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1. 发明授权

US08304737B2 Apparatus and method to achieve high-resolution microscopy with non-diffracting or refracting radiation 有权
$Apparatus and method to achieve high-resolution microscopy with non-diffracting or refracting radiation$
标题翻译：用非衍射或折射辐射实现高分辨率显微镜的装置和方法
公开(公告)号：US08304737B2
公开(公告)日：2012-11-06
申请号：US12572536
申请日：2009-10-02
申请人： Kenneth W. Tobin, Jr. , Philip R. Bingham , Ayman I. Hawari
发明人： Kenneth W. Tobin, Jr. , Philip R. Bingham , Ayman I. Hawari
IPC分类号： G01T1/16
CPC分类号： G01T1/295
摘要： An imaging system employing a coded aperture mask having multiple pinholes is provided. The coded aperture mask is placed at a radiation source to pass the radiation through. The radiation impinges on, and passes through an object, which alters the radiation by absorption and/or scattering. Upon passing through the object, the radiation is detected at a detector plane to form an encoded image, which includes information on the absorption and/or scattering caused by the material and structural attributes of the object. The encoded image is decoded to provide a reconstructed image of the object. Because the coded aperture mask includes multiple pinholes, the radiation intensity is greater than a comparable system employing a single pinhole, thereby enabling a higher resolution. Further, the decoding of the encoded image can be performed to generate multiple images of the object at different distances from the detector plane. Methods and programs for operating the imaging system are also disclosed.
摘要翻译：提供了采用具有多个针孔的编码孔径掩模的成像系统。编码的孔径掩模放置在辐射源处以使辐射通过。辐射照射并穿过物体，其通过吸收和/或散射来改变辐射。当通过物体时，在检测器平面处检测辐射以形成编码图像，其包括关于物质的材料和结构属性引起的吸收和/或散射的信息。编码图像被解码以提供对象的重建图像。由于编码孔径掩模包括多个针孔，因此辐射强度大于采用单个针孔的可比系统，从而能够实现更高的分辨率。此外，可以执行编码图像的解码以在与检测器平面不同的距离处产生对象的多个图像。还公开了用于操作成像系统的方法和程序。

2. 发明申请

US20110079725A1 APPARATUS AND METHOD TO ACHIEVE HIGH-RESOLUTION MICROSCOPY WITH NON-DIFFRACTING OR REFRACTING RADIATION 有权
标题翻译：用非衍射或者折射辐射实现高分辨率显微镜的装置和方法
公开(公告)号：US20110079725A1
公开(公告)日：2011-04-07
申请号：US12572536
申请日：2009-10-02
申请人： Kenneth W. Tobin, JR. , Philip R. Bingham , Ayman I. Hawari
发明人： Kenneth W. Tobin, JR. , Philip R. Bingham , Ayman I. Hawari
IPC分类号： G01T1/161
CPC分类号： G01T1/295
摘要： An imaging system employing a coded aperture mask having multiple pinholes is provided. The coded aperture mask is placed at a radiation source to pass the radiation through. The radiation impinges on, and passes through an object, which alters the radiation by absorption and/or scattering. Upon passing through the object, the radiation is detected at a detector plane to form an encoded image, which includes information on the absorption and/or scattering caused by the material and structural attributes of the object. The encoded image is decoded to provide a reconstructed image of the object. Because the coded aperture mask includes multiple pinholes, the radiation intensity is greater than a comparable system employing a single pinhole, thereby enabling a higher resolution. Further, the decoding of the encoded image can be performed to generate multiple images of the object at different distances from the detector plane. Methods and programs for operating the imaging system are also disclosed.
摘要翻译：提供了采用具有多个针孔的编码孔径掩模的成像系统。编码的孔径掩模放置在辐射源处以使辐射通过。辐射照射并穿过物体，其通过吸收和/或散射来改变辐射。当通过物体时，在检测器平面处检测辐射以形成编码图像，其包括关于物质的材料和结构属性引起的吸收和/或散射的信息。编码图像被解码以提供对象的重建图像。由于编码孔径掩模包括多个针孔，因此辐射强度大于采用单个针孔的可比系统，从而能够实现更高的分辨率。此外，可以执行编码图像的解码以在与检测器平面不同的距离处产生对象的多个图像。还公开了用于操作成像系统的方法和程序。

