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1. 发明授权

US5179009A Process for producing L-aspartyl-L-phenylalanine and its diketopiperazine 失效
标题翻译： L-天冬氨酰-L-苯丙氨酸及其二酮哌嗪的制备方法
公开(公告)号：US5179009A
公开(公告)日：1993-01-12
申请号：US707306
申请日：1991-05-29
申请人： Kenzo Yokozeki , Naoki Usui , Toshihide Yukawa , Yoshiteru Hirose , Koji Kubota
发明人： Kenzo Yokozeki , Naoki Usui , Toshihide Yukawa , Yoshiteru Hirose , Koji Kubota
IPC分类号： C07D241/08 , C07K5/072 , C07K5/075 , C12P17/12
CPC分类号： C07D241/08 , C07K5/0613 , C12P17/12 , Y10S435/822
摘要： The present invention is directed to a process for producing L-aspartyl-L-phenylalanine and/or L-aspartyl-L-phenylalanine diketopiperazine comprising contacting and reacting a culture, cell or a cell-treated product of a microorganism capable of hydrolyzing DKP into AP or capable of performing intramolecular condensation of AP into DKP with DKP and/or AP, in an aqueous medium.
摘要翻译：本发明涉及一种L-天冬氨酰基-L-苯丙氨酸和/或L-天冬氨酰基-L-苯丙氨酸二酮哌嗪的制备方法，其包括将能够水解DKP的微生物的培养物，细胞或细胞处理的产物与 AP或能够在水性介质中使用DKP和/或AP在AP中进行DK分子内缩合。

2. 发明授权

US4968606A Methods for producing ribose-1-phosphoric acid and ribavirin 失效
标题翻译：制备核糖-1-磷酸和利巴韦林的方法
公开(公告)号：US4968606A
公开(公告)日：1990-11-06
申请号：US407697
申请日：1989-09-15
申请人： Kenzo Yokozeki , Hideyuki Shirae , Koji Kubota
发明人： Kenzo Yokozeki , Hideyuki Shirae , Koji Kubota
IPC分类号： C12P19/02 , C07H19/056 , C12P19/28 , C12R1/06 , C12R1/07 , C12R1/13 , C12R1/15 , C12R1/185 , C12R1/365 , C12R1/38 , C12R1/425 , C12R1/465 , C12R1/63 , C12R1/64
CPC分类号： C12P19/28 , Y10S435/847 , Y10S435/852
摘要： The present invention relates to methods for producing ribavirin utilizing microorganisms and a method for producing ribose-1-phosphoric acid which is a precursor of ribavirin. The methods involve contacting certain microorganisms with orotidine, orotidic acid, or salts thereof, and inorganic phosphoric acid or a salt thereof (to produce ribose-1-phosphoric acid), and further with 1,2,4-triazole-3-carboxamide or a salt thereof (to produce ribavirin) in an aqueous solvent.
摘要翻译：本发明涉及利用微生物生产利巴韦林的方法以及作为利巴韦林前体的核糖-1-磷酸的制备方法。所述方法包括将某些微生物与乳清酸，orotidic酸或其盐，和无机磷酸或其盐（产生核糖-1-磷酸），以及进一步与1,2,4-三唑-3-甲酰胺或其盐（以产生利巴韦林）在水性溶剂中。

3. 发明授权

US4711846A Process for the production of L-aspartyl-L-phenylalanine methy ester or L-aspartyl-L-phenylalanine 失效
标题翻译：生产L-天冬氨酰-L-苯丙氨酸甲酯或L-天冬氨酰-L-苯丙氨酸的方法
公开(公告)号：US4711846A
公开(公告)日：1987-12-08
申请号：US604523
申请日：1984-04-27
申请人： Kenzo Yokozeki , Koji Kubota
发明人： Kenzo Yokozeki , Koji Kubota
IPC分类号： C07K5/072 , C07K5/075 , C12P21/02 , A23L1/236 , C12R1/19
CPC分类号： C07K5/0613 , Y10S435/849
摘要： A process for the production of L-aspartyl-L-phenylalanine methyl ester of L-aspartyl-L-phenylalanine by contacting an appropriate microorganism or enzyme-containing fraction of said microorganism with L-aspartic acid and L-phenylalanine methyl ester or L-phenylalanine in an aqueous medium so that L-aspartyl-L-phenylalanine methyl ester or L-aspartyl-L-phenylalanine is produced.
摘要翻译：通过使所述微生物的适当微生物或含酶部分与L-天冬氨酸和L-苯丙氨酸甲酯或L-天冬氨酰基-L-苯丙氨酸接触来制备L-天冬氨酰基-L-苯丙氨酸的L-天冬氨酰基-L-苯丙氨酸甲酯的方法，苯丙氨酸在水性介质中的溶液，从而产生L-天冬氨酰基-L-苯丙氨酸甲酯或L-天冬氨酰基-L-苯丙氨酸。

