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    • 3. 发明申请
    • Ion trap time-of-flight mass spectrometer
    • 离子阱飞行时间质谱仪
    • US20080245962A1
    • 2008-10-09
    • US11889264
    • 2007-08-10
    • Hiroshi NakamuraTsukasa ShishikaYasushi TeruiTakuya Saeki
    • Hiroshi NakamuraTsukasa ShishikaYasushi TeruiTakuya Saeki
    • H01J49/26
    • H01J49/42H01J49/401
    • An ion trap time-of-flight mass spectrometer capable of obtaining highly-sensitive mass spectra even on the lower mass number side is realized. The ion trap time-of-flight mass spectrometer includes an ion source that operates at atmospheric pressure, an ion optical system for introducing the ions generated by the ion source into a vacuum chamber and converging the ions introduced into the vacuum chamber, an ion trap part for trapping ions in the vacuum chamber, a multipole part for converging the kinetic energy of the ions discharged from the ion trap, and a time-of-flight mass spectrometry part for measuring the ions discharged from the multipole part. The period of high-voltage pulses generated by an electrode provided in the time-of-flight mass spectrometry part can be changed depending on an ion content introduced into the multipole part.
    • 实现了即使在较低质量数侧也可获得高灵敏度质谱的离子阱飞行时间质谱仪。 离子阱飞行时间质谱仪包括在大气压下工作的离子源,离子光学系统,用于将由离子源产生的离子引入真空室并会聚进入真空室的离子,离子阱 在真空室中捕获离子的部分,用于会聚从离子阱排出的离子的动能的多极部分和用于测量从多极部分排出的离子的飞行时间质谱部分。 通过设置在飞行时间质谱部分中的电极产生的高电压脉冲的周期可以根据引入多极部分的离子含量而改变。
    • 7. 发明申请
    • Ion trap/time-of-flight mass analyzing apparatus and mass analyzing method
    • 离子阱/飞行时间质量分析仪和质量分析方法
    • US20050279926A1
    • 2005-12-22
    • US11149263
    • 2005-06-10
    • Yasushi TeruiToyoharu OkumotoTsukasa ShishikaShinji NagaiMasaru Tomioka
    • Yasushi TeruiToyoharu OkumotoTsukasa ShishikaShinji NagaiMasaru Tomioka
    • G01N27/62B01D59/44H01J49/40H01J49/42
    • H01J49/424H01J49/0009H01J49/0031H01J49/004H01J49/40H01J49/427
    • An “ion trap-TOF/MS” capable of calibrating the observed mass for each of an ion trap and a TOF. In the ion trap-TOF/MS, sample ions having known mass numbers and ionized by an ion source are trapped within an ion trap. Auxiliary AC voltages having a frequency component ω are applied to the end cap electrodes of the ion trap to expel unwanted ions out of the ion trap. A measurement process is carried out by applying DC voltages to the ring electrode and the end cap electrodes to expel an ion remaining within the ion trap, and measuring the mass number of the expelled ion by the time-of-flight mass spectrometer. The measurement process is repeated while changing the frequency component ω, and the ion signal intensity measured by the time-of-flight mass spectrometer is compared with a previously stored threshold, thereby making calibration of the frequency component ω for the ion having the known mass number. Thus, the calibrating of the observed mass can be realized for each of the ion trap and the TOF.
    • 能够校准每个离子阱和TOF的观察质量的“离子阱TOF / MS”。 在离子阱TOF / MS中,已知质量数和离子源电离的样品离子被捕获在离子阱内。 具有频率分量ω的辅助AC电压被施加到离子阱的端盖电极以将不需要的离子排出离子阱。 通过向环形电极和端盖电极施加直流电压以排出留在离子阱内的离子,并且通过飞行时间质谱仪测量排出的离子的质量数来进行测量处理。 在改变频率分量ω时重复测量过程,并将通过飞行时间质谱仪测量的离子信号强度与先前存储的阈值进行比较,从而对具有已知质量的离子进行频率分量ω的校准 数。 因此,可以为每个离子阱和TOF实现观察质量的校准。
    • 9. 发明授权
    • Time-of-flight mass spectrometer
    • 飞行时间质谱仪
    • US07999222B2
    • 2011-08-16
    • US12474992
    • 2009-05-29
    • Tsukasa ShishikaYasushi Terui
    • Tsukasa ShishikaYasushi Terui
    • H01J49/00
    • H01J49/025H01J49/40
    • A time-of-flight mass spectrometer includes a detector and is adapted to measure the time it takes for an accelerated ion to reach the detector and thereby measure the mass of the ion. The time-of-flight mass spectrometer scans a voltage applied to an ion incident side surface of the detector in accordance with a mass to be measured. An electrode is provided between the detector and a space in which an ion flies. The time-of-flight mass spectrometer is capable of measuring ions of a wide range of masses with high detection efficiency by scanning a voltage applied to the electrode.
    • 飞行时间质谱仪包括检测器,并且适于测量加速离子到达检测器所需的时间,从而测量离子的质量。 飞行时间质谱仪根据要测量的质量扫描施加到检测器的离子入射侧表面的电压。 在检测器和离子飞行的空间之间设置电极。 飞行时间质谱仪通过扫描施加到电极的电压,能够以高检测效率测量宽范围的质量离子。
    • 10. 发明申请
    • METHOD AND APPARATUS FOR MASS SPECTROMETRY
    • 用于质谱分析的方法和装置
    • US20110192970A1
    • 2011-08-11
    • US13090009
    • 2011-04-19
    • Fujio OonishiKenichi ShinboRitsuro OrihashiYasushi TeruiTsukasa Shishika
    • Fujio OonishiKenichi ShinboRitsuro OrihashiYasushi TeruiTsukasa Shishika
    • H01J49/40
    • H01J49/0036H01J49/40
    • For the achievement of data transfer time reduction, removal of noise data, and analytical efficiency improvement in an ADC data processing function of a time-of-flight mass spectrometer, the mass spectrometer comprises a data acquisition circuit including: an ND converter; a signal intensity addition memory that stores data of ion signals such as a time range and the number of measurements and performs an addition process; a voltage value frequency addition memory that performs an addition process of frequencies of voltage values of the predetermined time range and the number of measurements and stores addition results; a threshold level computation circuit that computes a predetermined threshold level from the results in the memory; a compression memory that extracts only data exceeding the threshold level from the data in the signal intensity addition memory; and a counter that controls a measurement time for data acquisition and the operation of each circuit.
    • 为了实现数据传输时间的减少,噪声数据的去除以及飞行时间质谱仪的ADC数据处理功能的分析效率改进,质谱仪包括数据采集电路,包括:ND转换器; 信号强度相加存储器,其存储诸如时间范围和测量次数的离子信号的数据,并执行加法处理; 电压值频率相加存储器,其执行预定时间范围的电压值的频率和测量次数的加法处理,并存储加法结果; 阈值电平计算电路,用于根据存储器中的结果计算预定的阈值电平; 压缩存储器,其从信号强度相加存储器中的数据中仅提取超过阈值电平的数据; 以及控制数据采集和每个电路的操作的测量时间的计数器。