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1. 发明申请

WO2002076336A3 IMPLANTABLE PROSTHETIC OR TISSUE EXPANDING DEVICE 审中-公开
公开(公告)号：WO2002076336A3
公开(公告)日：2002-10-03
申请号：PCT/US2002/008576
申请日：2002-03-20
申请人： KERAPLAST TECHNOLOGIES, LTD. , ZUCHERMAN, James, F. , HSU, Ken, Y. , YERBY, Scott , SMITH, Robert, A.
发明人： ZUCHERMAN, James, F. , HSU, Ken, Y. , YERBY, Scott , SMITH, Robert, A.
IPC分类号： A61F2/44
摘要： A keratin hydrogel-filled implantable prosthetic device is claimed. The device is an implant for the intervertebral disc space. One source of keratin is human hair. The device (504) can comprise envelopes of a keratin hydrogel (502) that may be used for partial or full disc replacement. The envelopes may be encased in an outer wall (506).

2. 发明公开

EP1383444A2 IMPLANTABLE PROSTHETIC OR TISSUE EXPANDING DEVICE 审中-公开
标题翻译：植入假体或组织扩张
公开(公告)号：EP1383444A2
公开(公告)日：2004-01-28
申请号：EP02753791.9
申请日：2002-03-20
申请人： Keraplast Technologies Ltd.
发明人： ZUCHERMAN, James, F. , HSU, Ken, Y. , YERBY, Scott , SMITH, Robert, A.
IPC分类号： A61F2/00
CPC分类号： A61F2/12 , A61F2/441 , A61F2/442 , A61F2002/2817 , A61F2002/30004 , A61F2002/30006 , A61F2002/30009 , A61F2002/30586 , A61F2002/30677 , A61F2002/30971 , A61F2002/4435 , A61F2002/444 , A61F2250/0014 , A61F2250/0015 , A61F2250/0028 , A61F2310/00365 , A61L27/227 , A61L27/306 , A61L27/34 , A61L27/52 , A61L2430/04 , A61L2430/38 , A61L27/38 , C08L83/04
摘要： A keratin hydrogel-filled implantable prosthetic device is claimed. The device is an implant for the intervertebral disc space. One source of keratin is human hair. The device (504) can comprise envelopes of a keratin hydrogel (502) that may be used for partial or full disc replacement. The envelopes may be encased in an outer wall (506).

3. 发明公开

EP1039873A1 KERATIN-BASED HYDROGEL FOR BIOMEDICAL APPLICATIONS AND METHOD OF PRODUCTION 有权
标题翻译：水凝角蛋白基地，为生物医学应用及其制造方法
公开(公告)号：EP1039873A1
公开(公告)日：2000-10-04
申请号：EP98958709.2
申请日：1998-11-25
申请人： Keraplast Technologies Ltd.
发明人： BLANCHARD, Cheryl, R. , TIMMONS, Scott, F. , SMITH, Robert, A.
IPC分类号： A61K7/06 , A61K38/00 , A61K38/17 , C08G63/48 , C08G63/91 , C07K1/00 , C07K14/00 , C07K16/00 , C07K17/00 , C08H1/06
CPC分类号： C08H1/06 , A61K8/042 , A61K8/65 , A61K38/1709 , A61K38/39 , A61L26/0047 , A61L26/008 , A61L27/227 , A61L27/34 , A61L27/52 , A61L27/60 , A61L31/047 , A61L31/10 , A61Q19/00 , C07K14/4741 , Y10S514/944 , Y10S530/842 , C08L89/04 , C08L89/00
摘要： A keratin hydrogel which can be used as a wound dressing and cell scaffolding. The keratin hydrogel is formed from clean, washed hair by partially oxidizing a significant percentage of disulfide linkages to form cysteic acid groups, while some disulfide linkages remain intact. The partially oxidized hair is treated with a reducing agent, thereby reducing most of the remaining disulfide linkages to cysteine-thioglycollate disulfide and cysteine groups. A soluble fraction of hair is collected and oxidized, such that the reduced sulfur groups are allowed to reform disulfide linkages, thereby binding the keratin together. The cysteic acid groups remain, providing hydrophilic sites within the hydrogel. A higher degree of partial oxidation results in a greater abundance of hydrophilic cysteic acid groups in the hydrogel.

