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1. 发明授权

US06838680B2 Multiplexed fluorescent detection in microfluidic devices 有权
标题翻译：微流体装置中多重荧光检测
公开(公告)号：US06838680B2
公开(公告)日：2005-01-04
申请号：US10202298
申请日：2002-07-23
申请人： Kevin Maher , Timothy F. Smith , Torleif O. Bjornson
发明人： Kevin Maher , Timothy F. Smith , Torleif O. Bjornson
IPC分类号： G01N21/64
CPC分类号： G01N21/6452 , G01N21/253 , G01N21/645 , G01N2021/0346 , G01N2021/6439
摘要： An optical detection and orientation device is provided comprising a housing having an excitation light source, an optical element for reflecting the excitation light to an aspherical lens and transmitting light emitted by a fluorophore excited by said excitation light, a focusing lens for focusing the emitted light onto the entry of an optical fiber, which serves as a confocal aperture, and a moveable carrier for accurately moving said housing over a small area in relation to a channel in a microfluidic device. The optical detection and orientation device finds use in detecting fluorophores in the channel during operations involving fluorescent signals.

2. 发明授权

US06614030B2 Multiplexed fluorescent detection in microfluidic devices 有权
公开(公告)号：US06614030B2
公开(公告)日：2003-09-02
申请号：US10147940
申请日：2002-05-15
申请人： Kevin Maher , Timothy F. Smith , Torleif Ove Bjornson
发明人： Kevin Maher , Timothy F. Smith , Torleif Ove Bjornson
IPC分类号： G01N2164
CPC分类号： G01N21/6452 , B01L3/5027 , B01L2200/14 , G01N21/6428 , G01N21/6458 , G01N2021/6419 , G01N2021/6421 , G01N2021/6439 , G01N2021/6478 , G01N2201/101
摘要： An optical detection and orientation device is provided comprising housing having an excitation light source, an optical element for reflecting the excitation light to an aspherical lens and transmitting light emitted by a fluorophore excited by said excitation light, a focussing lens for focusing the emitted light onto the entry of an optical fiber, which serves as a confocal aperture, and means for accurately moving said housing over a small area in relation to a channel in a microfluidic device. The optical detection and orientation device finds use in identifying the center of the channel and detecting fluorophores in the channel during operations involving fluorescent signals.

3. 发明授权

US06399952B1 Multiplexed fluorescent detection in microfluidic devices 有权
标题翻译：微流体装置中多重荧光检测
公开(公告)号：US06399952B1
公开(公告)日：2002-06-04
申请号：US09569963
申请日：2000-05-12
申请人： Kevin Maher , Timothy F. Smith , Torleif Ove Bjornson
发明人： Kevin Maher , Timothy F. Smith , Torleif Ove Bjornson
IPC分类号： G01N2164
CPC分类号： G01N21/6452 , B01L3/5027 , B01L2200/14 , G01N21/6428 , G01N21/6458 , G01N2021/6419 , G01N2021/6421 , G01N2021/6439 , G01N2021/6478 , G01N2201/101
摘要： An optical detection and orientation device is provided comprising housing having an excitation light source, an optical element for reflecting the excitation light to an aspherical lens and transmitting light emitted by a fluorophore excited by said excitation light, a focussing lens for focusing the emitted light onto the entry of an optical fiber, which serves as a confocal aperture, and means for accurately moving said housing over a small area in relation to a channel in a microfluidic device. The optical detection and orientation device finds use in identifying the center of the channel and detecting fluorophores in the channel during operations involving fluorescent signals.
摘要翻译：提供了一种光学检测和取向装置，包括具有激发光源的壳体，用于将激发光反射到非球面透镜并透射由所述激发光激发的荧光团发射的光的光学元件，用于将发射的光聚焦到聚焦透镜用作共焦孔的光纤的进入以及用于相对于微流体装置中的通道在小的区域上精确地移动所述壳体的装置。光学检测和取向装置用于识别通道的中心并且在涉及荧光信号的操作期间检测通道中的荧光团。

