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1. 发明申请

US20060129104A1 Encoding and sensing of syringe information 有权
公开(公告)号：US20060129104A1
公开(公告)日：2006-06-15
申请号：US11254061
申请日：2005-10-19
申请人： Kevin Cowan , Barry Iddon , Michael Yanniello , John Brosovich , Alan Hirschman
发明人： Kevin Cowan , Barry Iddon , Michael Yanniello , John Brosovich , Alan Hirschman
IPC分类号： A61M5/00
CPC分类号： G01D5/12 , A61M5/1452 , A61M5/3129 , A61M2005/3125 , A61M2205/6036 , A61M2205/6063
摘要： A syringe for use with a powered injector to inject a fluid into a patient that includes a length of material adapted to transmit or propagate electromagnetic energy therethrough. The length of material includes at least a first indicator positioned along the length of material. The first indicator is adapted to interact with at least a portion of the energy being propagated through the length of material in a manner that is detectable. The presence (or absence) of the first indicator provides or corresponds to information about the syringe configuration. The indicator(s) of the present invention can, for example, provide information about syringe configuration by the number and/or position thereof. A plurality or set of such syringes can be provided, with the configuration of each such syringe being represented by the presence or absence of indicator(s) of that syringe.

2. 发明申请

US20070106208A1 DELIVERY OF AGENTS TO TISSUE 失效
标题翻译：交付代理组织
公开(公告)号：US20070106208A1
公开(公告)日：2007-05-10
申请号：US11460635
申请日：2006-07-28
申请人： Arthur Uber , Frederick Trombley , Eugene Gelblum , Edward Rhinehart , David Reilly , Page Cedarholm , Kevin Cowan , Mark Trocki , Alan Hirschman
发明人： Arthur Uber , Frederick Trombley , Eugene Gelblum , Edward Rhinehart , David Reilly , Page Cedarholm , Kevin Cowan , Mark Trocki , Alan Hirschman
IPC分类号： A61M31/00 , A01N1/02 , C12M1/12 , C12M1/24 , B65D25/04 , A01N1/00 , C12M3/00 , B65D1/24 , B65D1/36 , B65D57/00 , B65D85/00
CPC分类号： A61J1/1443 , A61J1/1456 , A61J1/1475 , A61M5/142 , A61M5/1723 , A61M5/3145 , A61M31/005 , B01L3/502 , B01L2300/044 , B01L2300/0681 , G06F19/3468
摘要： A system for injecting an injectate into patient includes a first pressurizable container for holding the injectate; a patient interface in fluid connection with the first pressurizable container, the patient interface being adapted to pass the injectate into tissue of the patient; a powered injector in operative connection with the first pressurizable container to pressurize the injectate; a controller system in operative connection with powered injector; and a stereotactic localization frame adapted to be placed in operative connection with the patient interface to assist in controlling localization of the patient interface. A system for processing cells (and/or other injectate components) includes a container and a plunger adapted to be slidably positioned within the container. The system includes at least one inlet port through which a fluid can enter the system and at least one effluent port through which an effluent can exit the system. The plunger section forms a sealing engagement with the inner wall of the container such that rearward motion of the plunger is adapted to draw fluid into the system via the inlet and forward motion of the plunger is adapted to force effluent out of the system via the effluent port.
摘要翻译：用于将注射器注射到患者体内的系统包括用于保持注射器的第一可加压容器; 与所述第一可加压容器流体连接的患者接口，所述患者接口适于将所述注射器通入患者的组织; 动力注射器，其与所述第一可加压容器可操作地连接以对所述注射器加压; 与动力注射器操作连接的控制器系统; 以及适于与病人界面操作连接的立体定向定位框架，以协助控制患者界面的定位。用于处理细胞（和/或其它注射组分）的系统包括适于可滑动地定位在容器内的容器和柱塞。该系统包括至少一个入口，流体可以通过该入口进入系统和至少一个流出物端口，流出物可通过该至少一个出口端口离开系统。柱塞部分形成与容器的内壁的密封接合，使得柱塞的向后运动适于通过入口将流体引入系统，并且柱塞的向前运动适于通过流出物强制流出系统的流出物港口。

