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1. 发明授权

US10537741B2 System and method for choosing electrodes in an implanted stimulator device 有权
公开(公告)号：US10537741B2
公开(公告)日：2020-01-21
申请号：US11295168
申请日：2005-12-05
申请人： Kerry Bradley , Ljubomir Manola , Jan Holsheimer
发明人： Kerry Bradley , Ljubomir Manola , Jan Holsheimer
IPC分类号： A61N1/36
摘要： A method of selecting a subset of electrodes in a stimulator device implanted in a patient for further clinical evaluation is disclosed. The method comprises measuring at least first and second measurement for each of the plurality of electrodes that are indicative of the ability of the electrode if activated to provide useful therapy to the patient in which the stimulator device is implanted A weight is then determined for each of the measurements. The weight is then applied to each electrode measurement, which measurement may be normalized, and the weighted measurements for each electrode are preferably summed to arrive at a value which itself is indicative of a particular electrode's ability to provide useful therapy to the patient. These values can then be used to determine a subset of the electrodes useful for further clinical evaluation in the patient, which improved the accuracy and speeding determining appropriate patient therapy.

2. 发明申请

US20060195159A1 System and method for choosing electrodes in an implanted stimulator device 审中-公开
标题翻译：用于在植入的刺激器装置中选择电极的系统和方法
公开(公告)号：US20060195159A1
公开(公告)日：2006-08-31
申请号：US11295168
申请日：2005-12-05
申请人： Kerry Bradley , Ljubomir Manola , Jan Holsheimer
发明人： Kerry Bradley , Ljubomir Manola , Jan Holsheimer
IPC分类号： A61N1/18
CPC分类号： A61N1/36135 , A61N1/36132 , A61N1/36185
摘要： A method of selecting of subset of electrodes in a stimulator device implanted in a patient for further clinical evaluation is disclosed. In one embodiment, the method comprises measuring at least first and second measurement for each of the plurality of electrodes that are indicative of the ability of the electrode if activated to provide useful therapy to the patient in which the stimulator device is implanted, such as electrode impedance, field potential, and nerve response. The measurements can be objective such as those measurements just mentioned, or can comprise subjective measurements which are quantified in response to qualitative feedback from the patient. A weight is then determined for each of the measurements, which may be a predetermined weight or determined on the basis of the variance of the measurement between the electrodes. The weight is then applied to each electrode measurement, which measurement may be normalized, and the weighted measurements for each electrode are preferably summed to arrive at a value which itself is indicative of a particular electrode's ability to provide useful therapy to the patient. These values can then be used to determine a subset of the electrodes useful for further clinical evaluation in the patient, which improved the accuracy and speeding determining appropriate patient therapy.
摘要翻译：公开了一种在植入患者中的刺激器装置中选择电极子集的方法，用于进一步的临床评价。在一个实施例中，该方法包括测量多个电极中的每个电极的至少第一和第二测量，其指示如果被激活的电极的能力为其中植入刺激器装置的患者提供有用的治疗，例如电极阻抗，场电位和神经反应。测量可以是客观的，例如刚刚提到的那些测量，或者可以包括根据来自患者的定性反馈量化的主观测量。然后为每个测量确定权重，其可以是预定权重，或者基于电极之间的测量方差来确定。然后将重量施加到每个电极测量，该测量可以被归一化，并且优选地将每个电极的加权测量相加以得到其本身指示特定电极向患者提供有用治疗的能力的值。然后可以使用这些值来确定用于患者进一步临床评估的电极子集，这提高了准确性并加快了确定适当的患者治疗。

