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1. 发明申请

US20100292441A1 Antibodies that specifically bind to GMAD 审中-公开
标题翻译：特异性结合GMAD的抗体
公开(公告)号：US20100292441A1
公开(公告)日：2010-11-18
申请号：US12320513
申请日：2009-01-28
申请人： Kevin P. Baker , Vivian R. Albert , Partha Chowdhury
发明人： Kevin P. Baker , Vivian R. Albert , Partha Chowdhury
IPC分类号： C07K16/18 , C12N5/16
CPC分类号： A61K51/1018 , A61K47/6843 , A61K2039/505 , C07K16/18 , C07K16/26 , C07K2317/21 , C07K2317/56 , C07K2317/622
摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to GMAD. Such antibodies have uses, for example, in the prevention and treatment of both insulin- and non insulin-dependent diabetes mellitus (i.e. Type I and Type II diabetes) and other related disorders. The invention also relates to nucleic acid molecules encoding anti-GMAD antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially diabetes and other related disorders, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that immunospecifically bind to GMAD.
摘要翻译：本发明涉及免疫特异性结合GMAD的抗体和相关分子。这样的抗体具有例如用于预防和治疗胰岛素和非胰岛素依赖型糖尿病（即I型和II型糖尿病）和其它相关疾病。本发明还涉及编码抗GMAD抗体的核酸分子，含有这些核酸的载体和宿主细胞及其制备方法。本发明涉及用于预防，检测，诊断，治疗或改善疾病或病症，特别是糖尿病和其它相关病症的方法和组合物，包括向动物，优选人类施用有效量的一种或多种抗体或片段或其变体，或免疫特异性结合GMAD的相关分子。

2. 发明授权

US07783713B2 Method and apparatus for response enabled messaging 有权
标题翻译：响应启用消息的方法和设备
公开(公告)号：US07783713B2
公开(公告)日：2010-08-24
申请号：US11876717
申请日：2007-10-22
申请人： Venkat Easwar , Partha Chowdhury , Chirag Bakshi , Amit Agarwal
发明人： Venkat Easwar , Partha Chowdhury , Chirag Bakshi , Amit Agarwal
IPC分类号： G06F15/16
CPC分类号： G06Q10/107
摘要： A method and apparatus for creating associations between messages in a stateless system. The method comprises adding a unique identification to a notification message at a gateway, and upon receiving a response from a user, identifying the unique identification within the response, and utilizing the unique identification to associate the response with the notification message.
摘要翻译：一种在无状态系统中创建消息之间的关联的方法和装置。该方法包括向网关上的通知消息添加唯一标识，以及在接收到来自用户的响应时，识别响应内的唯一标识，以及利用唯一标识将响应与通知消息相关联。

3. 发明申请

US20100166746A1 HIGH POTENCY RECOMBINANT ANTIBODIES, METHODS FOR PRODUCING THEM AND USE IN CANCER THERAPY 审中-公开
标题翻译：高分辨率重组抗体，其制备方法和用于癌症治疗
公开(公告)号：US20100166746A1
公开(公告)日：2010-07-01
申请号：US12517300
申请日：2007-12-04
申请人： Partha Chowdhury , Herren Wu , Laura Richman
发明人： Partha Chowdhury , Herren Wu , Laura Richman
IPC分类号： A61K39/395 , C07K16/30 , A61P35/00
CPC分类号： C07K16/005 , C07K16/2866 , C07K2317/24 , C07K2317/92
摘要： The present invention contemplates improved recombinant anti-tumor antibodies having faster Kon and faster Koff rates, resulting in a uniform tumor penetrance, as compared to the same recombinant anti-tumor antibody without said faster Kon and faster Koff rates, and methods of improving the same.
摘要翻译：本发明考虑到与相同的重组抗肿瘤抗体相比，具有更快的Kon和更快的Koff速率的改进的重组抗肿瘤抗体，导致均匀的肿瘤外显率，而没有所述更快的Kon和更快的Koff率，以及改进相同的方法。

