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1. 发明授权

US5171905A Olefin dimer products 失效
标题翻译：烯属二聚体产物
公开(公告)号：US5171905A
公开(公告)日：1992-12-15
申请号：US736242
申请日：1991-07-26
申请人： Kevin J. Theriot , Ronald L. Shubkin
发明人： Kevin J. Theriot , Ronald L. Shubkin
IPC分类号： C07C2/20 , C07C9/22 , C10M107/10
CPC分类号： C07C2/20 , C07C9/22 , C10M107/10 , C07C2527/1213 , C07C2531/02 , C10M2205/028 , C10N2240/02 , C10N2240/06 , C10N2240/201 , C10N2240/202 , C10N2240/40 , C10N2240/401 , C10N2240/402 , C10N2240/403 , C10N2240/404 , C10N2240/405 , C10N2240/406 , C10N2240/407 , C10N2240/408 , C10N2240/409 , C10N2270/02
摘要： A 1-octene and/or 1-decene dimer and/or 1-octene/1-decene co-dimer product composition having improved low temperature properties contains less than about 2.5 weight percent of, respectively, the 7-methylpentadecene, 9-methylnonadecene isomers, or 7- and 9-methylheptadecene isomers.
摘要翻译：具有改进的低温性质的1-辛烯和/或1-癸烯二聚体和/或1-辛烯/ 1-癸烯共二聚体产物组合物分别含有小于约7.5重量％的7-甲基十五碳烯，9-甲基十九碳烯异构体或7-和9-甲基十七烯异构体。

2. 发明授权

US5250750A Apparatus and oil compositions containing olefin dimer products 失效
标题翻译：含有烯烃二聚体产物的装置和油组合物
公开(公告)号：US5250750A
公开(公告)日：1993-10-05
申请号：US942016
申请日：1992-09-08
申请人： Ronald L. Shubkin , Kevin J. Theriot
发明人： Ronald L. Shubkin , Kevin J. Theriot
IPC分类号： C07C2/20 , C07C9/22 , C10M107/10 , H01B3/22
CPC分类号： C10M107/10 , C07C2/20 , C07C9/22 , C07C2527/1213 , C07C2531/02 , C10M2205/028 , C10N2240/02 , C10N2240/06 , C10N2240/201 , C10N2240/202 , C10N2240/40 , C10N2240/401 , C10N2240/402 , C10N2240/403 , C10N2240/404 , C10N2240/405 , C10N2240/406 , C10N2240/407 , C10N2240/408 , C10N2240/409 , C10N2270/02
摘要： Heat transfer, lubricating, functional and/or insulating fluid compositions for use in apparatus such as electrical transformers contain up to 25 weight percent of one or more oil additives and a 1-octene and/or 1-decene dimer and/or a 1-octene and 1-decene co-dimer oil having improved low temperature properties which oil contains less than about 2.5 weight percent of, respectively, the 7-methylpentadecene, 9-methylnonadecene and, 7- and 9-methylheptadecene isomers. The dimers can be hydrogenated to provide the saturated counterparts of the isomers.
摘要翻译：用于诸如电力变压器的装置中的热传递，润滑，功能和/或绝缘流体组合物含有至多25重量％的一种或多种油添加剂和1-辛烯和/或1-癸烯二聚体和/ 辛烯和1-癸烯共二聚油具有改善的低温性能，其中油分别含有7-甲基十五碳烯，9-甲基十九碳烯和7-甲基十七碳烯异构体的小于约2.5重量％。二聚体可以被氢化以提供异构体的饱和对应物。