3. 发明申请

US20100231896A1 QUANTITATIVE PHASE-CONTRAST AND EXCITATION-EMISSION SYSTEMS 有权
标题翻译：量化相对和激发排放系统
公开(公告)号：US20100231896A1
公开(公告)日：2010-09-16
申请号：US12405089
申请日：2009-03-16
申请人： Christopher J. Mann , Philip R. Bingham
发明人： Christopher J. Mann , Philip R. Bingham
IPC分类号： G01B9/021 , G01N21/63
CPC分类号： G01B9/021 , G01B11/0675 , G01B11/2441 , G01N21/4133 , G02B21/0056
摘要： An optical system includes an optical interferometer that generates interference phenomena between optical waves to measure multiple distances, thicknesses, and indices of refraction of a sample. An excitation-emission device allows an electromagnetic excitation and emission to pass through an objective in optical communication with the sample. An electromagnetic detector receives the output of the optical interferometer and the excitation-emission device to render a magnified image of the sample. A digital delay generator synchronizes the optical interferometer and excitation-emission device to operate in substantially unison to generate a noninvasive depth of field of the portion of the sample that corrects a plurality of optical aberrations in real-time.
摘要翻译：光学系统包括光学干涉仪，其产生光波之间的干涉现象，以测量样品的多个距离，厚度和折射率。激发发射装置允许电磁激发和发射通过与样品光学通信的物镜。电磁检测器接收光干涉仪和激发发射装置的输出，以呈现样品的放大图像。数字延迟发生器使光学干涉仪和激发发射装置同步，以基本上一致地操作，以便实时地产生校正多个光学像差的样本部分的非侵入式景深。

4. 发明授权

US06999178B2 Spatial-heterodyne interferometry for reflection and transmission (SHIRT) measurements 失效
标题翻译：用于反射和透射（SHIRT）测量的空间外差干涉测量
公开(公告)号：US06999178B2
公开(公告)日：2006-02-14
申请号：US10649474
申请日：2003-08-26
申请人： Gregory R. Hanson , Philip R. Bingham , Ken W. Tobin
发明人： Gregory R. Hanson , Philip R. Bingham , Ken W. Tobin
IPC分类号： G01B9/02
CPC分类号： G03H1/0866 , G01B11/0675 , G03F1/84 , G03H2001/0456 , G03H2001/0469 , G03H2001/0471 , G03H2210/12
摘要： Systems and methods are described for spatial-heterodyne interferometry for reflection and transmission (SHIRT) measurements. A method includes digitally recording a first spatially-heterodyned hologram using a first reference beam and a first object beam; digitally recording a second spatially-heterodyned hologram using a second reference beam and a second object beam; Fourier analyzing the digitally recorded first spatially-heterodyned hologram to define a first analyzed image; Fourier analyzing the digitally recorded second spatially-heterodyned hologram to define a second analyzed image; digitally filtering the first analyzed image to define a first result; and digitally filtering the second analyzed image to define a second result; performing a first inverse Fourier transform on the first result, and performing a second inverse Fourier transform on the second result. The first object beam is transmitted through an object that is at least partially translucent, and the second object beam is reflected from the object.
摘要翻译：描述了用于反射和透射（SHIRT）测量的空间 - 外差干涉测量的系统和方法。一种方法包括使用第一参考光束和第一物体光束数字地记录第一空间外差的全息图; 使用第二参考光束和第二物体光束数字地记录第二空间外差的全息图; 傅里叶分析数字记录的第一空间外差全息图以定义第一分析图像; 对数字记录的第二空间外差全息图进行傅立叶分析以定义第二分析图像; 对第一分析图像进行数字滤波以定义第一结果; 并且数字地过滤第二分析图像以定义第二结果; 对所述第一结果执行第一傅立叶逆变换，并对所述第二结果执行第二傅里叶逆变换。第一物体光束通过至少部分半透明的物体透射，并且第二物体光束从物体反射。

5. 发明申请

US20100231895A1 QUANTITATIVE PHASE-IMAGING SYSTEMS 有权
标题翻译：定量相位成像系统
公开(公告)号：US20100231895A1
公开(公告)日：2010-09-16
申请号：US12405063
申请日：2009-03-16
申请人： Christopher J. Mann , Philip R. Bingham , Shaun S. Gleason
发明人： Christopher J. Mann , Philip R. Bingham , Shaun S. Gleason
IPC分类号： G01N21/00
CPC分类号： G01N21/45 , G01B9/02007 , G01B9/02012 , G01B9/02024 , G01B9/02027 , G01B9/02069 , G01B9/021 , G01B11/0675 , G01N21/453 , G01N21/6458 , G01N2021/1787
摘要： An optical system performs imaging in a transmissive and reflective mode. The system includes an optical interferometer that generates interference phenomena between optical waves to measure multiple distances, thicknesses, and indices of refraction of a sample. Measurements are made through a galvanometer that scans a pre-programmed angular arc. An excitation-emission device allows an electromagnetic excitation and emission to pass through an objective in optical communication with the sample. An electromagnetic detector receives the output of the optical interferometer and the excitation-emission device to render a magnified three dimensional image of the sample.
摘要翻译：光学系统以透射和反射模式执行成像。该系统包括光学干涉仪，其产生光波之间的干涉现象，以测量样品的多个距离，厚度和折射率。通过扫描预编程角弧的电流计进行测量。激发发射装置允许电磁激发和发射通过与样品光学通信的物镜。电磁检测器接收光干涉仪和激发发射装置的输出，以呈现样品的放大三维图像。

