专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US07109480B2 Ion source and methods for MALDI mass spectrometry 有权
标题翻译：离子源和MALDI质谱法的方法
公开(公告)号：US07109480B2
公开(公告)日：2006-09-19
申请号：US11065341
申请日：2005-02-23
申请人： Marvin L. Vestal , Kevin M. Hayden , Philip J. Savickas
发明人： Marvin L. Vestal , Kevin M. Hayden , Philip J. Savickas
IPC分类号： H01J49/10 , H01J49/00 , B01D59/44
CPC分类号： H01J49/0418 , H01J49/061 , H01J49/164
摘要： Provided are MALDI ion sources, methods of forming ions and mass analyzer systems. In various embodiments, provided are MALDI ion sources configured to irradiate a sample on a sample surface with a pulse of laser energy at angle within 10 degrees or less of the surface normal, and a first ion optics system configured to extract sample ions in a direction within 5 degrees or less of the surface normal. In various embodiments, MALDI ion sources having substantially coaxial sample irradiation and ion extraction are provided. In various embodiments, methods are provided, which produce sample ions by MALDI and extract sample ions using an accelerating electrical field to form an ion beam, such that, the angle of the trajectory at the exit from the accelerating electrical field of sample ions substantially at the center of the ion beam is substantially independent of sample ion mass.
摘要翻译：提供的是MALDI离子源，形成离子的方法和质量分析仪系统。在各种实施例中，提供了配置成用样品表面上的样品以表面法线的10度或更小的角度的激光能量的脉冲照射的MALDI离子源，以及第一离子光学系统，其被配置为沿着方向在5度以内的表面正常。在各种实施例中，提供具有基本上同轴的样品照射和离子提取的MALDI离子源。在各种实施例中，提供了通过MALDI产生样品离子并使用加速电场提取样品离子以形成离子束的方法，使得在离开加速电场的出口处的轨迹的角度基本上在离子束的中心基本上与样品离子质量无关。

2. 发明授权

US06534764B1 Tandem time-of-flight mass spectrometer with damping in collision cell and method for use 有权
标题翻译：串联飞行时间质谱仪在碰撞池中具有阻尼和使用方法
公开(公告)号：US06534764B1
公开(公告)日：2003-03-18
申请号：US09590878
申请日：2000-06-09
申请人： Anatoli N. Verentchikov , Marvin L. Vestal , Kevin M. Hayden
发明人： Anatoli N. Verentchikov , Marvin L. Vestal , Kevin M. Hayden
IPC分类号： B01D5944
CPC分类号： H01J49/40 , H01J49/004
摘要： A tandem mass spectrometer is disclosed having a collisional damping cell that slows down and adapts an ion beam, from a time-of-flight mass spectrometer (TOF MS) to a second mass spectrometer, preferably an orthogonal TOF MS. The cell provides a substantial damping of the energy of the ions in multiple collisions with a gas. An RF-only quadrupole is used to spatially focus the ion beam in the collision cell. As result, the operation of second mass spectrometer can be decoupled from the rest of the instrument, or in some cases with the energy being sufficiently damped the pulsed nature of the primary ion beam can be partially preserved and used to enhance the sensitivity of the second mass spectrometer. An ion selector passes only stable parent ions of interest, thereby introducing ions into the cell at a well controlled low energy. The ion beam can be injected into the collision cell with or without separation as well as with or without fragmentation. Thus, the results obtained with the second mass spectrometer can be used to control each individual step of the tandem MS, including ion formation in the source, ion focusing, metastable fragmentation in the first time of-flight spectrometer, primary ion selection and fragmentation in the cell as well as provide mass analysis of fragment ions. By using a high repetition rate laser at increased energy levels, the acquisition of data is significantly accelerated and adjustments on each individual step may be conveniently automated. The MS analysis can be also applied to analysis of analytes from continuous ion sources by using an orthogonal pulser in the first TOF MS to modulate the beam followed by spatial focusing of the pulsed beam.
摘要翻译：公开了一种串联质谱仪，其具有从飞行时间质谱仪（TOF MS）到第二质谱仪（优选正交TOF MS）减慢并适应离子束的碰撞阻尼单元。电池在与气体的多次碰撞中提供离子的能量的实质阻尼。仅使用RF的四极杆用于将碰撞室中的离子束空间聚焦。因此，第二质谱仪的操作可以与仪器的其余部分分离，或者在某些情况下，能量被充分阻尼，主离子束的脉冲特性可被部分保留并用于提高第二质谱仪的灵敏度质谱仪离子选择器仅通过感兴趣的稳定的母体离子，从而以良好控制的低能量将离子引入电池。可以将离子束注入到具有或不具有分离的碰撞池中，以及是否具有分段。因此，使用第二质谱仪获得的结果可用于控制串联MS的每个单独步骤，包括源中的离子形成，离子聚焦，第一次飞行时光谱仪中的亚稳碎裂，初级离子选择和碎裂并提供碎片离子的质量分析。通过在增加的能量水平下使用高重复率激光器，数据的采集被显着加速，并且可以方便地自动地对每个单独步骤进行调整。 MS分析还可以应用于通过使用第一TOF MS中的正交脉冲发生器来对来自连续离子源的分析物进行分析，以调制光束，然后进行脉冲束的空间聚焦。

