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1. 发明授权

US07598071B2 Infectious clone of human parvovirus B19 and methods 有权
标题翻译：人类细小病毒B19的传染性克隆及方法
公开(公告)号：US07598071B2
公开(公告)日：2009-10-06
申请号：US10887770
申请日：2004-07-09
申请人： Kevin Brown , Ning Zhi , Peter Tijssen , Zoltan Zadori
发明人： Kevin Brown , Ning Zhi , Peter Tijssen , Zoltan Zadori
IPC分类号： C12N7/00 , C12N15/00 , C12N5/00 , C07H21/00
CPC分类号： C12Q1/701 , C12N7/00 , C12N2750/14251
摘要： The invention relates to infectious clones of parvovirus B19, methods of cloning infectious B19 clones, and methods of cloning viral genomes that have secondary DNA structures that are unstable in bacterial cells. A B19 infectious clone and methods of producing B19 infectious clones are useful for producing infectious virus. Infectious virus is useful for identifying and developing therapeutically effective compositions for treatment and/or prevention of human parvovirus B19 infections.
摘要翻译：本发明涉及细小病毒B19的感染性克隆，克隆感染性B19克隆的方法，以及克隆具有在细菌细胞中不稳定的二级DNA结构的病毒基因组的方法。 B19感染性克隆和生产B19感染性克隆的方法可用于产生感染性病毒。感染性病毒可用于鉴定和开发用于治疗和/或预防人细小病毒B19感染的治疗有效组合物。

2. 发明申请

US20060008469A1 Infectious clone of human parvovirus B19 and methods 有权
公开(公告)号：US20060008469A1
公开(公告)日：2006-01-12
申请号：US10887770
申请日：2004-07-09
申请人： Kevin Brown , Ning Zhi , Peter Tijssen , Zoltan Zadori
发明人： Kevin Brown , Ning Zhi , Peter Tijssen , Zoltan Zadori
IPC分类号： C12Q1/68 , A61K39/12 , C12N7/02
CPC分类号： C12Q1/701 , C12N7/00 , C12N2750/14251
摘要： The invention relates to infectious clones of parvovirus B19, methods of cloning infectious B19 clones, and methods of cloning viral genomes that have secondary DNA structures that are unstable in bacterial cells. A B19 infectious clone and methods of producing B19 infectious clones are useful for producing infectious virus. Infectious virus is useful for identifying and developing therapeutically effective compositions for treatment and/or prevention of human parvovirus B19 infections.

3. 发明授权

US08603784B2 Infectious clone of human parvovirus B19 and methods 有权
公开(公告)号：US08603784B2
公开(公告)日：2013-12-10
申请号：US12569848
申请日：2009-09-29
申请人： Kevin Edward Brown , Ning Zhi , Peter Tijssen , Zoltan Zadori
发明人： Kevin Edward Brown , Ning Zhi , Peter Tijssen , Zoltan Zadori
IPC分类号： C12N15/35 , C12N15/79
CPC分类号： C12Q1/701 , C12N7/00 , C12N2750/14251
摘要： The invention relates to infectious clones of parvovirus B19, methods of cloning infectious B19 clones, and methods of cloning viral genomes that have secondary DNA structures that are unstable in bacterial cells. A B19 infectious clone and methods of producing B19 infectious clones are useful for producing infectious virus. Infectious virus is useful for identifying and developing therapeutically effective compositions for treatment and/or prevention of human parvovirus B19 infections.

4. 发明申请

US20100136514A1 INFECTIOUS CLONE OF HUMAN PARVOVIRUS B19 AND METHODS 有权
标题翻译：人类PARVOVIRUS B19的感染性克隆和方法
公开(公告)号：US20100136514A1
公开(公告)日：2010-06-03
申请号：US12569848
申请日：2009-09-29
申请人： Kevin Edward Brown , Ning Zhi , Peter Tijssen , Zoltan Zadori
发明人： Kevin Edward Brown , Ning Zhi , Peter Tijssen , Zoltan Zadori
IPC分类号： C12N7/00 , C12N5/10 , C12Q1/70
CPC分类号： C12Q1/701 , C12N7/00 , C12N2750/14251
摘要： The invention relates to infectious clones of parvovirus B19, methods of cloning infectious B19 clones, and methods of cloning viral genomes that have secondary DNA structures that are unstable in bacterial cells. A B19 infectious clone and methods of producing B19 infectious clones are useful for producing infectious virus. Infectious virus is useful for identifying and developing therapeutically effective compositions for treatment and/or prevention of human parvovirus B19 infections.
摘要翻译：本发明涉及细小病毒B19的感染性克隆，克隆感染性B19克隆的方法，以及克隆具有在细菌细胞中不稳定的二级DNA结构的病毒基因组的方法。 B19感染性克隆和生产B19感染性克隆的方法可用于产生感染性病毒。感染性病毒可用于鉴定和开发用于治疗和/或预防人细小病毒B19感染的治疗有效组合物。