4. 发明授权

US4650759A Method of producing L-carnitine 失效
标题翻译：生产左旋肉碱的方法
公开(公告)号：US4650759A
公开(公告)日：1987-03-17
申请号：US599923
申请日：1984-04-13
申请人： Kenzo Yokozeki , Koji Kubota
发明人： Kenzo Yokozeki , Koji Kubota
IPC分类号： C12P13/00 , C12R1/01 , C12R1/05 , C12R1/06 , C12R1/07 , C12R1/13 , C12R1/15 , C12R1/185 , C12R1/20 , C12R1/22 , C12R1/265 , C12R1/325 , C12R1/37 , C12R1/38 , C12R1/425 , C12R1/45 , C12R1/64 , C12R1/645 , C12R1/78 , C12R1/84 , C12R1/88 , C12P7/40 , C12P7/42
CPC分类号： C12P13/007
摘要： A method for producing L-carnitine which involves contacting crotonbetaine or a non-toxic, soluble salt of this compound with a microorganism or an enzyme fraction of this microorganism which is capable of converting crotonbetaine or its salts into L-carnitine. The conversion is conducted in an aqueous medium under conditions suitable for production of L-carnitine.
摘要翻译：一种生产左旋肉碱的方法，其涉及将该化合物的巴豆甜菜碱或无毒可溶性盐与能够将巴豆甜菜碱或其盐转化成L-肉碱的该微生物的微生物或酶级分。转化在适于生产L-肉碱的条件下在水性介质中进行。

5. 发明授权

US5036004A Process for producing L-serine 失效
标题翻译：生产L-丝氨酸的方法
公开(公告)号：US5036004A
公开(公告)日：1991-07-30
申请号：US348112
申请日：1989-05-05
申请人： Eiji Majima , Hiroaki Takino , Kunisuke Izawa , Kenzo Yokozeki , Koji Kubota
发明人： Eiji Majima , Hiroaki Takino , Kunisuke Izawa , Kenzo Yokozeki , Koji Kubota
IPC分类号： C12P13/06 , C12P17/14
CPC分类号： C12P13/06 , C12P17/14
摘要： A process for producing L-serine by the combination of chemical synthesis and enzyme chemical synthesis is disclosed. In this process L-serine is biochemically produced from 2-oxo-axazolidine-4-carboxylic acid or a salt thereof.
摘要翻译：公开了通过化学合成和酶化学合成的组合生产L-丝氨酸的方法。在该方法中，L-丝氨酸由2-氧代 - 唑烷-4-羧酸或其盐生物化学产生。

6. 发明授权

US07527756B2 Mold temperature adjusting apparatus/method and mold temperature control unit 失效
标题翻译：模具温度调节装置/方法和模具温度控制单元
公开(公告)号：US07527756B2
公开(公告)日：2009-05-05
申请号：US11708561
申请日：2007-02-21
申请人： Satoshi Miyagawa , Koji Kubota
发明人： Satoshi Miyagawa , Koji Kubota
IPC分类号： B29C45/73
CPC分类号： B29C35/007 , B29C45/7306 , B29C2045/7393 , Y02P70/26
摘要： A mold temperature adjusting apparatus is provided in which change-over timing of high temperature medium and low temperature medium is adjusted by a heat transmission delay in heating and cooling of a mold being taken into consideration. The mold temperature adjusting apparatus comprises a high temperature fluid tank and a low temperature fluid tank, a high temperature fluid supply system and a high temperature fluid return system between the mold and the high temperature fluid tank, a low temperature fluid supply system and a low temperature fluid return system between the mold and the low temperature fluid tank, a high temperature fluid by-pass system and a low temperature fluid by-pass system, a heat recovery tank connected to the high temperature fluid tank and a pressure adjusting device.
摘要翻译：提供了一种模具温度调节装置，其中通过考虑到模具的加热和冷却中的热传递延迟来调节高温介质和低温介质的转换时间。模具温度调节装置包括高温流体箱和低温流体箱，高温流体供应系统和模具与高温流体箱之间的高温流体回流系统，低温流体供应系统和低温流体供应系统模具与低温流体箱之间的高温流体回流系统，高温流体旁通系统和低温流体旁通系统，连接到高温流体箱的热回收罐和压力调节装置。