4. 发明授权

US06284113B1 Apparatus and method for transferring liquids 有权
标题翻译：液体转移装置及方法
公开(公告)号：US06284113B1
公开(公告)日：2001-09-04
申请号：US09153814
申请日：1998-09-15
申请人： Torleif Ove Bjornson , Timothy F. Smith
发明人： Torleif Ove Bjornson , Timothy F. Smith
IPC分类号： G01N2726
CPC分类号： B01L3/0268 , B01J19/0046 , B01J2219/00317 , B01J2219/00351 , B01J2219/00358 , C40B60/14 , G01N35/1065 , G01N35/1074 , G01N2035/1037
摘要： The present invention concerns devices, apparatus and methods for transferring liquids. One aspect of the present invention is a device comprising a plate having a plurality of transfer elements. Each of the transfer elements comprises an aperture in the plate where the aperture is capable of being electrically activated. The plate has one of more attaching elements for attaching the plate to a multiwell plate to form a sealed system except for the apertures of the transfer elements. Usually, the device is adapted for sealing attachment to a multiwell plate. In a method in accordance with the present invention a quantity of liquid is disposed to a second side of a plate having a plurality of apertures in the plate. The apertures are capable of being electrically activated. The liquid is present in a closed well except for the apertures in the plate. To simultaneously expel liquid from the apertures, the apertures are electrically activated. Also disclosed are kits comprising a device in accordance with the present invention.
摘要翻译：本发明涉及用于转移液体的装置，装置和方法。本发明的一个方面是包括具有多个转移元件的板的装置。每个传送元件包括板中的孔，其中孔能够被电激活。板具有用于将板连接到多孔板以形成除了转移元件的孔之外的密封系统的更多附接元件之一。通常，该装置适于密封附着到多孔板。在根据本发明的方法中，一定量的液体被设置在板的具有多个孔的板的第二面上。孔能够被电活动。除了板中的孔之外，液体存在于封闭的井中。为了同时从孔中排出液体，孔被电激活。还公开了包括根据本发明的装置的试剂盒。

5. 发明申请

US20100196925A1 Methods for Screening Cells and Antibodies 有权
标题翻译：筛选细胞和抗体的方法
公开(公告)号：US20100196925A1
公开(公告)日：2010-08-05
申请号：US12758928
申请日：2010-04-13
申请人： Christine C. Genick , Lance G. Laing , Peter Li , Timothy F. Smith , Lara Madison , William C. Karl , Bo Lin
发明人： Christine C. Genick , Lance G. Laing , Peter Li , Timothy F. Smith , Lara Madison , William C. Karl , Bo Lin
IPC分类号： G01N33/53 , C12Q1/02
CPC分类号： G01N33/543 , B01L3/5085 , C12Q1/6816 , C40B30/04 , C40B30/10 , G01N21/253 , G01N21/255 , G01N21/4788 , G01N21/7743 , G01N33/5026 , G01N33/5029 , G01N33/5032 , G01N33/54366 , G01N33/54373 , G02B5/1809 , Y10S436/805 , Y10S436/809
摘要： The invention provides methods of detecting a change in cell growth patterns, methods of screening many different antibodies in one receptacle, and methods of detecting specific binding of an antibody to a protein or cell, wherein the antibody is in a mixture of many different antibodies.
摘要翻译：本发明提供检测细胞生长模式变化的方法，在一个容器中筛选许多不同抗体的方法，以及检测抗体与蛋白质或细胞的特异性结合的方法，其中所述抗体是许多不同抗体的混合物。