3. 发明授权

US08494640B2 System and method for increasing relative intensity between cathodes and anodes of neurostimulation system 有权
标题翻译：增加阴极和神经刺激系统阳极之间的相对强度的系统和方法
公开(公告)号：US08494640B2
公开(公告)日：2013-07-23
申请号：US12508407
申请日：2009-07-23
申请人： David K. L. Peterson , Kerry Bradley , Jan Holsheimer
发明人： David K. L. Peterson , Kerry Bradley , Jan Holsheimer
IPC分类号： A61N1/00
CPC分类号： A61N1/0551 , A61N1/0553 , A61N1/3605 , A61N1/36157
摘要： A method and neurostimulation system for providing therapy to a patient is provided. A plurality of electrodes is placed adjacent to tissue of the patient. The electrodes include first and second electrodes, with the first electrode having a first tissue contacting surface area and the second electrode having a second tissue contact surface area greater than the first tissue contacting surface area. Anodic electrical current is simultaneously sourced from one of the first and second electrodes to the tissue and while cathodic electrical current is sunk from the tissue to another of the first and second electrodes to provide the therapy to the patient.
摘要翻译：提供了一种用于向患者提供治疗的方法和神经刺激系统。多个电极邻近患者的组织放置。电极包括第一和第二电极，第一电极具有第一组织接触表面区域，第二电极具有大于第一组织接触表面积的第二组织接触表面积。阳极电流同时从第一和第二电极之一提供到组织，同时阴极电流从组织下沉到另一个第一和第二电极，以向患者提供治疗。

4. 发明申请

US20100023097A1 SYSTEM AND METHOD FOR INCREASING RELATIVE INTENSITY BETWEEN CATHODES AND ANODES OF NEUROSTIMULATION SYSTEM 有权
标题翻译：阴茎和神经系统阳极相对强度的增加系统与方法
公开(公告)号：US20100023097A1
公开(公告)日：2010-01-28
申请号：US12508407
申请日：2009-07-23
申请人： David K.L. Peterson , Kerry Bradley , Jan Holsheimer
发明人： David K.L. Peterson , Kerry Bradley , Jan Holsheimer
IPC分类号： A61N1/36 , A61N1/05
CPC分类号： A61N1/0551 , A61N1/0553 , A61N1/3605 , A61N1/36157
摘要： A method and neurostimulation system for providing therapy to a patient is provided. A plurality of electrodes is placed adjacent to tissue of the patient. The electrodes include first and second electrodes, with the first electrode having a first tissue contacting surface area and the second electrode having a second tissue contact surface area greater than the first tissue contacting surface area. Anodic electrical current is simultaneously sourced from one of the first and second electrodes to the tissue and while cathodic electrical current is sunk from the tissue to another of the first and second electrodes to provide the therapy to the patient.
摘要翻译：提供了一种用于向患者提供治疗的方法和神经刺激系统。多个电极邻近患者的组织放置。电极包括第一和第二电极，第一电极具有第一组织接触表面区域，第二电极具有大于第一组织接触表面积的第二组织接触表面积。阳极电流同时从第一和第二电极之一提供到组织，同时阴极电流从组织下沉到另一个第一和第二电极，以向患者提供治疗。

5. 发明授权

US09511229B2 System and method for using impedance to determine proximity and orientation of segmented electrodes 有权
标题翻译：使用阻抗来确定分段电极的接近和取向的系统和方法
公开(公告)号：US09511229B2
公开(公告)日：2016-12-06
申请号：US13533532
申请日：2012-06-26
申请人： Kerry Bradley
发明人： Kerry Bradley
IPC分类号： A61N1/36 , A61N1/05 , A61B5/053 , A61N1/08 , A61B5/06
CPC分类号： A61N1/08 , A61B5/0538 , A61B5/06 , A61B5/068 , A61N1/0551 , A61N1/36125 , A61N1/36182 , A61N1/37217 , A61N1/37241 , A61N1/3787
摘要： A method for implanting a neurostimulation lead within a patient includes measuring impedances of electrodes on the lead in order to correctly position the lead relative to a target tissue region. The electrodes are circumferentially segmented electrodes that are spaced from each other about the longitudinal axis of the lead. When the difference between the impedances of the electrodes exceeds a threshold value, the lead is in the correct position. In accordance with another embodiment, impedance measurements are used to select which one of the electrodes is closest to the target tissue region. By determining which electrode has the highest impedance and which electrode has the lowest impedance, the type of tissue adjacent to each electrode can be determined based on the conductivity properties of the tissue. The target tissue region may be a spinal cord, a posterior longitudinal ligament, white matter, or gray matter.
摘要翻译：用于在患者体内植入神经刺激引线的方法包括测量引线上的电极的阻抗，以便使引线相对于目标组织区域正确定位。电极是周向分段的电极，其围绕导线的纵向轴线彼此间隔开。当电极的阻抗差超过阈值时，引线处于正确的位置。根据另一个实施例，使用阻抗测量来选择哪个电极最靠近目标组织区域。通过确定哪个电极具有最高阻抗并且哪个电极具有最低的阻抗，可以基于组织的电导率特性来确定与每个电极相邻的组织的类型。目标组织区域可以是脊髓，后纵韧带，白质或灰质。

