摘要翻译：形成中空的药物洗脱医疗装置的方法包括利用具有外部构件的外部构件和内腔的中空丝，并且用流体填充内腔以形成支撑的中空丝。支撑的中空丝被成形为支架图案。开口通过外部构件形成。处理支撑的中空丝线以从外部构件的内腔中除去流体，而不会对外部构件产生不利影响，从而将空心线材成形为支架图案。管腔充满生物或药理活性物质。

3. 发明申请

US20120197246A1 ABLATION CATHETER 审中-公开
标题翻译：橡胶导管
公开(公告)号：US20120197246A1
公开(公告)日：2012-08-02
申请号：US13357488
申请日：2012-01-24
申请人： Kevin MAUCH
发明人： Kevin MAUCH
IPC分类号： A61B18/18 , A61B18/14
CPC分类号： A61B18/1492 , A61B2017/00092 , A61B2017/00867 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61B2018/00797 , A61B2018/00815 , A61B2018/00821 , A61B2018/1435
摘要： An ablation catheter system including a radio frequency generator and an elongate catheter having an ablation element at the distal portion thereof The ablation element has at least one electrode electrically connected to the radio frequency generator and a shape memory component formed from a shape memory material. The shape memory component transforms the ablation element between a first straightened delivery configuration and a second deployed configuration. Thermal energy transfer between the electrode and the shape memory component transforms the shape memory component into the deployed configuration and places the electrode of the ablation element into contact with tissue at a treatment site. The transformation temperature of the shape memory material is a temperature above body temperature such that the transformation of the shape memory component is not activated by mere placement within the body but rather is activated by heat transfer from the electrodes.
摘要翻译：消融导管系统，包括射频发生器和在其远端部分具有消融元件的细长导管。消融元件具有电连接到射频发生器的至少一个电极和由形状记忆材料形成的形状记忆部件。形状记忆部件在第一直线传送配置和第二部署配置之间转换消融元件。电极和形状记忆组件之间的热能转移将形状记忆组件转变成展开的构型，并将消融元件的电极与处理部位的组织接触。形状记忆材料的转变温度是高于体温的温度，使得形状记忆组分的转变不仅仅通过放置在体内而被激活，而是通过从电极传热而被激活。

4. 发明申请

US20120143293A1 CATHETER APPARATUSES HAVING MULTI-ELECTRODE ARRAYS FOR RENAL NEUROMODULATION AND ASSOCIATED SYSTEMS AND METHODS 有权
公开(公告)号：US20120143293A1
公开(公告)日：2012-06-07
申请号：US13281395
申请日：2011-10-25
申请人： Kevin Mauch , Mario Alvarado , Robert Beetel , William Chang , Justin Goshgarian , Leonila Rivera , Sukyoung Shin , Michele Silver , Sina Som , Andrew Wu , Denise Zarins , Juanita Sanchez-Cole , Maria G. Aboytes
发明人： Kevin Mauch , Mario Alvarado , Robert Beetel , William Chang , Justin Goshgarian , Leonila Rivera , Sukyoung Shin , Michele Silver , Sina Som , Andrew Wu , Denise Zarins , Juanita Sanchez-Cole , Maria G. Aboytes
IPC分类号： A61N1/18 , A61F7/12
CPC分类号： A61B18/1492 , A61B2018/00023 , A61B2018/00404 , A61B2018/00434 , A61B2018/00505 , A61B2018/00511 , A61B2018/00577 , A61B2018/1435 , A61B2018/1467 , A61M25/0041 , A61M25/0074 , A61M25/0133 , A61M25/0138 , A61M25/0147
摘要： Catheter apparatuses, systems, and methods for achieving renal neuromodulation by intravascular access are disclosed herein. One aspect of the present technology, for example, is directed to a treatment device having a multi-electrode array configured to be delivered to a renal blood vessel. The array is selectively transformable between a delivery or low-profile state (e.g., a generally straight shape) and a deployed state (e.g., a radially expanded, generally helical shape). The multi-electrode array is sized and shaped so that the electrodes or energy delivery elements contact an interior wall of the renal blood vessel when the array is in the deployed (e.g., helical) state. The electrodes or energy delivery elements are configured for direct and/or indirect application of thermal and/or electrical energy to heat or otherwise electrically modulate neural fibers that contribute to renal function or of vascular structures that feed or perfuse the neural fibers.