3. 发明授权

US5171918A Apparatus and oil compositions containing olefin dimer products 失效
标题翻译：含有二烯产品的装置和油组合物
公开(公告)号：US5171918A
公开(公告)日：1992-12-15
申请号：US705960
申请日：1991-05-28
申请人： Ronald L. Shubkin , Kevin J. Theriot
发明人： Ronald L. Shubkin , Kevin J. Theriot
IPC分类号： C08F4/12 , C07C2/20 , C07C9/22 , C08F4/06 , C08F10/00 , C10M107/10
CPC分类号： C10M107/10 , C07C2/20 , C07C9/22 , C07C2527/1213 , C07C2531/02 , C10M2205/028 , C10M2205/0285 , C10N2240/02 , C10N2240/06 , C10N2240/201 , C10N2240/202 , C10N2240/40 , C10N2240/401 , C10N2240/402 , C10N2240/403 , C10N2240/404 , C10N2240/405 , C10N2240/406 , C10N2240/407 , C10N2240/408 , C10N2240/409 , C10N2270/02
摘要： Heat transfer, lubricating, functional and/or insulating fluid compositions for use in apparatus such as electrical transformers contain up to 25 weight percent of one or more oil additives and a 1-octene and/or 1-decene dimer and/or a 1-octene and 1-decene co-dimer oil having improved low temperature properties which oil contains less than about 2.5 weight percent of, respectively, the 7-methylpentadecene, 9-methylnonadecene and, 7- and 9-methylheptadecene isomers. The dimers can be hydrogenated to provide the saturated counterparts of the isomers.

4. 发明授权

US5892117A Preparation and uses of N-methylnitrone 失效
标题翻译： N-甲基硝酮的制备与应用
公开(公告)号：US5892117A
公开(公告)日：1999-04-06
申请号：US873606
申请日：1997-06-12
申请人： Kevin J. Theriot
发明人： Kevin J. Theriot
IPC分类号： C07C213/06 , C07C213/08 , C07C215/08 , C07C217/20 , C07C239/10 , C07C291/02 , C07D261/02 , C07C213/00
CPC分类号： C07D261/02 , C07C213/06 , C07C213/08 , C07C239/10 , C07C291/02
摘要： Oxidation of secondary amines with hydrogen peroxide and sodium tungstate is reported to give good yields of nitrones. However, when using dimethylamine in this manner, a considerable amount of N,N-dimethylformamide was produced as a co-product. To more selectively produce N-methylnitrone from dimethylamine, a two-step process is used which comprises (a) mixing together dimethylamine and a peroxidic compound, and subjecting the resultant mixture to reaction conditions effective to form a reaction mixture in which N,N-dimethylhydroxylamine has been formed; and (b) mixing together (i) reaction mixture from (a), (ii) a peroxidic compound, and (iii) a transition metal-containing oxidation catalyst, and subjecting the resultant mixture to reaction conditions effective to form a reaction mixture in which N-methylnitrone has been formed. Highest yields of N-methylnitrone are achieved by conducting step (b) at a pH in the range of 7 to about 12, and at a temperature in the range of about -10.degree. to about 100.degree. C.
摘要翻译：报道了用过氧化氢和钨酸钠氧化仲胺以产生良好的硝酸镍产率。然而，当以这种方式使用二甲胺时，产生大量的N，N-二甲基甲酰胺作为副产物。为了从二甲胺更有选择地生产N-甲基硝酮，使用两步法，其包括（a）将二甲胺和过氧化合物混合在一起，并将所得混合物进行有效形成反应混合物的反应条件，其中N，已形成二甲基羟胺; 和（b）混合（i）来自（a），（ii）过氧化合物的反应混合物和（iii）含过渡金属的氧化催化剂，并将所得混合物进行有效形成反应混合物的反应条件已经形成了N-甲基硝酮。通过在7至约12的pH范围内进行步骤（b），并且在约-10℃至约100℃的温度范围内实现最高的N-甲基硝酮收率。