4. 发明公开

EP1265570A1 SOLUBLE KERATIN PEPTIDE 有权
标题翻译：可溶性KERATINPEPTID
公开(公告)号：EP1265570A1
公开(公告)日：2002-12-18
申请号：EP00942727.9
申请日：2000-06-09
申请人： Keraplast Technologies Ltd.
发明人： VAN DYKE, Mark, E. , BLANCHARD, Cheryl, R. , TIMMONS, Scott, F. , SILLER-JACKSON, Arlene, J. , SMITH, Robert, A.
IPC分类号： A61F13/00 , A61F13/02 , A61K7/06
CPC分类号： C07K14/4741 , A61K8/02 , A61K8/0208 , A61K8/64 , A61K8/65 , A61K8/66 , A61K38/17 , A61Q19/00 , A61Q19/08
摘要： A peptide derived from keratin, which can be used as a wound-healing agent. In one method for making the peptide, a keratin source such as human hair is washed, dried, and treated with an oxidizing agent such as peracetic acid for a time and temperature sufficient to swell the keratin and oxidize some of the disulfide bonds to form sulfonic acid groups. The oxidation is believed to form a series of water-soluble peptides. The oxidized hair can be filtered, and the filtrate collected and concentrated under vacuum distillation to a viscous syrup, which can be neutralized with base. The concentrate can be mixed with an excess of a water-miscible organic solvent such as methanol, and the precipitate collected and dried to form the wound-healing agent. The wound-healing agent is believed to include peptides having a molecular weight centered around 850 daltons and having at least one ionizeable group such as sulfonic acid.

5. 发明公开

EP1274369A2 IMPLANTABLE PROSTHETIC OR TISSUE EXPANDING DEVICE 审中-公开
标题翻译：植入或可在织物扩张GRAFT
公开(公告)号：EP1274369A2
公开(公告)日：2003-01-15
申请号：EP00961854.7
申请日：2000-09-13
申请人： Keraplast Technologies Ltd.
发明人： VAN DYKE, Mark, E. , BLANCHARD, Cheryl, R. , TIMMONS, Scott, F. , SILLER-JACKSON, Arlene, J. , SMITH, Robert, A.
IPC分类号： A61F2/00 , A61F2/54 , A61B19/00 , A61B17/06 , A61K38/17
CPC分类号： A61L27/52 , A61F2/0059 , A61F2/12 , A61F2/441 , A61F2002/30971 , A61L27/227 , A61L27/306 , A61L27/34 , A61L2430/04 , A61L2430/38 , A61L27/38 , C08L83/04
摘要： A keratin hydrogel-filled implantable prosthetic device. One device is a breast implant for augmenting or reconstructing a human breast including an envelope containing a keratin hydrogel. One keratin hydrogel is formed from a solid precursor which forms a keratin hydrogel upon addition of water. One source of keratin is human hair. In one method, an envelope suitable for implantation and a solid keratin hydrogel precursor are provided. The solid can be in fibrous or powder form. The solid precursor can be inserted into the envelope interior. A small incision near the breast can be made and the envelope inserted into the incision. After insertion, water can be injected into the envelope interior, preferably through the incision and through a self-sealing port in the envelope. In one method, the implant is provided as a kit, with the envelope and keratin hydrogel provided. The hydrogel can be injected into the envelope either before or after insertion into the breast area. One kit has a powdered, keratin hydrogel precursor disposed within the envelope interior, awaiting the addition of water, preferably after insertion of the implant into the body.

