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1. 发明申请

US20110190166A1 ERYTHROID PROGENITOR CELLS AND METHODS FOR PRODUCING PARVOVIRUS B19 THEREIN 审中-公开
标题翻译：红霉素预防细胞及其生产PARVOVIRUS B19 THEREIN的方法
公开(公告)号：US20110190166A1
公开(公告)日：2011-08-04
申请号：US12301960
申请日：2007-05-25
申请人： Susan Wong , Neal S. Young , Ning Zhi , Kevin Brown
发明人： Susan Wong , Neal S. Young , Ning Zhi , Kevin Brown
IPC分类号： C12N7/00 , C12Q1/70 , C12N5/0789 , C40B40/00
CPC分类号： C07K14/005 , C12N5/0641 , C12N5/0647 , C12N7/00 , C12N2501/125 , C12N2501/14 , C12N2501/23 , C12N2501/39 , C12N2510/04 , C12N2750/14222 , C12N2750/14243 , G01N33/56983
摘要： The disclosure relates to erythroid progenitor cells and methods for producing parvovirus B 19 in the cells. The invention includes transformed and/or immortalized CD36+ erythroid progenitor cells permissive for B19 infection and methods for producing useful quantities of B 19 in the cells described herein. Infectious virus produced by the cells of the disclosure is useful for identifying and developing therapeutically effective compositions for treatment and/or prevention of human parvovirus B 19 infections.
摘要翻译：本公开涉及红细胞祖细胞和在细胞中产生细小病毒B19的方法。本发明包括允许B19感染的转化和/或永生化的CD36 +红系祖细胞和在本文所述的细胞中产生有用量的B 19的方法。由本公开的细胞产生的传染病毒可用于鉴定和开发用于治疗和/或预防人细小病毒B19感染的治疗有效组合物。

2. 发明申请

US20130052226A1 COMPOSITIONS AND METHODS FOR PREVENTING OR TREATING A HUMAN PARVOVIRUS INFECTION 审中-公开
标题翻译：用于预防或治疗人类寄生虫感染的组合物和方法
公开(公告)号：US20130052226A1
公开(公告)日：2013-02-28
申请号：US13578577
申请日：2011-02-09
申请人： Ning Zhi , Neal S. Young , Sachiko Kajigaya
发明人： Ning Zhi , Neal S. Young , Sachiko Kajigaya
IPC分类号： A61K39/23 , A61P37/04 , C12N5/10 , C12N15/85 , C12P21/02 , C12N15/35 , A61P31/20
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/5258 , A61K2039/53 , C12N2750/14322 , C12N2750/14323
摘要： The invention provides a codon-optimized parvovirus polynucleotide composition and methods of expressing this polynucleotide in a variety of mammalian cells, including non-erythroid progenitor cells, to produce immunogenic compositions.
摘要翻译：本发明提供密码子优化的细小病毒多核苷酸组合物和在多种哺乳动物细胞（包括非红系祖细胞）中表达该多核苷酸以产生免疫原性组合物的方法。

3. 发明授权

US5827647A Parvovirus capsids 失效
标题翻译：细小病毒衣壳
公开(公告)号：US5827647A
公开(公告)日：1998-10-27
申请号：US463332
申请日：1995-06-05
申请人： Neal S. Young , Sachiko Kajigaya , Takashi Shimada
发明人： Neal S. Young , Sachiko Kajigaya , Takashi Shimada
IPC分类号： G01N33/569 , A61K39/00 , A61K39/23 , A61K49/00 , A61P31/02 , A61P31/12 , C07K14/015 , C07K14/435 , C07K16/08 , C12N5/10 , C12N7/04 , C12N15/09 , C12N15/864 , C12P21/00 , C12R1/91 , C12Q1/70
CPC分类号： C07K14/005 , C07K16/081 , C12N15/86 , A61K39/00 , C12N2710/14043 , C12N2750/14122 , C12N2750/14222 , C12N2750/14223 , C12N2750/14243 , C12N2750/14322 , C12N2750/14323 , C12N2750/14343 , Y10S977/742 , Y10S977/802 , Y10S977/803 , Y10S977/898 , Y10S977/917 , Y10S977/92 , Y10S977/927
摘要： The present invention relates to a method of producing non-infectious-parvovirus capsids and to diagnostic assays and vaccines utilizing same. The invention further relates to recombinant baculoviruses encoding parvovirus structural proteins and host cells infected therewith. The invention also relates to a method of packaging and delivering genetic information utilizing the noninfectious capsids.
摘要翻译：本发明涉及产生非传染性细小病毒衣壳的方法以及利用其的诊断测定和疫苗。本发明还涉及编码细小病毒结构蛋白的重组杆状病毒和其感染的宿主细胞。本发明还涉及利用非传染性衣壳包装和递送遗传信息的方法。