5. 发明授权

US5792886A Production of racemic 2-(6-methoxy-2-naphthyl) propionic acid of precursors thereof 失效
标题翻译：外消旋的2-（6-甲氧基-2-萘基）丙酸的前体的制备
公开(公告)号：US5792886A
公开(公告)日：1998-08-11
申请号：US780309
申请日：1997-01-08
申请人： Mahmood Sabahi , Kevin J. Theriot , Brian F. Becnel
发明人： Mahmood Sabahi , Kevin J. Theriot , Brian F. Becnel
IPC分类号： B01J31/34 , C07B61/00 , C07C29/58 , C07C37/00 , C07C39/38 , C07C41/09 , C07C41/16 , C07C41/30 , C07C41/40 , C07C41/42 , C07C43/215 , C07C43/225 , C07C51/09 , C07C51/14 , C07C59/64 , C07C59/72 , C07C67/343 , C07C69/734 , C07F3/02 , C07F3/06 , C07C62/06
CPC分类号： C07C41/16 , C07C29/58 , C07C59/64
摘要： In producing (.+-.)-2-(6-methoxy-2-naphthyl)propionic acid or precursor thereof from 2-bromo-6-methoxynaphthalene, use is made of 2-bromo-6-methoxynaphthalene formed by (a) methylating 6-bromo-2-naphthol with methyl chloride in a solvent comprising one or more compounds, RZ, where R is a hydrogen atom or an alkyl group, and Z is --OH or --CN provided that if Z is --CN, R is alkyl, and in the presence of a strong base; and (b) recovering and purifying 2-bromo-6-methoxynaphthalene so formed. Preferably, the 6-bromo-2-naphthol is formed by (1) reacting 1,6-dibromo-2-naphthol with hydrogen, in a solvent comprising (a) organic halide in which the halogen has an atomic number of 35 or less or (b) a mixture of water and such organic halide, and in the presence of catalytically effective amounts of (i) a tungsten carbide-based catalyst, and (ii) phase transfer catalyst; and (2) separating 6-bromo-2-naphthol from the organic halide solvent so that the 6-bromo-2-naphthol is substantially free of halogen-containing impurities before use in the above methylation reaction. This technology makes possible reductions in quantities of co-products formed, eliminates need for use of excess iron and/or dimethyl sulfate as reaction components, and makes possible improvements in plant operating efficiency. Precursors of (.+-.)-2-(6-methoxy-2-naphthyl)propionic acid formed from such 2-bromo-6-methoxynaphthalene are Grignard reagent of 2-bromo-6-methoxynaphthalene, bis(6-methoxy-2-naphthyl)zinc, 6-methoxy-2-naphthylzinc halide, 6-methoxy-2-naphthyllithium, 6-methoxy-2-naphthylcopper(I), bis(6-methoxy-2-naphthyl)cadmium, 6-methoxy-2-naphthylcadmium halide, and 6-methoxy-2-vinylnaphthalene.
摘要翻译：在2-溴-6-甲氧基萘中制备（+/-） - （6-甲氧基-2-萘基）丙酸或其前体时，使用通过（a）甲基化形成的2-溴-6-甲氧基萘 6-溴-2-萘酚与甲基氯在溶剂中的一种或多种化合物RZ，其中R是氢原子或烷基，Z是-OH或-CN，条件是如果Z是-CN，则R是烷基，并在强碱存在下进行。和（b）回收和纯化如此形成的2-溴-6-甲氧基萘。优选地，6-溴-2-萘酚通过以下步骤形成：（1）使1,6-二溴-2-萘酚与氢反应，在包含（a）卤素原子数为35以下的有机卤化物的溶剂中和（b）水和这种有机卤化物的混合物，并且在催化有效量的存在下，（i）碳化钨基催化剂和（ii）相转移催化剂; 和（2）从有机卤化物溶剂中分离出6-溴-2-萘酚，使得6-溴-2-萘酚在上述甲基化反应中使用前基本上不含含卤杂质。该技术可以减少形成的共同产品的数量，消除了使用过量的铁和/或硫酸二甲酯作为反应组分的需要，并且可以提高设备运行效率。由这种2-溴-6-甲氧基萘形成的（+/-） - （6-甲氧基-2-萘基）丙酸的前体是2-溴-6-甲氧基萘的格利雅试剂，双（6-甲氧基-2 - 萘基）锌，6-甲氧基-2-萘基锌卤化物，6-甲氧基-2-萘基锂，6-甲氧基-2-萘基铜（I），双（6-甲氧基-2-萘基）镉，6-甲氧基-2 - 萘基镉卤化物和6-甲氧基-2-乙烯基萘。