6. 发明授权

EP1265570B1 SOLUBLE KERATIN PEPTIDE 有权
标题翻译：可溶性角蛋白肽
公开(公告)号：EP1265570B1
公开(公告)日：2004-11-10
申请号：EP00942727.9
申请日：2000-06-09
申请人： Keraplast Technologies Ltd.
发明人： VAN DYKE, Mark, E. , BLANCHARD, Cheryl, R. , TIMMONS, Scott, F. , SILLER-JACKSON, Arlene, J. , SMITH, Robert, A.
IPC分类号： A61K38/17 , A61K9/70 , A61P17/02
CPC分类号： C07K14/4741 , A61K8/02 , A61K8/0208 , A61K8/64 , A61K8/65 , A61K8/66 , A61K38/17 , A61Q19/00 , A61Q19/08
摘要： A peptide derived from keratin, which can be used as a wound-healing agent. In one method for making the peptide, a keratin source such as human hair is washed, dried, and treated with an oxidizing agent such as peracetic acid for a time and temperature sufficient to swell the keratin and oxidize some of the disulfide bonds to form sulfonic acid groups. The oxidation is believed to form a series of water-soluble peptides. The oxidized hair can be filtered, and the filtrate collected and concentrated under vacuum distillation to a viscous syrup, which can be neutralized with base. The concentrate can be mixed with an excess of a water-miscible organic solvent such as methanol, and the precipitate collected and dried to form the wound-healing agent. The wound-healing agent is believed to include peptides having a molecular weight centered around 850 daltons and having at least one ionizeable group such as sulfonic acid.
摘要翻译：角蛋白衍生的肽，可用作伤口愈合剂。在一种制备肽的方法中，将角蛋白来源如人的头发洗涤，干燥并用氧化剂如过乙酸处理足够的时间和温度以使角蛋白溶胀并氧化一些二硫键以形成磺酸酸基团。认为氧化形成一系列水溶性肽。可以过滤氧化的头发，收集滤液并在真空蒸馏下浓缩成粘性糖浆，其可以用碱中和。可以将浓缩物与过量的与水混溶的有机溶剂如甲醇混合，收集沉淀并干燥以形成伤口愈合剂。认为伤口愈合剂包括具有以850道尔顿为中心的分子量并具有至少一个可电离基团如磺酸的肽。

7. 发明授权

EP1033953B1 METHOD OF CROSS-LINKING KERATIN-BASED FILMS, SHEETS, AND BULK MATERIALS 有权
标题翻译：方法联网薄膜，薄膜和BULK
公开(公告)号：EP1033953B1
公开(公告)日：2008-03-26
申请号：EP98958109.5
申请日：1998-11-25
申请人： Keraplast Technologies Ltd.
发明人： TIMMONS, Scott, F. , BLANCHARD, Cheryl, R. , SMITH, Robert, A.
IPC分类号： A61F13/00 , A61K9/70 , A61K38/00 , A61K38/17 , A61L15/00 , C08G63/48 , C08G63/91 , C08L89/00 , C07K1/00 , C07K14/00 , C07K16/00 , C07K17/00 , C08H1/06
CPC分类号： C12N5/0068 , A61K9/70 , A61K35/36 , A61K38/1709 , A61K38/39 , A61L15/32 , A61L26/0047 , A61L26/008 , A61L27/227 , A61L27/34 , A61L27/60 , A61L31/047 , A61L31/10 , C07K14/4741 , C08H1/06 , C12N2533/50 , Y10S530/842 , C08L89/04 , C08L89/00
摘要： Methods for producing thin keratin films, sheets, and bulk materials, and products formed using these methods. One method includes providing hair, reducing the hair such that the disulfide linkages are broken and free cysteine thiol groups formed, separating out a more soluble keratin fraction in solution, forming a thin layer from the more soluble fraction, and air drying the keratin fraction in the presence of oxygen, thereby forming new disulfide bonds imparting strength to the resulting thin keratin film. One method includes reducing hair by heating the hair under nitrogen in an ammonium hydroxide and ammonium thioglycolate solution followed by centrifuging and collecting the supernatant containing the more soluble keratin fraction. The more soluble keratin in this method is precipitated using HCl, removed, and resuspended in ammonium hydroxide. The keratin solution thus formed is poured onto a flat surface and allowed to air dry into a thin keratin film. The film may be used as a wound dressing, a tissue-engineering scaffold, a diffusion membrane, a coating for implantable devices, and as a cell encapsulant. In another method, the keratin solution thus formed is concentrated, poured into a mold, and allowed to air dry into a three dimensional keratin product. The resulting bulk product can be used as a cross-linked implantable biomaterial for soft and hard tissue replacement. In another method, a keratin solution is emulsified and freeze dried, forming a porous, open cell keratin material.