5. 发明申请

US20110190166A1 ERYTHROID PROGENITOR CELLS AND METHODS FOR PRODUCING PARVOVIRUS B19 THEREIN 审中-公开
标题翻译：红霉素预防细胞及其生产PARVOVIRUS B19 THEREIN的方法
公开(公告)号：US20110190166A1
公开(公告)日：2011-08-04
申请号：US12301960
申请日：2007-05-25
申请人： Susan Wong , Neal S. Young , Ning Zhi , Kevin Brown
发明人： Susan Wong , Neal S. Young , Ning Zhi , Kevin Brown
IPC分类号： C12N7/00 , C12Q1/70 , C12N5/0789 , C40B40/00
CPC分类号： C07K14/005 , C12N5/0641 , C12N5/0647 , C12N7/00 , C12N2501/125 , C12N2501/14 , C12N2501/23 , C12N2501/39 , C12N2510/04 , C12N2750/14222 , C12N2750/14243 , G01N33/56983
摘要： The disclosure relates to erythroid progenitor cells and methods for producing parvovirus B 19 in the cells. The invention includes transformed and/or immortalized CD36+ erythroid progenitor cells permissive for B19 infection and methods for producing useful quantities of B 19 in the cells described herein. Infectious virus produced by the cells of the disclosure is useful for identifying and developing therapeutically effective compositions for treatment and/or prevention of human parvovirus B 19 infections.
摘要翻译：本公开涉及红细胞祖细胞和在细胞中产生细小病毒B19的方法。本发明包括允许B19感染的转化和/或永生化的CD36 +红系祖细胞和在本文所述的细胞中产生有用量的B 19的方法。由本公开的细胞产生的传染病毒可用于鉴定和开发用于治疗和/或预防人细小病毒B19感染的治疗有效组合物。

6. 发明申请

US20130052226A1 COMPOSITIONS AND METHODS FOR PREVENTING OR TREATING A HUMAN PARVOVIRUS INFECTION 审中-公开
标题翻译：用于预防或治疗人类寄生虫感染的组合物和方法
公开(公告)号：US20130052226A1
公开(公告)日：2013-02-28
申请号：US13578577
申请日：2011-02-09
申请人： Ning Zhi , Neal S. Young , Sachiko Kajigaya
发明人： Ning Zhi , Neal S. Young , Sachiko Kajigaya
IPC分类号： A61K39/23 , A61P37/04 , C12N5/10 , C12N15/85 , C12P21/02 , C12N15/35 , A61P31/20
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/5258 , A61K2039/53 , C12N2750/14322 , C12N2750/14323
摘要： The invention provides a codon-optimized parvovirus polynucleotide composition and methods of expressing this polynucleotide in a variety of mammalian cells, including non-erythroid progenitor cells, to produce immunogenic compositions.
摘要翻译：本发明提供密码子优化的细小病毒多核苷酸组合物和在多种哺乳动物细胞（包括非红系祖细胞）中表达该多核苷酸以产生免疫原性组合物的方法。

7. 发明授权

US07807810B2 Nucleic acids encoding the major outer membrane protein of the causative agent of human granulocytic ehrlichiosis and peptides encoded thereby 有权
标题翻译：编码人粒细胞性肝炎病原体的主要外膜蛋白的核酸和由此编码的肽
公开(公告)号：US07807810B2
公开(公告)日：2010-10-05
申请号：US10223598
申请日：2002-08-19
申请人： Yasuko Rikihisa , Ning Zhi , Norio Ohashi
发明人： Yasuko Rikihisa , Ning Zhi , Norio Ohashi
IPC分类号： C07H21/04 , A61K39/02 , A61K39/00
CPC分类号： C07K16/1246 , C07K14/195 , C07K14/29 , G01N2333/29 , G01N2469/20 , Y02A50/57
摘要： The present invention relates to diagnostic tools for serodiagnosing HGE. The diagnostic tools are structurally related proteins, the “Group 44 proteins”, and to antibodies to such proteins. the Group 44 proteins comprise a single central hypervariable region of approximately 94 amino acid residues, a first conserved region and a second conserved region which flank the central hypervariable region. The hypervariable region of each Group 44 protein has a higher hydrophilicity, a higher antigenic index, and a higher surface probability than either the first conserved region or the second conserved region of the respective protein. The hypervariable region is basic and has an isoelectric point, i.e., a pI, of from about 7.1 to about 9.2 and a molecular mass, i.e., an Mr, of from about 8.5 kDa to about 11 kDa. The Group 44 proteins comprise the P44 protein, the P44-2 protein, the P44-12 protein, the P44-15 protein, the P44-18 protein, and the P44-19 protein and variants of such proteins. The present invention also provides isolated polynucleotides or nucleic acids, referred to collectively hereinafter as the “Group 44 polynucleotides”, which encode the Group 44 proteins and fragments thereof. The present invention provides synthetic oligopeptides of 14-16 amino acids in length. Each of the oligopeptides comprise a sequence which is specific to one Group 44 protein. The present invention also relates to antibodies which are immunospecific for and bind to members of the P44 family of proteinss. The present invention also relates to kits containing reagents for diagnosing HGE.
摘要翻译：本发明涉及用于血清诊断HGE的诊断工具。诊断工具是结构相关的蛋白质，“第44组蛋白”，以及与这些蛋白质的抗体。第44组蛋白质包含约94个氨基酸残基的单个中心高变区，第一保守区和位于中心高变区侧翼的第二保守区。每组44蛋白质的高变区具有比相应蛋白质的第一保守区域或第二保守区域更高的亲水性，更高的抗原指数和更高的表面概率。高变区是碱性的，具有约7.1至约9.2的等电点，即pI，分子量，即约8.5kDa至约11kDa的Mr。第44组蛋白包含P44蛋白，P44-2蛋白，P44-12蛋白，P44-15蛋白，P44-18蛋白和P44-19蛋白以及这些蛋白的变体。本发明还提供分离的多核苷酸或核酸，其统称为“第44族多核苷酸”，其编码第44族蛋白及其片段。本发明提供长度为14-16个氨基酸的合成寡肽。每个寡肽包含对一组44蛋白特异的序列。本发明还涉及对蛋白质P44家族的成员具有免疫特异性和结合的抗体。本发明还涉及含有用于诊断HGE的试剂的试剂盒。