6. 发明授权

US5998627A Preparation and uses of hydrocarbylnitrones 失效
标题翻译：烃基硝基酮的制备和用途
公开(公告)号：US5998627A
公开(公告)日：1999-12-07
申请号：US905525
申请日：1997-08-04
申请人： Kevin J. Theriot
发明人： Kevin J. Theriot
IPC分类号： C07C217/26 , C07C291/02 , C07D263/04 , C07C249/00 , C07C249/02
CPC分类号： C07C291/02 , C07C217/26
摘要： Nitrones are produced by reaction of primary amine with aldehyde or ketone, in the presence of a transition metal-containing oxidation catalyst, and a peroxidic compound. The nitrone can then be reacted with a vinylaromatic compound to produce a 2-hydrocarbyl-5-arylisoxazolidine. Both such reactions can be conducted concurrently by including the vinylaromatic compound in the initial reaction mixture. Hydrogenation of the 2-hydrocarbyl-5-arylisoxazolidine, e.g., using hydrogen and a palladium-carbon catalyst, forms an N-hydrocarbyl-3-aryl-3-hydroxypropylamine. Such reactions enable, inter alia, synthesis of the racemic hydrochloride salt of N-methyl-3-phenyl-3-[4-trifluoromethyl)phenoxy]-propylamine, known generically as fluoxetine hydrochloride, a widely used antidepressant.
摘要翻译：硝基酮通过伯胺与醛或酮在含过渡金属的氧化催化剂和过氧化合物的存在下反应制备。然后可以将硝酮与乙烯基芳族化合物反应以产生2-烃基-5-芳基异恶唑烷。两种这样的反应可以通过在初始反应混合物中包括乙烯基芳族化合物同时进行。 2-烃基-5-芳基异恶唑烷的氢化，例如使用氢气和钯 - 碳催化剂，形成N-烃基-3-芳基-3-羟基丙基胺。这样的反应尤其可以合成N-甲基-3-苯基-3- [4-三氟甲基）苯氧基] - 丙胺的外消旋盐酸盐，一般称为盐酸氟西汀，广泛使用的抗抑郁药。

7. 发明授权

US5929297A Olefin oligomerization process 失效
标题翻译：烯烃低聚方法
公开(公告)号：US5929297A
公开(公告)日：1999-07-27
申请号：US936410
申请日：1997-09-25
申请人： Kevin J. Theriot , Robert G. Irwin
发明人： Kevin J. Theriot , Robert G. Irwin
IPC分类号： C07C2/20 , C07C2/04 , C07C2/02
CPC分类号： C07C2/20 , C07C2527/1213 , C07C2531/02
摘要： Alpha-olefin oligomers are produced by oligomering alpha-olefin monomer with a catalyst system comprising boron trifluoride, a protic promoter, and a special type of modifier. The modifier is a compound that satisfies the following criteria: (a) it has at least one moiety in which a carbonyl group is directly bonded to a nitrogen atom which is in turn bonded to two separate carbon atoms, (b) it is devoid of any nitrogen atom other than a nitrogen atom that is either (i) directly bonded to two separate carbon atoms and to a carbonyl group or (ii) is triply bonded to a single carbon atom, and (c) it is devoid of any protonic functional substituent. These modifiers control the oligomer product distribution and provide higher percentages of lower oligomers, especially dimers.
摘要翻译：通过用包含三氟化硼，质子促进剂和特殊类型的改性剂的催化剂体系低聚α-烯烃单体制备α-烯烃低聚物。改性剂是满足以下标准的化合物：（a）至少有一个部分，其中羰基直接键合到氮原子上，氮原子又连接到两个单独的碳原子上，（b）没有（i）直接键合到两个单独的碳原子和羰基的氮原子以外的任何氮原子或（ii）三键键合到单个碳原子上，（c）没有任何质子功能取代基。这些改性剂控制低聚物产物分布并提供较高百分比的低级低聚物，特别是二聚体。