6. 发明授权

US06963406B2 Fused off-axis object illumination direct-to-digital holography with a plurality of illumination sources 失效
标题翻译：具有多个照明源的熔断离轴物体照明直接数字全息术
公开(公告)号：US06963406B2
公开(公告)日：2005-11-08
申请号：US10234042
申请日：2002-09-03
申请人： Jeffery R. Price , Philip R. Bingham
发明人： Jeffery R. Price , Philip R. Bingham
IPC分类号： G01B9/021 , G03H1/08 , G03H1/24 , G01B9/02
CPC分类号： G03H1/0866 , G01B9/021 , G03H1/0891 , G03H1/24 , G03H2001/0456
摘要： Systems and methods are described for rapid acquisition of fused off-axis illumination direct-to-digital holography. A method of recording a plurality of off-axis object illuminated spatially heterodyne holograms, each of the off-axis object illuminated spatially heterodyne holograms including spatially heterodyne fringes for Fourier analysis, includes digitally recording, with a first illumination source of an interferometer, a first off-axis object illuminated spatially heterodyne hologram including spatially heterodyne fringes for Fourier analysis; and digitally recording, with a second illumination source of the interferometer, a second off-axis object illuminated spatially heterodyne hologram including spatially heterodyne fringes for Fourier analysis.
摘要翻译：描述了用于快速获取融合的离轴照明直接数字全息术的系统和方法。一种用于记录多个离轴对象照明的空间外差全息图的方法，每个离轴对象照明的空间外差全息图包括用于傅立叶分析的空间外差条纹，包括用干涉仪的第一照明源数字记录第一离轴对象照明的空间外差全息图，包括用于傅立叶分析的空间外差条纹; 并且用干涉仪的第二照明源数字地记录第二离轴物体照明的空间外差全息图，其包括用于傅立叶分析的空间外差条纹。

7. 发明授权

US07423763B2 Faster processing of multiple spatially-heterodyned direct to digital holograms 有权
标题翻译：更快地处理多个空间外置直接数字全息图
公开(公告)号：US07423763B2
公开(公告)日：2008-09-09
申请号：US11375898
申请日：2006-03-15
申请人： Gregory R. Hanson , Philip R. Bingham
发明人： Gregory R. Hanson , Philip R. Bingham
IPC分类号： G01B9/02
CPC分类号： G03H1/0406 , G03H1/0443 , G03H1/0866 , G03H1/265 , G03H1/28 , G03H2001/0456 , G03H2001/046 , G03H2001/0469 , G03H2001/2655 , G03H2222/13 , G03H2223/16 , G03H2226/11 , G03H2226/13
摘要： Systems and methods are described for faster processing of multiple spatially-heterodyned direct to digital holograms. A method includes of obtaining multiple spatially-heterodyned holograms, includes: digitally recording a first spatially-heterodyned hologram including spatial heterodyne fringes for Fourier analysis; digitally recording a second spatially-heterodyned hologram including spatial heterodyne fringes for Fourier analysis; Fourier analyzing the recorded first spatially-heterodyned hologram by shifting a first original origin of the recorded first spatially-heterodyned hologram including spatial heterodyne fringes in Fourier space to sit on top of a spatial-heterodyne carrier frequency defined as a first angle between a first reference beam and a first object beam; applying a first digital filter to cut off signals around the first original origin and performing an inverse Fourier transform on the result; Fourier analyzing the recorded second spatially-heterodyned hologram by shifting a second original origin of the recorded second spatially-heterodyned hologram including spatial heterodyne fringes in Fourier space to sit on top of a spatial-heterodyne carrier frequency defined as a second angle between a second reference beam and a second object beam; and applying a second digital filter to cut off signals around the second original origin and performing an inverse Fourier transform on the result, wherein digitally recording the first spatially-heterodyned hologram is completed before digitally recording the second spatially-heterodyned hologram and a single digital image includes both the first spatially-heterodyned hologram and the second spatially-heterodyned hologram.
摘要翻译：描述了用于更快处理多空间外差直接数字全息图的系统和方法。一种包括获得多空间外差全息图的方法，包括：数字记录包括用于傅立叶分析的空间外差条纹的第一空间外差全息图; 数字记录包括用于傅立叶分析的空间外差条纹的第二空间外差全息图; 通过将所记录的第一空间外差全息图的第一原始原始位置（包括傅立叶空间中的空间外差条纹）移位到位于第一参考点之间的第一角度的空间外差载波频率之上，从而傅里叶分析所记录的第一空间外差全息图光束和第一物体光束; 施加第一数字滤波器以切断围绕第一原始原点的信号，并对该结果执行逆傅里叶变换; 通过将所记录的第二空间外差全息图的第二原始原点移动到傅立叶空间中的空间外差条纹，以置于空间外差载波频率的顶部上来对第二空间外差全息图进行傅立叶分析，该空间外差载波频率定义为第二参考光束和第二物体光束; 以及施加第二数字滤波器以截断所述第二原始原点周围的信号并对所述结果执行逆傅里叶变换，其中在对所述第二空间外差全息图和单个数字图像进行数字记录之前完成数字记录所述第一空间外差全息图包括第一空间外差全息图和第二空间外差全息图。

