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1. 发明授权

US5645796A Process for plasma sterilizing with pulsed antimicrobial agent treatment 失效
标题翻译：用脉冲抗菌剂处理等离子体灭菌的方法
公开(公告)号：US5645796A
公开(公告)日：1997-07-08
申请号：US461412
申请日：1995-06-05
申请人： Ross A. Caputo , Thomas J. Amsler , Kangyan Du , Jeffery Jones , Kern A. Moulton , Bryant A. Campbell, deceased
发明人： Ross A. Caputo , Thomas J. Amsler , Kangyan Du , Jeffery Jones , Kern A. Moulton , Bryant A. Campbell, deceased
IPC分类号： A61L2/14 , A61L2/20 , A61L2/00
CPC分类号： A61L2/208 , A61L2/14 , A61L2/20 , A61L2202/23 , A61L2202/24 , Y10S422/906 , Y10S422/907
摘要： A process for plasma sterilization in which articles in a sterilizing chamber are taken through at least one combination sterilizing cycle. The articles to be sterilized may include the interior of a vessel or chamber. In that case, the vessel or chamber itself may serve as a sterilizing chamber and connects to the plasma generating chamber. Each combination sterilizing cycle includes a pulsed treatment with gaseous antimicrobial agent, removal of the gaseous antimicrobial agent, and a plasma treatment. The pulsed treatment includes one or more pulse-vacuum cycles, each pulse-vacuum cycle includes the steps of evacuating the sterilizing chamber and exposing the article to the gaseous antimicrobial agent with a predetermined pressure profile during a predetermined time. The gaseous antimicrobial agent is preferably carried in a gas mixture with a nonreactive carrier gas. In one embodiment, the predetermined pressure is pulsed. In another embodiment, it is ramped. After the pulsed treatment, the antimicrobial agent is removed by evacuating the sterilizing chamber. The plasma treatment includes exposure of the article to a plasma having essentially uncharged, highly reactive free radicals, molecules and atoms.
摘要翻译：一种用于血浆灭菌的方法，其中灭菌室中的物品通过至少一个组合灭菌循环。待消毒的物品可以包括容器或室的内部。在这种情况下，容器或室本身可以用作灭菌室并连接到等离子体产生室。每个组合灭菌循环包括用气体抗微生物剂进行脉冲处理，去除气态抗微生物剂和等离子体处理。脉冲处理包括一个或多个脉冲真空循环，每个脉冲真空循环包括在预定时间内以预定的压力分布排空灭菌室并将制品暴露于气态抗微生物剂的步骤。气态抗微生物剂优选在与非反应性载气的气体混合物中携带。在一个实施例中，预定压力是脉冲的。在另一个实施例中，它是斜坡的。脉冲处理后，通过抽空灭菌室除去抗菌剂。等离子体处理包括将物品暴露于具有基本上不带电的，高反应性的自由基，分子和原子的等离子体。

2. 发明授权

US5244629A Plasma sterilizing process with pulsed antimicrobial agent pretreatment 失效
标题翻译：具有脉冲抗病毒剂预处理的等离子体灭菌方法
公开(公告)号：US5244629A
公开(公告)日：1993-09-14
申请号：US749041
申请日：1991-08-27
申请人： Ross A. Caputo , Kern A. Moulton , Bryant A. Campbell, deceased , by Louise A. Campbell, legal representative
发明人： Ross A. Caputo , Kern A. Moulton , Bryant A. Campbell, deceased , by Louise A. Campbell, legal representative
IPC分类号： A61L2/14 , A61L2/20
CPC分类号： A61L2/20 , A61L2/14 , Y10S422/906 , Y10S422/907
摘要： A process for plasma sterilization including exposing an article in a sterilizing chamber to at least one combination sterilizing cycle. Each combination sterilizing cycle includes a pulsed treatment with gaseous antimicrobial agent, removal of the gaseous antimicrobial agent, and a plasma treatment. The pulsed treatment includes one or more pulse-vacuum cycles, each pulse-vacuum cycle includes the steps of evacuating the sterilizing chamber and exposing the article to the gaseous antimicrobial agent with a predetermined pressure profile during a predetermined time. The gaseous antimicrobial agent is preferably carried in a gas mixture with a nonreactive carrier gas. In one embodiment, the predetermined pressure is pulsed. In another embodiment, it is ramped. After the pulsed treatment, the antimicrobial agent is removed by evacuating the sterilizing chamber. The plasma treatment includes exposing the article to a plasma having essentially uncharged, highly reactive free radicals and atoms.