7. 发明授权

US06235371B1 Polyethylene-2,6-naphthalate film for capacitor 有权
标题翻译：用于电容器的聚2,6-萘二甲酸乙二醇酯薄膜
公开(公告)号：US06235371B1
公开(公告)日：2001-05-22
申请号：US09456754
申请日：1999-12-08
申请人： Katsuzo Mitsuhashi , Koji Kubota
发明人： Katsuzo Mitsuhashi , Koji Kubota
IPC分类号： B32B100
CPC分类号： H01G4/18 , Y10T428/24355 , Y10T428/31681 , Y10T428/31786
摘要： The present invention relates to a capacitor installed in the automobile engine room, comprising polyethylene-2,6-naphthalate film comprising polyethylene-2,6-naphthalate with an intrinsic viscosity (IV) of not less than 0.56 and having a degree of crystallinity of 32 to 42%, the film elongation retention after a 3,000-hour degradation test at 170° C. being not less than 50%, and the residual elongation of the film after said test being not less than 30%.
摘要翻译：本发明涉及一种安装在汽车发动机房内的电容器，其特征在于，其特征粘度（Ⅳ）不小于0.56，聚乙烯-2,6-萘二甲酸乙二醇酯膜的结晶度为 32〜42％，170℃下3000小时降解试验后的膜延伸率保持率不小于50％，所述试验后的膜的残余伸长率不小于30％。

8. 发明授权

US06192299B1 Method of measuring operation characteristic of proportional electromagnetic control valve, method of controlling operation of hydraulic cylinder, and method of modifying operation characteristic of proportional electromagnetic control valve 失效
标题翻译：比例电磁阀的运行特性测量方法，液压缸运行控制方法及比例电磁阀的运行特性修正方法
公开(公告)号：US06192299B1
公开(公告)日：2001-02-20
申请号：US09021414
申请日：1998-02-10
申请人： Koji Kubota , Masaaki Ikarashi , Satoshi Miyagawa
发明人： Koji Kubota , Masaaki Ikarashi , Satoshi Miyagawa
IPC分类号： G05D706
CPC分类号： F15B19/002 , B29C45/77 , B29C2945/76006 , B29C2945/76033 , B29C2945/76066 , B29C2945/76096 , B29C2945/7611 , B29C2945/76307 , B29C2945/76381 , B29C2945/76488 , B29C2945/76498 , B29C2945/76551 , B29C2945/76785 , G05D16/2013
摘要： A method by which an operation characteristic of a proportional electromagnetic control valve can be automatically measured in a short period of time. For this purpose, in the operation characteristic measuring method of the present invention, when the proportional electromagnetic control valve to be measured is a proportional electromagnetic pressure control valve, at each step for measuring a pressure of a hydraulic circuit, the pressure is measured with a predetermined interval of time, the pressure is assumed to be stabilized at a point of time when a difference &Dgr;P between the measured pressure value and the previously measured pressure value becomes a predeterminied level or less, and the measured pressure value at this point of time is employed as a pressure corresponding to a load current at this step. The present invention is used at the time when an injection molding machine is inspected at its manufacturing site upon shipping and at the time when the injection molding machine is controlled while being actually operated.
摘要翻译：可以在短时间内自动测量比例电磁控制阀的操作特性的方法。为此，在本发明的操作特性测量方法中，当要测量的比例电磁控制阀是比例电磁控制阀时，在用于测量液压回路压力的每个步骤中，用在预定的时间间隔，假设在测量的压力值和先前测量的压力值之间的差值DELTAP变为预定水平或更低的时间点处的压力被稳定，并且在该时间点的测量的压力值是在该步骤中用作对应于负载电流的压力。本发明是在注塑机在运输时在其制造现场进行检查，并且在注射成型机被实际操作的同时进行控制的时候使用的。