4. 发明授权

US06558676B1 Parvovirus capsids 有权
标题翻译：细小病毒衣壳
公开(公告)号：US06558676B1
公开(公告)日：2003-05-06
申请号：US09611066
申请日：2000-07-06
申请人： Neal S. Young , Sachiko Kajigaya , Shimada Takashi
发明人： Neal S. Young , Sachiko Kajigaya , Shimada Takashi
IPC分类号： A61K3923
CPC分类号： C07K14/005 , A61K39/00 , C07K16/081 , C12N15/86 , C12N2710/14043 , C12N2750/14122 , C12N2750/14222 , C12N2750/14223 , C12N2750/14243 , C12N2750/14322 , C12N2750/14323 , C12N2750/14343 , Y10S977/742 , Y10S977/802 , Y10S977/803 , Y10S977/898 , Y10S977/917 , Y10S977/92 , Y10S977/927
摘要： The present invention relates to a method of producing non-infections parvovirus capsids and to diagnostic assays and vaccines utilizing same. The invention further relates to recombinant baculoviruses encoding parvovirus structural proteins and host cells infected therewith. The invention also relates to a method of packaging and delivering genetic information utilizing the noninfectious capsids.
摘要翻译：本发明涉及产生非感染细小病毒衣壳的方法以及利用其的诊断测定和疫苗。本发明还涉及编码细小病毒结构蛋白的重组杆状病毒和其感染的宿主细胞。本发明还涉及利用非传染性衣壳包装和递送遗传信息的方法。

5. 发明授权

US5449608A Parvovirus B19 receptor and parvovirus B19 detection 失效
标题翻译：细小病毒B19受体和细小病毒B19检测
公开(公告)号：US5449608A
公开(公告)日：1995-09-12
申请号：US34132
申请日：1993-03-22
申请人： Neal S. Young , Kevin E. Brown
发明人： Neal S. Young , Kevin E. Brown
IPC分类号： G01N33/566 , A61K35/76 , A61K38/00 , A61K39/23 , A61K48/00 , A61P31/12 , C07H21/04 , C07K14/015 , C12N5/10 , C12N7/00 , C12N15/09 , C12N15/866 , G01N33/569 , C12Q1/70
CPC分类号： C12N15/86 , C07K14/005 , G01N33/56983 , A61K38/00 , A61K48/00 , C12N2710/14143 , C12N2750/14322
摘要： The invention provides a method of detecting the presence of a parvovirus in a sample comprising contacting the sample with a purified receptor for a parvovirus, and detecting the presence of binding of parvovirus to the receptor, the presence of binding indicating the presence of parvovirus in the sample. The present invention also provides methods of purifying and removing parvoviruses from samples. The invention further provides a composition comprising a globoside, or the parvovirus B19 binding domain of globoside, in a pharmaceutically acceptable carrier. Also provided are methods of preventing or treating parvovirus B19 infection in a human subject by preventing the binding of parvovirus B19 to P antigen and methods of gene therapy utilizing parvovirus B19 and the parvovirus B19 cellular receptor.
摘要翻译：本发明提供了一种检测样品中细小病毒存在的方法，包括使样品与细小病毒的纯化受体接触，并检测细胞病毒与受体的结合，存在结合，指示细小病毒存在于样品。本发明还提供从样品中纯化和去除细小病毒的方法。本发明进一步提供了一种组合物，其在药学上可接受的载体中包含球苷或球状蛋白的细小病毒B19结合结构域。还提供了通过防止细小病毒B19与P抗原的结合以及使用细小病毒B19和细小病毒B19细胞受体的基因治疗方法来预防或治疗人受试者中的细小病毒B19感染的方法。