4. 发明申请

US20140072577A1 ANTIBODIES THAT SPECIFICALLY BIND STAPHYLOCOCCUS AUREUS ALPHA TOXIN AND METHODS OF USE 有权
标题翻译：特异性印迹黄曲霉毒素的毒物和使用方法
公开(公告)号：US20140072577A1
公开(公告)日：2014-03-13
申请号：US13983804
申请日：2012-02-07
申请人： Bret Sellman , Christine Tkaczyk , Lei Hua , Partha Chowdhury , Reena Varkey , Melissa Damschroder , Li Peng , Vaheh Oganesyan , Jamese Johnson Hilliard
发明人： Bret Sellman , Christine Tkaczyk , Lei Hua , Partha Chowdhury , Reena Varkey , Melissa Damschroder , Li Peng , Vaheh Oganesyan , Jamese Johnson Hilliard
IPC分类号： C07K16/12
CPC分类号： C07K16/1271 , A61K38/14 , A61K39/40 , A61K45/06 , A61K2039/505 , C07K2299/00 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/76 , C07K2317/90 , C07K2317/92 , G01N33/56938 , G01N2333/31 , G01N2800/20 , G01N2800/44 , G01N2800/709 , A61K2300/00
摘要： Herein provided are compositions, methods of manufacture and methods of use pertaining to anti-alpha toxin antibodies and fragments.
摘要翻译：本文提供了与抗-α毒素抗体和片段有关的组合物，制备方法和使用方法。

5. 发明申请

US20050214304A1 Antibodies, including FV molecules, and immunoconjugates having high binding affinity for mesothelin and methods for their use 有权
标题翻译：包括FV分子的抗体和对间皮素具有高结合亲和力的免疫缀合物及其使用方法
公开(公告)号：US20050214304A1
公开(公告)日：2005-09-29
申请号：US10973718
申请日：2004-10-25
申请人： Ira Pastan , Partha Chowdhury
发明人： Ira Pastan , Partha Chowdhury
IPC分类号： A61K47/48 , C07K16/30 , G01N33/574 , A61K39/395 , C07H21/04 , C12N1/21 , C12N15/74
CPC分类号： G01N33/57492 , A61K47/6829 , A61K47/6851 , A61K2039/505 , C07K16/3069 , C07K2317/565 , G01N33/57449
摘要： Mesothelin ins a differentiation antigen present on the surface of ovarian cancers, mesotheliomas and several other types of human cancers. Because among normal tissues, mesothelin is only present on mesothelial cells, it represents a good target for antibody mediated delivery of cytotoxic agents. The present invention is directed to anti-mesothelin antibodies, including Fv molecules with particularly high affinity for mesothelin, and immunoconjugates employing them. Also described are diagnostic and therapeutic methods using the antibodies. The anti-mesothelin antibodies are well-suited for the diagnosis and treatment of cancers of the ovary, stomach, squamous cells, mesotheliomas and other malignant cells expressing mesothelin.
摘要翻译：间皮素含有存在于卵巢癌，间皮瘤和其他几种类型人类癌症表面的分化抗原。因为在正常组织中，间皮素仅存在于间皮细胞上，它代表抗体介导的细胞毒性剂递送的良好靶标。本发明涉及抗间皮素抗体，包括对间皮素具有特别高亲和力的Fv分子和使用它们的免疫缀合物。还描述了使用抗体的诊断和治疗方法。抗间皮素抗体非常适合于诊断和治疗卵巢癌，胃癌，鳞状细胞癌，间皮瘤等表达间皮素的恶性细胞癌。