8. 发明授权

EP1039873B1 KERATIN-BASED HYDROGEL FOR BIOMEDICAL APPLICATIONS AND METHOD OF PRODUCTION 有权
标题翻译：水凝角蛋白基地，为生物医学应用及其制造方法
公开(公告)号：EP1039873B1
公开(公告)日：2008-02-20
申请号：EP98958709.2
申请日：1998-11-25
申请人： Keraplast Technologies Ltd.
发明人： BLANCHARD, Cheryl, R. , TIMMONS, Scott, F. , SMITH, Robert, A.
IPC分类号： A61Q5/00 , A61K38/00 , A61K38/17 , C08G63/48 , C08G63/91 , C07K1/00 , C07K14/00 , C07K16/00 , C07K17/00 , C08H1/06 , C07K14/47 , C07K1/113
CPC分类号： C08H1/06 , A61K8/042 , A61K8/65 , A61K38/1709 , A61K38/39 , A61L26/0047 , A61L26/008 , A61L27/227 , A61L27/34 , A61L27/52 , A61L27/60 , A61L31/047 , A61L31/10 , A61Q19/00 , C07K14/4741 , Y10S514/944 , Y10S530/842 , C08L89/04 , C08L89/00
摘要： A keratin hydrogel which can be used as a wound dressing and cell scaffolding. The keratin hydrogel is formed from clean, washed hair by partially oxidizing a significant percentage of disulfide linkages to form cysteic acid groups, while some disulfide linkages remain intact. The partially oxidized hair is treated with a reducing agent, thereby reducing most of the remaining disulfide linkages to cysteine-thioglycollate disulfide and cysteine groups. A soluble fraction of hair is collected and oxidized, such that the reduced sulfur groups are allowed to reform disulfide linkages, thereby binding the keratin together. The cysteic acid groups remain, providing hydrophilic sites within the hydrogel. A higher degree of partial oxidation results in a greater abundance of hydrophilic cysteic acid groups in the hydrogel.

9. 发明公开

EP1033953A1 METHOD OF CROSS-LINKING KERATIN-BASED FILMS, SHEETS, AND BULK MATERIALS 有权
标题翻译：方法联网薄膜，薄膜和BULK
公开(公告)号：EP1033953A1
公开(公告)日：2000-09-13
申请号：EP98958109.5
申请日：1998-11-25
申请人： Keraplast Technologies Ltd.
发明人： TIMMONS, Scott, F. , BLANCHARD, Cheryl, R. , SMITH, Robert, A.
IPC分类号： A61F13/00 , A61K9/70 , A61K38/00 , A61K38/17 , A61L15/00 , C08G63/48 , C08G63/91 , C08L89/00 , C07K1/00 , C07K14/00 , C07K16/00 , C07K17/00 , C08H1/06
CPC分类号： C12N5/0068 , A61K9/70 , A61K35/36 , A61K38/1709 , A61K38/39 , A61L15/32 , A61L26/0047 , A61L26/008 , A61L27/227 , A61L27/34 , A61L27/60 , A61L31/047 , A61L31/10 , C07K14/4741 , C08H1/06 , C12N2533/50 , Y10S530/842 , C08L89/04 , C08L89/00
摘要： Methods for producing thin keratin films, sheets, and bulk materials, and products formed using these methods. One method includes providing hair, reducing the hair such that the disulfide linkages are broken and free cysteine thiol groups formed, separating out a more soluble keratin fraction in solution, forming a thin layer from the more soluble fraction, and air drying the keratin fraction in the presence of oxygen, thereby forming new disulfide bonds imparting strength to the resulting thin keratin film. One method includes reducing hair by heating the hair under nitrogen in an ammonium hydroxide and ammonium thioglycolate solution followed by centrifuging and collecting the supernatant containing the more soluble keratin fraction. The more soluble keratin in this method is precipitated using HCl, removed, and resuspended in ammonium hydroxide. The keratin solution thus formed is poured onto a flat surface and allowed to air dry into a thin keratin film. The film may be used as a wound dressing, a tissue-engineering scaffold, a diffusion membrane, a coating for implantable devices, and as a cell encapsulant. In another method, the keratin solution thus formed is concentrated, poured into a mold, and allowed to air dry into a three dimensional keratin product. The resulting bulk product can be used as a cross-linked implantable biomaterial for soft and hard tissue replacement. In another method, a keratin solution is emulsified and freeze dried, forming a porous, open cell keratin material.

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