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1. 发明授权

US06261518B1 Process and apparatus for plasma sterilizing with pulsed antimicrobial agent treatment 失效
标题翻译：用脉冲抗菌剂处理等离子体灭菌的方法和装置
公开(公告)号：US06261518B1
公开(公告)日：2001-07-17
申请号：US09183775
申请日：1998-10-30
申请人： Ross A. Caputo , Thomas J. Amsler , Kangyan Du , Jeffery Jones , Kern A. Moulton , Bryant A. Campbell
发明人： Ross A. Caputo , Thomas J. Amsler , Kangyan Du , Jeffery Jones , Kern A. Moulton , Bryant A. Campbell
IPC分类号： A61L214
CPC分类号： A61L2/208 , A61L2/14 , A61L2/20 , A61L2202/23 , A61L2202/24 , Y10S422/906 , Y10S422/907
摘要： A process and equipment for plasma sterilization in which articles in a sterilizing chamber are taken through at least one combination sterilizing cycle. The articles to be sterilized may include the interior of a vessel or chamber. In that case, the vessel or chamber itself may serve as a sterilizing chamber and connects to the plasma generating chamber. Each combination sterilizing cycle includes a pulsed treatment with gaseous antimicrobial agent, removal of the gaseous antimicrobial agent, and a plasma treatment. The pulsed treatment includes one or more pulse-vacuum cycles, each pulse-vacuum cycle includes the steps of evacuating the sterilizing chamber and exposing the article to the gaseous antimicrobial agent with a predetermined pressure profile during a predetermined time. The gaseous antimicrobial agent is preferably carried in a gas mixture with a nonreactive carrier gas. In one embodiment, the predetermined pressure is pulsed. In another embodiment, it is ramped. After the pulsed treatment, the antimicrobial agent is removed by evacuating the sterilizing chamber. The plasma treatment includes exposure of the article to a plasma having essentially uncharged, highly reactive free radicals, molecules and atoms.
摘要翻译：用于等离子体灭菌的方法和设备，其中消毒室中的物品通过至少一个组合灭菌循环。待消毒的物品可以包括容器或室的内部。在这种情况下，容器或室本身可以用作灭菌室并连接到等离子体产生室。每个组合灭菌循环包括用气体抗微生物剂进行脉冲处理，去除气态抗微生物剂和等离子体处理。脉冲处理包括一个或多个脉冲真空循环，每个脉冲真空循环包括在预定时间内以预定的压力分布排空灭菌室并将制品暴露于气态抗微生物剂的步骤。气态抗微生物剂优选在与非反应性载气的气体混合物中携带。在一个实施例中，预定压力是脉冲的。在另一个实施例中，它是斜坡的。脉冲处理后，通过抽空灭菌室除去抗菌剂。等离子体处理包括将物品暴露于具有基本上不带电的，高反应性的自由基，分子和原子的等离子体。

2. 发明授权

US06790410B2 Use of a hydrogen peroxide plasma sterilization method for the mild sterilization of temperature-sensitive products 有权
标题翻译：使用过氧化氢等离子体灭菌方法对温敏产品进行温和灭菌
公开(公告)号：US06790410B2
公开(公告)日：2004-09-14
申请号：US10052469
申请日：2002-01-23
申请人： Hubert Metzner , Joerg Lemmer , Horst Naumann
发明人： Hubert Metzner , Joerg Lemmer , Horst Naumann
IPC分类号： A61L214
CPC分类号： A61L2/186 , A61L2/0011 , A61L2/0088 , A61L2/0094 , A61L2/14 , A61L2/208 , A61L2202/23 , B65B55/10
摘要： The invention relates to a method for hydrogen peroxide plasma sterilization, wherein the chamber temperature is set at less than 39° C. throughout, and containers with temperature-sensitive products can be efficiently sterilized without the temperature-sensitive products showing a significant loss of activity or degradation.
摘要翻译：本发明涉及一种用于过氧化氢等离子体灭菌的方法，其中室温度设定在低于39℃，并且具有温度敏感产品的容器可以被有效地消毒，而不会导致显着的活性损失的温度敏感产品或降解。

3. 发明授权

US06627163B1 Process for sterilizing containers 失效
标题翻译：灭菌容器的方法
公开(公告)号：US06627163B1
公开(公告)日：2003-09-30
申请号：US09251443
申请日：1999-02-17
申请人： Peter Awakowicz , Robert Frost
发明人： Peter Awakowicz , Robert Frost
IPC分类号： A61L214
CPC分类号： A61L2/14 , B65B55/06
摘要： In order to sterilize previously washed containers in an evacuable reactor, a low pressure plasma is generated by a high frequency generator. A microwave generator is also and can be switched on for drying the container before the plasma is ignited.
摘要翻译：为了对可抽真空的反应器中的先前洗过的容器进行灭菌，通过高频发生器产生低压等离子体。在等离子体点火之前，微波发生器也可以被接通以干燥容器。