3. 发明授权

US07937134B2 Systems for controlling injection and/or imaging procedures 有权
标题翻译：用于控制注射和/或成像过程的系统
公开(公告)号：US07937134B2
公开(公告)日：2011-05-03
申请号：US11752463
申请日：2007-05-23
申请人： Arthur E. Uber , Edward J. Rhinehart , Rosemary Almon-Martin , David M. Griffiths , Francis J. Sciulli , Walter Grumski , Vera Pagano , Karen Zelenski , Alan Hirschman
发明人： Arthur E. Uber , Edward J. Rhinehart , Rosemary Almon-Martin , David M. Griffiths , Francis J. Sciulli , Walter Grumski , Vera Pagano , Karen Zelenski , Alan Hirschman
IPC分类号： A61B6/00
CPC分类号： A61B8/481 , A61B6/481 , A61B6/504 , A61B8/06 , A61M5/007 , A61M5/14546 , A61M5/1723 , A61M2205/581 , A61M2205/80 , G06F19/00 , G06F19/321 , G06F19/3468
摘要： A system for producing a contrast-enhanced medical image of a patient includes a source of a contrast or enhancement medium, a pressurizing unit in fluid connection with the source of contrast or enhancement medium, an energy source operable to apply energy to a region of the patient, an imaging unit providing a visual display of an internal view of the patient based upon a signal resulting from the energy applied to the region of the patient, and a control unit. In an embodiment, the signal is affected by a condition of the contrast or enhancement medium in the patient. To control the procedures, the control unit adjusts the condition of the contrast or enhancement medium in the patient based upon the signal. A communication interface preferably enables information between an injector subsystem and an imaging subsystem.
摘要翻译：用于产生患者的对比度增强的医学图像的系统包括对比度或增强介质的源，与对比度或增强介质源流体连接的加压单元，可操作以将能量施加到所述对比度或增强介质的区域的能量源患者，成像单元，其基于由施加到患者的区域的能量产生的信号以及控制单元提供患者的内部视图的视觉显示。在一个实施例中，该信号受到患者中的对比度或增强介质的状况的影响。为了控制程序，控制单元基于该信号来调整患者的对比度或增强介质的状况。通信接口优选地实现喷射器子系统和成像子系统之间的信息。

4. 发明申请

US20080056920A1 ACTUATORS AND FLUID DELIVERY SYSTEMS USING SUCH ACTUATORS 审中-公开
标题翻译：使用这种执行器的执行器和流体输送系统
公开(公告)号：US20080056920A1
公开(公告)日：2008-03-06
申请号：US11876875
申请日：2007-10-23
申请人： David Griffiths , Amy Pomaybo , Alan Hirschman
发明人： David Griffiths , Amy Pomaybo , Alan Hirschman
IPC分类号： F04B39/08 , A61M5/145
CPC分类号： H01L41/042 , F03G7/065 , F04B43/043 , Y10S310/80
摘要： An actuator includes a non-magnetic, electroactive material that is suitable to impart force upon application of an electric current, a power supply to provide an electric current to the electroactive material and a controller in operative connection with the power supply to control application of electric current to the electroactive material. In one embodiment, the controller is adapted to limit rates at which electric current is applied to or removed from the electroactive material to predefined rates, thereby reducing the potential for high frequency harmonic emissions.
摘要翻译：致动器包括适于在施加电流时施加力的非磁性电活性材料，用于向电活性材料提供电流的电源以及与电源可操作地连接以控制电力的应用的控制器电流至电活性材料。在一个实施例中，控制器适于限制向电活性材料施加电流或从电活性材料移除电流的速率到预定速率，从而降低高频谐波发射的可能性。