5. 发明申请

US20110155149A1 Percutanous Methods for Creating Native Tissue Venous Valves 审中-公开
标题翻译：用于创建本土组织静脉瓣的经皮方法
公开(公告)号：US20110155149A1
公开(公告)日：2011-06-30
申请号：US13041182
申请日：2011-03-04
申请人： Kevin Mauch
发明人： Kevin Mauch
IPC分类号： A61B17/00
CPC分类号： A61F2/2475 , A61F2/958
摘要： Percutaneous methods of forming a venous valve from autologous tissue are disclosed. The methods include percutaneously creating one or two subintimal dissections for forming one or two flaps of intimal tissue. In one method, a puncture element is delivered by a catheter based delivery system to a treatment site where a new venous valve is to be created. The puncture element is deployed to gain access to a subintimal layer of the vein wall. A dilation balloon is than positioned and inflated within the subintimal layer to create a flap and corresponding pocket/sinus in the vein, which than acts as a one-way monocuspid valve in the manner of a native venous valve. In a similar manner, methods of forming new bicuspid venous valves by subintimal dissections are also disclosed.
摘要翻译：公开了从自体组织形成静脉瓣的经皮方法。所述方法包括经皮创建一个或两个内膜消融以形成一个或两个内膜组织瓣。在一种方法中，穿刺元件通过基于导管的递送系统递送到将要创建新的静脉瓣的治疗部位。部分穿刺元件以进入静脉壁的内膜层。扩张气囊不是在内膜层内定位和充气，以在静脉中产生瓣和相应的口袋/窦，其以天然静脉瓣的方式用作单向单瓣阀。以类似的方式，还公开了通过底内夹层形成新的二尖瓣静脉瓣的方法。

6. 发明申请

US20090182361A1 Obstruction Removal System 失效
标题翻译：阻塞移除系统
公开(公告)号：US20090182361A1
公开(公告)日：2009-07-16
申请号：US11972743
申请日：2008-01-11
申请人： Dustin Thompson , D.H. Perkins , Jeremy Johnson , Michele Silver , Kevin Mauch
发明人： Dustin Thompson , D.H. Perkins , Jeremy Johnson , Michele Silver , Kevin Mauch
IPC分类号： A61B17/22
CPC分类号： A61B17/320758 , A61B10/0266 , A61B17/32002 , A61B17/320708 , A61B17/320725 , A61B2010/0225 , A61B2017/00345 , A61B2017/00867 , A61B2017/320008 , A61B2017/320012 , A61B2017/32006 , A61B2017/320064 , A61B2017/320741
摘要： An obstruction removal system for percutaneous removal of clots or obstructions within the vascular system is disclosed. The obstruction removal system includes a multi-lumen catheter with a plurality of circulating capture devices occurring along a drive belt. The plurality of capture devices may be basket-like devices attached to the drive belt, or may be formed by integral coiled or protuberant sections of the drive belt. The circulating capture or interference devices affect removal of the clot or obstruction bit-by-bit through a series of passes.
摘要翻译：公开了一种用于经皮去除血管系统内的血块或障碍物的阻塞去除系统。阻塞移除系统包括具有多个沿传动带发生的循环捕获装置的多腔导管。多个捕获装置可以是连接到驱动带的篮状装置，或者可以由驱动带的一体的卷绕的或突出的部分形成。循环捕获或干扰装置通过一系列通路影响凝块的清除或逐位阻塞。