4. 发明授权

US06737029B2 Method and apparatus for sterilizing mail 失效
标题翻译：消毒邮件的方法和设备
公开(公告)号：US06737029B2
公开(公告)日：2004-05-18
申请号：US10223919
申请日：2002-08-20
申请人： Jimmie D. Miller , Blair Sutton
发明人： Jimmie D. Miller , Blair Sutton
IPC分类号： A61L214
CPC分类号： A62D3/38 , A61L2/202 , A62D2101/02 , G01N2001/025
摘要： An apparatus for sterilizing an article of mail includes a chamber defining an airtight space and having an entrance for receiving the article of mail. A vacuum pump is coupled to the chamber for withdrawing air therefrom and, specifically, from the article of mail, this air withdrawal reducing the chamber air pressure. An ozone generator is coupled to the chamber for introducing ozone at atmospheric pressure therein following air withdrawal. This causes efficient diffusing of the ozone into the article of mail for sterilizing it against anthrax. The ozone is then withdrawn into an ozone filter that includes a non-consumable manganese dioxide catalyst for converting the ozone back into oxygen. The article of mail may be initially perforated to enhance air withdrawal and ozone diffusion. The article of mail may be embossed following ozone withdrawal to indicate completion of sterilization. The apparatus may be implemented using multiple chambers.
摘要翻译：用于消毒邮件的设备包括限定气密空间并具有用于接收邮件的入口的室。真空泵联接到室以从其中抽出空气，特别是从邮件中抽出空气，这种空气抽吸降低了室内的空气压力。臭氧发生器耦合到室，用于在空气抽出之后在大气压下引入臭氧。这导致将臭氧有效地扩散到邮件中以对其进行针对炭疽消毒。然后将臭氧抽回到臭氧过滤器中，臭氧过滤器包括用于将臭氧转化为氧气的非消耗性二氧化锰催化剂。邮件可以最初被穿孔以增强空气抽出和臭氧扩散。在臭氧消除后，邮件可以被压印以指示灭菌完成。该装置可以使用多个腔室来实现。

5. 发明授权

US06403029B1 System and method of applying energetic ions for sterilization 失效
标题翻译：将能量离子用于灭菌的系统和方法
公开(公告)号：US06403029B1
公开(公告)日：2002-06-11
申请号：US09760513
申请日：2001-01-12
申请人： John A. Schmidt
发明人： John A. Schmidt
IPC分类号： A61L214
CPC分类号： B65B55/04 , A23L3/26 , A61L2/14
摘要： A method of sterilization of a container is provided whereby a cold plasma is caused to be disposed near a surface to be sterilized, and the cold plasma is then subjected to a pulsed voltage differential for producing energized ions in the plasma. Those energized ions then operate to achieve spore destruction on the surface to be sterilized. Further, a system for sterilization of a container which includes a conductive or non-conductive container, a cold plasma in proximity to the container, and a high voltage source for delivering a pulsed voltage differential between an electrode and the container and across the cold plasma, is provided.
摘要翻译：提供容器的灭菌方法，由此使冷等离子体设置在待消毒表面附近，然后将冷等离子体经受用于在等离子体中产生激发离子的脉冲电压差。然后，那些通电的离子然后操作以在待消毒的表面上实现孢子破坏。此外，用于灭菌容器的系统包括导电或非导电容器，靠近容器的冷等离子体，以及用于在电极和容器之间以及穿过冷等离子体之间递送脉冲电压差的高压源，被提供。

6. 发明授权

US06667007B1 System and method of applying energetic ions for sterilization 失效
公开(公告)号：US06667007B1
公开(公告)日：2003-12-23
申请号：US10164838
申请日：2002-06-07
申请人： John A. Schmidt
发明人： John A. Schmidt
IPC分类号： A61L214
CPC分类号： B65B55/04 , A23L3/26 , A61L2/14
摘要： A method of sterilization of a container is provided whereby a cold plasma is caused to be disposed near a surface to be sterilized, and the cold plasma is then subjected to a pulsed voltage differential for producing energized ions in the plasma. Those energized ions then operate to achieve spore destruction on the surface to be sterilized. Further, a system for sterilization of a container which includes a conductive or non-conductive container, a cold plasma in proximity to the container, and a high voltage source for delivering a pulsed voltage differential between an electrode and the container and across the cold plasma, is provided.

7. 发明授权

US06365102B1 Method of enhanced sterilization with improved material compatibility 失效
标题翻译：增强灭菌方法，提高材料的相容性
公开(公告)号：US06365102B1
公开(公告)日：2002-04-02
申请号：US09470246
申请日：1999-12-22
申请人： Su-Syin S. Wu , Nancy S. Chu , Abraham Merhazion
发明人： Su-Syin S. Wu , Nancy S. Chu , Abraham Merhazion
IPC分类号： A61L214
CPC分类号： A61L2/202 , A61L2/14 , A61L2/206
摘要： A method of enhanced sterilization with improved material compatibility. The following enhancements have been made. First, repeated venting, evacuation, and plasma treatments can be performed in the pre-plasma stage. Second, a lower power level can be used in the post-plasma stage than in the pre-plasma stage. Third, after the post-plasma stage, the chamber can be held at atmospheric pressure or sub-atmospheric pressure for a period of time after venting, before re-evacuating the chamber, rather than evacuating after the chamber is vented to atmospheric pressure or sub-atmospheric pressure. Any of the three enhancements may be used separately, and it is not necessary to practice all three enhancements to obtain at least some of the benefits of enhanced sterilization with improved material compatibility.
摘要翻译：一种增强灭菌的方法，具有改善的材料相容性。进行了以下改进。首先，可以在预等离子体阶段进行反复排气，排空和等离子体处理。其次，在等离子体后阶段中可以使用比在等离子体前阶段更低的功率水平。第三，在后等离子体阶段之后，在排气之后，室可以在大气压或低于大气压的压力下保持一段时间，而不是在室被排放到大气压之后抽真空 -气压。三种增强中的任一种可以单独使用，并且不需要实施所有三种增强方式以获得具有改善的材料相容性的增强灭菌的至少一些益处。

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