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1. 发明专利

JP2010155859A Bioactive keratin protein 审中-公开
标题翻译：生物科学蛋白质
公开(公告)号：JP2010155859A
公开(公告)日：2010-07-15
申请号：JP2010067081
申请日：2010-03-23
申请人： Keraplast Technologies Ltd , ケラプラストテクノロジーズ, リミテッド
发明人： COWSAR DONALD R
IPC分类号： A61K9/06 , A61K38/00 , A61F13/00 , A61K8/00 , A61K8/04 , A61K8/06 , A61K8/64 , A61K8/65 , A61K8/72 , A61K9/08 , A61K9/10 , A61K9/107 , A61K9/14 , A61K9/70 , A61K38/17 , A61K47/42 , A61L15/00 , A61L15/32 , A61L27/00 , A61L27/22 , A61P17/00 , A61P17/02 , A61P17/04 , A61P17/16 , A61P19/00 , A61P43/00 , A61Q1/04 , A61Q1/10 , A61Q3/02 , A61Q5/00 , A61Q5/02 , A61Q5/12 , A61Q19/00 , A61Q19/08 , C07K5/08 , C07K5/093 , C07K5/103 , C07K5/113 , C07K7/06 , C07K14/47
CPC分类号： A61K8/64 , A61K38/17 , A61L15/32 , A61L27/227 , A61Q19/00 , C07K5/1021 , C07K14/4741
摘要： PROBLEM TO BE SOLVED: To provide an improved bandage for aiding a traumatotherapy process. SOLUTION: A composition including a bioactive peptide is disclosed. An active peptide is isolated from fragments derived from human hair keratin protein or sheep wool keratin protein. The composition is prepared for pharmaceutical or topical administration or for use in cosmetic preparations. The activity of the peptide is shown by capability of stimulating the growth of skin fibroblasts in comparison with heretofore known fibroblast growth factor. Therefore, the composition including the peptide is useful for treating the conditions including an injured organization and skin, an aged organization and skin, or a morbid organization and skin. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供改进的绷带以帮助创伤治疗过程。解决方案：公开了包含生物活性肽的组合物。从源自人毛角蛋白蛋白或羊毛角蛋白的片段中分离出活性肽。制备组合物用于药物或局部给药或用于化妆品制剂。通过与迄今为止已知的成纤维细胞生长因子相比刺激皮肤成纤维细胞生长的能力来显示肽的活性。因此，包含肽的组合物可用于治疗包括受伤组织和皮肤，老化组织和皮肤，病态组织和皮肤的病症。版权所有（C）2010，JPO＆INPIT

2. 发明专利

JP2012011233A Bioactive coating for medical device comprising keratin 审中-公开
标题翻译：用于包含KERATIN的医疗设备的生物涂料
公开(公告)号：JP2012011233A
公开(公告)日：2012-01-19
申请号：JP2011227392
申请日：2011-10-14
申请人： Keraplast Technologies Ltd , ケラプラストテクノロジーズ, リミテッド
发明人： VAN DYKE MARK , SILLER-JACKSON ARLENE J
IPC分类号： A61L27/00 , A61L27/34 , A61L31/00 , B60Q1/26 , C09D189/04 , C09D189/06 , F21W107/10
CPC分类号： A61L27/34 , B60Q1/2661 , B60R2019/505 , C09D189/04 , C09D189/06 , C08L89/04 , C08L2666/28
摘要： PROBLEM TO BE SOLVED: To provide a medical device (and method for manufacturing the same) comprising a passivating coating comprising keratin.SOLUTION: The passivating coating comprises a bonding region and a bioactive region. The bonding region comprises at least one organosilane compound comprising a silane component bound to a surface of a substrate. The bioactive region comprises an organic component of the organosilane bound to a reactive pendant group on the keratin. The medical device is preferably selected from the group consisting of tissue engineering constructs, orthopedic implants, dental implants, and ventricular assist devices.
摘要翻译：解决的问题：提供一种包含包含角蛋白的钝化涂层的医疗装置（及其制造方法）。解决方案：钝化涂层包括粘合区域和生物活性区域。键合区域包括至少一种包含与基底表面结合的硅烷组分的有机硅烷化合物。生物活性区域包含与角蛋白上的反应性侧基结合的有机硅烷的有机组分。医疗装置优选地选自组织工程构造物，矫形植入物，牙种植体和心室辅助装置。版权所有（C）2012，JPO＆INPIT