6. 发明申请

US20050069542A1 Antibodies that specifically bind to GMAD 失效
标题翻译：特异性结合GMAD的抗体
公开(公告)号：US20050069542A1
公开(公告)日：2005-03-31
申请号：US10935290
申请日：2004-09-08
申请人： Kevin Baker , Vivian Albert , Partha Chowdhury
发明人： Kevin Baker , Vivian Albert , Partha Chowdhury
IPC分类号： A61K47/48 , A61K51/10 , C07K16/18 , C07K16/26 , C12P21/08 , A61K39/395 , C07K16/28
CPC分类号： A61K51/1018 , A61K47/6843 , A61K2039/505 , C07K16/18 , C07K16/26 , C07K2317/21 , C07K2317/56 , C07K2317/622
摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to GMAD. Such antibodies have uses, for example, in the prevention and treatment of both insulin- and non insulin-dependent diabetes mellitus (i.e. Type I and Type II diabetes) and other related disorders. The invention also relates to nucleic acid molecules encoding anti-GMAD antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially diabetes and other related disorders, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that immunospecifically bind to GMAD.
摘要翻译：本发明涉及免疫特异性结合GMAD的抗体和相关分子。这样的抗体具有例如用于预防和治疗胰岛素和非胰岛素依赖型糖尿病（即I型和II型糖尿病）和其它相关疾病。本发明还涉及编码抗GMAD抗体的核酸分子，含有这些核酸的载体和宿主细胞及其制备方法。本发明涉及用于预防，检测，诊断，治疗或改善疾病或病症，特别是糖尿病和其它相关病症的方法和组合物，包括向动物，优选人类施用有效量的一种或多种抗体或片段或其变体，或免疫特异性结合GMAD的相关分子。

7. 发明授权

US09527905B2 Antibodies that specifically bind Staphylococcus aureus alpha toxin and methods of use 有权
标题翻译：特异性结合金黄色葡萄球菌α毒素的抗体及其使用方法
公开(公告)号：US09527905B2
公开(公告)日：2016-12-27
申请号：US13983804
申请日：2012-02-07
申请人： Bret Sellman , Christine Tkaczyk , Lei Hua , Partha Chowdhury , Reena Varkey , Melissa Damschroder , Li Peng , Vaheh Oganesyan , Jamese Johnson Hilliard
发明人： Bret Sellman , Christine Tkaczyk , Lei Hua , Partha Chowdhury , Reena Varkey , Melissa Damschroder , Li Peng , Vaheh Oganesyan , Jamese Johnson Hilliard
IPC分类号： A61K51/00 , C07K16/12 , G01N33/569 , A61K38/14 , A61K39/40 , A61K45/06 , A61K39/00
CPC分类号： C07K16/1271 , A61K38/14 , A61K39/40 , A61K45/06 , A61K2039/505 , C07K2299/00 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/76 , C07K2317/90 , C07K2317/92 , G01N33/56938 , G01N2333/31 , G01N2800/20 , G01N2800/44 , G01N2800/709 , A61K2300/00
摘要： Herein provided are compositions, methods of manufacture and methods of use pertaining to anti-alpha toxin antibodies and fragments.
摘要翻译：本文提供了与抗-α毒素抗体和片段有关的组合物，制备方法和使用方法。

8. 发明授权

US07550569B2 Antibodies that specifically bind to GMAD 失效
标题翻译：特异性结合GMAD的抗体
公开(公告)号：US07550569B2
公开(公告)日：2009-06-23
申请号：US10935290
申请日：2004-09-08
申请人： Kevin P. Baker , Vivian R. Albert , Partha Chowdhury
发明人： Kevin P. Baker , Vivian R. Albert , Partha Chowdhury
IPC分类号： C12P21/08 , C07K16/00
CPC分类号： A61K51/1018 , A61K47/6843 , A61K2039/505 , C07K16/18 , C07K16/26 , C07K2317/21 , C07K2317/56 , C07K2317/622
摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to GMAD. Such antibodies have uses, for example, in the prevention and treatment of both insulin- and non insulin-dependent diabetes mellitus (i.e. Type I and Type II diabetes) and other related disorders. The invention also relates to nucleic acid molecules encoding anti-GMAD antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially diabetes and other related disorders, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that immunospecifically bind to GMAD.
摘要翻译：本发明涉及免疫特异性结合GMAD的抗体和相关分子。这样的抗体具有例如用于预防和治疗胰岛素和非胰岛素依赖型糖尿病（即I型和II型糖尿病）和其它相关疾病。本发明还涉及编码抗GMAD抗体的核酸分子，含有这些核酸的载体和宿主细胞及其制备方法。本发明涉及用于预防，检测，诊断，治疗或改善疾病或病症，特别是糖尿病和其它相关病症的方法和组合物，包括向动物，优选人类施用有效量的一种或多种抗体或片段或其变体，或免疫特异性结合GMAD的相关分子。

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