8. 发明授权

US06436399B1 Nucleic acid encoding the major outer membrane protein of the causative agent of human granulocytic ehrlichiosis and peptides encoded thereby 有权
标题翻译：编码人类粒细胞性肝炎病原体的主要外膜蛋白的核酸和由此编码的肽
公开(公告)号：US06436399B1
公开(公告)日：2002-08-20
申请号：US09288339
申请日：1999-04-08
申请人： Yasuko Rikihisa , Ning Zhi , Norio Ohashi
发明人： Yasuko Rikihisa , Ning Zhi , Norio Ohashi
IPC分类号： A61K39395
CPC分类号： G01N33/6893 , C07K14/29 , C07K16/1246 , G01N2333/29 , G01N2333/43556 , G01N2469/20 , Y02A50/57
摘要： The present invention relates to diagnostic tools for serodiagnosing HGE. The diagnostic tools are structurally related proteins, the “Group 44 proteins”, and to antibodies to such proteins. the Group 44 proteins comprise a single central hypervariable region of approximately 94 amino acid residues, a first conserved region and a second conserved region which flank the central hypervariable region. The hypervariable region of each Group 44 protein has a higher hydrophilicity, a higher antigenic index, and a higher surface probability than either the first conserved region or the second conserved region of the respective protein. The hypervariable region is basic and has an isoelectric point, i.e., a pI, of from about 7.1 to about 9.2 and a molecular mass, i.e., an Mr, of from about 8.5 kDa to about 11 kDa. The Group 44 proteins comprise the P44 protein, the P44-2 protein, the P44-12 protein, the P44-15 protein, the P44-18 protein, and the P44-19 protein and variants of such proteins. The present invention also provides isolated polynucleotides or nucleic acids, referred to collectively hereinafter as the “Group 44 polynucleotides”, which encode the Group 44 proteins and fragments thereof. The present invention provides synthetic oligopeptides of 14-16 amino acids in length. Each of the oligopeptides comprise a sequence which is specific to one Group 44 protein. The present invention also relates to antibodies which are immunospecific for and bind to members of the P44 family of proteinss. The present invention also relates to kits containing reagents for diagnosing HGE.
摘要翻译：本发明涉及用于血清诊断HGE的诊断工具。诊断工具是结构相关的蛋白质，“第44组蛋白”，以及与这些蛋白质的抗体。第44组蛋白质包含约94个氨基酸残基的单个中心高变区，第一保守区和位于中心高变区侧翼的第二保守区。每组44蛋白质的高变区具有比相应蛋白质的第一保守区域或第二保守区域更高的亲水性，更高的抗原指数和更高的表面概率。高变区是碱性的，具有约7.1至约9.2的等电点，即pI，分子量，即约8.5kDa至约11kDa的Mr。第44组蛋白包含P44蛋白，P44-2蛋白，P44-12蛋白，P44-15蛋白，P44-18蛋白和P44-19蛋白以及这些蛋白的变体。本发明还提供分离的多核苷酸或核酸，其统称为“第44族多核苷酸”，其编码第44族蛋白及其片段。本发明提供长度为14-16个氨基酸的合成寡肽。每个寡肽包含对一组44蛋白特异的序列。本发明还涉及对蛋白质P44家族的成员具有免疫特异性和结合的抗体。本发明还涉及含有用于诊断HGE的试剂的试剂盒。

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