3. 发明授权

US07385186B2 Methods of operating ion optics for mass spectrometry 有权
标题翻译：操作离子光学用于质谱的方法
公开(公告)号：US07385186B2
公开(公告)日：2008-06-10
申请号：US11129661
申请日：2005-05-13
申请人： Kevin M. Hayden , Marvin L. Vestal
发明人： Kevin M. Hayden , Marvin L. Vestal
IPC分类号： B01D59/44 , H01J49/00
CPC分类号： H01J49/06
摘要： In various embodiments, provided are methods for focusing ions for an ion fragmentor, and methods for operating an ion optics assembly. In various embodiments, the present teachings provide methods that substantially maintain the position of the focal point of the an incoming ion beam over a wide range of collision energies, and thereby provide a collimated ion beam for a collision cell over a wide range of energies. In various embodiments, the present teachings provide methods that facilitate decreasing ion transmission losses over a wide range of collision energies.
摘要翻译：在各种实施例中，提供了用于聚焦离子用于离子碎片的方法，以及用于操作离子光学组件的方法。在各种实施例中，本教导提供了在大范围的碰撞能量上基本上保持入射离子束的焦点的位置的方法，从而在宽范围的能量下为碰撞单元提供准直的离子束。在各种实施例中，本教导提供了有助于在宽范围的碰撞能量下减少离子传播损失的方法。

4. 发明授权

US07351959B2 Mass analyzer systems and methods for their operation 有权
标题翻译：质量分析仪系统及其操作方法
公开(公告)号：US07351959B2
公开(公告)日：2008-04-01
申请号：US11129204
申请日：2005-05-13
申请人： Kevin M. Hayden , Marvin L. Vestal , Jennifer M. Campbell
发明人： Kevin M. Hayden , Marvin L. Vestal , Jennifer M. Campbell
IPC分类号： H01J49/16 , H01J49/40
CPC分类号： H01J49/164 , H01J49/004
摘要： The present teachings relate to MALDI-TOF instruments, instrument components, and methods of operation thereof. In various aspects, the MALDI-TOF instrument can serve and be operated as a MS/MS instrument. In various embodiments, provided are MALDI-TOF instruments, and methods of operating one or more components of a MALDI-TOF instrument, that facilitate one or more of increasing sensitivity, increasing resolution, increasing dynamic mass range, increasing sample support throughput, and decreasing operational downtime.
摘要翻译：本教导涉及MALDI-TOF仪器，仪器部件及其操作方法。在各个方面，MALDI-TOF仪器可以作为MS / MS仪器进行操作。在各种实施方案中，提供了MALDI-TOF仪器，以及操作MALDI-TOF仪器的一个或多个组分的方法，其促进增加灵敏度，增加分辨率，增加动态质量范围，增加样品支持产量和降低运行停机

5. 发明授权

US06953928B2 Ion source and methods for MALDI mass spectrometry 有权
公开(公告)号：US06953928B2
公开(公告)日：2005-10-11
申请号：US10700300
申请日：2003-10-31
申请人： Marvin L. Vestal , Kevin M. Hayden , Philip J. Savickas
发明人： Marvin L. Vestal , Kevin M. Hayden , Philip J. Savickas
IPC分类号： H01J27/24 , H01J49/16 , H01J49/40 , B01D59/44 , H01J49/00
CPC分类号： H01J49/0418 , H01J49/061 , H01J49/164
摘要： Provided are MALDI ion sources, methods of forming ions and mass analyzer systems. In various embodiments, provided are MALDI ion sources configured to irradiate a sample on a sample surface with a pulse of laser energy at angle within 10 degrees or less of the surface normal, and a first ion optics system configured to extract sample ions in a direction within 5 degrees or less of the surface normal. In various embodiments, MALDI ion sources having substantially coaxial sample irradiation and ion extraction are provided. In various embodiments, methods are provided, which produce sample ions by MALDI and extract sample ions using an accelerating electrical field to form an ion beam, such that, the angle of the trajectory at the exit from the accelerating electrical field of sample ions substantially at the center of the ion beam is substantially independent of sample ion mass.