3. 发明申请

WO2005124011A1 KERATIN BASED HYDROGEL SHEETS PREPARED FROM FABRIC FOR BIOMEDICAL AND OTHER APPLICATIONS AND METHOD OF PRODUCTION 审中-公开
标题翻译：用于生物医学和其他应用的织物制备的基于凯氏素的水凝胶片和生产方法
公开(公告)号：WO2005124011A1
公开(公告)日：2005-12-29
申请号：PCT/US2005/020404
申请日：2005-06-09
申请人： KERAPLAST TECHNOLOGIES, LTD. , BRANHAM, Keith, Edward , ENGLISH, James, Perry , COWSAR, Donald, R.
发明人： BRANHAM, Keith, Edward , ENGLISH, James, Perry , COWSAR, Donald, R.
IPC分类号： D06L3/02
CPC分类号： D06M11/50 , A61L15/225 , A61L15/32 , C08F2438/01 , C08J5/18 , C08J2389/00 , D06M11/38 , D06M23/10 , D06M2101/12 , C08L89/00
摘要： Keratin hydrogels and films are produced from woven and non-woven wool fabrics. The hydrogels and films retain the structure of the fabric and are useful for wound dressings and other medical applications.
摘要翻译：角蛋白水凝胶和薄膜由机织和非织造羊毛织物生产。水凝胶和胶片保留织物的结构，并且可用于伤口敷料和其它医疗应用。

4. 发明申请

US20040082717A1 Keratin-silicone copolymers and interpenetrating networks (IPN's), methods of production and methods of use thereof 审中-公开
标题翻译：角蛋白 - 硅氧烷共聚物和互穿网络（IPN），生产方法及其使用方法
公开(公告)号：US20040082717A1
公开(公告)日：2004-04-29
申请号：US10606279
申请日：2003-06-24
申请人： Southwest Research Institute , Keraplast Technologies, Ltd.
发明人： Mark E. Van Dyke , Cheryl R. Blanchard , Robert A. Smith
IPC分类号： C08H001/00
CPC分类号： C08G77/42 , C07K14/4741 , C07K2319/00 , C08H1/04 , G02B1/043 , C08L83/10
摘要： Materials comprising proteinaceous prepolymers comprising at least one first reactive group reacted with one or more reactive groups on synthetic prepolymers, and methods of making and using same.
摘要翻译：包含至少一种与合成预聚物上的一个或多个反应性基团反应的第一反应性基团的蛋白质预聚物的材料，及其制备和使用方法。

5. 发明申请

WO2010132673A1 BIOPOLYMER MATERIALS 审中-公开
标题翻译：生物材料
公开(公告)号：WO2010132673A1
公开(公告)日：2010-11-18
申请号：PCT/US2010/034723
申请日：2010-05-13
申请人： KERAPLAST TECHNOLOGIES, LTD. , KELLY, Robert, James , MARSH, Clive
发明人： KELLY, Robert, James , MARSH, Clive
IPC分类号： C07K1/00
CPC分类号： C08H1/06 , C08J3/24 , C08J2389/04 , C08K5/0016 , C08K5/0025 , C08K5/053 , C08L2205/16 , C08L89/04
摘要： Molded articles of pure keratin protein, keratin copolymers or crosslinked keratin proteins are produced from a wetted protein powder by application of compression and optionally heat. Stabile materials can be molded or machined.
摘要翻译：通过施加压缩和任选加热从湿润的蛋白质粉末制备纯的角蛋白蛋白质，角蛋白共聚物或交联的角蛋白蛋白质的成型制品。稳定材料可以模制或加工。

6. 发明申请

WO2005124013A1 NEW AND GENTLE PROCESS FOR CONVERSION OF CYSTINE IN KERATIN-CONTAINING MATERIALS TO LANTHIONINE 审中-公开
标题翻译：用于将含有含钾素的材料中的CYSTINE转化为LANTHIONINE的新型和GENTLE方法
公开(公告)号：WO2005124013A1
公开(公告)日：2005-12-29
申请号：PCT/US2005/020405
申请日：2005-06-09
申请人： KERAPLAST TECHNOLOGIES, LTD. , BRANHAM, Keith, Edward , ENGLISH, James, Perry , COWSAR, Donald, R.
发明人： BRANHAM, Keith, Edward , ENGLISH, James, Perry , COWSAR, Donald, R.
IPC分类号： D06M11/32
CPC分类号： A61L15/32 , A61L15/42
摘要： Useful materials are produced from keratin containing raw materials by a process that includes gentle lanthionization of cystine disulfide bonds. Hydratable materials are produced for use in medical and cosmetic applications.
摘要翻译：有用的材料是由包含原料的角蛋白通过包括胱氨酸二硫键的温和促磷酸化过程产生的。生产用于医疗和化妆品应用的可水合材料。