7. 发明授权

US09504572B2 Apparatus and methods for creating a venous valve from autologous tissue 有权
标题翻译：用于从自体组织产生静脉瓣的装置和方法
公开(公告)号：US09504572B2
公开(公告)日：2016-11-29
申请号：US12706904
申请日：2010-02-17
申请人： Kevin Mauch , Melissa Jeffries , Ryan Bienvenu , Maria Arreguin
发明人： Kevin Mauch , Melissa Jeffries , Ryan Bienvenu , Maria Arreguin
IPC分类号： A61F2/24 , A61F2/01 , A61F2/00 , A61B17/12 , A61B17/00
CPC分类号： A61F2/2475 , A61B17/12022 , A61B17/12036 , A61B17/12109 , A61B17/12145 , A61B2017/00783 , A61F2/0036 , A61F2/24 , A61F2/2445 , A61F2002/016 , A61F2220/0016
摘要： An implantable prosthesis for percutaneous placement within a vein that forces opposing portions of the vessel wall of a vein together to create a new valve of autologous vein tissue to be operable to alternate between a valve closed configuration and a valve open configuration. When in a preset closed configuration, the implantable prosthesis pushes or pulls portions of the vessel wall of the vein together to substantially close the vein lumen and prevent retrograde blood flow from backflowing through the new valve in the valve closed configuration. The implantable prosthesis has leg portions that may be pushed apart in response to antegrade blood flow through the vein to allow the new valve to achieve the valve open configuration.
摘要翻译：一种用于经皮放置在静脉内的可植入假体，其将静脉血管壁的相对部分压在一起以产生自动静脉组织的新瓣膜，以可操作以在阀关闭构型和阀打开构型之间交替。当处于预设的闭合配置中时，可植入假体将静脉血管壁的一部分推入或拉出，以基本上关闭静脉腔，并防止逆流血流在阀关闭构型中回流通过新阀。可植入假体具有腿部，其可以响应于穿过静脉的顺行血液流动而被推开，以允许新阀实现阀打开构造。

8. 发明授权

US08292948B2 Apparatus and methods for creating a venous valve from autologous tissue 有权
标题翻译：用于从自体组织产生静脉瓣的装置和方法
公开(公告)号：US08292948B2
公开(公告)日：2012-10-23
申请号：US12706900
申请日：2010-02-17
申请人： Kevin Mauch , Melissa Jeffries , Ryan Bienvenu , Maria Arreguin
发明人： Kevin Mauch , Melissa Jeffries , Ryan Bienvenu , Maria Arreguin
IPC分类号： A61F2/06
CPC分类号： A61F2/2475 , A61B2017/00783 , A61F2/2427 , A61F2/2442
摘要： An implantable prosthesis for percutaneous placement within a vein that forces opposing portions of the vessel wall of a vein together to create a new valve of autologous vein tissue to be operable to alternate between a valve closed configuration and a valve open configuration. When in a preset closed configuration, the implantable prosthesis pushes or pulls portions of the vessel wall of the vein together to substantially close the vein lumen and prevent retrograde blood flow from backflowing through the new valve in the valve closed configuration. The implantable prosthesis has leg portions that may be pushed apart in response to antegrade blood flow through the vein to allow the new valve to achieve the valve open configuration.
摘要翻译：一种用于经皮放置在静脉内的可植入假体，其将静脉血管壁的相对部分压在一起以产生自动静脉组织的新瓣膜，以可操作以在阀关闭构型和阀打开构型之间交替。当处于预设的闭合配置中时，可植入假体将静脉血管壁的一部分推入或拉出，以基本上关闭静脉腔，并防止逆流血流在阀关闭构型中回流通过新阀。可植入假体具有腿部，其可以响应于穿过静脉的顺行血液流动而被推开，以允许新阀实现阀打开构造。