6. 发明授权

US09504818B2 Multiple tunable central cathodes on a paddle for increased medial-lateral and rostral-caudal flexibility via current steering 有权
公开(公告)号：US09504818B2
公开(公告)日：2016-11-29
申请号：US12204170
申请日：2008-09-04
申请人： Michael Moffitt , Dongchul Lee , Kerry Bradley , David K. L. Peterson
发明人： Michael Moffitt , Dongchul Lee , Kerry Bradley , David K. L. Peterson
IPC分类号： A61N1/34 , A61N1/05 , A61N1/36
CPC分类号： A61N1/0551 , A61N1/0553 , A61N1/36071
摘要： A neurostimulation paddle lead, method of neurostimulation, and neurostimulation system are provided. The neurostimulation paddle lead carries a plurality of electrodes comprising at least four columns of electrodes having a spacing between two inner electrode columns less than a spacing between the inner electrode columns and adjacent outer electrode columns. The inner electrode columns may also be longitudinally offset from the outer electrode columns. The methods and neurostimulation systems steer current between the electrodes to modify a medial-lateral electrical field created adjacent spinal cord tissue.

7. 发明授权

US09352161B2 Method of maintaining intensity output while adjusting pulse width or amplitude 有权
标题翻译：调整脉冲宽度或幅度时保持强度输出的方法
公开(公告)号：US09352161B2
公开(公告)日：2016-05-31
申请号：US11553447
申请日：2006-10-26
申请人： James R. Thacker , Harold Haut , Robert Nathan , David K. L. Peterson , Kerry Bradley
发明人： James R. Thacker , Harold Haut , Robert Nathan , David K. L. Peterson , Kerry Bradley
IPC分类号： A61N1/372 , A61N1/36
CPC分类号： A61N1/37247 , A61N1/36071 , A61N1/36146 , A61N1/36171 , A61N1/36175
摘要： Tissue stimulation systems generally include a pulse generating device for generating electrical stimulation pulses, at least one implanted electrode for delivering the electrical stimulation pulses generated by the pulse generating device, and a programmer capable of communicating with the pulse generating device. Stimulation pulses may be defined by several parameters, such as pulse width and amplitude. In methods of stimulating the tissue with the stimulation system, a user may adjust one of the parameters such as pulse width. The programmer may automatically adjust the pulse amplitude in response to the change in pulse width in order to maintain a substantially constant effect of the stimulation pulses.
摘要翻译：组织刺激系统通常包括用于产生电刺激脉冲的脉冲产生装置，用于传递由脉冲发生装置产生的电刺激脉冲的至少一个注入电极以及能够与脉冲发生装置通信的编程器。刺激脉冲可以由几个参数定义，例如脉冲宽度和幅度。在用刺激系统刺激组织的方法中，用户可以调整诸如脉冲宽度的参数之一。编程器可以响应于脉冲宽度的变化自动调节脉冲幅度，以便保持刺激脉冲的基本恒定的效果。

