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1. 发明申请

US20050197312A1 Transcription factor RNA interference reagents and methods of use thereof 审中-公开
标题翻译：转录因子RNA干扰试剂及其使用方法
公开(公告)号：US20050197312A1
公开(公告)日：2005-09-08
申请号：US11070767
申请日：2005-03-02
申请人： Kevin Fitzgerald , Donald Jackson , Qi Guo
发明人： Kevin Fitzgerald , Donald Jackson , Qi Guo
IPC分类号： A61K48/00 , C12N9/00 , C12N15/113 , C12N15/85
CPC分类号： C12N15/1137 , C12N15/113 , C12N2310/14
摘要： The present invention concerns methods and reagents useful in modulating transcription factor gene expression in a variety of applications, including methods of use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to small nucleic acid molecules, such as short interfering nucleic acid (siRNA), short interfering RNA (siRNA), and doublestranded RNA (dsRNA) molecules capable of mediating RNA interference (RNAi) against E2F1, NFkB, CREB-1, and/or CDC2A gene expression, useful in the treatment of cell cycle disorders, inflammatory conditions, reproductive disorders, cancers and any other condition that responds to modulation of E2F1, NFkB, CREB-1, and/or CDC2A expression and/or activity.
摘要翻译：本发明涉及可用于调节多种应用中的转录因子基因表达的方法和试剂，包括在治疗，诊断，靶标验证和基因组发现应用中使用的方法。具体而言，本发明涉及能够介导针对E2F1，NFkB，CREB-1的RNA干扰（RNAi）的短干扰核酸（siRNA），短干扰RNA（siRNA）和双链RNA（dsRNA）分子的小核酸分子， 1和/或CDC2A基因表达，其可用于治疗细胞周期障碍，炎性病症，生殖障碍，癌症以及对E2F1，NFkB，CREB-1和/或CDC2A表达的调节作出响应的任何其它病症和/或活动。

2. 发明申请

US20060234973A1 Transcription factor RNA interference reagents and methods of use thereof 审中-公开
标题翻译：转录因子RNA干扰试剂及其使用方法
公开(公告)号：US20060234973A1
公开(公告)日：2006-10-19
申请号：US11402608
申请日：2006-04-12
申请人： Kevin Fitzgerald , Donald Jackson , Qi Guo
发明人： Kevin Fitzgerald , Donald Jackson , Qi Guo
IPC分类号： A61K48/00 , C12N15/09
CPC分类号： C12N15/113 , C12N2310/14
摘要： The present invention concerns methods and reagents useful in modulating transcription factor gene expression in a variety of applications, including methods of use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), and doublestranded RNA (dsRNA) molecules capable of mediating RNA interference (RNAi) against E2F1 gene expression, useful in the treatment of cell cycle disorders, inflammatory conditions, reproductive disorders, cancers and any other condition that responds to modulation of E2F1 expression and/or activity.
摘要翻译：本发明涉及可用于调节多种应用中的转录因子基因表达的方法和试剂，包括在治疗，诊断，靶标验证和基因组发现应用中使用的方法。具体地，本发明涉及能够介导针对E2F1基因表达的RNA干扰（RNAi）的短核酸（siNA），短干扰RNA（siRNA）和双链RNA（dsRNA）分子的小核酸分子，其可用于治疗细胞周期障碍，炎性病症，生殖障碍，癌症以及任何其它对E2F1表达和/或活性调节作用的病症。

3. 发明申请

US20070259375A1 Biomarkers and Methods for Determining Sensitivity to Epidermal Growth Factor Receptor Modulators in Non-Small Cell Lung Cancer 审中-公开
标题翻译：用于测定非小细胞肺癌中表皮生长因子受体调节剂敏感性的生物标志物和方法
公开(公告)号：US20070259375A1
公开(公告)日：2007-11-08
申请号：US10594211
申请日：2005-03-28
申请人： Shirin Ford , Nancy-Anne Perkins , Donald Jackson , Shirin Ford , Nancy-Anne Perkins , Donald Jackson
发明人： Shirin Ford , Nancy-Anne Perkins , Donald Jackson , Shirin Ford , Nancy-Anne Perkins , Donald Jackson
IPC分类号： G01N33/53
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/158
摘要： EGFR biomarkers useful in a method for identifying a mammal that will respond therapeutically to a method of treating cancer comprising administering an EGFR modulator, wherein the method comprises (a) exposing a biological sample from the mammal to the EGFR modulator and (b) measuring in the biological sample the level of the at least one biomarker, wherein a difference in the level of the at least one biomarker measured in (b) compared to the level of the biomarker in a mammal that has not been exposed to the EGFR modulator indicates that the mammal will respond therapeutically to the method of treating cancer.
摘要翻译： EGFR生物标志物可用于鉴定将对治疗癌症治疗的治疗反应的哺乳动物的方法，其包括施用EGFR调节剂，其中所述方法包括（a）将生物样品从哺乳动物暴露于EGFR调节剂和（b）所述生物样品中所述至少一种生物标志物的水平，其中在（b）中测量的所述至少一种生物标志物的水平与未暴露于EGFR调节剂的哺乳动物中的生物标志物水平相比的差异表明：哺乳动物将对治疗癌症的方法进行治疗反应。