9. 发明授权

US08550800B2 Injection molding machine for two-material molding 有权
标题翻译：注塑机用于双材料成型
公开(公告)号：US08550800B2
公开(公告)日：2013-10-08
申请号：US13377748
申请日：2009-12-07
申请人： Satoshi Miyagawa , Naoki Kato , Yasuaki Ozeki , Hiroto Matsushita , Masamitsu Saji , Yasuo Okochi , Toshihiko Kariya , Koji Kubota
发明人： Satoshi Miyagawa , Naoki Kato , Yasuaki Ozeki , Hiroto Matsushita , Masamitsu Saji , Yasuo Okochi , Toshihiko Kariya , Koji Kubota
IPC分类号： B29C45/73
CPC分类号： B29C45/1628 , B29C45/73
摘要： It is an object to prevent dies from interfering with each other when the dies are closed and effectively prevent overshoot of cavity temperature while efficiently performing heating of the dies. In an injection molding machine for two-material molding including two sets of a first injecting unit and a second injecting unit that respectively plasticize different resin materials and inject and fill the resin materials, prior to performing injection molding on the first injecting unit side on a secondary side, after injection molding on the second injecting unit side on a primary side, heating of the dies is started before 180-degree rotation of a rotary die plate is completed. After the start of heating, until the 180-degree rotation of the rotary die plate is completed, i.e., die closing is performed, die temperatures are maintained within a temperature range set higher than die temperatures during the heating start and lower than die temperatures during injection.
摘要翻译：本发明的目的是在模具闭合时防止模具相互干扰，并且有效地防止腔体温度的过冲，同时有效地执行模具的加热。在用于双材料成型的注射成型机中，包括两组分别塑化不同树脂材料并注入和填充树脂材料的第一注射单元和第二注射单元，在第一注射单元侧进行注射成型之前，次级侧，在一次侧的第二注射单元侧注射成型后，在旋转模板的180度旋转完成之前开始模具的加热。开始加热后，直到旋转模板的180度旋转完成，即执行模具闭合，模具温度保持在设定为高于加热开始时的模具温度的温度范围内，并且低于模具温度注射。

10. 发明授权

US08183031B2 Composition containing β-glucan, method of producing the same and foods, drinks or skin moisturizers containing the composition 有权
标题翻译：含有β-葡聚糖的组合物，其制备方法以及含有该组合物的食品，饮料或皮肤保湿剂
公开(公告)号：US08183031B2
公开(公告)日：2012-05-22
申请号：US11575047
申请日：2005-08-03
申请人： Naoyuki Moriya , Yukiko Moriya , Koji Kubota
发明人： Naoyuki Moriya , Yukiko Moriya , Koji Kubota
IPC分类号： A01N63/00 , A01N63/04 , C12N1/00
CPC分类号： A61K8/73 , A23L29/271 , A23L33/10 , A23V2002/00 , A61Q19/00 , C12R1/645 , Y10S435/911 , A23V2250/5034 , A23V2200/318 , A23V2200/30
摘要： It is intended to utilize β-glucan produced by a bacterium belonging to Aureobasidium sp. From a bacterium belonging to Aureobasidium sp., a mutant with little pigment accumulation is constructed by a mutagenesis means of, for example, irradiating with ultraviolet light or treating with a mutagen. A culture obtained by culturing this mutant in a liquid culture medium is usable as a composition with a large β-glucan content without showing any intense dark green color caused by the accumulation of melanin-like pigments. This composition may be taken as such as a functional food having the physiologically active functions of the β-glucan-containing composition. Alternatively, it may be added to foods, drinks. food additives, cosmetics and so on.
摘要翻译：用于利用属于Aureobasidium sp。的细菌产生的葡聚糖。从属于Aureobasidium sp。的细菌，通过例如用紫外线照射或用诱变剂处理的诱变方法构建具有少量颜料积累的突变体。通过在液体培养基中培养该突变体获得的培养物可用作具有大量葡萄糖含量的组合物，而不会由黑色素样颜料的积累引起任何强烈的深绿色。该组合物可以作为具有含葡聚糖组合物的生理活性功能的功能性食品。或者，它可以添加到食物，饮料中。食品添加剂，化妆品等。

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