5. 发明申请

US20080045834A1 SYSTEM AND METHOD FOR DELIVERING FLUIDS TO A BALLOON CATHETER 审中-公开
标题翻译：将流体输送到气泡导管的系统和方法
公开(公告)号：US20080045834A1
公开(公告)日：2008-02-21
申请号：US11842325
申请日：2007-08-21
申请人： Arthur Uber , Alan Hirschman , Thomas Welch , Rosemary Almon-Martin
发明人： Arthur Uber , Alan Hirschman , Thomas Welch , Rosemary Almon-Martin
IPC分类号： A61B6/00
CPC分类号： A61B8/06 , A61B8/481 , A61M5/007 , A61M5/1723 , A61M2205/581 , A61M2205/80 , G06F19/321 , G06F19/3468 , Y10S128/12 , Y10S128/13
摘要： A fluid delivery system includes a first pressurizing device, a second pressurizing device, a reusable fluid path for delivering fluid to multiple patients and a per-patient disposable fluid path adapted to be connected to the reusable fluid path and operable to deliver fluid media to a balloon catheter in a patient. The reusable fluid path includes a first portion in fluid communication with a first source of fluid medium and a second portion in fluid communication with a second source of fluid medium. The first pressurizing device is associated with the first portion of the reusable fluid path and the second pressurizing device is associated with the second portion of the reusable fluid path. A control unit in communication with the first and second pressurizing devices is adapted to actuate the first and second pressurizing devices to deliver one or both of the fluid media to a balloon on the balloon catheter.
摘要翻译：流体递送系统包括第一加压装置，第二加压装置，用于将流体输送到多个患者的可重复使用的流体路径，以及适于连接到可重复使用的流体路径并且可操作以将流体介质输送到气囊导管在病人身上。可重复使用的流体路径包括与第一流体介质源流体连通的第一部分和与第二流体介质源流体连通的第二部分。第一加压装置与可再利用流体路径的第一部分相关联，第二加压装置与可重复使用流体路径的第二部分相关联。与第一和第二加压装置连通的控制单元适于致动第一和第二加压装置，以将一种或两种流体介质输送到球囊导管上的气球。

6. 发明申请

US20060178628A1 Method for agitating and injecting a multi-component medium 审中-公开
标题翻译：用于搅拌和注入多组分介质的方法
公开(公告)号：US20060178628A1
公开(公告)日：2006-08-10
申请号：US11395552
申请日：2006-03-31
申请人： Frederick Trombley , Arthur Uber , Edward Rhinehart , Rosemary Almon-Martin , Alan Hirschman
发明人： Frederick Trombley , Arthur Uber , Edward Rhinehart , Rosemary Almon-Martin , Alan Hirschman
IPC分类号： A61M37/00
CPC分类号： A61M5/142 , A61M5/007 , A61M5/14546 , A61M5/14566 , A61M5/445 , A61M2205/3673 , B01F9/103 , B01F13/005
摘要： A system for dispensing a medium includes at least a first container to hold the medium, a pressurizing device, such as a pump, in fluid connection with the container for pressurizing the medium, and an agitation mechanism or device to maintain the components of the medium in a mixed state. The container and the pressurizing device can be separate units, as in the case of an bag or bottle in fluid connection with a peristaltic or other type of pump. The container and the pump can also be combined in a single unit, as in the case of a syringe, wherein the syringe barrel of the syringe acts to contain the medium and the syringe plunger pressurizes the medium within the syringe barrel. A method of injecting a multi-component medium includes the step of agitating the medium (for example, as described above) before or during an injection procedure to maintain the components of the medium in a mixed state.
摘要翻译：用于分配介质的系统至少包括用于保持介质的第一容器，与容器流体连接的用于对介质加压的加压装置，例如泵，以及用于维持介质的组分的搅拌机构或装置处于混合状态。容器和加压装置可以是分离的单元，如在与蠕动或其它类型的泵流体连接的袋或瓶的情况下。容器和泵也可以在单个单元中组合，如在注射器的情况下，其中注射器的注射器筒用于容纳介质，并且注射器柱塞对注射器筒内的介质加压。注射多组分培养基的方法包括在注射过程之前或过程中搅拌培养基（例如，如上所述）以将培养基的组分维持在混合状态的步骤。