3. 发明授权

US5178829A Flash sterilization with plasma 失效
标题翻译：用等离子体灭菌
公开(公告)号：US5178829A
公开(公告)日：1993-01-12
申请号：US576325
申请日：1990-08-31
申请人： Kern A. Moulton , Bryant A. Campbell , Ross A. Caputo
发明人： Kern A. Moulton , Bryant A. Campbell , Ross A. Caputo
IPC分类号： A61L2/14 , H05H1/46
CPC分类号： H05H1/46 , A61L2/14 , Y10S422/906
摘要： A method for flash sterilization with a plasma gas includes exposing an unpackaged article in a sterilizing chamber to a gas plasma flowing from a plasma generating chamber until the temperature in the sterilizing chamber rises to a preselected maximum temperature of at least 100.degree. C. The flow of the plasma gas to the sterilizing chamber is terminated until the temperature in the sterilizing chamber falls to a temperature below the preselected maximum temperature. These steps are repeated until sterilization of the article is effected. The temperature below the preselected maximum temperature when gas plasma flow is again initiated is preferably not more than 3.degree. C. below the preselected maximum temperature. The gas plasma can be generated from a mixture of gases consisting essentially of argon, helium, nitrogen or mixtures thereof; from 1 to 21 (v/v) % oxygen; and from 1 to 20 (v/v) % hydrogen; or a mixture containing from 1 to 10 (v/v) % oxygen and from 3 to 7 (v/v) % hydrogen; or a mixture containing 1 to 10 (v/v) % hydrogen and from 90 to 99 (v/v) % of argon, helium, nitrogen or mixtures thereof. Preferably the pressure in the sterilizing chamber rises to from 0.1 to 10 torr when the gas plasma is flowing into the chamber, and the pressure in the sterilizing chamber falls to a lower pressure when the gas plasma flow into the sterilizing chamber is terminated.
摘要翻译：用等离子体气体进行闪光灭菌的方法包括将消毒室中的未包装的物品暴露于从等离子体发生室流出的气体等离子体直到灭菌室内的温度上升到预选的最高温度至少为100℃。流量直到灭菌室内的温度降至低于预选的最高温度的温度。重复这些步骤直到制品的灭菌。当再次启动气体等离子体流时，低于预选最高温度的温度优选不超过预选最高温度3℃。气体等离子体可以由基本上由氩，氦，氮或其混合物组成的气体的混合物产生; 1至21（v / v）％氧气; 和1至20（v / v）％氢; 或含有1至10（v / v）％氧和3至7（v / v）％氢的混合物; 或含有1至10（v / v）％氢和90至99（v / v）％氩，氦，氮或其混合物的混合物。当气体等离子体流入室时，灭菌室中的压力优选上升至0.1〜10乇，当终止气体等离子体流入灭菌室时，灭菌室内的压力下降到较低的压力。