4. 发明申请

US20070264662A1 Polynucleotides encoding human SLAP-2 variants, hSLAP-2v3 and hSLAP-2v4 有权
标题翻译：编码人SLAP-2变体的多核苷酸，hSLAP-2v3和hSLAP-2v4
公开(公告)号：US20070264662A1
公开(公告)日：2007-11-15
申请号：US11789322
申请日：2007-04-24
申请人： Donald Jackson , Stanley Krystek , Donna Bassolino , Rolf-Peter Ryseck , Thomas Nelson , Gena Whitney
发明人： Donald Jackson , Stanley Krystek , Donna Bassolino , Rolf-Peter Ryseck , Thomas Nelson , Gena Whitney
IPC分类号： C12Q1/68 , G01N33/53 , C07H21/04 , C12P21/06 , C12N9/12
CPC分类号： G01N33/6893 , C07K14/47 , G01N33/564 , G01N33/57407 , G01N33/57426 , G01N33/57484 , G01N2800/065 , G01N2800/102 , G01N2800/104 , G01N2800/12 , G01N2800/122 , G01N2800/205 , G01N2800/24 , G01N2800/245
摘要： The invention relates to the identification and cloning of a two novel full-length human SLAP-2 variants and their encoded polypeptides, hSLAP-2v3 and hSLAP-2v4. hSLAP-2v3 and hSLAP-2v4 are members of the SLAP family of adapter proteins and are involved in the negative regulation of intracellular T-cell signal transduction. The invention further relates to the use of these novel hSLAP-2v3 and hSLAP-2v4 polynucleotides and their encoded polypeptides as targets for therapeutic intervention in immunological and inflammatory disorders, autoimmune diseases, pulmonary diseases, proliferative immune disorders, and cancer.
摘要翻译：本发明涉及两种新型全长人SLAP-2变体及其编码多肽hSLAP-2v3和hSLAP-2v4的鉴定和克隆。 hSLAP-2v3和hSLAP-2v4是SLAP家族接头蛋白的成员，并且参与细胞内T细胞信号转导的负调控。本发明还涉及这些新型hSLAP-2v3和hSLAP-2v4多核苷酸及其编码多肽作为免疫学和炎症性疾病，自身免疫疾病，肺部疾病，增殖性免疫病症和癌症中的治疗性干预的靶标的用途。

5. 发明授权

US07239311B2 Global visualization process (GVP) and system for implementing a GVP 失效
标题翻译：全球可视化过程（GVP）和实施GVP的系统
公开(公告)号：US07239311B2
公开(公告)日：2007-07-03
申请号：US10255413
申请日：2002-09-26
申请人： Richard S. Dunn , Walter P. Gatewood, Jr. , Wayne Erchak , Donald Jackson , Christopher S. Allport , Joseph A. Hamilton
发明人： Richard S. Dunn , Walter P. Gatewood, Jr. , Wayne Erchak , Donald Jackson , Christopher S. Allport , Joseph A. Hamilton
IPC分类号： G06T15/00 , G06T17/00
CPC分类号： G06T17/05 , G06T19/003 , G06T2210/36
摘要： A system and process that incorporates hardware and software as elements to be combined with procedures and processes to obtain, format, store, combine, control, display, record, and visualize dynamic scenarios by interacting with accurate, realistic models and actual events within, on, and above a three-dimensional surface to be observed or modeled. One application provides a user-manipulated large-scale dynamic display of systems testing in a real world environment for real time visualization by test personnel. The Global Visualization Process (GVP) system is an integrated software solution for high-performance visualization. GVP software and process is capable of displaying extremely high resolution terrain models and imagery in real time over the entire surface of the planet, as well as a large number of moving entities and their associated graphical models. The system can display imagery at 2 cm/pixel, and infinitely detailed terrain in real time over the whole surface of a planet. All displayed data is referenced to the World Geodetic System 1984 (WGS-84) ellipsoid for true round-earth effects, and can be rendered in correct asymmetric stereo. These features, combined with a network application progamming interface (API), make GVP suitable for flight simulation out-the-window displays, command and control scenarios, and mission review or rehearsal.
摘要翻译：将硬件和软件作为要素组合的系统和过程，与程序和过程相结合，以通过与准确，现实的模型和实际事件进行交互来获取，格式化，存储，组合，控制，显示，记录和可视化动态场景，以及待观察或建模的三维表面以上。一个应用程序提供用户操纵的大规模动态显示在现实世界环境中的系统测试，由测试人员进行实时可视化。全球可视化过程（GVP）系统是用于高性能可视化的集成软件解决方案。 GVP软件和过程能够在地球的整个表面以及大量移动实体及其相关的图形模型上实时显示极高分辨率的地形模型和图像。该系统可以在地球的整个表面上实时显示2厘米/像素的图像和无限细节的地形。所有显示的数据参考世界大地测量系统1984（WGS-84）椭圆体，用于真正的圆球效应，并且可以以正确的非对称立体声渲染。这些功能与网络应用程序编程接口（API）相结合，使GVP适用于飞行模拟窗外显示，命令和控制场景以及任务回顾或排练。