7. 发明授权

US08160679B2 Methods of coordinating an imaging procedure and an injection procedure 有权
标题翻译：协调成像程序和注射程序的方法
公开(公告)号：US08160679B2
公开(公告)日：2012-04-17
申请号：US12477456
申请日：2009-06-03
申请人： Arthur E. Uber , Edward J. Rhinehart , Rosemary Almon-Martin , David M. Griffiths , Francis J. Sciulli , Walter Grumski , Vera Pagano , Karen Zelenski , Alan Hirschman
发明人： Arthur E. Uber , Edward J. Rhinehart , Rosemary Almon-Martin , David M. Griffiths , Francis J. Sciulli , Walter Grumski , Vera Pagano , Karen Zelenski , Alan Hirschman
IPC分类号： A61B6/00
CPC分类号： A61B8/481 , A61B6/481 , A61B6/504 , A61B8/06 , A61M5/007 , A61M5/14546 , A61M5/1723 , A61M2205/581 , A61M2205/80 , G06F19/00 , G06F19/321 , G06F19/3468
摘要： A method of coordinating an imaging procedure and an injection procedure, the method comprising the steps of providing an injector system having first and second pressurizing units for pressurizing a contrast medium and a diluent for injection into a patient; providing an imaging system for producing an image of an internal region of the patient from a signal resulting from energy applied to the patient; and providing a data interface interconnecting the injector and imaging systems for enabling exchange of digital information therebetween such that the digital information transmitted between the systems is usable to enable closed loop control of at least one of the injection and the imaging procedures during which the contrast medium and the diluent injected into the patient is adjustable so as to achieve a desired level of enhancement within the internal region of the patient of which the images are acquired during the imaging procedure.
摘要翻译：一种协调成像过程和注射程序的方法，所述方法包括以下步骤：提供具有用于加压造影剂的第一和第二加压单元和用于向患者注射的稀释剂的注射器系统; 提供成像系统，用于从施加到患者的能量产生的信号产生患者的内部区域的图像; 并且提供互连注射器和成像系统的数据接口，以使得能够在其间进行数字信息的交换，使得在系统之间传输的数字信息可用于对注射和成像过程中的至少一个进行闭环控制，并且注射到患者体内的稀释剂是可调节的，以便在成像过程期间获取图像的患者的内部区域内实现期望的增强水平。

8. 发明申请

US20090247866A1 DATA COMMUNICATION AND CONTROL FOR MEDICAL IMAGING SYSTEMS 有权
标题翻译：医学成像系统的数据通信与控制
公开(公告)号：US20090247866A1
公开(公告)日：2009-10-01
申请号：US12477456
申请日：2009-06-03
申请人： Arthur E. Uber, III , Edward J. Rhinehart , Rosemary Almon-Martin , David M. Griffiths , Alan Hirschman , Francis J. Sciulli , Walter Grumski , Vera Pagano , Karen Zelenski
发明人： Arthur E. Uber, III , Edward J. Rhinehart , Rosemary Almon-Martin , David M. Griffiths , Alan Hirschman , Francis J. Sciulli , Walter Grumski , Vera Pagano , Karen Zelenski
IPC分类号： A61B6/00
CPC分类号： A61B8/481 , A61B6/481 , A61B6/504 , A61B8/06 , A61M5/007 , A61M5/14546 , A61M5/1723 , A61M2205/581 , A61M2205/80 , G06F19/00 , G06F19/321 , G06F19/3468
摘要： A method of coordinating an imaging procedure and an injection procedure, the method comprising the steps of providing an injector system having first and second pressurizing units for pressurizing a contrast medium and a diluent for injection into a patient; providing an imaging system for producing an image of an internal region of the patient from a signal resulting from energy applied to the patient; and providing a data interface interconnecting the injector and imaging systems for enabling exchange of digital information therebetween such that the digital information transmitted between the systems is usable to enable closed loop control of at least one of the injection and the imaging procedures during which the contrast medium and the diluent injected into the patient is adjustable so as to achieve a desired level of enhancement within the internal region of the patient of which the images are acquired during the imaging procedure.
摘要翻译：一种协调成像过程和注射程序的方法，所述方法包括以下步骤：提供具有用于加压造影剂的第一和第二加压单元和用于向患者注射的稀释剂的注射器系统; 提供成像系统，用于从施加到患者的能量产生的信号产生患者的内部区域的图像; 并且提供互连注射器和成像系统的数据接口，以使得能够在其间进行数字信息的交换，使得在系统之间传输的数字信息可用于对注射和成像过程中的至少一个进行闭环控制，并且注射到患者体内的稀释剂是可调节的，以便在成像过程期间获取图像的患者的内部区域内实现期望的增强水平。