4. 发明授权

US06261518B1 Process and apparatus for plasma sterilizing with pulsed antimicrobial agent treatment 失效
标题翻译：用脉冲抗菌剂处理等离子体灭菌的方法和装置
公开(公告)号：US06261518B1
公开(公告)日：2001-07-17
申请号：US09183775
申请日：1998-10-30
申请人： Ross A. Caputo , Thomas J. Amsler , Kangyan Du , Jeffery Jones , Kern A. Moulton , Bryant A. Campbell
发明人： Ross A. Caputo , Thomas J. Amsler , Kangyan Du , Jeffery Jones , Kern A. Moulton , Bryant A. Campbell
IPC分类号： A61L214
CPC分类号： A61L2/208 , A61L2/14 , A61L2/20 , A61L2202/23 , A61L2202/24 , Y10S422/906 , Y10S422/907
摘要： A process and equipment for plasma sterilization in which articles in a sterilizing chamber are taken through at least one combination sterilizing cycle. The articles to be sterilized may include the interior of a vessel or chamber. In that case, the vessel or chamber itself may serve as a sterilizing chamber and connects to the plasma generating chamber. Each combination sterilizing cycle includes a pulsed treatment with gaseous antimicrobial agent, removal of the gaseous antimicrobial agent, and a plasma treatment. The pulsed treatment includes one or more pulse-vacuum cycles, each pulse-vacuum cycle includes the steps of evacuating the sterilizing chamber and exposing the article to the gaseous antimicrobial agent with a predetermined pressure profile during a predetermined time. The gaseous antimicrobial agent is preferably carried in a gas mixture with a nonreactive carrier gas. In one embodiment, the predetermined pressure is pulsed. In another embodiment, it is ramped. After the pulsed treatment, the antimicrobial agent is removed by evacuating the sterilizing chamber. The plasma treatment includes exposure of the article to a plasma having essentially uncharged, highly reactive free radicals, molecules and atoms.
摘要翻译：用于等离子体灭菌的方法和设备，其中消毒室中的物品通过至少一个组合灭菌循环。待消毒的物品可以包括容器或室的内部。在这种情况下，容器或室本身可以用作灭菌室并连接到等离子体产生室。每个组合灭菌循环包括用气体抗微生物剂进行脉冲处理，去除气态抗微生物剂和等离子体处理。脉冲处理包括一个或多个脉冲真空循环，每个脉冲真空循环包括在预定时间内以预定的压力分布排空灭菌室并将制品暴露于气态抗微生物剂的步骤。气态抗微生物剂优选在与非反应性载气的气体混合物中携带。在一个实施例中，预定压力是脉冲的。在另一个实施例中，它是斜坡的。脉冲处理后，通过抽空灭菌室除去抗菌剂。等离子体处理包括将物品暴露于具有基本上不带电的，高反应性的自由基，分子和原子的等离子体。

5. 发明授权

US5186893A Plasma cycling sterilizing process 失效
标题翻译：血浆循环灭菌过程
公开(公告)号：US5186893A
公开(公告)日：1993-02-16
申请号：US576294
申请日：1990-08-31
申请人： Kern A. Moulton , Bryant A. Campbell , Ross A. Caputo
发明人： Kern A. Moulton , Bryant A. Campbell , Ross A. Caputo
IPC分类号： A61L2/14 , H05H1/46
CPC分类号： H05H1/46 , A61L2/14 , Y10S422/906
摘要： A method for plasma sterilization within a controlled temperature range includes exposing an article in a sterilizing chamber to a gas plasma flowing from a plasma generating chamber until the temperature in the sterilizing chamber rises to a preselected maximum temperature. The flow of the plasma gas to the sterilizing chamber is terminated until the temperature in the sterilizing chamber falls to a temperature below the preselected maximum temperature. These steps are repeated until sterilization of the article is effected. The temperature below the preselected maximum temperature when gas plasma flow is again initiated is preferably not more than 3.degree. C. below the preselected maximum temperature. The gas plasma can be generated from a mixture of gases consisting essentially of argon, helium, nitrogen or mixtures thereof; from 1 to 21 (v/v) % oxygen; and from 1 to 20 (v/v) % hydrogen; or a mixture containing from 1 to 10 (v/v) % oxygen and from 3 to 7 (v/v) % hydrogen; or a mixture containing 1 to 10 (v/v) % hydrogen and from 90 to 99 (v/v) % of argon, helium, nitrogen or mixtures thereof. Preferably the pressure in the sterilizing chamber rises to from 0.1 to 10 torr when the gas plasma is flowing into the chamber, and the pressure in the sterilizing chamber falls to a lower pressure when the gas plasma flow into the sterilizing chamber is terminated.
摘要翻译：一种在受控温度范围内进行等离子体灭菌的方法，包括将灭菌室内的物品暴露于从等离子体发生室流出的气体等离子体直到灭菌室内的温度上升到预选的最高温度。终止等离子体气体到灭菌室的流动，直到灭菌室内的温度降到低于预选的最高温度的温度。重复这些步骤直到制品的灭菌。当再次启动气体等离子体流时，低于预选最高温度的温度优选不超过预选最高温度3℃。气体等离子体可以由基本上由氩，氦，氮或其混合物组成的气体的混合物产生; 1至21（v / v）％氧气; 和1至20（v / v）％氢; 或含有1至10（v / v）％氧和3至7（v / v）％氢的混合物; 或含有1至10（v / v）％氢和90至99（v / v）％氩，氦，氮或其混合物的混合物。当气体等离子体流入室时，灭菌室中的压力优选上升至0.1〜10乇，当终止气体等离子体流入灭菌室时，灭菌室内的压力下降到较低的压力。