6. 发明申请

US20070105114A1 Biomarkers of cyclin-dependent kinase modulation 审中-公开
标题翻译：细胞周期蛋白依赖性激酶调控的生物标志物
公开(公告)号：US20070105114A1
公开(公告)日：2007-05-10
申请号：US10567867
申请日：2004-07-29
申请人： Martha Li , Brent Rupnow , Kevin Webster , Donald Jackson , Tai Wong
发明人： Martha Li , Brent Rupnow , Kevin Webster , Donald Jackson , Tai Wong
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/485 , C12Q1/6886 , C12Q2600/106 , C12Q2600/16 , G01N2333/4739
摘要： Biomarkers having expression patterns that correlate with a response of cells to treatment with one or more cdk modulating agents, and uses thereof. Also provided are methods for testing or predicting whether a mammal will respond therapeutically to a method of treating cancer that comprises administering an agent that modulates cdk activity.
摘要翻译：具有与细胞对一种或多种cdk调节剂治疗反应相关的表达模式的生物标志物及其用途。还提供了用于测试或预测哺乳动物是否会治疗性治疗癌症的方法的方法，所述方法包括施用调节cdk活性的药剂。

7. 发明申请

US20080095147A1 METHOD AND APPARATUS FOR LOCALIZED VOICE OVER INTERNET PROTOCOL USAGE 有权
标题翻译：通过互联网协议使用本地化语音的方法和装置
公开(公告)号：US20080095147A1
公开(公告)日：2008-04-24
申请号：US11877556
申请日：2007-10-23
申请人： Donald Jackson , Michael Epstein , John Giannandrea , Mark Verber
发明人： Donald Jackson , Michael Epstein , John Giannandrea , Mark Verber
IPC分类号： H04L12/66
CPC分类号： H04M3/4938 , H04M7/1245
摘要： An approach to abstracting the circuit switched nature of the public switched telephone network (PSTN) by using VoIP to provide voice actuated services is disclosed. By carrying a telephone call using VoIP technology for a short distance (frequently within a server room) significant benefits to call handling and capacity management can be obtained. Specifically, a PSTN-to-IP gateway is used to receive (and place) calls over the PSTN and route those calls internally to servers over an IP network in a packet switched format. A number of computer systems can receive and handle the calls in the IP format, including: translating the packets into an audio format suitable for speech recognition and creating suitable packets from computer sound files for transmission back over the PSTN.
摘要翻译：公开了一种通过使用VoIP提供语音驱动服务来抽象公共交换电话网（PSTN）的电路交换特性的方法。通过使用VoIP技术短时间（通常在服务器机房内）进行电话呼叫，可以获得呼叫处理和容量管理的显着优点。具体来说，PSTN到IP网关用于通过PSTN接收（并放置）呼叫，并以数据包交换格式通过IP网络将这些呼叫内部路由到服务器。许多计算机系统可以接收和处理IP格式的呼叫，包括：将分组转换成适合于语音识别的音频格式，并从计算机声音文件创建合适的分组，以便通过PSTN传输。

8. 发明申请

US20060269559A1 Novel human histone deacetylases 有权
公开(公告)号：US20060269559A1
公开(公告)日：2006-11-30
申请号：US11497205
申请日：2006-08-01
申请人： Donald Jackson , Matthew Lorenzi , Ricardo Attar , Marco Gottardis
发明人： Donald Jackson , Matthew Lorenzi , Ricardo Attar , Marco Gottardis
IPC分类号： A61K48/00 , C07H21/04 , C12P21/06 , A61K39/395 , C07K14/82 , C07K16/30
CPC分类号： C12N9/16
摘要： The present invention relates to newly discovered human histone deacetylases (HDACs), also referred to as histone deacetylase-like polypeptides. The polynucleotide sequences and encoded polypeptides of the novel HDACs are encompassed by the invention, as well as vectors comprising these polynucleotides and host cells comprising these vectors. The invention also relates to antibodies that bind to the disclosed HDAC polypeptides, and methods employing these antibodies. Also related are methods of screening for modulators, such as inhibitors or antagonists, or agonists. The invention also relates to diagnostic and therapeutic applications which employ the disclosed HDAC polynucleotides, polypeptides, and antibodies, and HDAC modulators. Such applications can be used with diseases and disorders associated with abnormal cell growth or proliferation, cell differentiation, and cell survival, e.g., neoplastic cell growth, and especially breast and prostate cancers or tumors.