8. 发明授权

US07116425B2 Faster processing of multiple spatially-heterodyned direct to digital holograms 失效
标题翻译：更快地处理多个空间外置直接数字全息图
公开(公告)号：US07116425B2
公开(公告)日：2006-10-03
申请号：US10607840
申请日：2003-06-27
申请人： Gregory R. Hanson , Philip R. Bingham
发明人： Gregory R. Hanson , Philip R. Bingham
IPC分类号： G01B11/02
CPC分类号： G03H1/0406 , G03H1/0443 , G03H1/0866 , G03H1/265 , G03H1/28 , G03H2001/0456 , G03H2001/046 , G03H2001/0469 , G03H2226/11 , G03H2226/13
摘要： Systems and methods are described for faster processing of multiple spatially-heterodyned direct to digital holograms. A method includes of obtaining multiple spatially-heterodyned holograms, includes: digitally recording a first spatially-heterodyned hologram including spatial heterodyne fringes for Fourier analysis; digitally recording a second spatially-heterodyned hologram including spatial heterodyne fringes for Fourier analysis; Fourier analyzing the recorded first spatially-heterodyned hologram by shifting a first original origin of the recorded first spatially-heterodyned hologram including spatial heterodyne fringes in Fourier space to sit on top of a spatial-heterodyne carrier frequency defined as a first angle between a first reference beam and a first, object beam; applying a first digital filter to cut off signals around the first original origin and performing an inverse Fourier transform on the result; Fourier analyzing the recorded second spatially-heterodyned hologram by shifting a second original origin of the recorded second spatially-heterodyned hologram including spatial heterodyne fringes in Fourier space to sit on top of a spatial-heterodyne carrier frequency defined as a second angle between a second reference beam and a second object beam; and applying a second digital filter to cut off signals around the second original origin and performing an inverse Fourier transform on the result, wherein digitally recording the first spatially-heterodyned hologram is completed before digitally recording the second spatially-heterodyned hologram and a single digital image includes both the first spatially-heterodyned hologram and the second spatially-heterodyned hologram.
摘要翻译：描述了用于更快处理多空间外差直接数字全息图的系统和方法。一种包括获得多空间外差全息图的方法，包括：数字记录包括用于傅立叶分析的空间外差条纹的第一空间外差全息图; 数字记录包括用于傅立叶分析的空间外差条纹的第二空间外差全息图; 通过将所记录的第一空间外差全息图的第一原始原始位置（包括傅立叶空间中的空间外差条纹）移位到位于第一参考点之间的第一角度的空间外差载波频率之上，从而傅里叶分析所记录的第一空间外差全息图光束和第一个物体光束; 施加第一数字滤波器以切断围绕第一原始原点的信号，并对该结果执行逆傅里叶变换; 通过将所记录的第二空间外差全息图的第二原始原点移动到傅立叶空间中的空间外差条纹，以置于空间外差载波频率的顶部上来对第二空间外差全息图进行傅立叶分析，该空间外差载波频率定义为第二参考光束和第二物体光束; 以及施加第二数字滤波器以截断所述第二原始原点周围的信号并对所述结果执行逆傅里叶变换，其中在对所述第二空间外差全息图和单个数字图像进行数字记录之前完成数字记录所述第一空间外差全息图包括第一空间外差全息图和第二空间外差全息图。