6. 发明授权

US5413758A Apparatus for plasma sterilizing with pulsed antimicrobial agent treatment 失效
标题翻译：用脉冲抗菌剂处理等离子体灭菌的装置
公开(公告)号：US5413758A
公开(公告)日：1995-05-09
申请号：US65859
申请日：1993-05-21
申请人： Ross A. Caputo , Jeffrey Jones , Kern A. Moulton , Bryant A. Campbell, deceased
发明人： Ross A. Caputo , Jeffrey Jones , Kern A. Moulton , Bryant A. Campbell, deceased
IPC分类号： A61L2/14 , A61L2/20
CPC分类号： A61L2/20 , A61L2/14 , Y10S422/906 , Y10S422/907
摘要： A process and equipment for plasma sterilization in which articles in a sterilizing chamber are taken through at least one combination sterilizing cycle. The articles to be sterilized may include the interior of a vessel or chamber. In that case, the vessel or chamber itself may serve as a sterilizing chamber and connects to the plasma generating chamber. Each combination sterilizing cycle includes a pulsed treatment with gaseous antimicrobial agent, removal of the gaseous antimicrobial agent, and a plasma treatment. The pulsed treatment includes one or more pulse-vacuum cycles, each pulse-vacuum cycle includes the steps of evacuating the sterilizing chamber and exposing the article to the gaseous antimicrobial agent with a predetermined pressure profile during a predetermined time. The gaseous antimicrobial agent is preferably carried in a gas mixture with a nonreactive carrier gas. In one embodiment, the predetermined pressure is pulsed. In another embodiment, it is ramped. After the pulsed treatment, the antimicrobial agent is removed by evacuating the sterilizing chamber. The plasma treatment includes exposure of the article to a plasma having essentially uncharged, highly reactive free radicals, molecules and atoms.
摘要翻译：用于等离子体灭菌的方法和设备，其中消毒室中的物品通过至少一个组合灭菌循环。待消毒的物品可以包括容器或室的内部。在这种情况下，容器或室本身可以用作灭菌室并连接到等离子体产生室。每个组合灭菌循环包括用气体抗微生物剂进行脉冲处理，去除气态抗微生物剂和等离子体处理。脉冲处理包括一个或多个脉冲真空循环，每个脉冲真空循环包括在预定时间内以预定的压力分布排空灭菌室并将制品暴露于气态抗微生物剂的步骤。气态抗微生物剂优选在与非反应性载气的气体混合物中携带。在一个实施例中，预定压力是脉冲的。在另一个实施例中，它是斜坡的。脉冲处理后，通过抽空灭菌室除去抗菌剂。等离子体处理包括将物品暴露于具有基本上不带电的，高反应性的自由基，分子和原子的等离子体。