9. 发明授权

US07283860B2 Communication systems for use with magnetic resonance imaging systems 有权
标题翻译：用于磁共振成像系统的通信系统
公开(公告)号：US07283860B2
公开(公告)日：2007-10-16
申请号：US10622242
申请日：2003-07-18
申请人： Michael Frazier , Paul Reynolds , Alan Hirschman , John Gardner , Douglas Zatezalo , Bruno Fazi
发明人： Michael Frazier , Paul Reynolds , Alan Hirschman , John Gardner , Douglas Zatezalo , Bruno Fazi
IPC分类号： A61B5/05
CPC分类号： G01R33/283 , A61B5/0017 , A61B5/002 , A61B5/055
摘要： An injector system for injection of a fluid medium into a patient within an electromagnetic isolation area. The injector system includes a powered injector, a system controller therefor, and a plurality of communication units. The powered injector is positioned within the isolation area. A first communication unit integral with the powered injector enables the first communication unit and the powered injector to be moved as a unit. The system controller is positioned outside the isolation area and has a second communication unit integral therewith. An intermediate communication unit ensures communication between the first and the second communication units and therethrough between the powered injector and the system controller using an authentication technique therewith. The first, second and intermediate communication units are adapted to communicate by transmission of radio frequency (RF) energy. The RF energy is chosen to avoid interfering with the operation of MRI scanners.
摘要翻译：一种用于在电磁隔离区域内向患者注射流体介质的注射器系统。注射器系统包括动力注射器，其系统控制器和多个通信单元。动力注射器位于隔离区域内。与动力注射器集成的第一通信单元使得第一通信单元和动力注射器能够作为一个单元移动。系统控制器位于隔离区域外部并且具有与其成一体的第二通信单元。中间通信单元使用其认证技术来确保第一和第二通信单元之间的通信，并且在动力注射器和系统控制器之间通过。第一，第二和中间通信单元适于通过射频（RF）能量的传输进行通信。选择RF能量以避免干扰MRI扫描仪的操作。

10. 发明申请

US20070282199A1 METHODS OF INJECTING FLUIDS FOR USE IN IMAGING AND THERAPEUTIC PROCEDURES WHERE FEEDBACK ENABLES ADJUSTMENT OF INJECTION PARAMETERS 审中-公开
标题翻译：注射用于成像和治疗过程中的流体的方法在何处反馈使用注射参数的调整
公开(公告)号：US20070282199A1
公开(公告)日：2007-12-06
申请号：US11752478
申请日：2007-05-23
申请人： Arthur Uber , Alan Hirschman , Thomas Welch , Rosemary Almon-Martin
发明人： Arthur Uber , Alan Hirschman , Thomas Welch , Rosemary Almon-Martin
IPC分类号： A61M37/00
CPC分类号： A61B8/06 , A61B8/481 , A61M5/007 , A61M5/1723 , A61M2205/581 , A61M2205/80 , G06F19/321 , G06F19/3468 , Y10S128/12 , Y10S128/13
摘要： This invention relates generally to the field of medical devices for delivering contrast media during medical diagnostic and therapeutic imaging procedures and more particularly, this invention relates to improved contrast media delivery systems and methods of use which allow adjustment of contrast media concentration and injection parameters either before or during an injection procedure to provide patient specific dosing of contrast media, thus decreasing the waste and cost of these procedures while increasing their efficiency.
摘要翻译：本发明一般涉及在医疗诊断和治疗成像过程中用于输送造影剂的医疗装置领域，更具体地说，本发明涉及改进的造影剂递送系统和使用方法，其允许在之前调节造影剂浓度和注射参数或在注射过程期间以提供患者特异性剂量的造影剂，从而降低这些程序的浪费和成本，同时提高其效率。

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