7. 发明申请

US20040134248A1 Hydratable form of keratin for use as a soil amendment 审中-公开
标题翻译：角质的可水合形式用作土壤修复
公开(公告)号：US20040134248A1
公开(公告)日：2004-07-15
申请号：US10715337
申请日：2003-11-17
申请人： Southwest Research Institute , Keraplast Technologies, Ltd.
发明人： Robert Allen Smith , Scott F. Timmons , Mark E. Van Dyke , Cheryl R. Blanchard , Arlene J. Siller-Jackson
IPC分类号： C05F001/00
CPC分类号： C09K17/32 , C05F1/005 , C05F1/007 , C05F11/08 , Y02A40/201 , Y02A40/203 , Y02E50/343 , Y02P20/145 , Y02W30/47 , Y10S106/90 , Y10S530/842
摘要： A hydratable oxidized keratin composition comprising one or more metal ion species capable of absorbing water to form a hydrogel. The keratin material is useful as a soil amendment providing organic and inorganic nutrients. The keratin material is also useful as a nutrient source in the bioremediation of toxic contaminants soils and liquids.
摘要翻译：一种可水合的氧化角蛋白组合物，其包含一种或多种能够吸收水以形成水凝胶的金属离子种类。角蛋白材料可用作提供有机和无机营养物质的土壤修复。角蛋白材料也可用作生物修复有毒污染物土壤和液体的营养源。

8. 发明申请

US20030228353A1 Bioactive keratin peptides 有权
公开(公告)号：US20030228353A1
公开(公告)日：2003-12-11
申请号：US10352786
申请日：2003-01-28
申请人： Keraplast Technologies, Ltd.
发明人： Donald R. Cowsar
IPC分类号： A61L015/00 , A61K038/17 , A61K038/10 , A61K038/08 , A61K038/06
CPC分类号： A61K8/64 , A61K38/17 , A61L15/32 , A61L27/227 , A61Q19/00 , C07K5/1021 , C07K14/4741
摘要： Compositions containing biologically active peptides are disclosed. Active peptides are isolated fragments derived from human hair or sheep wool keratin proteins. Compositions may be prepared for pharmaceutical or topical administration or for use in cosmetic preparations.

9. 发明申请

US20040076599A1 Keratin-based powders and hydrogel for pharmaceutical applications 审中-公开
标题翻译：用于制药应用的角蛋白基粉末和水凝胶
公开(公告)号：US20040076599A1
公开(公告)日：2004-04-22
申请号：US10409018
申请日：2003-04-08
申请人： Southwest Research Institute , Keraplast Technologies, Ltd.
发明人： Arlene J. Siller-Jackson , Mark E. Van Dyke , Scott F. Timmons , Cheryl R. Blanchard , Robert A. Smith
IPC分类号： A61K007/06 , A61K007/11 , C07K014/78
CPC分类号： A61K8/042 , A61F2013/530481 , A61F2013/530613 , A61K8/65 , A61K9/0024 , A61K9/06 , A61K9/146 , A61K9/2063 , A61K9/7007 , A61K38/015 , A61K38/17 , A61K47/42 , A61K47/6953 , A61L15/32 , A61L15/60 , A61L27/227 , A61L27/52 , A61Q19/00
摘要： A hydratable, highly absorbent keratin solid fiber or powder capable of absorbing a large weight excess of water may be produced by partially oxidizing hair keratin disulfide bonds to sulfonic acid residues and reacting the sulfonic acid residues with a cation. The neutralized suspension can be filtered, washed, and dried, leaving keratin solid which can be shredded into fibers and further ground into powder. Addition of water to the solid produces a hydrogel. The powder or hydrogel may be useful as an absorbent material, as a therapeutic for skin, or as an excipient. The keratin materials can be incorporated into nonwoven films. The hydrogel can be used as a biocompatible viscoelastic filler for implant applications. Another use for the absorbent keratin and keratin hydrogel is as an excipient in pharmaceutical and cosmetic applications.
摘要翻译：可以通过将头发角蛋白二硫键部分氧化成磺酸残基并使磺酸残基与阳离子反应来制备能够吸收大量过量水分的可水合的高吸收性角蛋白固体纤维或粉末。中和的悬浮液可以过滤，洗涤和干燥，留下角蛋白固体，将其切成纤维并进一步研磨成粉末。向固体中加入水产生水凝胶。粉末或水凝胶可用作吸收材料，作为皮肤的治疗剂或赋形剂。角蛋白材料可以并入无纺膜中。水凝胶可用作植入物应用的生物相容性粘弹性填料。吸收性角蛋白和角蛋白水凝胶的另一用途是作为药物和化妆品应用中的赋形剂。