8. 发明授权

US5396013A Olefin oligomerization process 失效
标题翻译：烯烃低聚方法
公开(公告)号：US5396013A
公开(公告)日：1995-03-07
申请号：US90648
申请日：1993-07-12
申请人： Kevin J. Theriot
发明人： Kevin J. Theriot
IPC分类号： B01J31/06 , C07B61/00 , C07C2/20 , C07C2/26 , C07C11/02 , C10G50/00 , C10G50/02 , C07C2/04 , C07C2/02
CPC分类号： C07C2/20 , C07C2527/1213 , C07C2531/02
摘要： A process for making an .alpha.-olefin oligomer comprises contacting a C.sub.6 to C.sub.20 .alpha.-olefin monomer with a catalyst which includes boron trifluoride, a protic promotor and a polyether.
摘要翻译：制备α-烯烃低聚物的方法包括使C 6至C 20α-烯烃单体与包含三氟化硼，质子启动剂和聚醚的催化剂接触。

9. 发明授权

US5917091A Preparation and use of 2-methyl-5-phenylisoxazolidine 失效
标题翻译：制备和使用2-甲基-5-苯基异恶唑烷
公开(公告)号：US5917091A
公开(公告)日：1999-06-29
申请号：US46931
申请日：1998-03-23
申请人： Kevin J. Theriot
发明人： Kevin J. Theriot
IPC分类号： C07D261/02 , C07D261/04 , C07C213/08
CPC分类号： C07D261/02 , C07D261/04
摘要： (a) An alkali metal base (hydroxide, oxide, carbonate, bicarbonate or sesquicarbonate), an acid addition salt of N-methylhydroxylamine, and (iii) water are mixed together to form a reaction mixture in which the acid of the acid addition salt has been neutralized. (b) Reaction mixture from (a) and formaldehyde or formalin are mixed together and the resultant mixture is subjected to reaction conditions that produce a reaction mixture in which N-methylnitrone has been formed. (c) Reaction mixture from (b) and styrene are mixed and the resultant mixture to subjected to reaction conditions that produce a reaction mixture in which 2-methyl-5-phenylisoxazolidine has been formed. Preferably, 2-methyl-5-phenylisoxazolidine formed in (c) is hydrogenated such that N-methyl-3-phenyl-3-hydroxypropylamine is formed, which in turn is reacted with 4-halobenzotrifluoride such that N-methyl-3-phenyl-3-�4-trifluoromethyl)phenoxy!propylamine is formed. Conversion of the N-methyl-3-phenyl-3-�4-trifluoromethyl)phenoxy!propylamine to its racemic hydrochloride salt provides fluoxetine hydrochloride, a widely used antidepressant.
摘要翻译：（a）将碱金属碱（氢氧化物，氧化物，碳酸盐，碳酸氢盐或倍半碳酸盐），N-甲基羟胺的酸加成盐和（iii）水混合在一起形成反应混合物，其中酸加成盐已被中和。（b）将来自（a）和甲醛或福尔马林的反应混合物混合在一起，并将所得混合物进行产生其中形成N-甲基硝酮的反应混合物的反应条件。（c）将来自（b）和苯乙烯的反应混合物混合，并将所得混合物进行产生其中形成2-甲基-5-苯基异恶唑烷的反应混合物的反应条件。优选地，（c）中形成的2-甲基-5-苯基异恶唑烷被氢化，形成N-甲基-3-苯基-3-羟基丙胺，其又与4-卤代三氟甲苯反应，使得N-甲基-3-苯基 -3- [4-三氟甲基]苯氧基]丙胺。将N-甲基-3-苯基-3- [4-三氟甲基]苯氧基]丙胺转化为其外消旋盐酸盐提供氟西汀盐酸盐，广泛使用的抗抑郁药。