6. 发明授权

US6132732A Parvovirus capsids 失效
公开(公告)号：US6132732A
公开(公告)日：2000-10-17
申请号：US407939
申请日：1995-03-21
申请人： Neal S. Young , Sachiko Kajigaya , Shimada Takashi
发明人： Neal S. Young , Sachiko Kajigaya , Shimada Takashi
IPC分类号： G01N33/569 , A61K39/00 , A61K39/23 , A61K49/00 , A61P31/02 , A61P31/12 , C07K14/015 , C07K14/435 , C07K16/08 , C12N5/10 , C12N7/04 , C12N15/09 , C12N15/864 , C12P21/00 , C12R1/91 , C12N7/00 , C12Q1/70
CPC分类号： C07K14/005 , C07K16/081 , C12N15/86 , A61K39/00 , C12N2710/14043 , C12N2750/14122 , C12N2750/14222 , C12N2750/14223 , C12N2750/14243 , C12N2750/14322 , C12N2750/14323 , C12N2750/14343 , Y10S977/742 , Y10S977/802 , Y10S977/803 , Y10S977/898 , Y10S977/917 , Y10S977/92 , Y10S977/927
摘要： The present invention relates to a method of producing non-infections parvovirus capsids and to diagnostic assays and vaccines utilizing same. The invention further relates to recombinant baculoviruses encoding parvovirus structural proteins and host cells infected therewith. The invention also relates to a method of packaging and delivering genetic information utilizing the noninfectious capsids.

7. 发明授权

US6001371A Parvovirus capsids 失效
公开(公告)号：US6001371A
公开(公告)日：1999-12-14
申请号：US462464
申请日：1995-06-05
申请人： Neal S. Young , Sachiko Kajigaya , Takashi Shimada
发明人： Neal S. Young , Sachiko Kajigaya , Takashi Shimada
IPC分类号： A61K39/00 , A61P31/02 , C07K14/015 , C07K16/08 , C12N7/04 , C12N15/864 , A61K39/23 , A61K9/14
CPC分类号： C07K14/005 , C07K16/081 , C12N15/86 , A61K39/00 , C12N2710/14043 , C12N2750/14222 , C12N2750/14223 , C12N2750/14243 , Y10S977/803 , Y10S977/917 , Y10S977/918 , Y10S977/92
摘要： The present invention relates to a method of producing non-infections parvovirus capsids and to diagnostic assays and vaccines utilizing same. The invention further relates to recombinant baculoviruses encoding parvovirus structural proteins and host cells infected therewith. The invention also relates to a method of packaging and delivering genetic information utilizing the noninfectious capsids.

8. 发明授权

US5508186A B19 parvovirus capsids 失效
标题翻译： B19细小病毒衣壳
公开(公告)号：US5508186A
公开(公告)日：1996-04-16
申请号：US612672
申请日：1990-11-14
申请人： Neal S. Young , Sachiko Kajigaya , Takashi Shimada
发明人： Neal S. Young , Sachiko Kajigaya , Takashi Shimada
IPC分类号： G01N33/569 , A61K39/00 , A61K39/23 , A61K49/00 , A61P31/02 , A61P31/12 , C07K14/015 , C07K14/435 , C07K16/08 , C12N5/10 , C12N7/04 , C12N15/09 , C12N15/864 , C12P21/00 , C12R1/91 , C12N7/00 , C12Q1/70
CPC分类号： C07K14/005 , C07K16/081 , C12N15/86 , A61K39/00 , C12N2710/14043 , C12N2750/14122 , C12N2750/14222 , C12N2750/14223 , C12N2750/14243 , C12N2750/14322 , C12N2750/14323 , C12N2750/14343 , Y10S977/742 , Y10S977/802 , Y10S977/803 , Y10S977/898 , Y10S977/917 , Y10S977/92 , Y10S977/927
摘要： The present invention relates to a method of producing non-infections parvovirus capsids and to diagnostic assays and vaccines utilizing same. The invention further relates to recombinant baculoviruses encoding parvovirus structural proteins and host cells infected therewith. The invention also relates to a method of packaging and delivering genetic information utilizing the noninfectious capsids.
摘要翻译：本发明涉及产生非感染细小病毒衣壳的方法以及利用其的诊断测定和疫苗。本发明还涉及编码细小病毒结构蛋白的重组杆状病毒和其感染的宿主细胞。本发明还涉及利用非传染性衣壳包装和递送遗传信息的方法。

