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1. 发明申请

US20050069542A1 Antibodies that specifically bind to GMAD 失效
标题翻译：特异性结合GMAD的抗体
公开(公告)号：US20050069542A1
公开(公告)日：2005-03-31
申请号：US10935290
申请日：2004-09-08
申请人： Kevin Baker , Vivian Albert , Partha Chowdhury
发明人： Kevin Baker , Vivian Albert , Partha Chowdhury
IPC分类号： A61K47/48 , A61K51/10 , C07K16/18 , C07K16/26 , C12P21/08 , A61K39/395 , C07K16/28
CPC分类号： A61K51/1018 , A61K47/6843 , A61K2039/505 , C07K16/18 , C07K16/26 , C07K2317/21 , C07K2317/56 , C07K2317/622
摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to GMAD. Such antibodies have uses, for example, in the prevention and treatment of both insulin- and non insulin-dependent diabetes mellitus (i.e. Type I and Type II diabetes) and other related disorders. The invention also relates to nucleic acid molecules encoding anti-GMAD antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially diabetes and other related disorders, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that immunospecifically bind to GMAD.
摘要翻译：本发明涉及免疫特异性结合GMAD的抗体和相关分子。这样的抗体具有例如用于预防和治疗胰岛素和非胰岛素依赖型糖尿病（即I型和II型糖尿病）和其它相关疾病。本发明还涉及编码抗GMAD抗体的核酸分子，含有这些核酸的载体和宿主细胞及其制备方法。本发明涉及用于预防，检测，诊断，治疗或改善疾病或病症，特别是糖尿病和其它相关病症的方法和组合物，包括向动物，优选人类施用有效量的一种或多种抗体或片段或其变体，或免疫特异性结合GMAD的相关分子。

2. 发明授权

US07461852B2 Step device for assisting entry into vehicles 失效
标题翻译：用于协助进入车辆的步进装置
公开(公告)号：US07461852B2
公开(公告)日：2008-12-09
申请号：US11690465
申请日：2007-03-23
申请人： Wayne Richardson , Kevin Baker
发明人： Wayne Richardson , Kevin Baker
IPC分类号： B60R3/00
CPC分类号： B60R3/00
摘要： The invention includes a step device for assisting entry into and/or exit from a vehicle such as, for example, high road clearance truck. The step device comprises a generally “W” shaped bar which is separable into said two generally “U” shaped elements for easier packaging, shipping and manipulation of the device. Each of the “U” shaped elements include a cross-bar fixedly attached between, and spanning across, an interior of the generally “U” shaped element. The cross-bars are configured for separately mounting to the vehicle such that the generally “U” shaped elements are independently supported and the generally “U” shaped elements may be adjustable to multiple angles with respect to said vehicle.
摘要翻译：本发明包括用于辅助进入和/或从车辆例如高清关卡车出口的步进装置。台阶装置包括通常为“W”形的杆，其可分离成所述两个大致“U”形元件，以便于装置的装运，运输和操纵。 “U”形元件中的每一个包括固定地连接在大致“U”形元件的内部之间并跨越的一个横杆。横杆被配置为单独地安装到车辆上，使得大致“U”形的元件被独立地支撑，并且大体上“U”形的元件可以相对于所述车辆可调整到多个角度。

3. 发明申请

US20080050758A1 SECRETED AND TRANSMEMBRANE POLYPEPTIDES AND NUCLEIC ACIDS ENCODING THE SAME 审中-公开
标题翻译：分泌和转运蛋白多核苷酸和编码其的核酸
公开(公告)号：US20080050758A1
公开(公告)日：2008-02-28
申请号：US11929190
申请日：2007-10-30
申请人： Kevin Baker , Maureen Beresini , Laura DeForge , Luc Desnoyers , Ellen Filvaroff , Wei-Qiang Gao , Mary Gerritsen , Audrey Goddard , Paul Godowski , Austin Gurney , Steven Sherwood , Victoria Smith , Timothy Stewart , Daniel Tumas , Colin Watanabe , William Wood , Zemin Zhang
发明人： Kevin Baker , Maureen Beresini , Laura DeForge , Luc Desnoyers , Ellen Filvaroff , Wei-Qiang Gao , Mary Gerritsen , Audrey Goddard , Paul Godowski , Austin Gurney , Steven Sherwood , Victoria Smith , Timothy Stewart , Daniel Tumas , Colin Watanabe , William Wood , Zemin Zhang
IPC分类号： C07H21/04 , C07K16/00 , C12N15/00 , C12N5/00 , G01N33/53
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译：本发明涉及新型多肽和编码那些多肽的核酸分子。本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法发明。

4. 发明申请

US20070260045A1 Secreted and transmembrane polypeptides and nucleic acids encoding the same 有权
公开(公告)号：US20070260045A1
公开(公告)日：2007-11-08
申请号：US11258348
申请日：2005-10-24
申请人： Kevin Baker , Jian Chen , Luc Desnoyers , Audrey Goddard , Paul Godowski , Austin Gurney , James Pan , Victoria Smith , Colin Watanabe , William Wood , Zemin Zhang
发明人： Kevin Baker , Jian Chen , Luc Desnoyers , Audrey Goddard , Paul Godowski , Austin Gurney , James Pan , Victoria Smith , Colin Watanabe , William Wood , Zemin Zhang
IPC分类号： C07K16/18 , C07K14/00
CPC分类号： C07K14/47 , A01K2217/075 , A01K2227/105 , A61K38/00 , C07K14/4748 , C07K14/705 , C07K14/82 , C07K16/28 , C07K2319/30 , C12Q1/6816 , C12Q1/6883 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/5082 , G01N33/5308 , G01N33/574 , G01N33/57419 , G01N33/57423 , G01N33/57434 , G01N33/57484 , G01N33/57488 , G01N33/57492 , G01N2500/00 , C12Q2563/131 , C12Q2527/137
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