7. 发明授权

US5288460A Plasma cycling sterilizing process 失效
标题翻译：血浆循环灭菌过程
公开(公告)号：US5288460A
公开(公告)日：1994-02-22
申请号：US962895
申请日：1992-10-19
申请人： Ross A. Caputo , Jeffrey Jones , Kern A. Moulton , Bryant A. Campbell, deceased
发明人： Ross A. Caputo , Jeffrey Jones , Kern A. Moulton , Bryant A. Campbell, deceased
IPC分类号： A61L2/14 , H05H1/46 , A61L2/00
CPC分类号： H05H1/46 , A61L2/14
摘要： A method for plasma sterilization within a controlled temperature range includes exposing the interior of a chamber and any articles therein to a gas plasma flowing from a plasma generating chamber until the temperature in the chamber rises to a preselected maximum temperature. The flow of the plasma gas to the chamber is terminated when the temperature in the chamber falls to a temperature below the preselected maximum temperature. These steps are repeated until sterilization of the interior of the chamber or any articles therein is effected. The temperature below the preselected maximum temperature when gas plasma flow is again initiated is preferably not more than 3.degree. C. below the preselected maximum temperature. The gas plasma can be generated from a gas mixture that includes oxidizing and/or reducing agents. Preferably the pressure in the sterilizing chamber rises to from 0.1 to 10 torr when the gas plasma is flowing into the chamber, and the pressure in the sterilizing chamber falls to a lower pressure when the gas plasma flow into the sterilizing chamber is terminated. The articles to be sterilized include the interior of a vessel or chamber. The vessel or chamber itself serves as a sterilizing chamber and connects to the plasma generating chamber.
摘要翻译：在受控温度范围内的等离子体灭菌的方法包括将室内和其中的任何物品暴露于从等离子体发生室流出的气体等离子体，直到室内的温度上升到预选的最高温度。当室内的温度下降到低于预选的最高温度的温度时，等离子体气体流到室的流动被终止。重复这些步骤，直到对室内或其中的任何物品进行杀菌。当再次启动气体等离子体流时，低于预选最大温度的温度优选不低于预选最高温度3摄氏度。气体等离子体可以由包括氧化和/或还原剂的气体混合物产生。当气体等离子体流入室时，灭菌室中的压力优选上升至0.1〜10乇，当终止气体等离子体流入灭菌室时，灭菌室内的压力下降到较低的压力。待灭菌的物品包括容器或室的内部。容器或室本身用作灭菌室并连接到等离子体产生室。

8. 发明授权

US5084239A Plasma sterilizing process with pulsed antimicrobial agent treatment 失效
标题翻译：脉冲灭菌方法采用脉冲抗菌剂处理
公开(公告)号：US5084239A
公开(公告)日：1992-01-28
申请号：US576235
申请日：1990-08-31
申请人： Kern A. Moulton , Bryant A. Campbell , Ross A. Caputo
发明人： Kern A. Moulton , Bryant A. Campbell , Ross A. Caputo
IPC分类号： A61L2/14 , A61L2/20
CPC分类号： A61L2/14 , A61L2/20
摘要： A process for plasma sterilization comprising exposing an article in a sterilizing chamber to at least one cycle comprising a pulsed treatment with gaseous antimicrobial agent and a plasma treatment. The pulsed treatment comprises at least two pulse-vacuum cycles, each pulse-vacuum cycle comprising the steps of exposing the article to the gaseous antimicrobial agent at a pressure of from 4 to 18 torr and reducing the pressure in the sterilizing chamber to from 0.1 to 4 torr. The plasma treatment comprising exposing the article to a plasma generated from gases selected from the group consisting essentially of argon, helium, nitrogen, oxygen, hydrogen and mixtures thereof, the exposure to the plasma being carried out at a pressure of from 0.1 to 10 torr and a temperature of less than 80.degree. C. The antimicrobial agent is selected from the group consisting of hydrogen peroxide, a peracid antimicrobial agent, and mixtures thereof, the peracid antimicrobial agent being selected from the group consisting of saturated and unsaturated peralkanoic acids having from 1 to 8 carbon atoms and halogenated derivatives thereof.
摘要翻译：一种用于等离子体灭菌的方法，包括将消毒室中的物品暴露于至少一个循环，包括用气态抗微生物剂进行脉冲处理和等离子体处理。脉冲处理包括至少两个脉冲真空循环，每个脉冲真空循环包括以4至18托的压力将制品暴露于气态抗微生物剂的步骤，并将灭菌室中的压力降至0.1至 4托等离子体处理包括将制品暴露于从基本上由氩，氦，氮，氧，氢及其混合物组成的组中选出的气体产生的等离子体中，暴露于等离子体的压力为0.1至10托并且温度低于80℃。抗微生物剂选自过氧化氢，过酸性抗微生物剂及其混合物，所述过酸抗微生物剂选自饱和和不饱和的过氧烷酸，其具有 1至8个碳原子及其卤化衍生物。