9. 发明授权

US07255993B1 Detection of mutational frequency and related methods 有权
标题翻译：检测突变频率及相关方法
公开(公告)号：US07255993B1
公开(公告)日：2007-08-14
申请号：US10704283
申请日：2003-11-06
申请人： Neal S. Young , Sachiko Kajigaya
发明人： Neal S. Young , Sachiko Kajigaya
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/04
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： Methods are provided herein for measuring the mutational frequency of a DNA molecule in cells, for example stem cells or hematopoietic cells such as CD34+ cells or granulocytes. The method includes sequencing corresponding regions of mtDNA from a set of hematopoietic cells, or a set of clonal populations of hematopoietic cells, and comparing the sequence of the corresponding regions of mtDNA from the cells, or clonal populations of cells. The method also includes the comparison of mtDNA sequences with genomic DNA sequences. Also provided are methods for screening for an agent that has a mutagenic effect on a cell. The method includes contacting, or treating, clonal populations of cells with an agent and comparing the sequence of the mtDNA obtained from the treated clonal populations of cells, with the sequence of the corresponding region of mtDNA obtained from a control clonal populations of cells.
摘要翻译：本文提供了用于测量细胞中DNA分子的突变频率的方法，例如干细胞或造血细胞例如CD34 +细胞或粒细胞。该方法包括从一组造血细胞或一组造血细胞的克隆群体中对相应的mtDNA区域进行测序，并比较来自细胞或细胞的克隆群体的mtDNA的相应区域的序列。该方法还包括mtDNA序列与基因组DNA序列的比较。还提供了筛选对细胞具有诱变作用的试剂的方法。该方法包括使细胞与克隆的细胞群接触或处理，并将从经处理的细胞群体获得的mtDNA的序列与从对照克隆细胞群获得的mtDNA的相应区域的序列进行比较。

10. 发明授权

US5916563A Parvovirus protein presenting capsids 失效
标题翻译：细小病毒蛋白呈现衣壳
公开(公告)号：US5916563A
公开(公告)日：1999-06-29
申请号：US253539
申请日：1994-06-03
申请人： Neal S. Young , Sachiko Kajigaya , Shimada Takashi
发明人： Neal S. Young , Sachiko Kajigaya , Shimada Takashi
IPC分类号： A61K39/00 , A61P31/12 , C07K14/015 , C07K16/08 , C12N7/04 , C12N15/864 , A61K39/385 , A61K39/23 , C12N11/00
CPC分类号： C07K14/005 , C07K16/081 , C12N15/86 , A61K39/00 , C12N2710/14043 , C12N2750/14322 , C12N2750/14343 , C12N2750/14362 , Y10S977/803 , Y10S977/915 , Y10S977/918
摘要： The present invention relates to a parvovirus protein presenting capsid. Protein presenting capsid can be made by substituting nonparvovirus proteins, such as antigenic epitopes, ligands, enzymes, or peptide sequences, for the unique region of the parvovirus minor structural protein (e.g. VP1). Small regions of VP2 can also be replaced. Normal VP2 can be added to enhance capsid formation.
摘要翻译：本发明涉及呈现衣壳的细小病毒蛋白。可以通过将非细小病毒蛋白（例如抗原表位，配体，酶或肽序列）替换为细小病毒次要结构蛋白（例如VP1）的独特区域来制备蛋白呈递衣壳。 VP2的小区域也可以被替换。可以添加正常的VP2以增强衣壳形成。

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