9. 发明授权

US08021380B2 Obstruction removal system 失效
标题翻译：阻塞消除系统
公开(公告)号：US08021380B2
公开(公告)日：2011-09-20
申请号：US11972744
申请日：2008-01-11
申请人： Dustin Thompson , D. H. Perkins , Jeremy Johnson , Michele Silver , Kevin Mauch , Patrick Macaulay
发明人： Dustin Thompson , D. H. Perkins , Jeremy Johnson , Michele Silver , Kevin Mauch , Patrick Macaulay
IPC分类号： A61B17/22
CPC分类号： A61B17/320758 , A61B10/0266 , A61B17/320708 , A61B17/320725 , A61B2010/0225 , A61B2017/00345 , A61B2017/00398 , A61B2017/00867 , A61B2017/320008 , A61B2017/320012 , A61B2017/32006 , A61B2017/320064 , A61B2017/320741
摘要： An obstruction removal system for percutaneous removal of clots or obstructions within the vascular system is disclosed. The obstruction removal system includes a multi-lumen catheter with a plurality of circulating capture devices attached to or integral with a drive belt. The circulating capture or interference devices affect removal of the clot or obstruction bit-by-bit through a series of passes. The obstruction removal system may include one or more drive mechanisms, such as a pulley system and/or a vacuum source and/or a pressurization source, on its proximal end for driving the drive belt and capture devices through the catheter in a circulating manner. The obstruction removal system may also include one or more cleaning mechanisms, such as a vacuum chamber and/or a fluid rinse chamber, for removing the captured clot pieces from the capture devices.
摘要翻译：公开了一种用于经皮去除血管系统内的血块或障碍物的阻塞去除系统。阻塞去除系统包括多腔导管，其具有附接到驱动带或与传动带一体的多个循环捕获装置。循环捕获或干扰装置通过一系列通路影响凝块的清除或逐位阻塞。障碍物移除系统可以在其近端包括一个或多个驱动机构，例如皮带轮系统和/或真空源和/或加压源，用于驱动驱动带并以循环方式通过导管捕获装置。阻塞去除系统还可以包括一个或多个清洁机构，例如真空室和/或流体冲洗室，用于从捕获装置移除捕获的凝块。

10. 发明授权

US08021379B2 Obstruction removal system 失效
标题翻译：阻塞消除系统
公开(公告)号：US08021379B2
公开(公告)日：2011-09-20
申请号：US11972743
申请日：2008-01-11
申请人： Dustin Thompson , D.H. Perkins , Jeeremy Johnson , Michele Silver , Kevin Mauch
发明人： Dustin Thompson , D.H. Perkins , Jeeremy Johnson , Michele Silver , Kevin Mauch
IPC分类号： A61B17/22
CPC分类号： A61B17/320758 , A61B10/0266 , A61B17/32002 , A61B17/320708 , A61B17/320725 , A61B2010/0225 , A61B2017/00345 , A61B2017/00867 , A61B2017/320008 , A61B2017/320012 , A61B2017/32006 , A61B2017/320064 , A61B2017/320741
摘要： An obstruction removal system for percutaneous removal of clots or obstructions within the vascular system is disclosed. The obstruction removal system includes a multi-lumen catheter with a plurality of circulating capture devices occurring along a drive belt. The plurality of capture devices may be basket-like devices attached to the drive belt, or may be formed by integral coiled or protuberant sections of the drive belt. The circulating capture or interference devices affect removal of the clot or obstruction bit-by-bit through a series of passes.
摘要翻译：公开了一种用于经皮去除血管系统内的血块或障碍物的阻塞去除系统。阻塞移除系统包括具有多个沿传动带发生的循环捕获装置的多腔导管。多个捕获装置可以是连接到驱动带的篮状装置，或者可以由驱动带的整体的卷绕或突出部分形成。循环捕获或干扰装置通过一系列通路影响凝块的清除或逐位阻塞。

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