8. 发明授权

US08923974B2 System and method for electrical modulation of the posterior Longitudinal ligament 有权
标题翻译：后纵韧带电调制系统及方法
公开(公告)号：US08923974B2
公开(公告)日：2014-12-30
申请号：US13469880
申请日：2012-05-11
申请人： Kerry Bradley
发明人： Kerry Bradley
IPC分类号： A61N1/00 , A61N1/05 , A61N1/36
CPC分类号： A61N1/0551 , A61N1/36071
摘要： A method for treating a patient having discogenic pain includes implanting a neurostimulation lead within an anterior portion of the epidural space adjacent to the posterior longitudinal ligament. A plurality of electrodes is attached to the lead and the lead is implanted with at least a portion of the electrodes facing the posterior longitudinal ligament. The lead may be implanted in the lumbar region of the patient's spine, posterior and parallel to the posterior longitudinal ligament. Electrical stimulation energy applied to the patient through the electrode lead implanted in this manner inhibits the pain signals traveling within the posterior longitudinal ligament. Thus, the applied electrical stimulation energy has an anesthetic effect on the pain fibers adjacent to the posterior longitudinal ligament.
摘要翻译：用于治疗具有椎间性疼痛的患者的方法包括将神经刺激引线植入在与后纵韧带相邻的硬膜外腔的前部中。多个电极附接到引线，并且引线被注入，电极的至少一部分面向后纵向韧带。铅可以植入患者脊柱的腰部区域，后部并且平行于后纵韧带。通过以这种方式植入的电极引线施加到患者的电刺激能量抑制在后纵韧带内行进的疼痛信号。因此，所施加的电刺激能量对与后纵韧带相邻的疼痛纤维具有麻醉作用。

9. 发明授权

US08718757B2 Apparatus and methods for detecting migration of neurostimulation leads 有权
标题翻译：用于检测神经刺激导联迁移的装置和方法
公开(公告)号：US08718757B2
公开(公告)日：2014-05-06
申请号：US13367163
申请日：2012-02-06
申请人： Kerry Bradley , Sunil K. Kapoor
发明人： Kerry Bradley , Sunil K. Kapoor
IPC分类号： A61N1/00
CPC分类号： A61N1/37241 , A61N1/0551 , A61N1/08 , A61N1/36071 , A61N1/36135 , A61N1/36185 , A61N2001/083
摘要： Apparatus and methods for detecting lead migration through the use of measured artifactual data about the tissue in the vicinity of the lead.
摘要翻译：通过使用关于铅附近的组织的测量的人为因素来检测引线迁移的装置和方法。

10. 发明申请

US20120330391A1 SYSTEM AND METHOD FOR SPINAL CORD STIMULATION TO TREAT MOTOR DISORDERS 有权
标题翻译：用于脊髓刺激治疗电机障碍的系统和方法
公开(公告)号：US20120330391A1
公开(公告)日：2012-12-27
申请号：US13529906
申请日：2012-06-21
申请人： Kerry Bradley , Dongchul Lee
发明人： Kerry Bradley , Dongchul Lee
IPC分类号： A61N1/05
CPC分类号： A61N1/0551 , A61N1/0553 , A61N1/36067 , A61N1/36171 , A61N1/36175
摘要： A method for using spinal cord stimulation to treat symptoms of motor disorders includes implanting a stimulation lead within a ventral portion of the epidural space. The lead is implanted with at least a portion of the electrodes facing the spinal cord. In a method for providing therapy to a patient suffering from a motor disorder, electrical stimulation energy is applied to at least one ventral column nerve fiber through the implanted stimulation lead. A peripheral region of the patient's body exhibits the symptoms of the motor disorder, and the ventral column nerve fiber to which the stimulation is applied innervates that peripheral region.
摘要翻译：使用脊髓刺激来治疗运动障碍症状的方法包括将刺激引线植入硬膜外腔的腹侧部分。植入铅的至少一部分电极面向脊髓。在向患有运动障碍的患者提供治疗的方法中，通过植入的刺激引线向至少一个腹侧神经纤维施加电刺激能量。患者身体的周边区域表现出运动障碍的症状，并且施加刺激的腹侧柱神经纤维支配该外周区域。

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