6. 发明申请

US20090282931A1 Simultaneous aspirator and dispenser for multiwell plates and similar devices 失效
标题翻译：用于多孔板和类似装置的同时抽吸器和分配器
公开(公告)号：US20090282931A1
公开(公告)日：2009-11-19
申请号：US12460288
申请日：2009-07-15
申请人： Lance G. Laing , Timothy F. Smith , John Gerstenmeier, III , Gangadhar Jogikalmath
发明人： Lance G. Laing , Timothy F. Smith , John Gerstenmeier, III , Gangadhar Jogikalmath
IPC分类号： G01N1/00
CPC分类号： G01N35/1074 , G01N35/1011
摘要： A method of making a measurement of binding affinity of a sample comprises the steps of: introducing the sample into a well having a bottom formed as a photonic crystal biosensor, wherein a portion of the sample becomes bound to the biosensor; making a measurement of the change in the shift in peak wavelength value as a function of time (kon) from the well as the sample is introduced into the well; simultaneously dispensing the sample to the well and aspirating the sample from the well and measuring the change in the shift in peak wavelength value as a function of time (koff) during the simultaneous dispensing and aspirating, and calculating an equilibrium association constant or an equilibrium dissociation constant for the sample from the values of kon and koff.
摘要翻译：测量样品的结合亲和力的方法包括以下步骤：将样品导入具有形成为光子晶体生物传感器的底部的孔中，其中样品的一部分与生物传感器结合; 在将样品引入到井中时，测量作为时间（kon）的函数的峰值波长值的偏移的变化; 同时将样品分配到孔中并从孔中吸出样品，并测量在同时分配和抽吸期间作为时间（k off）的函数的峰值波长值的偏移的变化，并计算平衡缔合常数或平衡解离从kon和koff的值得到样本的常数。

7. 发明授权

US08551716B2 Methods for screening cells and antibodies 有权
标题翻译：筛选细胞和抗体的方法
公开(公告)号：US08551716B2
公开(公告)日：2013-10-08
申请号：US13527072
申请日：2012-06-19
申请人： Christine C. Genick , Lance G. Laing , Peter Li , Timothy F. Smith , Lara Madison , Bo Lin
发明人： Christine C. Genick , Lance G. Laing , Peter Li , Timothy F. Smith , Lara Madison , Bo Lin
IPC分类号： G01N33/53
CPC分类号： G01N33/543 , B01L3/5085 , C12Q1/6816 , C40B30/04 , C40B30/10 , G01N21/253 , G01N21/255 , G01N21/4788 , G01N21/7743 , G01N33/5026 , G01N33/5029 , G01N33/5032 , G01N33/54366 , G01N33/54373 , G02B5/1809 , Y10S436/805 , Y10S436/809
摘要： The invention provides methods of detecting a change in cell growth patterns, methods of screening many different antibodies in one receptacle, and methods of detecting specific binding of an antibody to a protein or cell, wherein the antibody is in a mixture of many different antibodies.
摘要翻译：本发明提供检测细胞生长模式变化的方法，在一个容器中筛选许多不同抗体的方法，以及检测抗体与蛋白质或细胞的特异性结合的方法，其中所述抗体是许多不同抗体的混合物。

8. 发明申请

US20130130926A1 Methods for Screening Cells and Antibodies 有权
标题翻译：筛选细胞和抗体的方法
公开(公告)号：US20130130926A1
公开(公告)日：2013-05-23
申请号：US13527072
申请日：2012-06-19
申请人： Christine C. Genick , Lance G. Laing , Peter Li , Timothy F. Smith , Lara Madison , William C. Karl , Bo Lin
发明人： Christine C. Genick , Lance G. Laing , Peter Li , Timothy F. Smith , Lara Madison , William C. Karl , Bo Lin
IPC分类号： G01N33/543
CPC分类号： G01N33/543 , B01L3/5085 , C12Q1/6816 , C40B30/04 , C40B30/10 , G01N21/253 , G01N21/255 , G01N21/4788 , G01N21/7743 , G01N33/5026 , G01N33/5029 , G01N33/5032 , G01N33/54366 , G01N33/54373 , G02B5/1809 , Y10S436/805 , Y10S436/809
摘要： The invention provides methods of detecting a change in cell growth patterns, methods of screening many different antibodies in one receptacle, and methods of detecting specific binding of an antibody to a protein or cell, wherein the antibody is in a mixture of many different antibodies.
摘要翻译：本发明提供检测细胞生长模式变化的方法，在一个容器中筛选许多不同抗体的方法，以及检测抗体与蛋白质或细胞的特异性结合的方法，其中所述抗体是许多不同抗体的混合物。