6. 发明申请

US20110049350A1 Tandem TOF Mass Spectrometer With Pulsed Accelerator To Reduce Velocity Spread 审中-公开
标题翻译：串联TOF质谱仪与脉冲加速器降低速度传播
公开(公告)号：US20110049350A1
公开(公告)日：2011-03-03
申请号：US12549076
申请日：2009-08-27
申请人： Marvin L. Vestal
发明人： Marvin L. Vestal
IPC分类号： H01J49/40
CPC分类号： H01J49/004 , H01J49/40
摘要： A tandem TOF mass spectrometer includes a pulsed ion source that generates a pulse of precursor ions from a sample to be analyzed. A first pulsed ion accelerator accelerates and refocuses a predetermined group of precursor ions. A first timed ion passes the predetermined group of precursor ions and rejects substantially all other ions. An ion fragmentation chamber fragments at least some of the precursor ions in the predetermined group. A second timed ion selector selects a predetermined range of masses centered on each precursor in the predetermined group and rejects substantially all other ions. A second pulsed ion accelerator accelerates and refocuses the selected precursor ions and fragments thereof. An ion mirror generates a reflected ion beam. An ion detector detects precursor ions and fragments, wherein a flight time from the second pulsed ion accelerator to the ion detector is dependent on a mass-to-charge ratio of the selected precursor ions and fragments thereof and nearly independent of an initial velocity distribution of ions in the pulse of ions.
摘要翻译：串联TOF质谱仪包括脉冲离子源，其从待分析的样品产生前体离子的脉冲。第一脉冲离子加速剂加速和重新聚焦预定组的前体离子。第一定时离子通过预定组的前体离子并且基本上排除所有其它离子。离子破碎室使预定组中的至少一些前体离子碎裂。第二定时离子选择器选择以预定组中的每个前体为中心的预定范围的质量，并且基本上拒绝所有其它离子。第二脉冲离子加速剂加速并重新聚焦所选择的前体离子及其片段。离子镜产生反射离子束。离子检测器检测前体离子和碎片，其中从第二脉冲离子加速器到离子检测器的飞行时间取决于所选择的前体离子及其片段的质荷比，几乎独立于初始速度分布离子脉冲中的离子。

7. 发明申请

US20080078931A1 Systems for interfacing separations with MALDI mass spectrometry 审中-公开
标题翻译：用MALDI质谱联用分离系统
公开(公告)号：US20080078931A1
公开(公告)日：2008-04-03
申请号：US11541467
申请日：2006-09-29
申请人： Marvin L. Vestal , Stephen J. Hattan
发明人： Marvin L. Vestal , Stephen J. Hattan
IPC分类号： H01J49/00
CPC分类号： H01J49/0418 , H01J49/0431
摘要： The present invention is directed to improved systems and components for coupling separations technology with MALDI-TOF mass spectroscopy. Specifically, this invention provides new apparatus configurations and methods for interfacing liquid-phase separations with MALDI mass spectrometry. The present invention exploits and expands the use of the collimated hole structure (CHS) sample plate as an integral component of the interface.
摘要翻译：本发明涉及用于将分离技术与MALDI-TOF质谱联用的改进的系统和组件。具体地说，本发明提供了用于将液相分离与MALDI质谱联用的新的装置配置和方法。本发明利用和扩展了准直孔结构（CHS）样品板作为界面的组成部分的用途。