5. 发明申请

US20070238859A1 PRO9925 POLYPEPTIDES 有权
公开(公告)号：US20070238859A1
公开(公告)日：2007-10-11
申请号：US10219529
申请日：2002-08-13
申请人： Kevin Baker , Luc Desnoyers , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Victoria Smith , Jean-Philippe Stephan , Colin Watanabe , William Wood
发明人： Kevin Baker , Luc Desnoyers , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Victoria Smith , Jean-Philippe Stephan , Colin Watanabe , William Wood
IPC分类号： C07K14/47 , C07K16/18 , C07H21/04 , C12P21/06 , C12N9/00
CPC分类号： C07K14/705 , C07K14/47 , G01N33/574
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译：本发明涉及新型多肽和编码那些多肽的核酸分子。本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法发明。

6. 发明申请

US20070026487A1 Secreted and transmembrane polypeptides and nucleic acids encoding the same 审中-公开
标题翻译：分泌和跨膜多肽和编码其的核酸
公开(公告)号：US20070026487A1
公开(公告)日：2007-02-01
申请号：US10964241
申请日：2004-10-12
申请人： Kevin Baker , Maureen Beresini , Laura DeForge , Luc Desnoyers , Ellen Filvaroff , Wei-Qiang Gao , Mary Gerritsen , Audrey Goddard , Paul Godowski , Austin Gurney , Steven Sherwood , Victoria Smith , Timothy Stewart , Daniel Tumas , Colin Watanabe , William Wood , Zemin Zhang
发明人： Kevin Baker , Maureen Beresini , Laura DeForge , Luc Desnoyers , Ellen Filvaroff , Wei-Qiang Gao , Mary Gerritsen , Audrey Goddard , Paul Godowski , Austin Gurney , Steven Sherwood , Victoria Smith , Timothy Stewart , Daniel Tumas , Colin Watanabe , William Wood , Zemin Zhang
IPC分类号： C12P21/06 , C07H21/04 , C12N9/00 , C07K14/47 , C07K16/18
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译：本发明涉及新型多肽和编码那些多肽的核酸分子。本文还包括包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明多肽的嵌合多肽分子，与本发明多肽结合的抗体以及本发明多肽的制备方法。

7. 发明申请

US20060246461A1 Secreted and transmembrane polypeptides and nucleic acids encoding the same 审中-公开
公开(公告)号：US20060246461A1
公开(公告)日：2006-11-02
申请号：US11038549
申请日：2005-01-18
申请人： Kevin Baker , Audrey Goddard , Paul Godowski , Austin Gurney , Victoria Smith , William Wood
发明人： Kevin Baker , Audrey Goddard , Paul Godowski , Austin Gurney , Victoria Smith , William Wood
IPC分类号： C12Q1/68 , G01N33/567
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

8. 发明申请

US20060078964A1 Secreted and transmembrane polypeptides and nucleic acids encoding the same 审中-公开
公开(公告)号：US20060078964A1
公开(公告)日：2006-04-13
申请号：US10216161
申请日：2002-08-09
申请人： Avi Ashkenazi , Kevin Baker , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Kenneth Hillan , Ivar Kljavin , Sophia Kuo , Mary Napier , James Pan , Nicholas Paoni , Margaret Roy , David Shelton , Timothy Stewart , Daniel Tumas , P. Williams , William Wood
发明人： Avi Ashkenazi , Kevin Baker , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Kenneth Hillan , Ivar Kljavin , Sophia Kuo , Mary Napier , James Pan , Nicholas Paoni , Margaret Roy , David Shelton , Timothy Stewart , Daniel Tumas , P. Williams , William Wood
IPC分类号： C07H21/04 , C12P21/06 , C12N9/00 , C07K16/18 , C07K14/47
CPC分类号： C07K14/705
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

9. 发明申请

US20060074224A1 Secreted and transmembrane polypeptides and nucleic acids encoding the same 有权
公开(公告)号：US20060074224A1
公开(公告)日：2006-04-06
申请号：US10219061
申请日：2002-08-12
申请人： Kevin Baker , Luc Desnoyers , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Victoria Smith , Jean-Philippe Stephan , Colin Watanabe , William Wood
发明人： Kevin Baker , Luc Desnoyers , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Victoria Smith , Jean-Philippe Stephan , Colin Watanabe , William Wood
IPC分类号： C07K16/18
CPC分类号： C07H21/04 , C07K14/435 , C12N5/06 , C12N9/00 , C12P21/02
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

10. 发明申请

US20060074220A1 Secreted and transmembrane polypeptides and nucleic acids encoding the same 有权
公开(公告)号：US20060074220A1
公开(公告)日：2006-04-06
申请号：US10219062
申请日：2002-08-12
申请人： Kevin Baker , Luc Desnoyers , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Victoria Smith , Jean-Philippe Stephan , Colin Watanabe , William Wood
发明人： Kevin Baker , Luc Desnoyers , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Victoria Smith , Jean-Philippe Stephan , Colin Watanabe , William Wood
IPC分类号： C07K14/47
CPC分类号： C07K14/705 , C07K14/47 , G01N33/574
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

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