9. 发明申请

US20060014180A1 Human phosphatase RET31, and variants thereof 有权
标题翻译：人磷酸酶RET31及其变体
公开(公告)号：US20060014180A1
公开(公告)日：2006-01-19
申请号：US11143984
申请日：2005-06-02
申请人： Donald Jackson , Chandra Ramanathan , John Feder , Gabe Mintier , Liana Lee , Thomas Nelson , Nathan Siemers , David Bol , Suzanne Suchard , Gary Schieven , Joshua Finger , C. Todderrud , Donna Bassolino , Stanley Krystek , Dana Banas , Patrick McAtee
发明人： Donald Jackson , Chandra Ramanathan , John Feder , Gabe Mintier , Liana Lee , Thomas Nelson , Nathan Siemers , David Bol , Suzanne Suchard , Gary Schieven , Joshua Finger , C. Todderrud , Donna Bassolino , Stanley Krystek , Dana Banas , Patrick McAtee
IPC分类号： C12Q1/68 , C07H21/04 , C12P21/06 , C12N9/16
CPC分类号： G06F19/16 , A61K38/00 , C07K2319/00 , C07K2319/30 , C12N9/16 , C12Q1/6883 , C12Q2600/158 , C12Y301/03048 , G01N33/573 , G01N33/6893 , G01N2333/916 , G01N2500/00 , G01N2500/04 , Y02A90/26
摘要： The present invention provides novel polynucleotides encoding human phosphatase polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel human phosphatase polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly cardiovascular diseases and/or disorders. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译：本发明提供编码人磷酸酶多肽，其片段和同源物的新型多核苷酸。还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。本发明还涉及将这些新型人磷酸酶多肽应用于诊断，治疗和/或预防与这些多肽，特别是心血管疾病和/或病症相关的各种疾病和/或病症的诊断和治疗方法。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

10. 发明申请

US20050130286A1 POLYNUCLEOTIDES ENCODING NOVEL HUMAN PHOSPHATASES 有权
标题翻译：多核苷酸编码新型人类磷酸酶
公开(公告)号：US20050130286A1
公开(公告)日：2005-06-16
申请号：US10029345
申请日：2001-12-20
申请人： Donald Jackson , Chandra Ramanathan , John Feder , Gabe Mintier , Liana Lee , Thomas Nelson , Nathan Siemers , David Bol , Suzanne Suchard , Gary Schieven , Joshua Finger , C. Todderrud , Donna Bassolino , Stanley Krystek , Dana Banas , Patrick McAtee
发明人： Donald Jackson , Chandra Ramanathan , John Feder , Gabe Mintier , Liana Lee , Thomas Nelson , Nathan Siemers , David Bol , Suzanne Suchard , Gary Schieven , Joshua Finger , C. Todderrud , Donna Bassolino , Stanley Krystek , Dana Banas , Patrick McAtee
IPC分类号： A61K38/00 , A61K38/43 , A61K48/00 , A61P1/16 , A61P11/00 , A61P13/12 , A61P15/00 , A61P25/00 , A61P29/00 , A61P35/00 , A61P43/00 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/16 , C12N15/09 , C12N15/55 , C12P21/00 , C12Q1/02 , C12Q1/68 , G01N33/573 , G01N33/68 , G06F19/16 , C07H21/04
CPC分类号： G06F19/16 , A61K38/00 , C07K2319/00 , C07K2319/30 , C12N9/16 , C12Q1/6883 , C12Q2600/158 , C12Y301/03048 , G01N33/573 , G01N33/6893 , G01N2333/916 , G01N2500/00 , G01N2500/04 , Y02A90/26
摘要： The present invention provides novel polynucleotides encoding human phosphatase polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel human phosphatase polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly cardiovascular diseases and/or disorders. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译：本发明提供编码人磷酸酶多肽，其片段和同源物的新型多核苷酸。还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。本发明还涉及将这些新型人磷酸酶多肽应用于诊断，治疗和/或预防与这些多肽，特别是心血管疾病和/或病症相关的各种疾病和/或病症的诊断和治疗方法。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

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