10. 发明申请

US20030035820A1 Keratin containing implant material 审中-公开
标题翻译：角蛋白含植入材料
公开(公告)号：US20030035820A1
公开(公告)日：2003-02-20
申请号：US10218100
申请日：2002-08-13
申请人： Southwest Research Institute and Keraplast Technologies, Ltd.
发明人： Scott F. Timmons , Cheryl R. Blanchard , Robert A. Smith
IPC分类号： A61K045/00 , A61K038/17
CPC分类号： C12N5/0068 , A61K9/70 , A61K35/36 , A61K38/1709 , A61K38/39 , A61L15/32 , A61L26/0047 , A61L26/008 , A61L27/227 , A61L27/34 , A61L27/60 , A61L31/047 , A61L31/10 , C07K14/4741 , C08H1/06 , C12N2533/50 , Y10S530/842 , C08L89/04 , C08L89/00
摘要： Methods for producing thin keratin films, sheets, and bulk materials, and products formed using these methods. One method includes providing hair, reducing the hair such that the disulfide linkages are broken and free cysteine thiol groups formed, separating out a more soluble keratin fraction in solution, forming a thin layer from the more soluble fraction, and air drying the keratin fraction in the presence of oxygen, thereby forming new disulfide bonds imparting strength to the resulting thin keratin film. One method includes reducing hair by heating the hair under nitrogen in an ammonium hydroxide and ammonium thioglycolate solution followed by centrifuging and collecting the supernatant containing the more soluble keratin fraction. The more soluble keratin in this method is precipitated using HCI, removed, and resuspended in ammonium hydroxide. The keratin solution thus formed is poured onto a flat surface and allowed to air dry into a thin keratin film. The film may be used as a wound dressing, a tissue-engineering scaffold, a diffusion membrane, a coating for implantable devices, and as a cell encapsulant. In another method, the keratin solution thus formed is concentrated, poured into a mold, and allowed to air dry into a three dimensional keratin product. The resulting bulk product can be used as a cross-linked implantable biomaterial for soft and hard tissue replacement. In another method, a keratin solution is emulsified and freeze dried, forming a porous, open cell keratin material.
摘要翻译：用于生产薄角蛋白薄膜，片材和散装材料的方法以及使用这些方法形成的产品。一种方法包括提供毛发，减少头发，使得二硫键断裂，形成游离的半胱氨酸硫醇基团，在溶液中分离出更可溶的角蛋白级分，从较可溶级分形成薄层，并将角蛋白级分空气干燥氧的存在，从而形成新的二硫键，赋予所得薄的角蛋白薄膜强度。一种方法包括通过在氮气下在氢氧化铵和巯基乙酸铵溶液中加热头发，然后离心并收集含有较可溶性角蛋白级分的上清液来减少头发。该方法中较易溶解的角蛋白使用HCl沉淀，除去并重新悬浮于氢氧化铵中。将如此形成的角蛋白溶液倒入平坦表面，并使其干燥成薄的角蛋白膜。该膜可以用作伤口敷料，组织工程支架，扩散膜，用于可植入装置的涂层，以及作为细胞密封剂。在另一种方法中，将如此形成的角蛋白溶液浓缩，倒入模具中，并使其风干至三维角蛋白产品。所得到的散装产品可用作用于软组织和硬组织置换的交联可植入生物材料。在另一种方法中，将角蛋白溶液乳化并冷冻干燥，形成多孔的开放细胞角蛋白材料。

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