8. 发明授权

US07351958B2 Ion optics systems 有权
标题翻译：离子光学系统
公开(公告)号：US07351958B2
公开(公告)日：2008-04-01
申请号：US11042592
申请日：2005-01-24
申请人： Marvin L. Vestal
发明人： Marvin L. Vestal
IPC分类号： B01D59/44
CPC分类号： H01J49/405
摘要： In various embodiments, provided are ion optics systems comprising an even number of ion mirrors arranged in pairs such that a trajectory of an ion exiting the ion optics system can be provided that intersects a surface substantially parallel to an image focal surface of the ion optics system at a position that is substantially independent of the kinetic energy the ion had on entering the ion optics system. In various embodiments, provided are ion optics systems comprising an even number of ion mirrors arranged in pairs where the first member and second member of each pair are disposed on opposite sides of a first plane such that the first member of the pair has a position that is substantially mirror-symmetric about the first plane relative to the position of the second member of the pair.
摘要翻译：在各种实施例中，提供了包括成对布置的偶数个离子镜的离子光学系统，使得可以提供离开离子光学系统的离子的轨迹，其与基本上平行于离子光学系统的图像焦点的表面相交在基本上独立于离子在离子光学系统上的动能的位置。在各种实施例中，提供了离子光学系统，其包括偶数排列成对的离子镜，其中每对的第一构件和第二构件设置在第一平面的相对侧上，使得该对的第一构件具有位置，相对于该对的第二构件的位置围绕第一平面基本上镜像对称。

9. 发明授权

US07064319B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US07064319B2
公开(公告)日：2006-06-20
申请号：US10401944
申请日：2003-03-31
申请人： Yuichiro Hashimoto , Izumi Waki , Kiyomi Yoshinari , Yasushi Terui , Tsukasa Shishika , Marvin L. Vestal
发明人： Yuichiro Hashimoto , Izumi Waki , Kiyomi Yoshinari , Yasushi Terui , Tsukasa Shishika , Marvin L. Vestal
IPC分类号： H01J49/42
CPC分类号： H01J49/4205 , H01J49/004 , H01J49/0481 , H01J49/063 , H01J49/40
摘要： A mass spectrometer according to the present invention has an ionization source for generating ions; an ion trap for accumulating the ions; a time-of-flight mass spectrometer for performing mass spectrometry analysis on the ions by use of a flight time; a collision damping chamber disposed between the ion trap and the time-of-flight mass spectrometer and having a plurality of electrodes therein, which produce a multi-pole electric field, wherein a gas is introduced into the collision damping chamber to reduce kinetic energy of the ions ejected from the ion trap; and an ion transmission adjusting mechanism disposed between the ion trap and the collision damping chamber to allow or prevent injection of the ions from the ion trap to the collision damping chamber. The mass spectrometer provides greatly enhanced qualitative and quantitative analysis capabilities, as compared with conventional techniques.
摘要翻译：根据本发明的质谱仪具有用于产生离子的电离源; 用于积聚离子的离子阱; 飞行时间质谱仪，用于通过使用飞行时间对离子进行质谱分析; 设置在离子阱和飞行时间质谱仪之间并且具有多个电极的碰撞阻尼室，其产生多极电场，其中气体被引入到碰撞阻尼室中以降低动能从离子阱排出的离子; 以及设置在所述离子阱和所述碰撞阻尼室之间的离子透射调节机构，以允许或防止离子从所述离子阱向所述碰撞阻尼室注入。与常规技术相比，质谱仪提供了大大提高的定性和定量分析能力。

10. 发明授权

US06770870B2 Tandem time-of-flight mass spectrometer with delayed extraction and method for use 有权
标题翻译：具有延迟提取的串联飞行时间质谱仪和使用方法
公开(公告)号：US06770870B2
公开(公告)日：2004-08-03
申请号：US10023203
申请日：2001-12-17
申请人： Marvin L. Vestal
发明人： Marvin L. Vestal
IPC分类号： B01D5144
CPC分类号： H01J49/061 , H01J49/004 , H01J49/40
摘要： A tandem time-of-flight mass spectrometry including a pulsed ion generator, a timed ion selector in communication with the pulsed ion generator, an ion fragmentor in communication with the ion selector, and an analyzer in communication with the fragmentation chamber. The fragmentation chamber not only produces fragment ions, but also serves as a delayed extraction ion source for the analyzing of the fragment ions by time-of-flight mass spectrometry.
摘要翻译：串联飞行时间质谱法，包括脉冲离子发生器，与脉冲离子发生器连通的定时离子选择器，与离子选择器连通的离子碎片机，以及与碎裂室连通的分析器。破碎室不仅产生碎片离子，而且还用作延迟提取离子源，用于通过飞行时间质谱法分析碎片离子。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式