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    • 4. 发明授权
    • Method for limiting the growth of microorganisms using metal-containing compounds
    • 使用含金属化合物限制微生物生长的方法
    • US06248733B1
    • 2001-06-19
    • US09004892
    • 1998-01-09
    • Kevin D. LandgrebeCharles E. ShelburneTerrance P. SmithGregory D. Cuny
    • Kevin D. LandgrebeCharles E. ShelburneTerrance P. SmithGregory D. Cuny
    • C07D22900
    • C07F15/0093A01N55/02A01N59/16A01N59/20
    • This invention relates to the use of compounds having the general structure: wherein: Z1 and Z2 each independently represent an arene nucleus, which has from 5 to 14 ring atoms; G1 and G2 each independently represent a metal ligating group; R represents a hydrogen atom, a halogen atom, an alkyl group, an acylamino group, an alkoxy group, a sulfonamido group, an aryl group, a thiol group, an alkylthio group, an arylthio group, an alkylamino group, an arylamino group, an amino group, an alkoxycarbonyl group, an acyloxy group, a nitro group, a cyano group, an alkylsulfonyl group, an arylsulfonyl group, an alkylsulfoxyl group, an arylsulfoxyl group, an aryloxyl group, a hydroxyl group, a thioamido group, a carbamoyl group, a suffamoyl group, a formyl group, an acyl group, a ureido group, an aryloxycarbonyl group, a silyl group, or a sulfoalkoxy group; L1 represents a nitrogen heterocycle; L2 represents a monodentate or polydentate (e.g., bidentate) ligand; X represents nitrogen or a methine (CH) group; M is a divalent or polyvalent transition metal ion where the coordination number is at least 4; and k, m, and n are whole numbers less than or equal to 3 as antimicrobial agents to inhibit the growth or replication of microorganisms such as viruses, bacteria, and fungi.
    • 本发明涉及具有以下通式结构的化合物的用途:其中:Z 1和Z 2各自独立地表示具有5至14个环原子的芳烃核; G1和G2各自独立地表示金属结合基团; R表示氢原子,卤素原子,烷基,酰氨基,烷氧基,亚磺酰氨基,芳基,硫醇基,烷硫基,芳硫基,烷基氨基,芳基氨基, 氨基,烷氧基羰基,酰氧基,硝基,氰基,烷基磺酰基,芳基磺酰基,烷基亚砜基,芳基亚砜基,芳氧基,羟基,硫代酰氨基,氨基甲酰基 氨基,酰基,脲基,芳氧基羰基,甲硅烷基或磺基烷氧基; L1表示氮杂环; L2表示单齿或多齿(例如双齿)配体; X表示氮或次甲基(CH)基团; M是配位数至少为4的二价或多价过渡金属离子; 和k,m和n是小于或等于3的整数作为抑制微生物如病毒,细菌和真菌的生长或复制的抗微生物剂。