10. 发明授权

US5907069A Production of nabumetone or precursors thereof 失效
标题翻译：萘丁酮或其前体的生产
公开(公告)号：US5907069A
公开(公告)日：1999-05-25
申请号：US9510
申请日：1998-01-20
申请人： Brian F. Becnel , Mahmood Sabahi , Kevin J. Theriot
发明人： Brian F. Becnel , Mahmood Sabahi , Kevin J. Theriot
IPC分类号： B01J31/24 , B01J31/34 , C07B61/00 , C07C37/00 , C07C39/38 , C07C41/16 , C07C41/42 , C07C43/225 , C07C45/00 , C07C45/51 , C07C45/62 , C07C45/68 , C07C45/69 , C07C45/74 , C07C47/575 , C07C49/255 , C07C39/14 , C07C41/00 , C07C47/52
CPC分类号： C07C49/255 , C07C37/00 , C07C41/16 , C07C41/34 , C07C41/40 , C07C41/42 , C07C45/004 , C07C45/512 , C07C45/62 , C07C45/68 , C07C45/74 , C07C47/575
摘要： In producing nabumetone or precursor thereof, use is made of 2-bromo-6-methoxynaphthalene formed by (a) methylating 6-bromo-2-naphthol with methyl bromide or methyl chloride, in a halogen-free liquid solvent comprising at least about 40% by weight of one or more compounds of the formula RZ where R is a hydrogen atom or an alkyl group, and Z is a hydroxyl group or a cyanide group with the proviso that if Z is a cyanide group, R is an alkyl group, and in the presence of at least one strong base; and (b) recovering and purifying 2-bromo-6-methoxynaphthalene so formed. The 6-bromo-2-naphthol in turn is preferably formed by reacting 1,6-dibromo-2-naphthol with hydrogen in a halogen-containing liquid solvent comprising at least about 50% by weight of (A) at least one liquid organic halide solvent in which the halogen content has an atomic number of 35 or less or (B) a mixture of water and at least one such liquid organic halide solvent, and in the presence of catalytic amounts of (i) a tungsten carbide-based catalyst, and (ii) at least one phase transfer catalyst, most preferably while purging HBr from the reaction mixture as it is formed. In this way, the quantities of by-products formed in the overall operation are reduced, the need for use of excess iron and/or dimethyl sulfate as reaction components is avoided, and the overall efficiency of plant operation is improved especially when conducted on a large scale.
摘要翻译：在制备萘布酮或其前体时，使用通过（a）在含卤素的液体溶剂中将6-溴-2-萘酚与甲基溴或甲基氯甲基化形成的2-溴-6-甲氧基萘，所述无卤液体溶剂包含至少约40 重量％的一种或多种式RZ化合物，其中R是氢原子或烷基，Z是羟基或氰基，条件是如果Z是氰基，则R是烷基，并且在至少一个强碱的存在下; 和（b）回收和纯化如此形成的2-溴-6-甲氧基萘。优选6-溴-2-萘酚通过在含卤素的液体溶剂中使1,6-二溴-2-萘酚与氢反应形成，该溶剂包含至少约50重量％的（A）至少一种液体有机物卤素溶剂，其中卤素含量为35或更小的原子序数或（B）水和至少一种这样的液体有机卤化物溶剂的混合物，并且在催化量（i）碳化钨基催化剂，和（ii）至少一种相转移催化剂，最优选当其形成时从反应混合物中吹扫HBr。以这种方式，减少了在整个操作中形成的副产物的数量，避免了使用过量的铁和/或硫酸二甲酯作为反应组分的需要，并且特别是当在大规模

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