9. 发明授权

US08061220B2 Simultaneous aspirator and dispenser for multiwell plates and similar devices 失效
标题翻译：用于多孔板和类似装置的同时抽吸器和分配器
公开(公告)号：US08061220B2
公开(公告)日：2011-11-22
申请号：US12589446
申请日：2009-10-23
申请人： Lance G. Laing , Timothy F. Smith , John Gerstenmeier, III , Gangadhar Jogikalmath
发明人： Lance G. Laing , Timothy F. Smith , John Gerstenmeier, III , Gangadhar Jogikalmath
IPC分类号： G01N1/00
CPC分类号： G01N35/1074 , G01N35/1011
摘要： A device for simultaneously dispensing a solution containing a sample to a test device and aspirating the sample from the device. In one embodiment the device is hand-held and includes a control mechanism, e.g., button for activating the dispensing and aspiration of the sample. The testing device may take the form of a multi-well plate with a plurality of wells arranged in rows and columns, with the bottom of the wells formed as a photonic crystal biosensor. The device can be configured with dispense and aspirate manifolds and associated dispense and aspirate ports which are positioned in all the wells along a row or column of wells so as to simultaneously aspirate and dispense solution to all the wells in a row or column of the multi-well plate.
摘要翻译：一种用于将含有样品的溶液同时分配到测试装置并从该装置抽吸样品的装置。在一个实施例中，该装置是手持式的并且包括控制机构，例如用于激活样品的分配和抽吸的按钮。测试装置可以采用具有排成行和列的多个孔的多孔板的形式，阱的底部形成为光子晶体生物传感器。该装置可以配置有分配和抽吸歧管以及相关联的分配和抽吸端口，这些端口位于沿着一列或多列井的所有井中，以便同时吸取并将溶液分配给该多层的一列或多列的所有孔 - 板。

10. 发明申请

US20100043571A1 Simultaneous aspirator and dispenser for multiwell plates and similar devices 失效
标题翻译：用于多孔板和类似装置的同时抽吸器和分配器
公开(公告)号：US20100043571A1
公开(公告)日：2010-02-25
申请号：US12589446
申请日：2009-10-23
申请人： Lance G. Laing , Timothy F. Smith , John Gerstenmeier, III , Gangadhar Jogikalmath
发明人： Lance G. Laing , Timothy F. Smith , John Gerstenmeier, III , Gangadhar Jogikalmath
IPC分类号： G01N1/00
CPC分类号： G01N35/1074 , G01N35/1011
摘要： A device for simultaneously dispensing a solution containing a sample to a test device and aspirating the sample from the device. In one embodiment the device is hand-held and includes a control mechanism, e.g., button for activating the dispensing and aspiration of the sample. The testing device may take the form of a multi-well plate with a plurality of wells arranged in rows and columns, with the bottom of the wells formed as a photonic crystal biosensor. The device can be configured with dispense and aspirate manifolds and associated dispense and aspirate ports which are positioned in all the wells along a row or column of wells so as to simultaneously aspirate and dispense solution to all the wells in a row or column of the multi-well plate.
摘要翻译：一种用于将含有样品的溶液同时分配到测试装置并从该装置抽吸样品的装置。在一个实施例中，该装置是手持式的并且包括控制机构，例如用于激活样品的分配和抽吸的按钮。测试装置可以采用具有排成行和列的多个孔的多孔板的形式，阱的底部形成为光子晶体生物传感器。该装置可以配置有分配和抽吸歧管以及相关联的分配和抽吸端口，这些端口位于沿着一列或多列井的所有井中，以便同时吸取并将溶液分配给该多层的一列或多列的所有孔 - 板。

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