9. 发明授权

US07978336B2 Three wavelength quantitative imaging systems 有权
标题翻译：三波长定量成像系统
公开(公告)号：US07978336B2
公开(公告)日：2011-07-12
申请号：US12381758
申请日：2009-03-16
申请人： Christopher J. Mann , Philip R. Bingham
发明人： Christopher J. Mann , Philip R. Bingham
IPC分类号： G01B9/02 , G01B11/02 , G01N21/41 , G01N21/43
CPC分类号： G01B9/021 , G01B11/0675 , G01B11/2441 , G03H1/0443 , G03H1/0866 , G03H2001/0038 , G03H2001/0456 , G03H2001/0875 , G03H2222/13
摘要： An optical system includes more than two optical interferometers that generate interference phenomena between optical waves to measure a plurality of distances, a plurality of thicknesses, and a plurality of indices of refraction of a sample. An electromagnetic detector receives an output of the optical interferometers to render a magnified image of at least a portion of the sample. A controller reduces or eliminates undesired optical signals through a hierarchical phase unwrapping of the output of the electromagnetic detector.
摘要翻译：光学系统包括两个以上的光学干涉仪，其在光波之间产生干涉现象，以测量样品的多个距离，多个厚度和多个折射率。电磁检测器接收光学干涉仪的输出，以呈现样品的至少一部分的放大图像。控制器通过电磁检测器的输出的分层相位展开来减少或消除不期望的光信号。

10. 发明授权

US07349100B2 Recording multiple spatially-heterodyned direct to digital holograms in one digital image 有权
标题翻译：在一个数字图像中记录多个空间外差的直接数字全息图
公开(公告)号：US07349100B2
公开(公告)日：2008-03-25
申请号：US10607824
申请日：2003-06-27
申请人： Gregory R. Hanson , Philip R. Bingham
发明人： Gregory R. Hanson , Philip R. Bingham
IPC分类号： G01B9/02
CPC分类号： G03H1/0406 , G03H1/0443 , G03H1/0866 , G03H1/265 , G03H1/28 , G03H2001/0456 , G03H2001/046 , G03H2001/0469 , G03H2226/11 , G03H2226/13
摘要： Systems and methods are described for recording multiple spatially-heterodyned direct to digital holograms in one digital image. A method includes digitally recording, at a first reference beam-object beam angle, a first spatially-heterodyned hologram including spatial heterodyne fringes for Fourier analysis; Fourier analyzing the recorded first spatially-heterodyned hologram by shifting a first original origin of the recorded first spatially-heterodyned hologram to sit on top of a first spatial-heterodyne carrier frequency defined by the first reference beam-object beam angle; digitally recording, at a second reference beam-object beam angle, a second spatially-heterodyned hologram including spatial heterodyne fringes for Fourier analysis; Fourier analyzing the recorded second spatially-heterodyned hologram by shifting a second original origin of the recorded second spatially-heterodyned hologram to sit on top of a second spatial-heterodyne carrier frequency defined by the second reference beam-object beam angle; applying a first digital filter to cut off signals around the first original origin and define a first result; performing a first inverse Fourier transform on the first result; applying a second digital filter to cut off signals around the second original origin and define a second result; and performing a second inverse Fourier transform on the second result, wherein the first reference beam-object beam angle is not equal to the second reference beam-object beam angle and a single digital image includes both the first spatially-heterodyned hologram and the second spatially-heterodyned hologram.
摘要翻译：描述了用于在一个数字图像中记录多个空间外差直接数字全息图的系统和方法。一种方法包括以第一参考光束对象光束角度数字地记录包括用于傅立叶分析的空间外差条纹的第一空间外差全息图; 通过将所记录的第一空间外差全息图的第一原始原点移位以位于由第一参考光束 - 物体光束角度限定的第一空间 - 外差载波频率的顶部上，傅里叶分析所记录的第一空间外差全息图; 以第二参考光束 - 物体光束角数字地记录包括用于傅立叶分析的空间外差条纹的第二空间外差全息图; 通过将所记录的第二空间外差全息图的第二原始原点移动到位于由第二参考光束 - 物体光束角度限定的第二空间 - 外差载波频率的顶部上来傅立叶分析所记录的第二空间外差全息图; 应用第一数字滤波器来切断围绕第一原始原点的信号并且定义第一结果; 对所述第一结果执行第一逆傅里叶变换; 施加第二数字滤波器以切断围绕第二原始原点的信号并限定第二结果; 以及对所述第二结果执行第二傅立叶逆变换，其中所述第一参考光束对象光束角度不等于所述第二参考光束对象光束角度，并且单个数字图像包括所述第一空间外差全息图和所述第二空间对象光束角度 - 全息全息图。

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