9. 发明授权

US07090808B2 Apparatus for testing sterilization methods and materials 失效
公开(公告)号：US07090808B2
公开(公告)日：2006-08-15
申请号：US09901389
申请日：2001-07-09
申请人： Ross A. Caputo , Robert R. Reich, Jr. , Robert J. Thrash , Jimmy Fisher , Davoud Khorzad , Thomas F. Cullen
发明人： Ross A. Caputo , Robert R. Reich, Jr. , Robert J. Thrash , Jimmy Fisher , Davoud Khorzad , Thomas F. Cullen
IPC分类号： A61L9/00 , B01J19/08 , G01N21/00
CPC分类号： A61L2/208 , A61L2/28 , A61L2202/122 , A61L2202/14 , G01N21/3504
摘要： Apparatus and method for testing one or more sterilization indicators (e.g., biological indicators or chemical indicators) or other articles by contacting them under controlled sterilization conditions with a flowing antimicrobial gas containing hydrogen peroxide vapor are disclosed. This invention also provides apparatus and method for testing sterilization processes that use a flowing antimicrobial gas containing hydrogen peroxide vapor under controlled sterilization conditions, or for testing materials for such processes under controlled sterilization conditions, or for testing both such processes and such materials under controlled sterilization conditions. There can be an essentially square-wave contact of the sterilization indicators or other articles with the antimicrobial gas (i.e., short rise time to reach full concentration of the antimicrobial gas in contact with the sterilization indicators or other articles and short fall time to remove all of the antimicrobial gas from contact with the sterilization indicators or other articles). A preferred way of generating a substantially constant flow of antimicrobial gas of substantially constant hydrogen peroxide concentration may be used to generate the antimicrobial gas. A preferred way of determining the hydrogen peroxide concentration in the antimicrobial gas may be used.

10. 发明授权

US5620656A Packaging systems for peracid sterilization processes 失效
标题翻译：用于过酸灭菌过程的包装系统
公开(公告)号：US5620656A
公开(公告)日：1997-04-15
申请号：US566477
申请日：1995-12-04
申请人： Afaf Wensky , Phillip A. Martens , Ross A. Caputo
发明人： Afaf Wensky , Phillip A. Martens , Ross A. Caputo
IPC分类号： A61L2/28 , C12Q1/22 , G01N31/22
CPC分类号： G01N31/226 , A61L2/28 , C12Q1/22
摘要： Devices useful to monitor whether or not an article has been exposed to sterilizing conditions are provided and comprise a package and an indicator associated with the package. The package is sufficiently permeable to admit sterilizing gas or vapor into the package. The indicator associated with the package changes color from a first color (indicating ambient conditions) to a second color (indicating exposure to acidic gas or vapor). Both the first and second colors of the indicator are stable and preferably substantially maintain their colors under ambient conditions. Particularly, preferred embodiments are adapted for use with peracetic acid sterilization processes.
摘要翻译：提供了用于监测物品是否已经暴露于消毒条件的装置，并且包括与包装件相关联的包装和指示器。该包装具有足够的渗透性，以将消毒气体或蒸气引入包装中。与包装件相关联的指示器将颜色从第一种颜色（指示环境条件）改变为第二种颜色（指示暴露于酸性气体或蒸汽）。指示器的第一和第二颜色都是稳定的，并且优选地在环境条件下基本保持其颜色。特别地，优选的实施方案适用于过乙酸灭菌方法。

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